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Evidence of Interaction Between MAP2K1 and RAB13

The interaction score between MAP2K1 and RAB13 is 1.03.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAP2K1 and RAB13 = -0.11

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.48E-3
Orthology
OrganismMAP2K1 OrthologueRAB13 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YJL128C 0.702 YFL005W 0.247

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains Domains present in MAP2K1 and RAB13:
Domains in MAP2K1Domains in RAB13
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR001806 Ras GTPase superfamily
IPR003579 Ras small GTPase, Rab type
IPR005225 Small GTP-binding protein domain
IPR002078 Sigma-54 factor interaction domain
IPR013753 Ras

The Chi square scores for co-occurrence of domains that are present in MAP2K1 and RAB13 are listed below.

Domain 1Domain 2Chi Square
IPR000719 Protein kinase IPR005225 Small GTP-binding protein domain 22.2209
IPR000719 Protein kinase IPR001806 Ras GTPase superfamily 21.6553
IPR000719 Protein kinase IPR003579 Ras small GTPase, Rab type 17.1866
IPR011009 Protein kinase-like IPR003579 Ras small GTPase, Rab type 9.73611
IPR011009 Protein kinase-like IPR005225 Small GTP-binding protein domain 8.50423
IPR000719 Protein kinase IPR013753 Ras 8.28186
IPR011009 Protein kinase-like IPR001806 Ras GTPase superfamily 8.19786
IPR002290 Serine/threonine protein kinase IPR005225 Small GTP-binding protein domain 4.76786
IPR002290 Serine/threonine protein kinase IPR001806 Ras GTPase superfamily 4.59383
IPR008271 Serine/threonine protein kinase, active site IPR003579 Ras small GTPase, Rab type 4.20243
IPR008271 Serine/threonine protein kinase, active site IPR005225 Small GTP-binding protein domain 3.57389
IPR008271 Serine/threonine protein kinase, active site IPR001806 Ras GTPase superfamily 3.38853
IPR011009 Protein kinase-like IPR013753 Ras 3.10535
IPR002290 Serine/threonine protein kinase IPR003579 Ras small GTPase, Rab type 2.19272
IPR002290 Serine/threonine protein kinase IPR013753 Ras 0.677359
IPR008271 Serine/threonine protein kinase, active site IPR013753 Ras 0.038789

The background colour of the table refers to:

  • Blue Domain is only present in MAP2K1
  • Yellow Domain is only present in RAB13
  • Green Domain is present in both MAP2K1 and RAB13

 0.014
Post-translational Modifications

Protein: MAP2K1

PTMResidueReference
Phosphorylation 218 PubMed, HPRD
Phosphorylation 222 PubMed, HPRD
Phosphorylation 286 PubMed, HPRD
Phosphorylation 292 PubMed, HPRD
Phosphorylation 298 PubMed, HPRD
Phosphorylation 304 PubMed, HPRD
Phosphorylation 386 PubMed, HPRD
Phosphoserine 217 PubMed, HPRD
Phosphoserine 221 PubMed, HPRD

Protein: RAB13

PTMResidueReference
Prenylation 200 PubMed, HPRD
Localisation

Protein: MAP2K1

LocalisationReference
Cytoplasm HPRD

Protein: RAB13

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between MAP2K1 and RAB13 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAP2K1 andRAB13. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAP2K1 has 1523 interactors and RAB13 has 209 interactors of which there are 123 common interactors.

Common InteractorName of Common InteractorScore for MAP2K1-Interactor (?)Score for RAB13-Interactor (?)
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 50.90 0.030
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 23.50 0.030
PLEK PLEK, P47: Pleckstrin 0.515 0.033
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.461 0.033
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.461 0.026
PSCD4 PSCD4, CYT4: Cytohesin-4 0.372 0.033
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.372 0.026
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.037
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.307 0.0416
GAB2 N/A 0.307 0.037
MSN MSN: Moesin 0.275 0.030
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.275 0.036
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.046
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.275 0.033
VAV1 VAV1, VAV: Proto-oncogene vav 0.275 0.0264
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.254 0.090
VASP VASP: Vasodilator-stimulated phosphoprotein 0.251 0.029
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.251 0.026
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.251 0.037
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.233 0.026
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.225 0.026
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.225 0.0296
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.225 0.026
VIL2 N/A 0.225 0.026
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.037
DOK1 DOK1: Docking protein 1 0.225 0.037
IRS2 IRS2: Insulin receptor substrate 2 0.191 0.0416
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.188 0.026
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.171 0.026
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.171 0.033
PSD TYL: TYL protein 0.171 0.037
RIN1 RIN1: Ras and Rab interactor 1 0.171 0.037
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.171 0.029
APS SH2B2, APS: SH2B adapter protein 2 0.171 0.0264
SOS1 SOS1: Son of sevenless homolog 1 0.171 0.037
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.171 0.060
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.044
PSCD2 N/A 0.165 0.056
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.044
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.056
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.044
NF2 NF2, SCH: Merlin 0.165 0.056
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.152 0.029
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.040
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.040
ARHGEF7 N/A 0.148 0.040
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.050
CDC25C CDC25C: M-phase inducer phosphatase 3 0.148 0.025
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.044
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.044
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.040
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.044
ELMO1 N/A 0.148 0.050
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.056
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.139 0.033
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.139 0.026
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.136 0.030
RDX RDX: Radixin 0.136 0.067
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.0264
PLD1 PLD1: Phospholipase D1 0.136 0.030
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.136 0.036
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.136 0.037
RASA3 RASA3: Ras GTPase-activating protein 3 0.136 0.026
NBN NBN, NBS, NBS1, P95: Nibrin 0.132 0.037
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.123 0.0416
GAB1 GAB1: GRB2-associated-binding protein 1 0.123 0.037
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.114 0.033
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.110 0.0296
PLD2 PLD2: Phospholipase D2 0.110 0.046
IRS1 IRS1: Insulin receptor substrate 1 0.109 0.085
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.109 0.064
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.109 0.029
BMX N/A 0.098 0.029
MCF2 MCF2, DBL: Proto-oncogene DBL 0.098 0.026
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.085
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.033
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.097 0.026
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.036
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.088 0.026
DAB1 DAB1: Disabled homolog 1 0.088 0.0296
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.087 1.94
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.046
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.078 0.037
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.075 0.040
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.040
NR3C1 NR3C1, GRL: Glucocorticoid receptor 0.070 0.026
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.069 0.046
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.069 0.0296
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.063 0.046
GRLF1 N/A 0.062 0.051
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.055 0.037
IRF3 IRF3: Interferon regulatory factor 3 0.052 0.033
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.052 0.037
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.049 0.046
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.046 0.039
HIF1A HIF1A, MOP1: Hypoxia-inducible factor 1 alpha 0.046 0.063
MYH9 MYH9: Myosin-9 0.046 0.046
SAT SAT1, SAT: Diamine acetyltransferase 1 0.0425 0.032
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.040 0.0296
SMAD3 SMAD3, MADH3: Mothers against decapentaplegic homolog 3 0.038 0.058
RAB8A RAB8A: RAB8A protein 0.032 0.028
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.029 0.046
ZFYVE16 ZFYVE16, KIAA0305: Zinc finger FYVE domain-containing protein 16 0.029 0.0416
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.029 0.033
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.028 0.056
SYTL4 Endocrine transmitter regulatory protein 0.028 0.056
MITF MITF: Microphthalmia-associated transcription factor 0.028 0.028
PLEKHA3 PLEKHA3, FAPP1: Pleckstrin homology domain-containing family A member 3 0.027 0.027
PSD3 N/A 0.027 0.027
FAM43A N/A 0.027 0.027
ARHGEF1 ARHGEF1: Rho guanine nucleotide exchange factor 1 0.027 0.027
CENTB5 KIAA1716, CENTB5: Centaurin-beta 5 0.027 0.027
SRA1 APBB3, FE65L2: Amyloid beta A4 precursor protein-binding family B member 3 0.027 0.027
RASGRF1 RASGRF1, CDC25: Guanine nucleotide-releasing protein 0.027 0.027
DOK5 DOK5, C20orf180: Docking protein 5 0.027 0.027
PARP9 N/A 0.027 0.027
VEPH1 VEPH1, KIAA1692, VEPH: Ventricular zone-expressed PH domain-containing protein h 0.027 0.027
RASGRF2 RASGRF2: Ras protein-specific guanine nucleotide-releasing factor 2 (Fragment) 0.027 0.027
APBB1 APBB1, FE65, RIR: Amyloid beta A4 precursor protein-binding family B member 1 0.027 0.027
OSBPL9 N/A 0.027 0.027
SMAD1 SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1 0.025 0.050
NCOA3 NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3 0.025 0.028
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.025 0.056
0.347
Total Score 1.03