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Evidence of Interaction Between SNRPF and WDR77

The interaction score between SNRPF and WDR77 is 60.20.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SNRPF and WDR77 = 0.81

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismSNRPF OrthologueWDR77 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
fly Q24297 1 Q9VIP8 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains Domains present in SNRPF and WDR77:
Domains in SNRPFDomains in WDR77
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain
IPR001680 G-protein beta WD-40 repeat
IPR011046 WD40-like

The Chi square scores for co-occurrence of domains that are present in SNRPF and WDR77 are listed below.

Domain 1Domain 2Chi Square
IPR010920 Small nuclear-like ribonucleoprotein IPR001680 G-protein beta WD-40 repeat 22.3132
IPR006649 snRNP domain IPR001680 G-protein beta WD-40 repeat 19.3621
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR001680 G-protein beta WD-40 repeat 18.7041
IPR010920 Small nuclear-like ribonucleoprotein IPR011046 WD40-like 13.0624
IPR006649 snRNP domain IPR011046 WD40-like 11.3909
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR011046 WD40-like 11.0178

The background colour of the table refers to:

  • Blue Domain is only present in SNRPF
  • Yellow Domain is only present in WDR77
  • Green Domain is present in both SNRPF and WDR77

 0.027
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: SNRPF

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: WDR77

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between SNRPF and WDR77 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPF andWDR77. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPF has 240 interactors and WDR77 has 118 interactors of which there are 29 common interactors.

Common InteractorName of Common InteractorScore for SNRPF-Interactor (?)Score for WDR77-Interactor (?)
SNRPD2 SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2 1.05E4 0.263
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 691.00 0.123
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 691.00 0.123
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 205.00 0.123
LSM7 LSM7: U6 snRNA-associated Sm-like protein LSm7 205.00 0.123
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 205.00 0.123
SNRPE SNRPE: Small nuclear ribonucleoprotein E 8.73 0.137
SNRPA SNRPA: U1 small nuclear ribonucleoprotein A 3.89 0.090
SNRPB SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B' 2.91 0.137
SNRPG SNRPG, PBSCG: Small nuclear ribonucleoprotein G 2.60 0.123
LSM3 LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3 2.60 0.074
SF3B3 N/A 1.82 0.123
TXNL4A TXNL4A, DIM1, TXNL4: Thioredoxin-like protein 4A 1.82 0.038
LSM6 LSM6: U6 snRNA-associated Sm-like protein LSm6 1.22 0.074
LSM4 LSM4: U6 snRNA-associated Sm-like protein LSm4 1.22 0.294
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 1.22 0.263
SNRPB2 SNRPB2: U2 small nuclear ribonucleoprotein B'' 0.782 0.038
LSM1 LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1 0.596 0.044
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.294 0.0278
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.294 0.0278
DDX21 DDX21: Nucleolar RNA helicase 2 0.137 0.0278
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.137 0.0278
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.123 0.053
NUTF2 NUTF2, NTF2: Nuclear transport factor 2 0.0968 0.0968
JMJD2C JMJD2C, GASC1, JHDM3C, KIAA0780: JmjC domain-containing histone demethylation pr 0.044 0.028
H2AFZ H2AFZ, H2AZ: Histone H2A.Z 0.044 0.081
BUB3 N/A 0.027 0.027
E2IG3 N/A 0.027 0.027
HSPC185 CGI-117, HSPC111: UPF0384 protein CGI-117 0.027 0.027
0.572
Total Score 60.20