PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between SNRPF and LSM8

The interaction score between SNRPF and LSM8 is 4.71E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between SNRPF and LSM8 = 0.87

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.027

Orthology

Organism

SNRPF Orthologue

LSM8 Orthologue

Experiment

Accession

Accession

worm

fly

Get References From PubMed

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.177

Domains

Domains present in SNRPF and LSM8:

Domains in SNRPF

Domains in LSM8

IPR001163	Small nuclear ribonucleoprotein (Sm protein)
IPR010920	Small nuclear-like ribonucleoprotein
IPR006649	snRNP domain

IPR001163	Small nuclear ribonucleoprotein (Sm protein)
IPR010920	Small nuclear-like ribonucleoprotein
IPR006649	snRNP domain

The Chi square scores for co-occurrence of domains that are present in SNRPF and LSM8 are listed below.

Domain 1		Domain 2		Chi Square
IPR001163	Small nuclear ribonucleoprotein (Sm protein)	IPR006649	snRNP domain	1325.87
IPR001163	Small nuclear ribonucleoprotein (Sm protein)	IPR001163	Small nuclear ribonucleoprotein (Sm protein)	1297.61
IPR006649	snRNP domain	IPR006649	snRNP domain	1206.57
IPR010920	Small nuclear-like ribonucleoprotein	IPR006649	snRNP domain	1168.89
IPR001163	Small nuclear ribonucleoprotein (Sm protein)	IPR010920	Small nuclear-like ribonucleoprotein	1143.95
IPR010920	Small nuclear-like ribonucleoprotein	IPR010920	Small nuclear-like ribonucleoprotein	355.236

The background colour of the table refers to:

Blue Domain is only present in SNRPF
Yellow Domain is only present in LSM8
Green Domain is present in both SNRPF and LSM8

0.265

Post-translational Modifications

Protein: SNRPF

PTM	Residue	Reference

Protein: LSM8

PTM	Residue	Reference
N-acetylthreonine	1	HPRD

Localisation

Protein: SNRPF

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Protein: LSM8

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between SNRPF and LSM8 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPF andLSM8. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPF has 240 interactors and LSM8 has 288 interactors of which there are 190 common interactors.

Common Interactor	Name of Common Interactor	Score for SNRPF-Interactor (?)	Score for LSM8-Interactor (?)
SNRPD2	SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2	1.05E4	2.60
SNRPD1	SNRPD1: Small nuclear ribonucleoprotein Sm D1	691.00	10.30
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	691.00	10.30
LSM5	LSM5: U6 snRNA-associated Sm-like protein LSm5	205.00	4.86
LSM7	LSM7: U6 snRNA-associated Sm-like protein LSm7	205.00	2.60
PRPF4	PRPF4, PRP4: U4/U6 small nuclear ribonucleoprotein Prp4	32.60	0.123
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	19.70	0.257
PRP19	PRPF19, NMP200, PRP19, SNEV: Pre-mRNA-processing factor 19	15.50	0.0968
SNRPE	SNRPE: Small nuclear ribonucleoprotein E	8.73	2.91
SNRPA	SNRPA: U1 small nuclear ribonucleoprotein A	3.89	0.048
SNRPB	SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B'	2.91	2.91
SNRPG	SNRPG, PBSCG: Small nuclear ribonucleoprotein G	2.60	2.60
LSM3	LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3	2.60	10.30
LSM6	LSM6: U6 snRNA-associated Sm-like protein LSm6	1.22	2.60
LSM4	LSM4: U6 snRNA-associated Sm-like protein LSm4	1.22	1.22
LSM2	LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2	1.22	383.00
SNRPB2	SNRPB2: U2 small nuclear ribonucleoprotein B''	0.782	0.048
LSM1	LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1	0.596	0.739
TIAL1	TIAL1: Nucleolysin TIAR	0.366	0.048
DHX15	DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase	0.294	0.294
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.294	0.287
WDR77	WDR77, HKMT1069, hCG_39991: Androgen receptor cofactor p44	0.263	0.123
RBBP4	RBBP4, RBAP48: Histone-binding protein RBBP4	0.263	0.257
LSM11	LSM11: U7 snRNA-associated Sm-like protein LSm11	0.237	0.237
LSM10	LSM10: U7 snRNA-associated Sm-like protein LSm10	0.237	0.237
SNRPN	HCERN3, SNRPN, SMN: Small nuclear ribonucleoprotein-associated protein N	0.158	0.158
DDX21	DDX21: Nucleolar RNA helicase 2	0.137	0.613
GNB2L1	Lung cancer oncogene 7	0.137	0.613
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.137	0.613
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.137	0.287
WDR41	N/A	0.137	0.083
DDX50	DDX50: ATP-dependent RNA helicase DDX50	0.137	0.137
GTF3C2	GTF3C2, KIAA0011: General transcription factor 3C polypeptide 2	0.137	0.137
BLM	BLM, RECQ2, RECQL3: Bloom syndrome protein	0.123	0.156
PPP2R2A	PPP2R2A: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alp	0.123	0.123
DDX10	DDX10: Probable ATP-dependent RNA helicase DDX10	0.123	0.074
DDX1	DDX1: ATP-dependent RNA helicase DDX1	0.123	0.074
CNOT7	CNOT7, CAF1: CCR4-NOT transcription complex subunit 7	0.123	0.263
DDX39	DDX39: ATP-dependent RNA helicase DDX39	0.123	0.123
SND1	SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1	0.123	0.257
POLE	POLE, POLE1: DNA polymerase epsilon catalytic subunit A	0.123	0.074
POLD1	POLD1, POLD: DNA polymerase delta catalytic subunit	0.123	0.123
CSTF1	CSTF1: Cleavage stimulation factor 50 kDa subunit	0.123	0.257
EIF3S2	EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2	0.123	0.257
NUP37	NUP37: Nucleoporin Nup37	0.123	0.123
RAD54L	RAD54L, RAD54A: DNA repair and recombination protein RAD54-like	0.123	0.074
WDR12	WDR12: WD repeat-containing protein 12	0.123	0.074
CGI-48	UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho	0.123	0.257
EIF4A1	EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I	0.123	0.123
CDC20	CDC20: Cell division cycle protein 20 homolog	0.123	0.156
RBBP7	RBBP7, RBAP46: Histone-binding protein RBBP7	0.123	0.123
DDX48	EIF4A3, DDX48, KIAA0111: Eukaryotic initiation factor 4A-III	0.123	0.123
BAT1	N/A	0.123	0.263
WDR3	WDR3: WD repeat-containing protein 3	0.123	0.123
NUP43	N/A	0.123	0.123
NUTF2	NUTF2, NTF2: Nuclear transport factor 2	0.0968	0.047
DDB2	DDB2: DNA damage-binding protein 2	0.083	0.083
KIAA0052	SKIV2L2, KIAA0052: Superkiller viralicidic activity 2-like 2	0.074	0.074
BOP1	BOP1, KIAA0124: Ribosome biogenesis protein BOP1	0.074	0.074
FLJ10439	WDR74, NSA1: WD repeat-containing protein 74	0.074	0.074
HELLS	HELLS, PASG, Nbla10143, SMARCA6: Lymphoid-specific helicase	0.074	0.067
DDX41	DDX41, ABS: Probable ATP-dependent RNA helicase DDX41	0.074	0.156
LRBA	LRBA, BGL, CDC4L, LBA: Lipopolysaccharide-responsive and beige-like anchor prote	0.074	0.074
WDR57	WDR57, PRP8BP, SFP38: WD repeat-containing protein 57	0.074	0.074
DDX23	DDX23: Probable ATP-dependent RNA helicase DDX23	0.074	0.123
TAF5	TAF5, TAF2D: Transcription initiation factor TFIID subunit 5	0.074	0.074
WDR18	N/A	0.074	0.074
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.074	0.257
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.074	0.257
RNU3IP2	RRP9, RNU3IP2, U355K: U3 small nucleolar RNA-interacting protein 2	0.074	0.074
WDR68	WDR68, HAN11: WD repeat-containing protein 68	0.074	0.074
TSSC1	TSSC1: Protein TSSC1	0.074	0.074
DDX27	DDX27, RHLP, HSPC259, PP3241: Probable ATP-dependent RNA helicase DDX27	0.074	0.123
DDX47	E4-DBP: DEAD box protein	0.074	0.123
DDX19A	DDX19A, DDX19L: ATP-dependent RNA helicase DDX19A	0.074	0.123
DDX49	DDX49: Probable ATP-dependent RNA helicase DDX49	0.074	0.074
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.074	0.257
CHAF1B	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B	0.074	0.156
DDX18	DDX18: ATP-dependent RNA helicase DDX18	0.074	0.123
STRAP	STRAP, MAWD, UNRIP: Serine-threonine kinase receptor-associated protein	0.074	0.074
SEC13L1	SEC13, D3S1231E, SEC13L1, SEC13R: Protein SEC13 homolog	0.067	0.083
FBXW2	FBXW2, FBW2, FWD2: F-box/WD repeat-containing protein 2	0.067	0.137
SMARCAL1	SMARCAL1, HARP: SWI/SNF-related matrix-associated actin-dependent regulator of c	0.067	0.083
WDR1	N/A	0.067	0.140
CDC40	CDC40, EHB3, PRP17, PRPF17: Pre-mRNA-processing factor 17	0.060	0.074
WDHD1	WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1	0.060	0.093
ASCC3	ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3	0.060	0.074
GRWD1	GRWD1, GRWD, WDR28: Glutamate-rich WD repeat-containing protein 1	0.060	0.060
DHX35	C20orf15, DHX35, DDX35: Probable ATP-dependent RNA helicase DHX35	0.060	0.060
Nle	NLE1, HUSSY-07: Notchless protein homolog 1	0.060	0.126
WDR39	CIAO1, WDR39: Protein CIAO1	0.060	0.074
RECQL	RECQL, RECQL1: ATP-dependent DNA helicase Q1	0.060	0.074
WRN	WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase	0.060	0.126
PWP2H	PWP2, PWP2H: Periodic tryptophan protein 2 homolog	0.060	0.074
IFIH1	IFIH1, MDA5, RH116: Interferon-induced helicase C domain-containing protein 1	0.060	0.074
PAK1IP1	PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1	0.060	0.126
SEC31L1	N/A	0.060	0.126
SMARCA3	HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor	0.060	0.104
XPMC2H	REXO4, PMC2, XPMC2H: RNA exonuclease 4	0.060	0.074
POLA	POLA1, POLA: DNA polymerase alpha catalytic subunit	0.060	0.060
COPB2	COPB2: Coatomer subunit beta'	0.060	0.126
DDX28	DDX28, MDDX28: Probable ATP-dependent RNA helicase DDX28	0.060	0.060
DHX16	DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN	0.060	0.156
TTF2	TTF2: Transcription termination factor 2	0.060	0.060
DDX54	DDX54: ATP-dependent RNA helicase DDX54	0.060	0.074
RAD54B	RAD54B: DNA repair and recombination protein RAD54B	0.050	0.050
WDR8	WDR8: WD repeat-containing protein 8	0.050	0.083
ISG20	ISG20, HEM45: Interferon-stimulated gene 20 kDa protein	0.050	0.083
HMGN1	HMGN1, HMG14: Non-histone chromosomal protein HMG-14	0.049	0.054
SET	SET: Protein SET	0.049	0.054
DDX5	DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5	0.044	0.156
WIPI2	WIPI2, CGI-50: WD repeat domain phosphoinositide-interacting protein 2	0.044	0.060
DHX38	DHX38, DDX38, KIAA0224, PRP16: Pre-mRNA-splicing factor ATP-dependent RNA helica	0.044	0.074
AAAS	AAAS, ADRACALA, GL003: Aladin	0.044	0.044
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	0.044	0.156
RECQL4	RECQL4, RECQ4: ATP-dependent DNA helicase Q4	0.044	0.036
DDX56	DDX56, DDX21, NOH61: Probable ATP-dependent RNA helicase DDX56	0.044	0.044
CORO1A	CORO1A, CORO1: Coronin-1A	0.044	0.074
CORO7	CORO7: Coronin-7	0.044	0.074
RAE1	RAE1, MRNP41: mRNA export factor	0.044	0.060
ARPC1A	ARPC1A, SOP2L: Actin-related protein 2/3 complex subunit 1A	0.044	0.036
WDR67	WDR67: WD repeat-containing protein 67	0.044	0.044
PARN	PARN, DAN: Poly(A)-specific ribonuclease PARN	0.044	0.044
DDX17	DDX17: Probable ATP-dependent RNA helicase DDX17	0.044	0.074
CORO1C	CORO1C, CRNN4: Coronin-1C	0.044	0.093
SKIV2L	SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti	0.044	0.126
AAMP	AAMP: Angio-associated migratory cell protein	0.044	0.060
REXO2	REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor	0.044	0.093
COPA	COPA: Coatomer subunit alpha	0.044	0.126
GNB1	GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.044	0.093
PIK3R4	PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4	0.044	0.044
JMJD2C	JMJD2C, GASC1, JHDM3C, KIAA0780: JmjC domain-containing histone demethylation pr	0.044	0.060
CNOT8	CNOT8, CALIF, POP2: CCR4-NOT transcription complex subunit 8	0.044	0.074
EML3	EML3: Echinoderm microtubule-associated protein-like 3	0.044	0.074
GNB1L	GNB1L, GY2, FKSG1, KIAA1645, WDR14: Guanine nucleotide-binding protein subunit b	0.041	0.041
REV3L	REV3L, POLZ, REV3: DNA polymerase zeta catalytic subunit	0.041	0.041
ERCC3	ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit	0.036	0.093
HIRA	HIRA, DGCR1, HIR, TUPLE1: Protein HIRA	0.036	0.093
LGP2	DHX58, D11LGP2E, LGP2: Probable ATP-dependent RNA helicase DHX58	0.036	0.050
WDR26	WDR26, CDW2, PRO0852, MIP2: WD repeat-containing protein 26	0.036	0.060
DDX52	DDX52, ROK1, HUSSY-19: Probable ATP-dependent RNA helicase DDX52	0.036	0.044
THRAP5	MED16, DRIP92, THRAP5: Mediator of RNA polymerase II transcription subunit 16	0.036	0.044
DICER1	DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer	0.036	0.093
WDR48	WDR48, KIAA1449: WD repeat-containing protein 48	0.036	0.036
NBEAL2	N/A	0.036	0.044
WDR42A	N/A	0.036	0.044
ARPC1B	ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B	0.036	0.126
GNB2	GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.036	0.093
SETDB1	SETDB1, KIAA0067: Histone-lysine N-methyltransferase SETDB1	0.036	0.036
BRIP1	BRIP1, BACH1, FANCJ: Fanconi anemia group J protein	0.036	0.076
DDX3Y	DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y	0.036	0.093
RNASEH1	RNASEH1, RNH1: Ribonuclease H1	0.0331	0.055
LBR	LBR: Lamin-B receptor	0.0331	0.0331
POLG	POLG, MDP1, POLG1, POLGA: DNA polymerase subunit gamma-1	0.0331	0.055
PHF20	PHF20, C20orf104, GLEA2, HCA58, NZF, TZP: PHD finger protein 20	0.032	0.053
BCDO2	PTS: 6-pyruvoyl tetrahydrobiopterin synthase	0.028	0.046
WDR37	N/A	0.028	0.036
EIF4A2	EIF4A2, DDX2B, EIF4F: Eukaryotic initiation factor 4A-II	0.028	0.036
DDX24	DDX24: ATP-dependent RNA helicase DDX24	0.028	0.076
DDX58	DDX58: Probable ATP-dependent RNA helicase DDX58	0.028	0.044
WDR45L	N/A	0.028	0.036
BUB3	N/A	0.027	0.027
DKFZP586L0724	NOL11, L14: Nucleolar protein 11	0.027	0.027
E2IG3	N/A	0.027	0.027
XTP3TPA	XTP3TPA, CDA03: XTP3-transactivated gene A protein	0.027	0.027
HNRPD	N/A	0.027	0.027
WDR72	N/A	0.027	0.027
TLE3	TLE3, KIAA1547: Transducin-like enhancer protein 3	0.027	0.056
ERCC8	ERCC8, CKN1, CSA: DNA excision repair protein ERCC-8	0.027	0.027
FBXW8	FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6: F-box/WD repeat-containing protein 8	0.027	0.027
SMARCAD1	SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator	0.027	0.056
PHF1	N/A	0.027	0.027
TLE6	TLE6: Transducin-like enhancer protein 6	0.027	0.027
BRWD1	N/A	0.027	0.027
KIF21A	N/A	0.027	0.027
NEDD1	N/A	0.027	0.027
TREX1	TREX1: Three prime repair exonuclease 1	0.027	0.027
TDRD4	TDRD4: Tudor domain-containing protein 4	0.027	0.027
WDR53	N/A	0.027	0.027
RFWD2	RFWD2, COP1, RNF200: E3 ubiquitin-protein ligase RFWD2	0.027	0.027
WDR34	N/A	0.027	0.027
WDR54	N/A	0.027	0.056
TAF5L	TAF5L, PAF65B: TAF5-like RNA polymerase II p300/CBP-associated factor-associated	0.027	0.027
DDX53	DDX53, CAGE: Probable ATP-dependent RNA helicase DDX53	0.027	0.027
FLJ12671	ISG20L2, HSD38, HSD-38: Interferon-stimulated 20 kDa exonuclease-like 2	0.027	0.027
WSB1	WSB1, SWIP1: WD repeat and SOCS box-containing protein 1	0.027	0.027
REXO1L1	REXO1L1, GOR: Exonuclease GOR	0.027	0.027
WDR17	N/A	0.027	0.027
EXOSC8	EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43	0.027	0.027
SNRPB	N/A	0.0258	0.0258

0.572

Total Score

4.71E4