Home
Advanced Search
Help
Update History
Statistics
Downloads
The Barton Group
<<< Back to SNRPF

Evidence of Interaction Between SNRPF and PRPF4

The interaction score between SNRPF and PRPF4 is 28.20.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SNRPF and PRPF4 = 0.75

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology
OrganismSNRPF OrthologuePRPF4 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YPR182W 1 YPR178W 1
  • Other
  • AffinityCaptureMS

Get References From PubMed
worm P34659 1 Q93339 1
fly Q24297 1 Q9VVI0 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in SNRPF and PRPF4:
Domains in SNRPFDomains in PRPF4
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain
IPR001680 G-protein beta WD-40 repeat
IPR003648 Splicing factor motif

The Chi square scores for co-occurrence of domains that are present in SNRPF and PRPF4 are listed below.

Domain 1Domain 2Chi Square
IPR010920 Small nuclear-like ribonucleoprotein IPR001680 G-protein beta WD-40 repeat 22.3132
IPR006649 snRNP domain IPR001680 G-protein beta WD-40 repeat 19.3621
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR001680 G-protein beta WD-40 repeat 18.7041

The background colour of the table refers to:

  • Blue Domain is only present in SNRPF
  • Yellow Domain is only present in PRPF4
  • Green Domain is present in both SNRPF and PRPF4

 0.027
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: SNRPF

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: PRPF4

LocalisationReference
Nucleus HPRD
Nucleolus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between SNRPF and PRPF4 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPF andPRPF4. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPF has 240 interactors and PRPF4 has 134 interactors of which there are 39 common interactors.

Common InteractorName of Common InteractorScore for SNRPF-Interactor (?)Score for PRPF4-Interactor (?)
SNRPD2 SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2 1.05E4 69.60
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 691.00 0.123
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 691.00 69.60
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 205.00 32.60
LSM7 LSM7: U6 snRNA-associated Sm-like protein LSm7 205.00 69.60
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 205.00 0.123
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 19.70 14.00
PRP19 PRPF19, NMP200, PRP19, SNEV: Pre-mRNA-processing factor 19 15.50 1.82
SNRPE SNRPE: Small nuclear ribonucleoprotein E 8.73 0.294
LOC645472 hCG_23490: Uncharacterized protein ENSP00000329276 3.01 0.119
SNRPB SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B' 2.91 0.294
SNRPG SNRPG, PBSCG: Small nuclear ribonucleoprotein G 2.60 69.60
LSM3 LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3 2.60 32.60
PRPF8 PRPF8, PRPC8: Pre-mRNA-processing-splicing factor 8 1.84 3.05
SF3B3 N/A 1.82 0.123
SNRPEL1 RP11-390F4.1-001: Small nuclear ribonucleoprotein polypeptide E-like protein 1. 1.79 0.354
LOC119358 similar to small nuclear ribonucleoprotein D2 1.79 0.071
PRPF3 PRPF3, HPRP3, PRP3: U4/U6 small nuclear ribonucleoprotein Prp3 1.49 1.49
LSM6 LSM6: U6 snRNA-associated Sm-like protein LSm6 1.22 32.60
LSM4 LSM4: U6 snRNA-associated Sm-like protein LSm4 1.22 69.60
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 1.22 32.60
PRPF6 PRPF6, C20orf14: Pre-mRNA-processing factor 6 0.890 6.05
PRPF31 PRPF31, PRP31: U4/U6 small nuclear ribonucleoprotein Prp31 0.890 1.82
LSM1 LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1 0.596 0.074
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.294 0.059
DDX21 DDX21: Nucleolar RNA helicase 2 0.137 0.059
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.137 0.0278
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.137 0.059
DDX50 DDX50: ATP-dependent RNA helicase DDX50 0.137 0.0278
EIF4A1 EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I 0.123 0.053
BAT1 N/A 0.123 0.053
NULL N/A 0.119 0.119
RNU3IP2 RRP9, RNU3IP2, U355K: U3 small nucleolar RNA-interacting protein 2 0.074 1.82
DDX19A DDX19A, DDX19L: ATP-dependent RNA helicase DDX19A 0.074 0.053
DDX18 DDX18: ATP-dependent RNA helicase DDX18 0.074 0.053
H2AFZ H2AFZ, H2AZ: Histone H2A.Z 0.044 0.038
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.027 0.027
BUB3 N/A 0.027 0.027
HNRPD N/A 0.027 0.027
2.15E-3
Total Score 28.20