PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between FOXO1A and STAT1

The interaction score between FOXO1A and STAT1 is 8.92.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

N/A

Orthology

Organism	FOXO1A Orthologue		STAT1 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
worm	Q86S42	0.285	Q9NAD6	0.067

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.22E-3

Domains

Domains present in FOXO1A and STAT1:

Domains in FOXO1A

Domains in STAT1

IPR001766	Fork head transcription factor
IPR011991	Wing_hlx_DNA_bd.

IPR000980	SH2 motif
IPR001217	STAT protein
IPR011992	EF-Hand_type.
IPR012345	STAT_DNA_bd.

The Chi square scores for co-occurrence of domains that are present in FOXO1A and STAT1 are listed below.

Domain 1		Domain 2		Chi Square
IPR011991	Wing_hlx_DNA_bd.	IPR000980	SH2 motif	7.84694
IPR011991	Wing_hlx_DNA_bd.	IPR001217	STAT protein	2.24264
IPR011991	Wing_hlx_DNA_bd.	IPR012345	STAT_DNA_bd.	2.24264
IPR011991	Wing_hlx_DNA_bd.	IPR011992	EF-Hand_type.	1.04692

The background colour of the table refers to:

Blue Domain is only present in FOXO1A
Yellow Domain is only present in STAT1
Green Domain is present in both FOXO1A and STAT1

0.083

Post-translational Modifications

Protein: FOXO1A

PTM	Residue	Reference
Phosphorylation	24	PubMed, HPRD
Phosphorylation	256	PubMed, HPRD
Phosphorylation	319	PubMed, HPRD
Phosphorylation	322	PubMed, HPRD
Phosphorylation	325	PubMed, HPRD
Phosphorylation	329	PubMed, HPRD
Phosphoserine	256	PubMed, HPRD
Phosphoserine	319	PubMed, HPRD
Phosphothreonine	24	PubMed, HPRD

Protein: STAT1

PTM	Residue	Reference
Dephosphorylation	701	PubMed, HPRD
Dephosphorylation	727	PubMed, HPRD
Methylation	31	PubMed, HPRD
Phosphorylation	701	PubMed, HPRD
Phosphorylation	727	PubMed, HPRD
Phosphoserine	727	HPRD
Phosphotyrosine	701	PubMed, HPRD
Sumoylation	703	PubMed, HPRD

Localisation

Protein: FOXO1A

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Protein: STAT1

Localisation	Reference
Nucleus	HPRD
Nucleolus	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between FOXO1A and STAT1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between FOXO1A andSTAT1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , FOXO1A has 805 interactors and STAT1 has 1786 interactors of which there are 697 common interactors.

Common Interactor	Name of Common Interactor	Score for FOXO1A-Interactor (?)	Score for STAT1-Interactor (?)
CCNB1	Cyclin B1	2.77	0.025
CDK2	CDK2: Cell division protein kinase 2	0.533	0.148
NFATC1	N/A	0.416	0.083
RBL2	RBL2, RB2: Retinoblastoma-like protein 2	0.372	0.025
NCOR1	NCOR1, KIAA1047: Nuclear receptor corepressor 1	0.307	0.025
IRF3	IRF3: Interferon regulatory factor 3	0.307	0.165
TGIF2	TGIF2: Homeobox protein TGIF2	0.307	0.028
SIRT1	SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1	0.275	0.025
BATF	BATF: Basic leucine zipper transcriptional factor ATF-like	0.251	0.083
MLL	MLL, ALL1, HRX, HTRX, TRX1: Zinc finger protein HRX	0.225	0.075
JUNB	JUNB: Transcription factor jun-B	0.225	0.075
ATF1	ATF1: Cyclic AMP-dependent transcription factor ATF-1	0.225	0.075
BAZ2A	BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A	0.225	0.075
SMAD4	SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4	0.225	0.025
TCF8	ZEB1, AREB6, TCF8: Zinc finger E-box-binding homeobox 1	0.225	0.025
SATB1	SATB1: DNA-binding protein SATB1	0.225	0.025
JUND	JUND: Transcription factor jun-D	0.225	0.075
CCNL1	CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1	0.225	0.025
BRD2	BRD2, KIAA9001, RING3: Bromodomain-containing protein 2	0.225	0.075
SMAD3	SMAD3, MADH3: Mothers against decapentaplegic homolog 3	0.225	0.025
SMAD2	SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2	0.225	0.025
ADPRT	PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1	0.216	1.37
ZNF148	ZNF148, ZBP89: Zinc finger protein 148	0.210	0.028
SP100	N/A	0.210	0.028
POU2F1	POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1	0.191	0.028
NBN	NBN, NBS, NBS1, P95: Nibrin	0.191	0.052
SF3B1	SF3B1, SAP155: Splicing factor 3B subunit 1	0.188	0.025
ATM	ATM: Serine-protein kinase ATM	0.188	0.148
GTF2B	GTF2B, TF2B, TFIIB: Transcription initiation factor IIB	0.171	0.025
ATF6	ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha	0.171	0.075
CREBBP	CREBBP, CBP: CREB-binding protein	0.171	35.90
BRPF1	BRPF1, BR140: Peregrin	0.171	0.075
JUN	JUN: Transcription factor AP-1	0.171	0.075
CUTL1	CUTL1: Homeobox protein cut-like 1	0.165	0.028
NFATC2	NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2	0.165	0.083
ZHX1	ZHX1: Zinc fingers and homeoboxes protein 1	0.165	0.028
KIAA1443	HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez	0.165	0.028
NFATC3	NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3	0.165	0.083
FOXM1	FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1	0.165	0.083
ZNF24	ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24	0.155	0.025
SCYL3	SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin	0.155	0.165
ELF1	ELF1: ETS-related transcription factor Elf-1	0.155	0.083
FOXJ2	FOXJ2, FHX: Forkhead box protein J2	0.152	0.083
SNAPC4	SNAPC4, SNAP190: snRNA-activating protein complex subunit 4	0.152	0.028
BAZ1B	BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain	0.152	0.083
RB1	RB1: Retinoblastoma-associated protein	0.152	0.028
FOSL2	FOSL2, FRA2: Fos-related antigen 2	0.152	0.075
TERF1	TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1	0.152	0.028
TRIM28	TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta	0.152	0.083
TERF2	TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2	0.152	0.028
BACH1	BACH1: Transcription regulator protein BACH1	0.152	0.083
RBL1	RBL1: Retinoblastoma-like protein 1	0.148	0.025
CCNT2	CCNT2: Cyclin-T2	0.148	0.025
C10orf9	CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y	0.148	0.025
CCNE1	CCNE1, CCNE: G1/S-specific cyclin-E1	0.148	0.025
BRD4	N/A	0.148	0.075
DLX3	DLX3: Homeobox protein DLX-3	0.148	0.025
HOXA10	HOXA10, HOX1H: Homeobox protein Hox-A10	0.148	0.025
SMAD1	SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1	0.148	0.025
CREB1	CREB1: cAMP response element-binding protein	0.148	0.075
ISL2	ISL2: Insulin gene enhancer protein ISL-2	0.148	0.075
STK38	STK38, NDR1: Serine/threonine-protein kinase 38	0.139	0.148
HIST1H1D	HIST1H1D, H1F3: Histone H1.3	0.139	0.075
RPS6KB1	N/A	0.139	0.148
ETS1	ETS1, EWSR2: Protein C-ets-1	0.139	0.075
RERE	RERE, ARG, ARP, ATN1L, KIAA0458: Arginine-glutamic acid dipeptide repeats protei	0.136	0.025
NFE2L2	NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2	0.136	0.075
CCNH	CCNH: Cyclin-H	0.136	0.025
NR3C1	NR3C1, GRL: Glucocorticoid receptor	0.127	0.083
SUZ12	SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12	0.127	0.028
UBTF	UBTF, UBF, UBF1: Nucleolar transcription factor 1	0.127	0.028
ZNF318	ZNF318, HRIHFB2436: Zinc finger protein 318	0.127	0.028
AKAP8	AKAP8, AKAP95: A-kinase anchor protein 8	0.127	0.025
RELA	RELA, NFKB3: Transcription factor p65	0.127	0.075
ZFX	ZFX: Zinc finger X-chromosomal protein	0.127	0.028
YY1	YY1: Transcriptional repressor protein YY1	0.127	0.025
CEBPB	CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta	0.123	0.075
FOS	FOS, G0S7: Proto-oncogene protein c-fos	0.123	0.075
ESR1	ESR1, ESR, NR3A1: Estrogen receptor	0.123	0.052
PRKD2	PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2	0.118	0.148
GRK5	GRK5, GPRK5: G protein-coupled receptor kinase 5	0.114	0.148
ZNF217	ZNF217, ZABC1: Zinc finger protein 217	0.114	0.025
ZNF76	ZNF76, D6S229E: Zinc finger protein 76	0.114	0.025
ZBTB40	ZBTB40, KIAA0478: Zinc finger and BTB domain-containing protein 40	0.114	0.025
STAT5B	STAT5B: Signal transducer and activator of transcription 5B	0.114	199.00
RPS6KB2	RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2	0.114	0.148
STAT4	STAT4: Signal transducer and activator of transcription 4	0.114	22.50
ADRBK1	ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1	0.114	0.148
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.114	0.025
PKN2	PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2	0.114	0.148
ZNF335	ZNF335: Zinc finger protein 335	0.114	0.025
ATR	ATR, FRP1: Serine/threonine-protein kinase ATR	0.114	0.028
PIP5K3	PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase	0.114	0.148
HIST1H1E	HIST1H1E, H1F4: Histone H1.4	0.114	0.075
ZNF224	ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27: Zinc finger protein 224	0.114	0.025
RPS6KA5	RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5	0.114	0.148
BRD3	BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3	0.110	0.075
MCM3	MCM3: DNA replication licensing factor MCM3	0.110	0.047
GCN5L2	GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2	0.110	0.075
MCM2	MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2	0.110	0.047
PCAF	PCAF: Histone acetyltransferase PCAF	0.110	0.075
CDK5R1	CDK5R1, CDK5R, NCK5A: Cyclin-dependent kinase 5 activator 1 precursor	0.110	0.083
NFIB	N/A	0.109	0.028
MAFG	MAFG: Transcription factor MafG	0.109	0.075
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.109	0.083
MYB	MYB: Myb proto-oncogene protein	0.109	0.028
ZHX3	ZHX3, KIAA0395, TIX1: Zinc fingers and homeoboxes protein 3	0.109	0.028
MYBL2	MYBL2, BMYB: Myb-related protein B	0.109	0.028
SMAD7	SMAD7, MADH7, MADH8: Mothers against decapentaplegic homolog 7	0.109	0.028
TERF2IP	TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1	0.109	0.052
CEBPE	CEBPE: CCAAT/enhancer-binding protein epsilon	0.109	0.075
TAF1	TAF1, BA2R, CCG1, CCGS, TAF2A: Transcription initiation factor TFIID subunit 1	0.109	0.083
CEBPA	CEBPA: CCAAT/enhancer-binding protein alpha	0.109	0.165
CDX2	CDX2, CDX3: Homeobox protein CDX-2	0.109	0.028
DDIT3	DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3	0.109	0.083
MCM4	MCM4, CDC21: DNA replication licensing factor MCM4	0.097	0.047
RFX1	RFX1: MHC class II regulatory factor RFX1	0.097	0.075
HOXB6	HOXB6, HOX2B: Homeobox protein Hox-B6	0.097	0.025
MLLT7	N/A	0.097	0.025
FOXL2	FOXL2: Forkhead box protein L2	0.097	0.075
CCND1	CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1	0.097	0.025
FOXO3A	FOXO3A, FKHRL1: Forkhead box protein O3A	0.097	0.075
ID2	ID2: DNA-binding protein inhibitor ID-2	0.096	0.028
XRCC1	XRCC1: DNA-repair protein XRCC1	0.096	0.052
HIVEP1	N/A	0.096	0.028
H1FX	H1FX: Histone H1x	0.096	0.083
MATR3	MATR3, KIAA0723: Matrin-3	0.096	0.028
ROCK1	ROCK1: Rho-associated protein kinase 1	0.096	0.165
SATB2	SATB2, KIAA1034: DNA-binding protein SATB2	0.088	0.025
NKX2-5	NKX2-5, CSX, NKX2.5, NKX2E: Homeobox protein Nkx-2.5	0.088	0.025
EN2	EN2: Homeobox protein engrailed-2	0.088	0.025
SOS1	SOS1: Son of sevenless homolog 1	0.087	0.148
KLF13	KLF13, BTEB3, NSLP1: Krueppel-like factor 13	0.086	0.025
SP3	SP3: Transcription factor Sp3	0.086	0.025
HSF2	HSF2, HSTF2: Heat shock factor protein 2	0.086	0.075
GTF2F1	GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha	0.086	0.075
TOPBP1	TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1	0.086	0.047
APEX1	APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase	0.086	0.025
EIF2B5	EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon	0.086	0.047
EXOSC2	EXOSC2, RRP4: Exosome complex exonuclease RRP4	0.086	0.047
RPA2	RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit	0.086	0.075
PPP1R8	N/A	0.086	0.025
MTF1	MTF1: Metal regulatory transcription factor 1	0.086	0.025
ZFP91	ZFP91, FKSG11: Zinc finger protein 91 homolog	0.083	0.028
ZNF579	ZNF579: Zinc finger protein 579	0.083	0.028
MAPK9	MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9	0.083	0.165
POGZ	POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain	0.083	0.028
ZNF295	ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295	0.083	0.028
SOX8	SOX8: Transcription factor SOX-8	0.083	0.028
PKN1	PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1	0.083	0.165
ZFPM1	ZFPM1, FOG1: Zinc finger protein ZFPM1	0.083	0.028
ELF2	ELF2, NERF: ETS-related transcription factor Elf-2	0.083	0.083
HTATIP	HTATIP, TIP60: Histone acetyltransferase HTATIP	0.083	0.083
ZNF644	ZNF644, KIAA1221, ZEP2: Zinc finger protein 644	0.083	0.028
TAL2	TAL2: T-cell acute lymphocytic leukemia protein 2	0.083	0.025
CARHSP1	CARHSP1: Calcium-regulated heat stable protein 1	0.083	0.047
STAT6	STAT6: Signal transducer and activator of transcription 6	0.0818	131.00
PIK3CD	PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i	0.080	0.165
CTDP1	CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase	0.077	0.052
ETV6	ETV6, TEL, TEL1: Transcription factor ETV6	0.077	0.148
AKAP8L	AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like	0.077	0.028
MYST4	MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4	0.077	0.075
TP53BP1	TP53BP1: Tumor suppressor p53-binding protein 1	0.077	0.052
ID3	ID3, 1R21, HEIR-1: DNA-binding protein inhibitor ID-3	0.077	0.028
ZBTB33	KAISO, ZBTB33, ZNF348: Transcriptional regulator Kaiso	0.077	0.028
SAT	SAT1, SAT: Diamine acetyltransferase 1	0.077	0.028
MEF2A	N/A	0.077	0.028
RBM10	RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10	0.075	0.025
PRKACA	PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit	0.075	0.148
PRDM2	PRDM2, RIZ: PR domain zinc finger protein 2	0.075	0.025
RPS6KA4	RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4	0.075	0.148
LATS1	LATS1, WARTS: Serine/threonine-protein kinase LATS1	0.075	0.148
GATAD2B	GATAD2B, KIAA1150: Transcriptional repressor p66 beta	0.075	0.025
ARID1A	ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A	0.075	0.025
AKT3	AKT3: RAC-gamma serine/threonine-protein kinase	0.075	0.148
RPS6KA2	RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2	0.075	0.148
ZNF174	ZNF174, ZSCAN8: Zinc finger protein 174	0.075	0.025
TFAP4	TFAP4: Transcription factor AP-4	0.075	0.025
HIST1H1C	HIST1H1C, H1F2: Histone H1.2	0.075	0.075
SGK2	SGK2: Serine/threonine-protein kinase Sgk2	0.075	0.165
LATS2	LATS2, KPM: Serine/threonine-protein kinase LATS2	0.075	0.148
FARSLA	FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain	0.075	0.075
TRERF1	TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1	0.075	0.025
CHEK2	CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2	0.075	0.148
NIPBL	N/A	0.075	0.025
OSR1	OSR1, ODD: Protein odd-skipped-related 1	0.075	0.025
ELMO1	N/A	0.075	0.148
RNF20		0.075	0.025
DHX8	DHX8, DDX8: ATP-dependent RNA helicase DHX8	0.075	0.047
PKN3	PKN3, PKNBETA: Serine/threonine-protein kinase N3	0.075	0.148
raptor	RAPTOR, KIAA1303: Regulatory-associated protein of mTOR	0.075	0.025
PLCG1	PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1	0.074	0.109
IKBKB	IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta	0.070	0.165
PHF3	PHF3, KIAA0244: PHD finger protein 3	0.070	0.028
USP34	USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34	0.070	0.028
NCOA3	N/A	0.070	0.028
DEF6	DEF6, IBP: Differentially expressed in FDCP 6	0.070	0.028
HIST1H1B	HIST1H1B, H1F5: Histone H1.5	0.069	0.187
SNAI1	SNAI1, SNAH: Zinc finger protein SNAI1	0.069	0.025
SRF	SRF: Serum response factor	0.069	0.028
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.069	0.025
BARD1	BARD1: BRCA1-associated RING domain protein 1	0.069	0.047
RPS6KA1	RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1	0.069	0.148
PPARG	CREB3L2-PPARgamma	0.069	0.047
NR5A1	NR5A1, AD4BP, FTZF1, SF1: Steroidogenic factor 1	0.069	0.047
MEF2D	MEF2D: Myocyte-specific enhancer factor 2D	0.069	0.025
YBX1	YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1	0.069	0.047
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	0.069	0.047
ELMO2	ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2	0.069	0.148
ZBTB16	ZBTB16, PLZF, ZNF145: Zinc finger and BTB domain-containing protein 16	0.069	0.025
EXOC2	N/A	0.067	0.044
DOCK2	DOCK2, KIAA0209: Dedicator of cytokinesis protein 2	0.067	0.098
ATAD2	ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2	0.064	0.044
CBLB	CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B	0.063	0.148
SFRS5	SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5	0.063	0.025
NACA	NACA, HSD48: Nascent polypeptide-associated complex subunit alpha	0.063	0.148
REST	REST, NRSF, XBR: RE1-silencing transcription factor	0.062	0.028
ZNF267	ZNF267: Zinc finger protein 267	0.062	0.028
BRCA2	BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein	0.062	0.083
STAT2	STAT2: Signal transducer and activator of transcription 2	0.062	0.165
DRIM	UTP20, DRIM: Small subunit processome component 20 homolog	0.062	0.028
PGR	PGR, NR3C3: Progesterone receptor	0.062	0.052
ERF	ERF: ETS domain-containing transcription factor ERF	0.062	0.083
EIF5AP1	EIF5A: Eukaryotic translation initiation factor 5A-1	0.062	0.052
ZBTB7A	ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A	0.062	0.025
PRKDC	PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit	0.062	0.028
SH3BP3		0.062	0.028
ETS2	ETS2: Protein C-ets-2	0.062	0.165
ERG	ERG: Transcriptional regulator ERG	0.062	0.083
GTF2F2	N/A	0.062	0.083
SH3BP2	SH3BP2: Uncharacterized protein SH3BP2	0.061	0.109
TP53	TP53, P53: Cellular tumor antigen p53	0.060	0.187
OSBPL11	OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11	0.060	0.165
TCF3	TCF3, E2A, ITF1: Transcription factor E2-alpha	0.060	0.025
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.060	0.028
FXR1	FXR1: Fragile X mental retardation syndrome-related protein 1	0.057	0.044
RPS6KA3	RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3	0.056	0.062
NR4A2	NR4A2, NOT, NURR1, TINUR: Orphan nuclear receptor NR4A2	0.056	0.047
MTA1	MTA1: Metastasis-associated protein MTA1	0.056	0.025
HMGB2	HMGB2, HMG2: High mobility group protein B2	0.056	0.025
SGK3	SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3	0.056	0.148
AHR	AHR: Aryl hydrocarbon receptor precursor	0.056	0.025
MEF2C	MEF2C: Myocyte-specific enhancer factor 2C	0.056	0.025
ZNF551	N/A	0.056	0.025
SLC4A1AP	SLC4A1AP: Uncharacterized protein SLC4A1AP	0.056	0.025
LIG4	LIG4: DNA ligase 4	0.056	0.047
HSF1	HSF1, HSTF1: Heat shock factor protein 1	0.056	0.075
AKT1	AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase	0.056	0.148
GTF2A1	GTF2A1, TF2A1: Transcription initiation factor IIA subunit 1	0.056	0.025
LEF1	LEF1: Lymphoid enhancer-binding factor 1	0.056	0.025
YARS	YARS: Tyrosyl-tRNA synthetase, cytoplasmic	0.056	0.047
WDHD1	WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1	0.056	0.025
SP1	SP1, TSFP1: Transcription factor Sp1	0.056	0.025
STK38L	STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like	0.056	0.148
FHOD1	FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1	0.056	0.025
CSDA	CSDA, DBPA: DNA-binding protein A	0.056	0.025
EEA1	EEA1, ZFYVE2: Early endosome antigen 1	0.056	0.025
MYF5	MYF5: Myogenic factor 5	0.056	0.075
NR4A1	CDNA FLJ16818 fis, clone TRACH1000193, highly similar to Orphan nuclear receptor	0.056	0.047
SOX11	SOX11: Transcription factor SOX-11	0.055	0.025
AANAT	AANAT, SNAT: Serotonin N-acetyltransferase	0.055	0.028
MYCN	MYCN, NMYC: N-myc proto-oncogene protein	0.055	0.025
GRK1	GRK1, RHOK: Rhodopsin kinase precursor	0.055	0.165
FRAP1	FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein	0.055	0.165
MKI67	MKI67: Antigen KI-67	0.055	0.028
SOX4	SOX4: Transcription factor SOX-4	0.055	0.028
PPARA	PPARA, NR1C1, PPAR: Peroxisome proliferator-activated receptor alpha	0.055	0.052
BNC1	BNC1, BNC: Zinc finger protein basonuclin-1	0.055	0.025
RXRA	RXRA, NR2B1: Retinoic acid receptor RXR-alpha	0.055	0.052
RASA3	RASA3: Ras GTPase-activating protein 3	0.054	0.098
ARHGEF6	ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6	0.054	0.098
VAV1	VAV1, VAV: Proto-oncogene vav	0.054	0.098
CENTB2	CENTB2, KIAA0041: Centaurin-beta 2	0.054	0.148
PSMD4	PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4	0.054	0.025
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.054	0.025
CDK3	CDK3: Cell division protein kinase 3	0.053	0.027
NCOA3	NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3	0.052	0.028
HES6	HES6: Transcription cofactor HES-6	0.052	0.083
ARNT	ARNT: Aryl hydrocarbon receptor nuclear translocator	0.052	0.028
MAPK15	N/A	0.052	0.165
C20orf18	N/A	0.052	0.028
SMARCAD1	SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator	0.052	0.028
RBM6	RBM6, DEF3: RNA-binding protein 6	0.052	0.028
RBM3	RBM3, RNPL: Putative RNA-binding protein 3	0.052	0.028
MARK2	N/A	0.052	0.028
IFI16	N/A	0.052	0.028
PTMA	N/A	0.052	0.028
GNB2L1	Lung cancer oncogene 7	0.052	0.028
PASK	PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase	0.052	0.165
TLK1	TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1	0.052	0.165
JMJD1A	JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr	0.052	0.028
FNBP4	FNBP4, FBP30, KIAA1014: Formin-binding protein 4	0.052	0.028
MAPK13	MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13	0.051	0.098
ELK1	ELK1: ETS domain-containing protein Elk-1	0.050	0.075
ROCK2	ROCK2, KIAA0619: Rho-associated protein kinase 2	0.050	0.148
ESRRA	ESRRA, ERR1, ESRL1, NR3B1: Steroid hormone receptor ERR1	0.049	0.052
KLF1	KLF1, EKLF: Krueppel-like factor 1	0.049	0.025
HAND1	HAND1, EHAND: Heart- and neural crest derivatives-expressed protein 1	0.049	0.025
ETV1	ETV1, ER81: ETS translocation variant 1	0.049	0.083
E2F1	E2F1, RBBP3: Transcription factor E2F1	0.049	0.083
TAL1	TAL1, SCL, TCL5: T-cell acute lymphocytic leukemia protein 1	0.049	0.028
MAPK10	MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10	0.049	0.109
MAPK8	MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8	0.049	0.109
YWHAG	YWHAG: 14-3-3 protein gamma	0.049	0.0333
VDR	VDR, NR1I1: Vitamin D3 receptor	0.049	0.047
PRKG1	PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme	0.049	0.148
SGK	SGK, SGK1: Serine/threonine-protein kinase Sgk1	0.049	0.148
NR1D1	NR1D1, EAR1, HREV, THRAL: Orphan nuclear receptor NR1D1	0.049	0.047
CLASP1	CLASP1, KIAA0622, MAST1: CLIP-associating protein 1	0.049	0.025
MAPK3	MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3	0.049	71.20
PSMD1	PSMD1: 26S proteasome non-ATPase regulatory subunit 1	0.049	0.025
ORC1L	ORC1L, ORC1, PARC1: Origin recognition complex subunit 1	0.049	0.075
HIST1H1A	HIST1H1A, H1F1: Histone H1.1	0.049	0.075
BRCA1	BRCA1, RNF53: Breast cancer type 1 susceptibility protein	0.049	0.075
EIF4G3	EIF4G3: Eukaryotic translation initiation factor 4 gamma 3	0.049	0.025
HES1	HES1, HL, HRY: Transcription factor HES-1	0.049	0.075
SYMPK	SYMPK, SPK: Symplekin	0.049	0.025
EGR1	EGR1, ZNF225: Early growth response protein 1	0.049	0.025
MAPK12	MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12	0.049	0.148
KLF5	KLF5, BTEB2, CKLF, IKLF: Krueppel-like factor 5	0.049	0.025
KIAA0690	N/A	0.049	0.025
PRKCA	PRKCA, PKCA, PRKACA: Protein kinase C alpha type	0.049	0.148
HIF1A	HIF1A, MOP1: Hypoxia-inducible factor 1 alpha	0.048	0.025
DOK1	DOK1: Docking protein 1	0.048	0.148
PLEK	PLEK, P47: Pleckstrin	0.048	0.165
IRS1	IRS1: Insulin receptor substrate 1	0.048	0.165
APPL	APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha	0.048	0.165
PDPK1	PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1	0.047	0.148
EWSR1	EWSR1, EWS: RNA-binding protein EWS	0.047	0.156
ATRX	ATRX, RAD54L, XH2: Transcriptional regulator ATRX	0.047	0.025
MLXIPL	MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein	0.047	0.025
MAX	MAX: Protein max	0.047	0.025
PAPOLA	PAPOLA, PAP: Poly(A) polymerase alpha	0.046	0.025
NEK9	NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9	0.046	0.148
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.046	0.025
JARID1A	JARID1A, RBBP2, RBP2: Histone demethylase JARID1A	0.046	0.025
STK4	STK4, MST1: Serine/threonine-protein kinase 4	0.046	0.148
UTX	UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein	0.046	0.025
PABPC1	PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1	0.046	0.025
EML4	EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4	0.046	0.025
PRPF4B	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol	0.046	0.148
EIF3S4	EIF3S4: Eukaryotic translation initiation factor 3 subunit 4	0.046	0.025
DDX5	DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5	0.046	0.025
KIAA1012	KIAA1012: Protein TRS85 homolog	0.046	0.025
SNRP70	SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa	0.046	0.025
PHF10	N/A	0.046	0.025
WBSCR20A	N/A	0.046	0.025
HDAC1	HDAC1, RPD3L1: Histone deacetylase 1	0.046	0.075
FNBP1	N/A	0.046	0.148
BTK	BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK	0.046	0.980
PRKCE	PRKCE, PKCE: Protein kinase C epsilon type	0.044	0.148
CDC6	CDC6, CDC18L: Cell division control protein 6 homolog	0.044	0.075
SALL1	SALL1, SAL1: Sal-like protein 1	0.044	0.025
PRKCG	PRKCG, PKCG: Protein kinase C gamma type	0.044	0.148
STAT3		0.044	14.80
HGS	HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate	0.043	0.047
PIK3CG	PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i	0.043	0.148
MAP4K1	MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1	0.0425	0.165
SFRS15	SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15	0.0425	0.028
TMEM1	TMEM1, EHOC1: Transmembrane protein 1	0.0425	0.028
USP24	USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24	0.0425	0.028
LCP2	LCP2: Lymphocyte cytosolic protein 2	0.0425	0.165
DAXX	DAXX, BING2, DAP6: Death domain-associated protein 6	0.0425	0.028
SAFB	SAFB, HAP, HET, SAFB1: Scaffold attachment factor B	0.0425	0.083
RFXDC2	RFXDC2: Regulatory factor X domain-containing protein 2.	0.0425	0.028
MAP3K14	MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14	0.0425	0.165
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.0425	0.028
VCPIP1	VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135	0.0425	0.028
CXorf9	N/A	0.0425	0.148
KIAA0853	N/A	0.0425	0.028
RANBP2	RANBP2, NUP358: E3 SUMO-protein ligase RanBP2	0.041	0.098
PSCD4	PSCD4, CYT4: Cytohesin-4	0.041	0.098
ARHGAP12	ARHGAP12: Rho GTPase-activating protein 12	0.041	0.098
STAT5A	STAT5A, STAT5: Signal transducer and activator of transcription 5A	0.041	131.00
PRKCQ	PRKCQ, PRKCT: Protein kinase C theta type	0.041	0.098
EPS15	EPS15, AF1P: Epidermal growth factor receptor substrate 15	0.041	0.036
RNF31	ISGF3G, IRF9: Transcriptional regulator ISGF3 subunit gamma	0.041	0.027
LNK	SH2B3, LNK: SH2B adapter protein 3	0.04	0.109
ITSN1	ITSN1, ITSN, SH3D1A: Intersectin-1	0.04	0.109
ITK	ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK	0.04	0.980
DNM3	DNM3: Uncharacterized protein DNM3	0.04	0.109
RASA1	RASA1, RASA: Ras GTPase-activating protein 1	0.04	0.109
PSCD2	N/A	0.04	0.109
AXIN1		0.04	0.049
PSCD1	PSCD1, D17S811E: Cytohesin-1	0.04	0.109
IRS2	IRS2: Insulin receptor substrate 2	0.039	0.165
MDM4	MDM4, MDMX: Mdm4 protein	0.039	0.028
PABPN1	PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2	0.038	0.025
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	0.038	0.025
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	0.038	0.025
SFRS2	SFRS2: Splicing factor, arginine/serine-rich 2	0.038	0.025
SEC31L1	N/A	0.038	0.025
SFRS4	SFRS4, SRP75: Splicing factor, arginine/serine-rich 4	0.038	0.025
STK10	STK10: Uncharacterized protein STK10	0.038	0.148
KLHDC4	N/A	0.038	0.028
PIK4CB	PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic,	0.038	0.025
TAOK3	TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3	0.038	0.148
SFRS10	SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10	0.038	0.025
STAG2	STAG2, SA2: Cohesin subunit SA-2	0.038	0.025
RBM15	RBM15, OTT: Putative RNA-binding protein 15	0.038	0.025
PPP1R12A	PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A	0.038	0.025
SFRS6	SFRS6, SRP55: Splicing factor, arginine/serine-rich 6	0.038	0.025
HIST3H3	HIST3H3, H3FT: Histone H3.1t	0.038	0.025
NEK7	NEK7: Serine/threonine-protein kinase Nek7	0.038	0.148
DDX24	DDX24: ATP-dependent RNA helicase DDX24	0.038	0.025
DHX16	DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN	0.038	0.025
CUL4B	N/A	0.038	0.028
MYH9	MYH9: Myosin-9	0.038	0.148
KIAA0683	DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized	0.038	0.025
FKBP5	FKBP5, AIG6, FKBP51: FK506-binding protein 5	0.038	0.075
NAP1L1	NAP1L1, NRP: Nucleosome assembly protein 1-like 1	0.038	0.025
HIST1H3A	HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD,	0.038	0.025
SAPS3	N/A	0.038	0.025
CUL5	CUL5, VACM1: Cullin-5	0.038	0.025
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	0.038	0.025
H3F3A	H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3	0.038	0.025
TEC	TEC, PSCTK4: Tyrosine-protein kinase Tec	0.037	422.00
IRS4	IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4	0.037	0.109
SQSTM1	SQSTM1: Uncharacterized protein SQSTM1	0.037	0.109
MGMT	MGMT: Methylated-DNA--protein-cysteine methyltransferase	0.037	0.049
TRADD	TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein	0.036	0.049
ARHGEF7	N/A	0.036	0.098
SPTBN1	SPTBN1, SPTB2: Spectrin beta chain, brain 1	0.036	0.098
DGKD	DGKD, KIAA0145: Diacylglycerol kinase delta	0.036	0.098
ITSN2	ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2	0.036	0.098
MAPK1	MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1	0.035	0.148
ARHGEF12	ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12	0.035	0.165
PLEKHA5	PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member	0.034	0.165
GAB1	GAB1: GRB2-associated-binding protein 1	0.034	0.165
OSBP	OSBP, OSBP1: Oxysterol-binding protein 1	0.033	0.098
JUP	JUP, CTNNG, DP3: Junction plakoglobin	0.033	0.036
FXR2	FXR2, FMR1L2: Fragile X mental retardation syndrome-related protein 2	0.033	0.044
UBAP2L	UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like	0.032	0.028
TDG	TDG: G/T mismatch-specific thymine DNA glycosylase	0.032	0.028
ZNF638	ZNF638, NP220, ZFML: Zinc finger protein 638	0.032	0.028
VIM	VIM: Vimentin	0.032	0.083
SH2BP1	CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog	0.032	0.028
API5	N/A	0.032	0.028
IKBKG	IKBKG, FIP3, NEMO: NF-kappa-B essential modulator	0.032	0.028
IRAK1	IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1	0.032	0.148
ABCF1	N/A	0.032	0.028
RBM14	RBM14, SIP: RNA-binding protein 14	0.032	0.028
MAP3K8	MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8	0.032	0.165
ZNF330	ZNF330, NOA36: Zinc finger protein 330	0.032	0.028
HMGN1	HMGN1, HMG14: Non-histone chromosomal protein HMG-14	0.032	0.028
RBMX	RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G	0.032	0.028
XRCC6	XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1	0.032	0.083
KHDRBS1	KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate	0.032	0.187
WDR1	N/A	0.032	0.028
TOPORS	TOPORS, LUN, TP53BPL: E3 ubiquitin-protein ligase Topors	0.032	0.028
PRKAA1	N/A	0.032	0.165
HDAC3	HDAC3: Histone deacetylase 3	0.032	0.083
ZCCHC8	ZCCHC8: Zinc finger CCHC domain-containing protein 8	0.032	0.028
KIAA0528	KIAA0528: Uncharacterized protein KIAA0528	0.032	0.028
ARFGAP1	N/A	0.032	0.052
AFF1	N/A	0.032	0.028
RIPK1	RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1	0.032	0.165
HMGN2	HMGN2, HMG17: Non-histone chromosomal protein HMG-17	0.032	0.028
TOP2B	N/A	0.032	0.028
HNRPA0	HNRPA0: Heterogeneous nuclear ribonucleoprotein A0	0.032	0.028
DDX21	DDX21: Nucleolar RNA helicase 2	0.032	0.028
SET	SET: Protein SET	0.032	0.028
NCK2	NCK2: Cytoplasmic protein NCK2	0.032	0.098
RAPGEF6	RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6	0.032	0.044
VIL2	N/A	0.032	0.098
TIAM1	TIAM1: T-lymphoma invasion and metastasis-inducing protein 1	0.031	0.165
KRT18	KRT18: Uncharacterized protein KRT18	0.031	0.028
GAB2	N/A	0.031	0.165
PIK3C2A	PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po	0.0308	0.148
SMARCA3	HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor	0.0308	0.028
APS	SH2B2, APS: SH2B adapter protein 2	0.030	0.098
PRKCZ	PRKCZ, PKC2: Protein kinase C zeta type	0.029	0.098
PRKCI	PRKCI, DXS1179E: Protein kinase C iota type	0.029	0.098
OXSR1	OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1	0.029	0.148
STK24	STK24, MST3, STK3: Serine/threonine-protein kinase 24	0.029	0.148
HNRPF	HNRPF: Heterogeneous nuclear ribonucleoprotein F	0.029	0.025
MDN1	MDN1, KIAA0301: Midasin	0.029	0.025
SKIIP	SNW1, SKIIP, SKIP: SNW domain-containing protein 1	0.029	0.025
DIAPH1	Diaphanous 1	0.029	0.025
SEC24C	SEC24C, KIAA0079: Protein transport protein Sec24C	0.029	0.025
ACIN1	ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus	0.029	0.075
EIF4G2	EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2	0.029	0.025
RBMX2	RBMX2, CGI-79: RNA-binding motif protein, X-linked 2	0.029	0.025
SFRS1	SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1	0.029	0.025
AIP	AIP, XAP2: AH receptor-interacting protein	0.029	0.075
SNRK	SNRK, KIAA0096, SNFRK: SNF-related serine/threonine-protein kinase	0.029	0.025
RBM8A	RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A	0.029	0.025
NUP153	N/A	0.029	0.028
DICER1	DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer	0.029	0.025
ELAVL1	ELAVL1, HUR: ELAV-like protein 1	0.029	0.025
EP300	N/A	0.029	0.137
NOL1	N/A	0.029	0.025
PAK1IP1	PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1	0.029	0.028
ANAPC5	ANAPC5, APC5: Anaphase-promoting complex subunit 5	0.029	0.025
PTEN	PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du	0.029	0.148
ADARB1	ADARB1, ADAR2, DRADA2, RED1: Double-stranded RNA-specific editase 1	0.029	0.025
CPSF1	CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1	0.029	0.025
WDR44	WDR44: WD repeat-containing protein 44	0.029	0.025
TIAL1	TIAL1: Nucleolysin TIAR	0.029	0.025
SNRPB2	SNRPB2: U2 small nuclear ribonucleoprotein B''	0.029	0.025
CDKN1B	CDKN1B, KIP1: Cyclin-dependent kinase inhibitor 1B	0.029	0.025
ARPC1B	ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B	0.029	0.025
PABPC4	PABPC4, APP1, PABP4: Polyadenylate-binding protein 4	0.029	0.025
CSPG6	SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3	0.029	0.025
CSTF2T	CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant	0.029	0.025
SYNCRIP	SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q	0.029	0.025
DDX51	DDX51: ATP-dependent RNA helicase DDX51	0.029	0.025
DUSP1	DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1	0.029	0.148
C14orf4	C14orf4, KIAA1865, My039: RING finger protein C14orf4	0.028	0.025
CPNE1	RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12	0.028	0.025
FBXO4	FBXO4, FBX4: F-box only protein 4	0.028	0.028
ZC3HAV1	ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1	0.028	0.165
RAB4A	N/A	0.028	0.028
CETN1	CETN1, CEN1, CETN: Centrin-1	0.028	0.052
BID	BID: BH3-interacting domain death agonist	0.028	0.028
SF1	SF1, ZFM1, ZNF162: Splicing factor 1	0.028	0.083
KIAA1804	MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase	0.028	0.165
C14orf151	C14orf151: Uncharacterized protein C14orf151 (Fragment)	0.028	0.028
HEXIM2	HEXIM2, L3: Protein HEXIM2	0.028	0.025
MAPKAPK5	N/A	0.028	0.165
CCAR1	CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1	0.028	0.083
AR	AR, DHTR, NR3C4: Androgen receptor	0.028	0.028
ARID4A	ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A	0.028	0.025
JDP2	jdp2, JDP2: Jun dimerization protein 2	0.028	0.028
PTBP1	PTBP1: Polypyrimidine tract binding protein 1	0.028	0.028
HNRPD	HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0	0.028	0.025
SNRPB	N/A	0.028	0.028
HNRPC	HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2	0.028	0.028
MINK1	MAP4K6, MINK1, MINK: Misshapen-like kinase 1	0.028	0.165
LOC642558	FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1	0.028	0.028
CABLES1	N/A	0.028	0.028
KIF1B	N/A	0.028	0.028
IRF7	N/A	0.028	0.028
NF2	NF2, SCH: Merlin	0.028	0.165
UHRF1		0.028	0.028
ZCCHC3	ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3	0.028	0.028
DYRK1A	DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin	0.028	0.165
ZNF598	ZNF598: Zinc finger protein 598	0.028	0.028
PPP1R12C	PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C	0.028	0.028
CDC2L1	CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1	0.028	0.165
RFFL	RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin	0.028	0.075
HMGA1	HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y	0.028	0.152
GPRASP2	GPRASP2: G-protein coupled receptor-associated sorting protein 2	0.028	0.028
FLJ21816	PALB2, FANCN: Partner and localizer of BRCA2	0.028	0.028
HDAC8	N/A	0.028	0.083
ILF3	ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3	0.028	0.028
MLL2	MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2	0.028	0.028
PSIP1	PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein	0.028	0.025
CDC2L2	CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2	0.028	0.165
TLE3	TLE3, KIAA1547: Transducin-like enhancer protein 3	0.028	0.028
CORO6	N/A	0.028	0.028
PHC2	PHC2, EDR2, PH2: Polyhomeotic-like protein 2	0.028	0.148
MSL3L1	MSL3L1: Male-specific lethal 3-like 1	0.028	0.028
GEMIN5	GEMIN5: Gem-associated protein 5	0.028	0.028
NFIA	NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A	0.028	0.028
NFYA	NFYA: Nuclear transcription factor Y subunit alpha	0.028	0.028
DUSP15	N/A	0.028	0.028
TMPO	TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha	0.028	0.028
NSBP1	NSBP1: Nucleosome-binding protein 1	0.028	0.028
PHLDB2	N/A	0.028	0.028
DSP	DSP: Desmoplakin	0.028	0.083
RAVER1	RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1	0.028	0.028
C13orf8	N/A	0.028	0.028
KCTD1		0.028	0.025
PPEF1	N/A	0.028	0.165
BMP2K	BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase	0.028	0.165
CBFA2T2	CBFA2T2, EHT, MTGR1: Protein CBFA2T2	0.028	0.028
TCF20	TCF20, KIAA0292, SPBP: Transcription factor 20	0.028	0.028
MITF	MITF: Microphthalmia-associated transcription factor	0.028	0.028
ZNF265	N/A	0.028	0.028
NHN1	NHN1: Conserved nuclear protein NHN1	0.028	0.028
WDR54	N/A	0.028	0.028
DDX20	DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20	0.028	0.028
SYTL4	Endocrine transmitter regulatory protein	0.028	0.028
NIPA1	NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1	0.028	0.028
DKFZp434K1815	DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815	0.028	0.028
ATXN2L	ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein	0.028	0.028
ZNF687	ZNF687, KIAA1441: Zinc finger protein 687	0.028	0.028
PIK3CB	PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit	0.028	0.148
SMARCA1	SMARCA1, SNF2L, SNF2L1: Probable global transcription activator SNF2L1	0.028	0.025
IQSEC1	IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein	0.027	0.098
PLD1	PLD1: Phospholipase D1	0.027	0.098
STAM2	STAM2: Signal transducing adapter molecule 2	0.027	0.098
FUBP1	N/A	0.027	0.049
TXK	TXK, PTK4: Tyrosine-protein kinase TXK	0.027	0.980
JAK1		0.027	0.980
BMX	N/A	0.0263	0.980
MCF2	MCF2, DBL: Proto-oncogene DBL	0.0263	0.109
MAP3K5	MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5	0.026	0.165
GTF3C1	N/A	0.026	0.028
RGS14	N/A	0.026	0.028
PHF8	PHF8, KIAA1111, ZNF422: PHD finger protein 8	0.026	0.028
OSR2	N/A	0.026	0.028
MAPK7	mitogen-activated protein kinase 7 isoform 1	0.026	0.028
RNPS1	RNPS1, LDC2: RNA-binding protein with serine-rich domain 1	0.026	0.028
NEK1	NEK1, KIAA1901: Serine/threonine-protein kinase Nek1	0.026	0.165
DUSP22	DUSP22, JSP1, MKPX: Dual specificity protein phosphatase 22	0.026	0.028
STRN3	STRN3, GS2NA, SG2NA: Striatin-3	0.026	0.028
SRPK2	SRPK2: Serine/threonine-protein kinase SRPK2	0.026	0.165
CHUK	N/A	0.026	0.028
MYBBP1A	MYBBP1A, P160: Myb-binding protein 1A	0.026	0.028
ITGB1BP1	ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1	0.026	0.028
MAPKAPK2	MAPKAPK2: MAP kinase-activated protein kinase 2	0.026	0.165
TCOF1	N/A	0.026	0.028
LIMD1	LIMD1: LIM domain-containing protein 1	0.026	0.075
SALF	GTF2A1L, ALF, GTF2A1LF: TFIIA-alpha and beta-like factor	0.026	0.028
TRAFD1	TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1	0.026	0.028
SMARCC2	N/A	0.026	0.028
PRKR	EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki	0.026	0.165
COIL	COIL, CLN80: Coilin	0.026	0.028
TRRAP	N/A	0.026	0.028
RREB1	RREB1, FINB: RAS-responsive element-binding protein 1	0.026	0.028
MAP3K11	MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11	0.026	0.165
RDBP	RDBP, NELFE, RD: Negative elongation factor E	0.026	0.028
TSC1	TSC1, KIAA0243, TSC: Hamartin	0.026	0.028
NFKBIA	NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha	0.026	0.028
PRKCB1	PRKCB1, PKCB, PRKCB: Protein kinase C beta type	0.0253	0.051
PLXND1	PLXND1, KIAA0620: Plexin-D1 precursor	0.025	0.034
PPP1R9B	PPP1R9B, PPP1R6: Neurabin-2	0.025	0.025
HNRPM	HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M	0.025	0.025
MAPK8IP3	N/A	0.025	0.025
HNRPUL1	HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1	0.025	0.025
POLR1C	POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1	0.025	0.025
CDC2L5	CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5	0.025	0.148
FLJ40432	FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227	0.025	0.025
ATXN2L	N/A	0.025	0.025
SYAP1	SYAP1, PRO3113: Synapse-associated protein 1	0.025	0.025
IWS1	IWS1, IWS1L: IWS1 homolog	0.025	0.025
SSBP4	SSBP4: Single-stranded DNA-binding protein 4	0.025	0.025
SFRS9	SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9	0.025	0.025
SMN2	SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein	0.025	0.025
TCEA1	N/A	0.025	0.025
TIA1	TIA1: Nucleolysin TIA-1 isoform p40	0.025	0.025
PRKCB1	N/A	0.025	0.025
MKNK2	MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2	0.025	0.148
RNF113A	RNF113A, RNF113, ZNF183: RING finger protein 113A	0.025	0.025
BUB3	BUB3: Mitotic checkpoint protein BUB3	0.025	0.025
EDF1	EDF1: Endothelial differentiation-related factor 1	0.025	0.025
PDE8B	PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies	0.025	0.025
SAP14	SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14	0.025	0.025
RAD51	RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1	0.025	0.025
BCOR	N/A	0.025	0.025
DUSP6	DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6	0.025	0.148
PHF16	PHF16, JADE3, KIAA0215: Protein Jade-3	0.025	0.025
SETD3	SETD3, C14orf154: SET domain-containing protein 3	0.025	0.025
RBBP6	RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6	0.025	0.025
EXO1	EXO1, EXOI, HEX1: Exonuclease 1	0.025	0.025
PHKG1	PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo	0.025	0.148
CAMKK1	N/A	0.025	0.025
NEDD4	NEDD4: Uncharacterized protein NEDD4	0.025	0.025
FBXL10	FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio	0.025	0.025
CDC25C	CDC25C: M-phase inducer phosphatase 3	0.025	0.025
SMARCA2	SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2	0.025	0.025
HNRPH3	HNRPH3: Heterogeneous nuclear ribonucleoprotein H3	0.025	0.137
MAP3K7	MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7	0.025	0.148
NUP98	N/A	0.025	0.025
H2-ALPHA	TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain	0.025	0.148
GIT2	N/A	0.025	0.047
MLL4	WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7	0.025	0.025
SSH2	SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2	0.025	0.148
NEK8	NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8	0.025	0.148
GRK6	N/A	0.025	0.025
WNK4	WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4	0.025	0.148
PURB	PURB: Transcriptional activator protein Pur-beta	0.025	0.025
SON		0.025	0.025
FLJ23436	N/A	0.025	0.025
NSUN2	NSUN2, SAKI, TRM4: tRNA	0.025	0.025
DUSP16	DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16	0.025	0.148
EEF2K	EEF2K: Elongation factor 2 kinase	0.025	0.148
WWTR1	WWTR1, TAZ: WW domain-containing transcription regulator protein 1	0.025	0.025
DYRK1B	DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0.025	0.148
ARL5A	ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A	0.025	0.025
HIST2H2AC	HIST2H2AC, H2AFQ: Histone H2A type 2-C	0.025	0.025
HDAC7A	N/A	0.025	0.075
DIDO1	N/A	0.025	0.028
NEK6	NEK6: Serine/threonine-protein kinase Nek6	0.025	0.148
SMU1	SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog	0.025	0.025
HTATIP	N/A	0.025	0.025
CDC25A	CDC25A: M-phase inducer phosphatase 1	0.025	0.025
NES	N/A	0.025	0.028
MKI67IP	MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein	0.025	0.025
C20orf77	N/A	0.025	0.025
PLK1	PLK1, PLK: Serine/threonine-protein kinase PLK1	0.025	0.148
FAF1	FAF1, CGI-03: FAS-associated factor 1	0.025	0.025
LMNA	LMNA, LMN1: Lamin-A/C	0.025	0.025
CDC2	CDC2: Cell division control protein 2 homolog	0.025	0.148
HIST3H2A	HIST3H2A: Histone H2A type 3	0.025	0.025
CAMK1D	CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D	0.025	0.148
MIER1	MIER1, KIAA1610: Mesoderm induction early response protein 1	0.025	0.025
REXO1	REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog	0.025	0.025
MKNK1	MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1	0.025	0.148
SEC13L1	N/A	0.025	0.025
MAP2K3	N/A	0.025	0.025
SMC4L1	SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4	0.025	0.025
ADK	ADK: Adenosine kinase	0.025	0.025
CAMK2A	N/A	0.025	0.025
HNRPA2B1	HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1	0.025	0.025

0.299

Total Score

8.92