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Evidence of Interaction Between FOXO1A and SMAD2

The interaction score between FOXO1A and SMAD2 is 31.20.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between FOXO1A and SMAD2 = 0.33

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 3.80E-3
Orthology
OrganismFOXO1A OrthologueSMAD2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm Q86S42 0.285 Q02330 0.185

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains Domains present in FOXO1A and SMAD2:
Domains in FOXO1ADomains in SMAD2
IPR001766 Fork head transcription factor
IPR011991 Wing_hlx_DNA_bd.
IPR003619 Dwarfin protein, domain A
IPR001132 Dwarfin protein
IPR013019 MAD_MH1.

The Chi square scores for co-occurrence of domains that are present in FOXO1A and SMAD2 are listed below.

Domain 1Domain 2Chi Square
IPR001766 Fork head transcription factor IPR001132 Dwarfin protein 46.3494
IPR001766 Fork head transcription factor IPR013019 MAD_MH1. 46.3494
IPR001766 Fork head transcription factor IPR003619 Dwarfin protein, domain A 45.9487
IPR011991 Wing_hlx_DNA_bd. IPR003619 Dwarfin protein, domain A 1.21319
IPR011991 Wing_hlx_DNA_bd. IPR001132 Dwarfin protein 0.326137
IPR011991 Wing_hlx_DNA_bd. IPR013019 MAD_MH1. 0.326137

The background colour of the table refers to:

  • Blue Domain is only present in FOXO1A
  • Yellow Domain is only present in SMAD2
  • Green Domain is present in both FOXO1A and SMAD2

 0.165
Post-translational Modifications

Protein: FOXO1A

PTMResidueReference
Phosphorylation 24 PubMed, HPRD
Phosphorylation 256 PubMed, HPRD
Phosphorylation 319 PubMed, HPRD
Phosphorylation 322 PubMed, HPRD
Phosphorylation 325 PubMed, HPRD
Phosphorylation 329 PubMed, HPRD
Phosphoserine 256 PubMed, HPRD
Phosphoserine 319 PubMed, HPRD
Phosphothreonine 24 PubMed, HPRD

Protein: SMAD2

PTMResidueReference
Phosphorylation 8 PubMed, HPRD
Phosphorylation 110 PubMed, HPRD
Phosphorylation 220 PubMed, HPRD
Phosphorylation 240 PubMed, HPRD
Phosphorylation 245 PubMed, HPRD
Phosphorylation 250 PubMed, HPRD
Phosphorylation 260 PubMed, HPRD
Phosphorylation 464 PubMed, HPRD
Phosphorylation 465 PubMed, HPRD
Phosphorylation 467 PubMed, HPRD
Phosphoserine 240 PubMed, HPRD
Phosphoserine 465 HPRD
Phosphoserine 467 HPRD
Phosphothreonine 8 PubMed, HPRD
Localisation

Protein: FOXO1A

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: SMAD2

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between FOXO1A and SMAD2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between FOXO1A andSMAD2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , FOXO1A has 805 interactors and SMAD2 has 1164 interactors of which there are 662 common interactors.

Common InteractorName of Common InteractorScore for FOXO1A-Interactor (?)Score for SMAD2-Interactor (?)
CCNB1 Cyclin B1 2.77 0.038
CDK2 CDK2: Cell division protein kinase 2 0.533 0.046
NFATC1 N/A 0.416 0.052
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.372 0.118
NCOR1 NCOR1, KIAA1047: Nuclear receptor corepressor 1 0.307 0.233
IRF3 IRF3: Interferon regulatory factor 3 0.307 0.260
TGIF2 TGIF2: Homeobox protein TGIF2 0.307 0.260
SIRT1 SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1 0.275 0.063
HSP90AA1 Hsp89-alpha-delta-N 0.273 0.032
BATF BATF: Basic leucine zipper transcriptional factor ATF-like 0.251 0.430
MLL MLL, ALL1, HRX, HTRX, TRX1: Zinc finger protein HRX 0.225 0.071
JUNB JUNB: Transcription factor jun-B 0.225 0.188
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.225 0.385
BAZ2A BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A 0.225 0.146
SMAD4 SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4 0.225 0.139
TCF8 ZEB1, AREB6, TCF8: Zinc finger E-box-binding homeobox 1 0.225 0.139
SATB1 SATB1: DNA-binding protein SATB1 0.225 0.114
JUND JUND: Transcription factor jun-D 0.225 0.188
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.225 0.063
BRD2 BRD2, KIAA9001, RING3: Bromodomain-containing protein 2 0.225 0.241
SMAD3 SMAD3, MADH3: Mothers against decapentaplegic homolog 3 0.225 66.70
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.216 0.426
ZNF148 ZNF148, ZBP89: Zinc finger protein 148 0.210 0.430
SP100 N/A 0.210 0.260
POU2F1 POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1 0.191 0.127
NBN NBN, NBS, NBS1, P95: Nibrin 0.191 0.917
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.188 0.129
ATM ATM: Serine-protein kinase ATM 0.188 0.046
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.171 0.078
ATF6 ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha 0.171 0.139
CREBBP CREBBP, CBP: CREB-binding protein 0.171 90.40
BRPF1 BRPF1, BR140: Peregrin 0.171 0.114
JUN JUN: Transcription factor AP-1 0.171 0.114
CUTL1 CUTL1: Homeobox protein cut-like 1 0.165 0.083
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.165 0.028
ZHX1 ZHX1: Zinc fingers and homeoboxes protein 1 0.165 0.083
KIAA1443 HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez 0.165 0.083
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.165 0.028
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.165 0.165
ZNF24 ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24 0.155 0.233
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.155 0.078
ELF1 ELF1: ETS-related transcription factor Elf-1 0.155 0.430
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.152 0.251
SNAPC4 SNAPC4, SNAP190: snRNA-activating protein complex subunit 4 0.152 0.155
BAZ1B BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain 0.152 0.132
RB1 RB1: Retinoblastoma-associated protein 0.152 0.132
FOSL2 FOSL2, FRA2: Fos-related antigen 2 0.152 0.086
TERF1 TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1 0.152 0.210
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.152 0.132
TERF2 TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2 0.152 0.155
BACH1 BACH1: Transcription regulator protein BACH1 0.152 0.155
RBL1 RBL1: Retinoblastoma-like protein 1 0.148 0.047
CCNT2 CCNT2: Cyclin-T2 0.148 0.025
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.148 0.025
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.148 0.025
BRD4 N/A 0.148 0.047
DLX3 DLX3: Homeobox protein DLX-3 0.148 0.075
HOXA10 HOXA10, HOX1H: Homeobox protein Hox-A10 0.148 0.075
SMAD1 SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1 0.148 35.90
CREB1 CREB1: cAMP response element-binding protein 0.148 0.075
ISL2 ISL2: Insulin gene enhancer protein ISL-2 0.148 0.075
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.139 0.078
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.139 0.139
RPS6KB1 N/A 0.139 0.129
ETS1 ETS1, EWSR2: Protein C-ets-1 0.139 0.139
RERE RERE, ARG, ARP, ATN1L, KIAA0458: Arginine-glutamic acid dipeptide repeats protei 0.136 0.086
NFE2L2 NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2 0.136 0.139
CCNH CCNH: Cyclin-H 0.136 0.046
NR3C1 NR3C1, GRL: Glucocorticoid receptor 0.127 0.144
SUZ12 SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12 0.127 0.385
UBTF UBTF, UBF, UBF1: Nucleolar transcription factor 1 0.127 0.260
ZNF318 ZNF318, HRIHFB2436: Zinc finger protein 318 0.127 0.430
AKAP8 AKAP8, AKAP95: A-kinase anchor protein 8 0.127 0.385
RELA RELA, NFKB3: Transcription factor p65 0.127 0.046
ZFX ZFX: Zinc finger X-chromosomal protein 0.127 0.155
YY1 YY1: Transcriptional repressor protein YY1 0.127 0.822
CEBPB CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta 0.123 0.114
FOS FOS, G0S7: Proto-oncogene protein c-fos 0.123 0.114
ESR1 ESR1, ESR, NR3A1: Estrogen receptor 0.123 0.049
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.118 0.078
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.114 0.046
ZNF217 ZNF217, ZABC1: Zinc finger protein 217 0.114 0.188
ZNF76 ZNF76, D6S229E: Zinc finger protein 76 0.114 0.188
ZBTB40 ZBTB40, KIAA0478: Zinc finger and BTB domain-containing protein 40 0.114 0.114
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.114 0.063
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.114 0.063
STAT4 STAT4: Signal transducer and activator of transcription 4 0.114 0.038
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.114 0.063
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.114 0.129
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.114 0.063
ZNF335 ZNF335: Zinc finger protein 335 0.114 0.188
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.114 0.129
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.114 0.385
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.114 0.139
ZNF224 ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27: Zinc finger protein 224 0.114 0.114
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.046
BRD3 BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3 0.110 0.087
MCM3 MCM3: DNA replication licensing factor MCM3 0.110 0.078
GCN5L2 GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2 0.110 41.40
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.110 0.046
PCAF PCAF: Histone acetyltransferase PCAF 0.110 0.086
NFIB N/A 0.109 0.031
MAFG MAFG: Transcription factor MafG 0.109 0.114
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.109 0.0971
MYB MYB: Myb proto-oncogene protein 0.109 0.077
ZHX3 ZHX3, KIAA0395, TIX1: Zinc fingers and homeoboxes protein 3 0.109 0.055
MYBL2 MYBL2, BMYB: Myb-related protein B 0.109 0.114
SMAD7 SMAD7, MADH7, MADH8: Mothers against decapentaplegic homolog 7 0.109 0.077
TERF2IP TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1 0.109 0.127
CEBPE CEBPE: CCAAT/enhancer-binding protein epsilon 0.109 0.069
TAF1 TAF1, BA2R, CCG1, CCGS, TAF2A: Transcription initiation factor TFIID subunit 1 0.109 0.034
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.109 0.062
CDX2 CDX2, CDX3: Homeobox protein CDX-2 0.109 0.049
DDIT3 DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3 0.109 0.062
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.097 0.063
RFX1 RFX1: MHC class II regulatory factor RFX1 0.097 0.049
HOXB6 HOXB6, HOX2B: Homeobox protein Hox-B6 0.097 0.044
MLLT7 N/A 0.097 0.110
FOXL2 FOXL2: Forkhead box protein L2 0.097 0.097
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.097 0.136
ID2 ID2: DNA-binding protein inhibitor ID-2 0.096 0.087
XRCC1 XRCC1: DNA-repair protein XRCC1 0.096 0.070
HIVEP1 N/A 0.096 0.127
H1FX H1FX: Histone H1x 0.096 0.155
MATR3 MATR3, KIAA0723: Matrin-3 0.096 0.430
ROCK1 ROCK1: Rho-associated protein kinase 1 0.096 0.087
SATB2 SATB2, KIAA1034: DNA-binding protein SATB2 0.088 0.049
NKX2-5 NKX2-5, CSX, NKX2.5, NKX2E: Homeobox protein Nkx-2.5 0.088 0.044
EN2 EN2: Homeobox protein engrailed-2 0.088 0.044
SOS1 SOS1: Son of sevenless homolog 1 0.087 0.118
KLF13 KLF13, BTEB3, NSLP1: Krueppel-like factor 13 0.086 0.188
SP3 SP3: Transcription factor Sp3 0.086 0.233
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.086 0.139
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.086 0.233
TOPBP1 TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1 0.086 0.129
APEX1 APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase 0.086 0.078
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.086 0.063
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.086 0.046
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.086 0.233
PPP1R8 N/A 0.086 0.385
MTF1 MTF1: Metal regulatory transcription factor 1 0.086 90.40
ZFP91 ZFP91, FKSG11: Zinc finger protein 91 homolog 0.083 0.083
ZNF579 ZNF579: Zinc finger protein 579 0.083 0.083
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.083
POGZ POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain 0.083 0.083
ZNF295 ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295 0.083 0.083
SOX8 SOX8: Transcription factor SOX-8 0.083 0.075
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.028
ZFPM1 ZFPM1, FOG1: Zinc finger protein ZFPM1 0.083 0.075
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.083 0.083
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.083 0.083
ZNF644 ZNF644, KIAA1221, ZEP2: Zinc finger protein 644 0.083 0.083
TAL2 TAL2: T-cell acute lymphocytic leukemia protein 2 0.083 0.025
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.083 0.025
SP140 SP140, LYSP100: Nuclear body protein SP140 0.083 0.050
STAT6 STAT6: Signal transducer and activator of transcription 6 0.0818 0.066
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.080 0.144
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.077 0.046
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.077 0.188
AKAP8L AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like 0.077 0.139
MYST4 MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4 0.077 0.056
TP53BP1 TP53BP1: Tumor suppressor p53-binding protein 1 0.077 0.052
ID3 ID3, 1R21, HEIR-1: DNA-binding protein inhibitor ID-3 0.077 0.026
ZBTB33 KAISO, ZBTB33, ZNF348: Transcriptional regulator Kaiso 0.077 0.077
SAT SAT1, SAT: Diamine acetyltransferase 1 0.077 0.155
MEF2A N/A 0.077 0.155
RBM10 RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10 0.075 0.075
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.075 0.025
PRDM2 PRDM2, RIZ: PR domain zinc finger protein 2 0.075 0.075
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.075 0.025
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.047
GATAD2B GATAD2B, KIAA1150: Transcriptional repressor p66 beta 0.075 0.025
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.075 0.025
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.075 0.025
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.075 0.025
ZNF174 ZNF174, ZSCAN8: Zinc finger protein 174 0.075 0.075
TFAP4 TFAP4: Transcription factor AP-4 0.075 0.025
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.075 0.075
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.075 0.028
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.047
FARSLA FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain 0.075 0.075
TRERF1 TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1 0.075 0.075
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.075 0.075
NIPBL N/A 0.075 0.025
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.075 0.025
OSR1 OSR1, ODD: Protein odd-skipped-related 1 0.075 0.075
ELMO1 N/A 0.075 0.025
RNF20 0.075 0.025
DHX8 DHX8, DDX8: ATP-dependent RNA helicase DHX8 0.075 0.025
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.025
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.075 0.075
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.070 0.163
PHF3 PHF3, KIAA0244: PHD finger protein 3 0.070 0.144
USP34 USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34 0.070 0.078
NCOA3 N/A 0.070 0.144
DEF6 DEF6, IBP: Differentially expressed in FDCP 6 0.070 0.070
HIST1H1B HIST1H1B, H1F5: Histone H1.5 0.069 0.056
SNAI1 SNAI1, SNAH: Zinc finger protein SNAI1 0.069 0.069
SRF SRF: Serum response factor 0.069 0.233
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.069 0.385
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.069 0.063
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.069 0.129
NR5A1 NR5A1, AD4BP, FTZF1, SF1: Steroidogenic factor 1 0.069 0.086
MEF2D MEF2D: Myocyte-specific enhancer factor 2D 0.069 0.139
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.069 0.063
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.069 0.129
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.069 0.063
ZBTB16 ZBTB16, PLZF, ZNF145: Zinc finger and BTB domain-containing protein 16 0.069 0.049
EXOC2 N/A 0.067 0.032
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.067 0.066
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.064 0.041
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.063 0.146
SFRS5 SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5 0.063 0.078
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.063 0.241
REST REST, NRSF, XBR: RE1-silencing transcription factor 0.062 0.096
ZNF267 ZNF267: Zinc finger protein 267 0.062 0.260
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.062 0.032
STAT2 STAT2: Signal transducer and activator of transcription 2 0.062 0.0425
DRIM UTP20, DRIM: Small subunit processome component 20 homolog 0.062 0.026
ERF ERF: ETS domain-containing transcription factor ERF 0.062 0.127
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.062 0.052
ZBTB7A ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A 0.062 0.069
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.062 0.087
SH3BP3 0.062 0.127
ETS2 ETS2: Protein C-ets-2 0.062 0.096
ERG ERG: Transcriptional regulator ERG 0.062 0.077
GTF2F2 N/A 0.062 0.127
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.061 0.036
TP53 TP53, P53: Cellular tumor antigen p53 0.060 0.146
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.060 0.070
TCF3 TCF3, E2A, ITF1: Transcription factor E2-alpha 0.060 0.063
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.060 0.144
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.057 0.040
HD HD, IT15: Huntingtin 0.057 0.0446
MTA1 MTA1: Metastasis-associated protein MTA1 0.056 0.063
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.056 0.188
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.056 0.046
AHR AHR: Aryl hydrocarbon receptor precursor 0.056 0.038
MEF2C MEF2C: Myocyte-specific enhancer factor 2C 0.056 0.069
ZNF551 N/A 0.056 0.069
SLC4A1AP SLC4A1AP: Uncharacterized protein SLC4A1AP 0.056 0.086
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.056 0.086
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.056 0.046
LEF1 LEF1: Lymphoid enhancer-binding factor 1 0.056 0.056
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.056 0.078
WDHD1 WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1 0.056 0.086
SP1 SP1, TSFP1: Transcription factor Sp1 0.056 0.069
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.056 0.078
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.056 0.046
EEA1 EEA1, ZFYVE2: Early endosome antigen 1 0.056 0.114
SOX11 SOX11: Transcription factor SOX-11 0.055 0.049
AANAT AANAT, SNAT: Serotonin N-acetyltransferase 0.055 0.062
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.055 0.026
MKI67 MKI67: Antigen KI-67 0.055 0.127
SOX4 SOX4: Transcription factor SOX-4 0.055 0.086
BNC1 BNC1, BNC: Zinc finger protein basonuclin-1 0.055 0.044
RXRA RXRA, NR2B1: Retinoic acid receptor RXR-alpha 0.055 0.032
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.054 0.111
VAV1 VAV1, VAV: Proto-oncogene vav 0.054 0.137
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.054 0.078
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.054 0.129
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.054 0.129
NCOA3 NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3 0.052 0.025
HES6 HES6: Transcription cofactor HES-6 0.052 0.028
ARNT ARNT: Aryl hydrocarbon receptor nuclear translocator 0.052 0.028
MAPK15 N/A 0.052 0.083
C20orf18 N/A 0.052 0.052
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.052 0.028
RBM6 RBM6, DEF3: RNA-binding protein 6 0.052 0.052
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.052 0.144
MARK2 N/A 0.052 0.070
IFI16 N/A 0.052 0.308
PTMA N/A 0.052 0.144
GNB2L1 Lung cancer oncogene 7 0.052 0.260
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.052 0.0425
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.052 0.144
JMJD1A JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr 0.052 0.087
FNBP4 FNBP4, FBP30, KIAA1014: Formin-binding protein 4 0.052 0.070
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.051 0.051
YWHAZ YWHAZ: 14-3-3 protein zeta/delta 0.051 0.040
XPO1 XPO1, CRM1: Exportin-1 0.051 0.066
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.051 0.137
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.051 0.040
PPP2R5A PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha 0.051 0.040
ELK1 ELK1: ETS domain-containing protein Elk-1 0.050 0.049
KLF1 KLF1, EKLF: Krueppel-like factor 1 0.049 0.056
ETV1 ETV1, ER81: ETS translocation variant 1 0.049 0.056
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.049 0.096
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.049
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.049
VDR VDR, NR1I1: Vitamin D3 receptor 0.049 0.086
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.049 0.056
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.049 0.029
NR1D1 NR1D1, EAR1, HREV, THRAL: Orphan nuclear receptor NR1D1 0.049 0.044
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.049 0.046
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.049 33.10
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.049 0.046
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.049 0.086
HIST1H1A HIST1H1A, H1F1: Histone H1.1 0.049 0.056
BRCA1 BRCA1, RNF53: Breast cancer type 1 susceptibility protein 0.049 0.114
EIF4G3 EIF4G3: Eukaryotic translation initiation factor 4 gamma 3 0.049 0.038
SYMPK SYMPK, SPK: Symplekin 0.049 0.046
EGR1 EGR1, ZNF225: Early growth response protein 1 0.049 0.056
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.049 0.069
KLF5 KLF5, BTEB2, CKLF, IKLF: Krueppel-like factor 5 0.049 0.044
KIAA0690 N/A 0.049 0.029
HIF1A HIF1A, MOP1: Hypoxia-inducible factor 1 alpha 0.048 0.063
DOK1 DOK1: Docking protein 1 0.048 0.063
PLEK PLEK, P47: Pleckstrin 0.048 0.144
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.048 0.052
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.047 0.025
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.047 0.025
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.047 0.025
MLXIPL MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein 0.047 0.025
MAX MAX: Protein max 0.047 0.025
PAPOLA PAPOLA, PAP: Poly(A) polymerase alpha 0.046 0.276
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.046 0.129
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.046 0.385
JARID1A JARID1A, RBBP2, RBP2: Histone demethylase JARID1A 0.046 0.129
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.046 0.063
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.046 0.063
PABPC1 PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1 0.046 0.078
EML4 EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4 0.046 0.114
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.046 0.129
EIF3S4 EIF3S4: Eukaryotic translation initiation factor 3 subunit 4 0.046 0.129
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.046 0.129
KIAA1012 KIAA1012: Protein TRS85 homolog 0.046 0.129
SNRP70 SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa 0.046 0.063
PHF10 N/A 0.046 0.063
WBSCR20A N/A 0.046 0.078
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 0.046 0.276
FNBP1 N/A 0.046 0.276
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.046 0.040
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.044 0.086
SALL1 SALL1, SAL1: Sal-like protein 1 0.044 0.049
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.043 0.188
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.043 0.078
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.0425 0.144
SFRS15 SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15 0.0425 0.0425
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.0425 0.129
USP24 USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24 0.0425 0.087
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.0425 0.210
DAXX DAXX, BING2, DAP6: Death domain-associated protein 6 0.0425 0.063
SAFB SAFB, HAP, HET, SAFB1: Scaffold attachment factor B 0.0425 0.385
RFXDC2 RFXDC2: Regulatory factor X domain-containing protein 2. 0.0425 0.070
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.0425 0.0425
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.0425 0.144
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.0425 0.052
CXorf9 N/A 0.0425 0.385
KIAA0853 N/A 0.0425 0.087
PSCD4 PSCD4, CYT4: Cytohesin-4 0.041 0.032
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.041 0.067
ATXN7 ATXN7, SCA7: Ataxin-7 0.0407 0.0407
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.041 0.032
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.041 0.032
RFX5 RFX5: DNA-binding protein RFX5 0.041 0.042
RNF31 ISGF3G, IRF9: Transcriptional regulator ISGF3 subunit gamma 0.041 0.0255
AXIN1 0.04 0.049
IRS2 IRS2: Insulin receptor substrate 2 0.039 0.032
MDM4 MDM4, MDMX: Mdm4 protein 0.039 0.026
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.038 0.129
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.038 0.129
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 0.038 0.129
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.038 0.129
SEC31L1 N/A 0.038 0.233
SFRS4 SFRS4, SRP75: Splicing factor, arginine/serine-rich 4 0.038 0.129
STK10 STK10: Uncharacterized protein STK10 0.038 0.129
KLHDC4 N/A 0.038 0.078
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.038 0.129
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.038 0.129
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.038 0.129
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.038 0.129
RBM15 RBM15, OTT: Putative RNA-binding protein 15 0.038 0.129
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.038 0.129
SFRS6 SFRS6, SRP55: Splicing factor, arginine/serine-rich 6 0.038 0.078
HIST3H3 HIST3H3, H3FT: Histone H3.1t 0.038 0.038
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.038 0.063
DDX24 DDX24: ATP-dependent RNA helicase DDX24 0.038 0.063
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.038 0.078
CUL4B N/A 0.038 0.078
MYH9 MYH9: Myosin-9 0.038 0.063
KIAA0683 DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized 0.038 0.063
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.038 0.063
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 0.038 0.078
HIST1H3A HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, 0.038 0.038
SAPS3 N/A 0.038 0.063
CUL5 CUL5, VACM1: Cullin-5 0.038 0.078
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.038 0.129
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 0.038 0.078
YWHAQ YWHAQ: 14-3-3 protein theta 0.037 0.036
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.037 0.057
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.037 0.057
IPO7 IPO7: Uncharacterized protein IPO7 0.037 0.027
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.037 0.027
FOXP1 FOXP1, HSPC215: Forkhead box protein P1 0.036 0.028
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.036 0.0446
ARHGEF7 N/A 0.036 6.17
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.036 0.036
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.036 0.044
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.035 0.233
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.035 0.031
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.034 0.062
GAB1 GAB1: GRB2-associated-binding protein 1 0.034 0.026
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.033 0.040
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.032 0.144
TDG TDG: G/T mismatch-specific thymine DNA glycosylase 0.032 0.129
ZNF638 ZNF638, NP220, ZFML: Zinc finger protein 638 0.032 0.087
VIM VIM: Vimentin 0.032 0.0425
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.032 0.144
API5 N/A 0.032 0.087
IKBKG IKBKG, FIP3, NEMO: NF-kappa-B essential modulator 0.032 0.144
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.032 0.078
ABCF1 N/A 0.032 0.144
RBM14 RBM14, SIP: RNA-binding protein 14 0.032 0.144
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.032 0.070
ZNF330 ZNF330, NOA36: Zinc finger protein 330 0.032 0.129
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.032 0.087
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.032 0.144
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.032 0.430
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.032 0.276
WDR1 N/A 0.032 0.430
TOPORS TOPORS, LUN, TP53BPL: E3 ubiquitin-protein ligase Topors 0.032 0.063
PRKAA1 N/A 0.032 0.032
HDAC3 HDAC3: Histone deacetylase 3 0.032 0.129
ZCCHC8 ZCCHC8: Zinc finger CCHC domain-containing protein 8 0.032 0.129
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.032 0.087
ARFGAP1 N/A 0.032 0.070
AFF1 N/A 0.032 0.070
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.032 0.052
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.032 0.087
TOP2B N/A 0.032 0.087
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.032 0.087
DDX21 DDX21: Nucleolar RNA helicase 2 0.032 0.144
SET SET: Protein SET 0.032 0.087
RPS10 RPS10: 40S ribosomal protein S10 0.032 0.040
EEF1G EEF1G, EF1G, PRO1608: Elongation factor 1-gamma 0.032 0.040
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.032 0.111
RPL3 RPL3, OK/SW-cl.32: 60S ribosomal protein L3 0.032 0.040
EEF1B2 EEF1B2, EEF1B, EF1B: Elongation factor 1-beta 0.032 0.040
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.031 0.0308
GAB2 N/A 0.031 0.032
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.0308 0.029
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.0308 0.032
ADNP ADNP, ADNP1, KIAA0784: Activity-dependent neuroprotector 0.0308 0.0255
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.029 0.026
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.029 0.067
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.029 0.276
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.029 0.078
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.029 0.276
MDN1 MDN1, KIAA0301: Midasin 0.029 0.063
SKIIP SNW1, SKIIP, SKIP: SNW domain-containing protein 1 0.029 0.129
DIAPH1 Diaphanous 1 0.029 0.129
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.029 0.129
ACIN1 ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus 0.029 0.188
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.029 0.129
RBMX2 RBMX2, CGI-79: RNA-binding motif protein, X-linked 2 0.029 0.046
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.029 0.129
AIP AIP, XAP2: AH receptor-interacting protein 0.029 0.046
SNRK SNRK, KIAA0096, SNFRK: SNF-related serine/threonine-protein kinase 0.029 0.029
RBM8A RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A 0.029 0.129
NUP153 N/A 0.029 0.129
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.029 0.129
ELAVL1 ELAVL1, HUR: ELAV-like protein 1 0.029 0.129
EP300 N/A 0.029 0.078
NOL1 N/A 0.029 0.078
PAK1IP1 PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1 0.029 0.188
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.029 0.129
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.029 0.129
CPSF1 CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1 0.029 0.063
WDR44 WDR44: WD repeat-containing protein 44 0.029 0.063
TIAL1 TIAL1: Nucleolysin TIAR 0.029 0.129
SNRPB2 SNRPB2: U2 small nuclear ribonucleoprotein B'' 0.029 0.129
CDKN1B CDKN1B, KIP1: Cyclin-dependent kinase inhibitor 1B 0.029 0.046
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.029 0.233
PABPC4 PABPC4, APP1, PABP4: Polyadenylate-binding protein 4 0.029 0.078
CSPG6 SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3 0.029 0.129
CSTF2T CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant 0.029 0.078
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.029 0.276
DDX51 DDX51: ATP-dependent RNA helicase DDX51 0.029 0.129
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.029 0.046
C14orf4 C14orf4, KIAA1865, My039: RING finger protein C14orf4 0.028 0.025
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.028 0.025
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.165
ZC3HAV1 ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1 0.028 0.028
RAB4A N/A 0.028 0.165
CETN1 CETN1, CEN1, CETN: Centrin-1 0.028 0.025
BID BID: BH3-interacting domain death agonist 0.028 0.028
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.028 0.025
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
HEXIM2 HEXIM2, L3: Protein HEXIM2 0.028 0.025
MAPKAPK5 N/A 0.028 0.028
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.083
AR AR, DHTR, NR3C4: Androgen receptor 0.028 0.028
ARID4A ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A 0.028 0.025
JDP2 jdp2, JDP2: Jun dimerization protein 2 0.028 0.028
PTBP1 PTBP1: Polypyrimidine tract binding protein 1 0.028 0.028
HNRPD HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0 0.028 0.025
SNRPB N/A 0.028 0.028
HNRPC HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2 0.028 0.028
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.028 0.028
LOC642558 FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1 0.028 0.028
CABLES1 N/A 0.028 0.028
KIF1B N/A 0.028 0.028
IRF7 N/A 0.028 0.028
NF2 NF2, SCH: Merlin 0.028 0.028
UHRF1 0.028 0.052
ZCCHC3 ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3 0.028 0.028
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.028 0.028
ZNF598 ZNF598: Zinc finger protein 598 0.028 0.025
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.028 0.028
RFFL RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin 0.028 0.075
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.028 0.028
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
FLJ21816 PALB2, FANCN: Partner and localizer of BRCA2 0.028 0.028
HDAC8 N/A 0.028 0.028
ILF3 ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3 0.028 0.028
MLL2 MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2 0.028 0.028
PSIP1 PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein 0.028 0.025
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.028 0.028
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.028 0.083
CORO6 N/A 0.028 0.028
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.028 0.025
MSL3L1 MSL3L1: Male-specific lethal 3-like 1 0.028 0.025
GEMIN5 GEMIN5: Gem-associated protein 5 0.028 0.075
NFIA NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A 0.028 0.028
NFYA NFYA: Nuclear transcription factor Y subunit alpha 0.028 0.025
DUSP15 N/A 0.028 0.028
TMPO TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha 0.028 0.028
NSBP1 NSBP1: Nucleosome-binding protein 1 0.028 0.028
PHLDB2 N/A 0.028 0.028
DSP DSP: Desmoplakin 0.028 0.028
RAVER1 RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1 0.028 0.028
C13orf8 N/A 0.028 0.028
KCTD1 0.028 0.025
PPEF1 N/A 0.028 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.028 0.028
CBFA2T2 CBFA2T2, EHT, MTGR1: Protein CBFA2T2 0.028 0.028
TCF20 TCF20, KIAA0292, SPBP: Transcription factor 20 0.028 0.028
MITF MITF: Microphthalmia-associated transcription factor 0.028 0.028
ZNF265 N/A 0.028 0.028
NHN1 NHN1: Conserved nuclear protein NHN1 0.028 0.025
WDR54 N/A 0.028 0.083
DDX20 DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20 0.028 0.025
SYTL4 Endocrine transmitter regulatory protein 0.028 0.083
NIPA1 NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1 0.028 0.083
DKFZp434K1815 DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815 0.028 0.028
ATXN2L ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein 0.028 0.028
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.028 0.029
HOXA7 HOXA7, HOX1A: Homeobox protein Hox-A7 0.028 5.36
FOXQ1 FOXQ1, HFH1: Forkhead box protein Q1 0.027 0.027
FUBP1 N/A 0.027 0.074
CASP8 N/A 0.027 0.036
JAK1 0.027 0.040
MAD1L1 MAD1L1, MAD1, TXBP181: Mitotic spindle assembly checkpoint protein MAD1 0.027 0.032
MCF2 MCF2, DBL: Proto-oncogene DBL 0.0263 0.0263
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.026 0.087
GTF3C1 N/A 0.026 0.070
RGS14 N/A 0.026 0.070
PHF8 PHF8, KIAA1111, ZNF422: PHD finger protein 8 0.026 0.032
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.026 0.052
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.026 0.087
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.026 0.026
DUSP22 DUSP22, JSP1, MKPX: Dual specificity protein phosphatase 22 0.026 0.063
STRN3 STRN3, GS2NA, SG2NA: Striatin-3 0.026 0.0425
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.026 0.0425
CHUK N/A 0.026 0.087
MYBBP1A MYBBP1A, P160: Myb-binding protein 1A 0.026 0.070
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.026 0.087
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.026 0.052
TCOF1 N/A 0.026 0.087
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.026 0.070
SMARCC2 N/A 0.026 0.052
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.026 0.052
COIL COIL, CLN80: Coilin 0.026 0.0425
TRRAP N/A 0.026 0.052
RREB1 RREB1, FINB: RAS-responsive element-binding protein 1 0.026 0.046
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.026 0.029
RDBP RDBP, NELFE, RD: Negative elongation factor E 0.026 0.052
TSC1 TSC1, KIAA0243, TSC: Hamartin 0.026 0.038
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.026 0.046
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
HNRPM HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M 0.025 0.025
MAPK8IP3 N/A 0.025 0.025
HNRPUL1 HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1 0.025 0.025
POLR1C POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1 0.025 0.025
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.025 0.025
FLJ40432 FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227 0.025 0.025
ATXN2L N/A 0.025 0.025
SYAP1 SYAP1, PRO3113: Synapse-associated protein 1 0.025 0.025
IWS1 IWS1, IWS1L: IWS1 homolog 0.025 0.025
SSBP4 SSBP4: Single-stranded DNA-binding protein 4 0.025 0.025
SFRS9 SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9 0.025 0.025
SMN2 SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein 0.025 0.025
TCEA1 N/A 0.025 0.025
TIA1 TIA1: Nucleolysin TIA-1 isoform p40 0.025 0.025
PRKCB1 N/A 0.025 0.025
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.025 0.025
RNF113A RNF113A, RNF113, ZNF183: RING finger protein 113A 0.025 0.025
BUB3 BUB3: Mitotic checkpoint protein BUB3 0.025 0.075
EDF1 EDF1: Endothelial differentiation-related factor 1 0.025 0.025
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.025
SAP14 SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14 0.025 0.025
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
BCOR N/A 0.025 0.025
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.025 0.025
PHF16 PHF16, JADE3, KIAA0215: Protein Jade-3 0.025 0.025
SETD3 SETD3, C14orf154: SET domain-containing protein 3 0.025 0.025
RBBP6 RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6 0.025 0.025
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.025
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.025 0.025
CAMKK1 N/A 0.025 0.025
NEDD4 NEDD4: Uncharacterized protein NEDD4 0.025 0.025
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.148
CDC25C CDC25C: M-phase inducer phosphatase 3 0.025 0.025
SMARCA2 SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2 0.025 0.025
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.025 0.025
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.025 0.025
NUP98 N/A 0.025 0.025
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.025 0.025
GIT2 N/A 0.025 0.025
MLL4 WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7 0.025 0.025
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.025 0.025
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.025 0.025
GRK6 N/A 0.025 0.025
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.025 0.025
PURB PURB: Transcriptional activator protein Pur-beta 0.025 0.025
SON 0.025 0.025
FLJ23436 N/A 0.025 0.025
NSUN2 NSUN2, SAKI, TRM4: tRNA 0.025 0.025
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.025 0.025
EEF2K EEF2K: Elongation factor 2 kinase 0.025 0.025
WWTR1 WWTR1, TAZ: WW domain-containing transcription regulator protein 1 0.025 0.075
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.025 0.025
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.148
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.025 0.025
HDAC7A N/A 0.025 0.025
DIDO1 N/A 0.025 0.025
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.025 0.025
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.025 0.075
HTATIP N/A 0.025 0.025
CDC25A CDC25A: M-phase inducer phosphatase 1 0.025 0.025
NES N/A 0.025 0.028
MKI67IP MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein 0.025 0.025
C20orf77 N/A 0.025 0.025
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.025 0.025
FAF1 FAF1, CGI-03: FAS-associated factor 1 0.025 0.025
LMNA LMNA, LMN1: Lamin-A/C 0.025 0.025
CDC2 CDC2: Cell division control protein 2 homolog 0.025 0.025
HIST3H2A HIST3H2A: Histone H2A type 3 0.025 0.025
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.025 0.025
MIER1 MIER1, KIAA1610: Mesoderm induction early response protein 1 0.025 0.025
REXO1 REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog 0.025 0.025
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.025 0.025
SEC13L1 N/A 0.025 0.025
MAP2K3 N/A 0.025 0.025
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
ADK ADK: Adenosine kinase 0.025 0.025
CAMK2A N/A 0.025 0.025
HNRPA2B1 HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1 0.025 0.025
0.347
Total Score 31.20