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Evidence of Interaction Between F9 and C1QTNF4

The interaction score between F9 and C1QTNF4 is 37.80.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology N/A N/A
Domains Domains present in F9 and C1QTNF4:
Domains in F9Domains in C1QTNF4
IPR000152 Aspartic acid and asparagine hydroxylation site
IPR001881 EGF-like calcium-binding
IPR006209 EGF-like domain
IPR006210 Type I EGF
IPR001438 Type II EGF-like signature
IPR001254 Peptidase S1, chymotrypsin
IPR001314 Peptidase S1A, chymotrypsin
IPR009003 Peptidase, trypsin-like serine and cysteine proteases
IPR000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic region
IPR002383 Coagulation factor, Gla region
IPR000742 EGF_2.
IPR013032 IPR006209.
IPR012224 Pept_S1A_FX.
IPR001073 Complement C1q protein

The Chi square scores for co-occurrence of domains that are present in F9 and C1QTNF4 are listed below.

Domain 1Domain 2Chi Square
IPR000152 Aspartic acid and asparagine hydroxylation site IPR001073 Complement C1q protein 9.11708
IPR001881 EGF-like calcium-binding IPR001073 Complement C1q protein 8.8622
IPR000742 EGF_2. IPR001073 Complement C1q protein 3.8625
IPR006209 EGF-like domain IPR001073 Complement C1q protein 2.49049

The background colour of the table refers to:

  • Blue Domain is only present in F9
  • Yellow Domain is only present in C1QTNF4
  • Green Domain is present in both F9 and C1QTNF4

 0.165
Post-translational Modifications

Protein: F9

PTMResidueReference
3-hydroxyaspartate 110 HPRD
4-carboxyglutamate 53 HPRD
4-carboxyglutamate 54 HPRD
4-carboxyglutamate 61 HPRD
4-carboxyglutamate 63 HPRD
4-carboxyglutamate 66 HPRD
4-carboxyglutamate 67 HPRD
4-carboxyglutamate 72 HPRD
4-carboxyglutamate 73 HPRD
4-carboxyglutamate 76 HPRD
4-carboxyglutamate 79 HPRD
4-carboxyglutamate 82 HPRD
4-carboxyglutamate 86 HPRD
Carboxylation 53 PubMed, HPRD
Carboxylation 54 PubMed, HPRD
Carboxylation 61 PubMed, HPRD
Carboxylation 63 PubMed, HPRD
Carboxylation 66 PubMed, HPRD
Carboxylation 67 PubMed, HPRD
Carboxylation 72 PubMed, HPRD
Carboxylation 73 PubMed, HPRD
Carboxylation 76 PubMed, HPRD
Carboxylation 79 PubMed, HPRD
Carboxylation 82 PubMed, HPRD
Carboxylation 86 PubMed, HPRD
Disulfide Bridge 145 PubMed, HPRD
Disulfide Bridge 155 PubMed, HPRD
Disulfide Bridge 170 PubMed, HPRD
Glycosylation 203 PubMed, HPRD
Glycosylation 213 PubMed, HPRD
N-linked 203 PubMed, HPRD
N-linked 213 PubMed, HPRD
O-linked 99 PubMed, HPRD
O-linked 107 PubMed, HPRD
O-linked 205 HPRD
O-linked 215 HPRD
O-linked 218 HPRD
O-linked 225 HPRD
Phosphoserine 114 PubMed, HPRD
Phosphoserine 204 HPRD
Proteolytic Cleavage 191 PubMed, HPRD
Proteolytic Cleavage 226 PubMed, HPRD
Sulfotyrosine 201 HPRD

Protein: C1QTNF4

PTMResidueReference
Phosphorylation 259 PubMed, HPRD
Localisation

Protein: F9

LocalisationReference
ER HPRD
Golgi HPRD
Secreted HPRD

Protein: C1QTNF4

No localisation data was used in calculating likelihood of interaction
Transitive Score

The common interactors between F9 and C1QTNF4 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between F9 andC1QTNF4. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , F9 has 1142 interactors and C1QTNF4 has 538 interactors of which there are 471 common interactors.

Common InteractorName of Common InteractorScore for F9-Interactor (?)Score for C1QTNF4-Interactor (?)
PLG PLG: Plasminogen precursor 386.00 0.028
F2 F2: Prothrombin precursor 386.00 0.028
SERPINB1 SERPINB1, ELANH2, MNEI, PI2: Leukocyte elastase inhibitor 333.00 0.028
F10 F10: Coagulation factor X precursor 234.00 0.165
AGT AGT, SERPINA8: Angiotensinogen precursor 7.89 0.028
SERPINA7 SERPINA7, TBG: Thyroxine-binding globulin precursor 7.89 0.028
SERPINA6 SERPINA6, CBG: Corticosteroid-binding globulin precursor 7.89 0.028
SERPIND1 SERPIND1, HCF2: Heparin cofactor 2 precursor 7.89 0.028
SERPINA4 SERPINA4, KST, PI4: Kallistatin precursor 7.89 0.028
SERPINA1 SERPINA1, AAT, PRO0684, PI, PRO2209: Alpha-1-antitrypsin precursor 7.89 0.028
ITIH1 ITIH1, IGHEP1: Inter-alpha-trypsin inhibitor heavy chain H1 precursor 7.89 0.028
SERPINC1 SERPINC1, AT3, PRO0309: Antithrombin-III precursor 7.07 0.028
SERPING1 SERPING1, C1IN, C1NH: Plasma protease C1 inhibitor precursor 4.77 0.028
SERPINA10 SERPINA10, ZPI, UNQ707/PRO1358: Protein Z-dependent protease inhibitor precursor 4.77 0.028
SERPINF2 SERPINF2, AAP, PLI: Alpha-2-antiplasmin precursor 4.77 0.028
F5 F5: Coagulation factor V precursor 3.85 0.028
SERPINA3 N/A 2.84 0.028
CP CP: Ceruloplasmin precursor 2.32 0.028
SERPINF1 SERPINF1, PEDF: Pigment epithelium-derived factor precursor 2.32 0.028
APOH APOH, B2G1: Beta-2-glycoprotein 1 precursor 1.91 0.028
APOA2 APOA2: Apolipoprotein A-II precursor 1.91 0.028
ALB ALB: Uncharacterized protein ALB 1.91 0.028
C8B C8B: Complement component C8 beta chain precursor 1.71 0.083
AHSG AHSG, FETUA, PRO2743: Alpha-2-HS-glycoprotein precursor 1.67 0.028
CD14 CD14: Monocyte differentiation antigen CD14 precursor 1.41 0.028
SERPINA5 SERPINA5, PCI, PLANH3, PROCI: Plasma serine protease inhibitor precursor 1.41 0.028
SLC14A2 SLC14A2, HUT2, UT2: Urea transporter, kidney 1.14 0.028
APOM APOM, G3A, HSPC336, NG20: Apolipoprotein M 1.07 0.028
ORM1 ORM1, AGP1: Alpha-1-acid glycoprotein 1 precursor 1.07 0.028
SERPINB13 SERPINB13, PI13: Serpin B13 1.02 0.028
SERPINE1 SERPINE1, PAI1, PLANH1: Plasminogen activator inhibitor 1 precursor 1.02 0.028
F8 F8, F8C: Coagulation factor VIII precursor 1.00 0.028
SERPINB4 SERPINB3, SCCA, SCCA1: Serpin B3 1.00 0.028
BMP7 BMP7, OP1: Bone morphogenetic protein 7 precursor 0.902 0.028
CFHR2 CFHR2, CFHL2, FHR2, HFL3: Complement factor H-related protein 2 precursor 0.898 0.028
AFM AFM, ALB2, ALBA: Afamin precursor 0.898 0.028
APOA1 APOA1: Apolipoprotein A-I precursor 0.898 0.028
HPX HPX: Hemopexin precursor 0.898 0.028
VTN VTN: Vitronectin precursor 0.898 0.028
C4BPB C4BPB: C4b-binding protein beta chain precursor 0.898 0.028
C2 C2: Complement C2 precursor 0.898 0.028
C8A C8A: Complement component C8 alpha chain precursor 0.898 0.083
HP HP: Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta c 0.898 0.028
CFB CFB, BF, BFD: Complement factor B precursor 0.898 0.028
AMBP AMBP, HCP, ITIL: AMBP protein precursor [Contains: Alpha-1-microglobulin 0.898 0.028
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.874 0.028
SERPINI1 SERPINI1, PI12: Neuroserpin precursor 0.813 0.028
MBL2 MBL2, MBL: Mannose-binding protein C precursor 0.804 0.165
FGB FGB: Fibrinogen beta chain precursor [Contains: Fibrinopeptide B] 0.804 0.028
APOC4 APOC2, APC2: Apolipoprotein C-II precursor 0.786 0.028
APOC3 APOC3: Apolipoprotein C-III precursor 0.786 0.028
RNASE4 ANG, RNASE5: Angiogenin precursor 0.786 0.028
ITIH2 N/A 0.786 0.028
PON1 N/A 0.786 0.028
MST1 N/A 0.704 0.028
ORM2 ORM2, AGP2: Alpha-1-acid glycoprotein 2 precursor 0.651 0.028
C8G C8G: Complement component C8 gamma chain precursor 0.651 0.028
ITIH4 ITIH4, IHRP, PRO1851, ITIHL1, PK120: Inter-alpha-trypsin inhibitor heavy chain H 0.651 0.028
IGFALS IGFALS, ALS: Insulin-like growth factor-binding protein complex acid labile chai 0.583 0.028
PTGS1 PTGS1, COX1: Prostaglandin G/H synthase 1 precursor 0.574 0.034
C4BPA C4BPA, C4BP: C4b-binding protein alpha chain precursor 0.543 0.028
F12 F12: Coagulation factor XII precursor 0.543 0.083
APCS APCS, PTX2: Serum amyloid P-component precursor 0.543 0.165
HGFAC HGFAC: Hepatocyte growth factor activator precursor 0.543 0.083
PROZ PROZ: Vitamin K-dependent protein Z precursor 0.543 0.165
C3 0.543 0.028
PROC PROC: Vitamin K-dependent protein C precursor 0.486 0.165
C6 C6: Complement component C6 precursor 0.486 0.083
HAMP HAMP, HEPC, UNQ487/PRO1003, LEAP1: Hepcidin precursor 0.475 0.028
HRG HRG: Histidine-rich glycoprotein precursor 0.475 0.028
PON3 PON3: Serum paraoxonase/lactonase 3 0.475 0.028
KNG1 N/A 0.475 0.028
APOE APOE: Apolipoprotein E precursor 0.438 0.028
AFP AFP, HPAFP: Alpha-fetoprotein precursor 0.438 0.028
F13B F13B: Coagulation factor XIII B chain precursor 0.438 0.028
ANGPTL3 ANGPTL3, ANGPT5, UNQ153/PRO179: Angiopoietin-related protein 3 precursor 0.438 0.028
MARCO MARCO, SCARA2: Macrophage receptor MARCO 0.429 0.0688
TF TF, PRO1400: Serotransferrin precursor 0.426 0.028
LPA LPA: Apolipoprotein(a) precursor 0.393 0.028
FGA N/A 0.393 0.028
LMAN2 LMAN2, C5orf8: Vesicular integral-membrane protein VIP36 precursor 0.384 0.0688
TTR TTR, PALB: Transthyretin precursor 0.384 0.028
A2M A2M, FWP007: Alpha-2-macroglobulin precursor 0.324 0.028
CFI CFI, IF: Complement factor I precursor 0.324 0.028
C1R C1R: Complement C1r subcomponent precursor 0.324 0.165
CFH CFH, HF, HF1, HF2: Complement factor H precursor 0.324 0.028
PZP PZP: Pregnancy zone protein precursor 0.324 0.028
C9 C9: Complement component C9 precursor [Contains: Complement component C9a; Compl 0.290 0.083
CETP CETP: Cholesteryl ester transfer protein precursor 0.283 0.028
SEPP1 SEPP1, SELP: Selenoprotein P precursor 0.283 0.028
PCOLCE PCOLCE, PCPE1: Procollagen C-endopeptidase enhancer 1 precursor 0.265 0.028
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.241 0.028
CNTNAP1 CNTNAP1, CASPR, NRXN4: Contactin-associated protein 1 precursor 0.237 0.027
TFF2 TFF2, SML1: Trefoil factor 2 precursor 0.232 0.028
CSF3 CSF3, GCSF: Granulocyte colony-stimulating factor precursor 0.209 0.028
RTN4R RTN4R, NOGOR, UNQ330/PRO526: Reticulon-4 receptor precursor 0.209 0.028
LRG1 LRG1, LRG: Leucine-rich alpha-2-glycoprotein precursor 0.209 0.028
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.209 0.028
DCN DCN: Decorin precursor 0.209 0.028
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.209 0.028
NULL A1BG: Alpha-1B-glycoprotein precursor 0.209 0.028
KITLG KITLG, MGF, SCF: Kit ligand precursor 0.209 0.028
IL4 IL4: Interleukin-4 precursor 0.209 0.028
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.209 0.028
OPTC OPTC, OPT: Opticin precursor 0.209 0.028
THPO THPO, MGDF: Thrombopoietin precursor 0.209 0.028
IFNG IFNG: Interferon gamma precursor 0.209 0.028
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.201 0.028
GAST GAST, GAS: Gastrin precursor [Contains: Gastrin-71 0.201 0.028
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.201 0.028
WNT2B WNT2B, WNT13: Protein Wnt-2b precursor 0.201 0.028
CXCL9 CXCL9, CMK, MIG, SCYB9: Small-inducible cytokine B9 precursor 0.201 0.028
PROS1 PROS1, PROS: Vitamin K-dependent protein S precursor 0.201 0.165
C1S C1S: Complement C1s subcomponent precursor 0.201 0.165
SHBG SHBG: Sex hormone-binding globulin precursor 0.201 0.165
EDN2 EDN2: Endothelin-2 precursor 0.201 0.028
CCL1 CCL1, SCYA1: Small-inducible cytokine A1 precursor 0.201 0.028
EDIL3 EDIL3, DEL1: EGF-like repeat and discoidin I-like domain-containing protein 3 pr 0.197 0.027
EPO EPO: Erythropoietin precursor 0.192 0.028
IL5 IL5: Interleukin-5 precursor 0.192 0.028
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.192 0.028
ASPN ASPN: ASPN protein 0.192 0.028
CSF2 CSF2, GMCSF: Granulocyte-macrophage colony-stimulating factor precursor 0.192 0.028
CSN2 CSN2, CASB: Beta-casein precursor 0.191 0.028
CNTN4 CNTN4: Contactin-4 precursor 0.187 0.028
CNTN1 CNTN1: Contactin-1 precursor 0.187 0.028
LIPF LIPF: Gastric triacylglycerol lipase precursor 0.180 0.028
IFNA14 IFNA14: Interferon alpha-14 precursor 0.176 0.028
RLN2 RLN2: Prorelaxin H2 precursor [Contains: Relaxin B chain; Relaxin A chain] 0.176 0.028
IFNB1 IFNB1, IFB, IFNB: Interferon beta precursor 0.176 0.028
NTF3 NTF3: Neurotrophin-3 precursor 0.176 0.028
IL22 IL22, ILTIF, UNQ3099/PRO10096: Interleukin-22 precursor 0.176 0.028
ECM1 ECM1: Extracellular matrix protein 1 precursor 0.174 0.028
CFHR1 CFHR1, CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, HFL1, HFL2: Complement factor H-relate 0.174 0.028
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.174 0.028
C4A C4A: Complement C4-A precursor 0.174 0.028
LOC643930 CCL3L1, D17S1718, G0S19-2, SCYA3L1: Small-inducible cytokine A3-like 1 precursor 0.174 0.028
BGLAP BGLAP: Osteocalcin precursor 0.174 0.028
GRN GRN: Granulins precursor 0.174 0.028
TFPI TFPI, LACI, TFPI1: Tissue factor pathway inhibitor precursor 0.174 0.028
FN1 N/A 0.174 0.028
CCL15 CCL15, MIP5, NCC3, SCYA15: Small-inducible cytokine A15 precursor 0.174 0.028
F11 F11: Coagulation factor XI precursor 0.174 0.028
C1QC C1QC, C1QG: Complement C1q subcomponent subunit C precursor 0.174 0.056
CCL26 CCL26, SCYA26, UNQ216/PRO242: Small-inducible cytokine A26 precursor 0.174 0.028
MMRN2 MMRN2, EMILIN3: Multimerin-2 precursor 0.174 0.165
CNTNAP2 CNTNAP2, CASPR2, KIAA0868: Contactin-associated protein-like 2 precursor 0.174 0.027
CD46 N/A 0.165 0.028
MMP13 MMP13: Collagenase 3 precursor 0.160 0.028
PRSS22 PRSS22, BSSP4, SP001LA, PRSS26, UNQ302/PRO343: Brain-specific serine protease 4 0.160 0.028
IL2RA IL2RA: Interleukin-2 receptor alpha chain precursor 0.160 0.028
MFAP2 MFAP2, MAGP1: Microfibrillar-associated protein 2 precursor 0.160 0.028
CCL24 CCL24, MPIF2, SCYA24: Small-inducible cytokine A24 precursor 0.160 0.028
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.160 0.028
COL5A1 N/A 0.160 0.165
THBD THBD, THRM: Thrombomodulin precursor 0.160 0.056
COL1A1 COL1A1: Collagen alpha-1(I) chain precursor 0.160 0.165
CXCL10 CXCL10, INP10, SCYB10: Small-inducible cytokine B10 precursor 0.160 0.028
EDN1 EDN1: Endothelin-1 precursor 0.160 0.028
CMA1 CMA1, CYH, CYM: Chymase precursor 0.160 0.028
COL5A2 N/A 0.160 0.165
F7 F7: Coagulation factor VII precursor 0.156 0.165
ANGPTL6 AGF, UNQ152/PRO178, ANGPTL6, ARP5: Angiopoietin-related protein 6 precursor 0.156 0.028
FGG FGG, PRO2061: Fibrinogen gamma chain precursor 0.156 0.028
FCN3 FCN3, FCNH, HAKA1: Ficolin-3 precursor 0.156 0.165
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.156 0.083
BMP1 N/A 0.156 0.165
CPB2 CPB2: Carboxypeptidase B2 precursor 0.156 0.028
PLAT PLAT: Tissue-type plasminogen activator precursor 0.156 0.083
LOC653509 SFTPA1, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A1 precursor 0.156 0.165
HGF HGF, HPTA: Hepatocyte growth factor precursor 0.156 0.028
COL18A1 N/A 0.156 0.056
COL12A1 COL12A1, COL12A1L: Collagen alpha-1(XII) chain precursor 0.156 0.056
KLK3 KLK3, APS: Prostate-specific antigen precursor 0.156 0.028
IL2 IL2: Interleukin 2 0.156 0.028
NDP NDP: Norrin precursor 0.156 0.028
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.156 0.028
FGF5 FGF5: Fibroblast growth factor 5 precursor 0.156 0.028
IL6 IL6, IFNB2: Interleukin-6 precursor 0.156 0.028
KERA KERA: Keratocan precursor 0.156 0.028
FGF23 FGF23, HYPF, UNQ3027/PRO9828: Fibroblast growth factor 23 precursor 0.156 0.028
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.156 0.028
OSM OSM: Oncostatin-M precursor 0.156 0.028
LUM LUM, LDC: Lumican precursor 0.156 0.028
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.156 0.028
IL3 IL3: Interleukin-3 precursor 0.156 0.028
PTHLH N/A 0.152 0.028
ZP3 ZP3, ZP3A, ZP3B, ZPC: Zona pellucida sperm-binding protein 3 precursor 0.152 0.028
GHRL GHRL, MTLRP, UNQ524/PRO1066: Appetite-regulating hormone precursor 0.152 0.028
GUCA2A GUCA2A, GUCA2: Guanylin precursor 0.152 0.028
GRP Gastrin-releasing peptide 0.152 0.028
LECT1 LECT1, CHMI: Chondromodulin-1 precursor 0.152 0.028
CCL14 N/A 0.152 0.028
CSF1 CSF1: Macrophage colony-stimulating factor 1 precursor 0.152 0.028
NOG NOG: Noggin precursor 0.152 0.028
CST4 CST4: Cystatin-S precursor 0.152 0.028
ACCN3 ACCN3, ASIC3, SLNAC1, TNAC1: Amiloride-sensitive cation channel 3 0.152 0.028
PCSK6 N/A 0.152 0.028
PLTP PLTP: Phospholipid transfer protein precursor 0.152 0.028
PLAU Plasminogen activator, urokinase 0.152 0.028
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.148 0.049
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.148 0.083
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.144 0.083
THBS1 THBS1, TSP, TSP1: Thrombospondin-1 precursor 0.144 0.165
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.144 0.028
PRG4 PRG4, MSF, SZP: Proteoglycan-4 precursor 0.144 0.028
TIMP1 TIMP1, CLGI, TIMP: Metalloproteinase inhibitor 1 precursor 0.144 0.028
HLA-DQB2 HLA-DQB2, DASS-256O6.1-002, XXbac-BCX231H22.1-002, XXbac-BPG3L13.3-002: Major hi 0.140 0.028
TFF1 TFF1, BCEI, PS2: Trefoil factor 1 precursor 0.140 0.028
CRP CRP, PTX1: C-reactive protein precursor [Contains: C-reactive protein(1-205)] 0.140 0.165
GUCA2B GUCA2B: Guanylate cyclase activator 2B precursor [Contains: Guanylate cyclase C- 0.140 0.028
PAEP PAEP: Glycodelin precursor 0.137 0.028
IL1B IL1B, IL1F2: Interleukin-1 beta precursor 0.137 0.028
PRL PRL: Prolactin precursor 0.137 0.028
GDF15 GDF15, MIC1, PDF, PLAB, PTGFB: Growth/differentiation factor 15 precursor 0.137 0.028
CSH2 GH1: Somatotropin precursor 0.137 0.028
LIF LIF, HILDA: Leukemia inhibitory factor precursor 0.137 0.028
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.137 0.028
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.137 0.028
CGA CGA: Glycoprotein hormones alpha chain precursor 0.137 0.028
LCN2 LCN2, HNL, NGAL: Neutrophil gelatinase-associated lipocalin precursor 0.137 0.028
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.137 0.028
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.137 0.028
ITM2C ITM2C, BRI3, hucep-14, NPD018, PSEC0047: Integral membrane protein 2C 0.137 0.028
VNN1 VNN1: Pantetheinase precursor 0.137 0.028
LOC641705 AMY2A: Pancreatic alpha-amylase precursor 0.137 0.028
CA11 CA11, CARP2, UNQ211/PRO237: Carbonic anhydrase-related protein 11 precursor 0.137 0.028
NOTCH4 N/A 0.130 0.165
CLEC3B CLEC3B, TNA: Tetranectin precursor 0.130 0.028
CXCL11 CXCL11, ITAC, SCYB11, SCYB9B: Small-inducible cytokine B11 precursor 0.130 0.028
CCL11 CCL11, SCYA11: Eotaxin precursor 0.130 0.028
MMP9 MMP9, CLG4B: Matrix metalloproteinase-9 precursor 0.130 0.028
CCL13 CCL13, MCP4, NCC1, SCYA13: Small-inducible cytokine A13 precursor 0.130 0.028
CCL8 CCL8, MCP2, SCYA10, SCYA8: Small-inducible cytokine A8 precursor 0.130 0.028
MUC2 MUC2, SMUC: Mucin-2 precursor 0.130 0.083
NOTCH3 NOTCH3: Neurogenic locus notch homolog protein 3 precursor 0.130 0.165
CXCL12 Stromal cell-derived factor 1 delta 0.130 0.028
CCL2 CCL2, MCP1, SCYA2: Small-inducible cytokine A2 precursor 0.130 0.028
EDN3 EDN3: Endothelin-3 precursor 0.130 0.028
C1QA C1QA: Complement C1q subcomponent subunit A precursor 0.130 0.165
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.130 0.083
FSTL1 FSTL1, FRP: Follistatin-related protein 1 precursor 0.130 0.028
TSHB TSHB: Thyrotropin subunit beta precursor 0.130 0.028
COL3A1 COL3A1: Collagen alpha-1(III) chain precursor 0.130 0.056
PRTN3 PRTN3, MBN: Myeloblastin precursor 0.130 0.028
CTSG CTSG: Cathepsin G precursor 0.130 0.028
FSHB FSHB: Follitropin subunit beta precursor 0.130 0.028
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.130 0.165
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.130 0.028
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.126 0.049
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.124 0.028
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.124 0.028
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.124 0.028
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.124 0.028
PTGDS PTGDS, PDS: Prostaglandin-H2 D-isomerase precursor 0.124 0.028
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.124 0.028
MGP MGP, MGLAP, GIG36: Matrix Gla protein precursor 0.123 0.028
PF4V1 PF4V1, SCYB4V1: Platelet factor 4 variant precursor 0.123 0.028
FGF9 FGF9: Glia-activating factor precursor 0.123 0.028
APOD APOD: Apolipoprotein D precursor 0.123 0.028
SPARC SPARC, ON: SPARC precursor 0.116 0.028
LAMA2 LAMA2: Uncharacterized protein LAMA2 0.116 0.165
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.116 0.028
C7 C7: Complement component C7 precursor 0.116 0.083
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.116 0.165
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.116 0.083
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.116 0.165
SPON1 SPON1, KIAA0762, VSGP: Spondin-1 precursor 0.116 0.028
TNC TNC, HXB: Tenascin precursor 0.116 0.083
MMP7 MMP7, MPSL1, PUMP1: Matrilysin precursor 0.116 0.028
MMP8 CLG1, MMP8: Neutrophil collagenase precursor 0.116 0.028
MMP2 MMP2, CLG4A: 72 kDa type IV collagenase precursor 0.116 0.028
CPM CPM: Carboxypeptidase M precursor 0.116 0.028
MFAP4 MFAP4: Microfibril-associated glycoprotein 4 precursor 0.116 0.028
PLA2G7 PAFAH, PLA2G7: Platelet-activating factor acetylhydrolase precursor 0.116 0.028
FIGF FIGF, VEGFD: Vascular endothelial growth factor D precursor 0.116 0.028
CTGF CTGF, CCN2, HCS24: Connective tissue growth factor precursor 0.116 0.028
COL4A1 N/A 0.116 0.165
MMP1 MMP1, CLG: Interstitial collagenase precursor 0.116 0.028
PRSS1 PRSS1, TRP1, TRY1, TRYP1: Trypsin-1 precursor 0.115 0.028
UMOD UMOD: Uromodulin precursor 0.115 0.165
LHB LHB: Lutropin subunit beta precursor 0.115 0.028
IL1A IL1A, IL1F1: Interleukin-1 alpha precursor 0.115 0.028
PRG2 PRG2, MBP: Bone marrow proteoglycan precursor 0.115 0.028
SLPI SLPI, WAP4, WFDC4: Antileukoproteinase precursor 0.115 0.028
REG3A REG3A, HIP, PAP, PAP1: Regenerating islet-derived protein 3 alpha precursor 0.115 0.028
LIPG LIPG, UNQ387/PRO719: Endothelial lipase precursor 0.115 0.028
GZMB Endogenous granzyme B 0.115 0.028
CGB CGB, CGB3, CGB5, CGB7, CGB8: Choriogonadotropin subunit beta precursor 0.115 0.028
CCK CCK: Cholecystokinins precursor 0.115 0.028
ELA3B ELA3B: Elastase-3B precursor 0.115 0.028
LTA LTA, TNFB, TNFSF1: Lymphotoxin-alpha precursor 0.115 0.028
CCL4 CCL4, CCL4L, LAG1, MIP1B, SCYA4, SCYA4L: Small-inducible cytokine A4 precursor 0.115 0.028
CSPG2 N/A 0.115 0.165
COL15A1 COL15A1: Collagen alpha-1(XV) chain precursor [Contains: Endostatin 0.115 0.165
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.115 0.028
ADIPOQ ADIPOQ, ACDC, ACRP30, APM1, GBP28: Adiponectin precursor 0.115 0.165
SFTPA2 SFTPA2, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A2 precursor 0.115 0.165
PPBP PPBP, CTAP3, SCYB7, TGB1, THBGB1: Platelet basic protein precursor 0.115 0.028
CEL CEL, RP11-326L24.2-001: Carboxyl ester lipase 0.115 0.028
AZU1 AZU1: Azurocidin precursor 0.115 0.028
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.115 0.028
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.115 0.028
IL8 IL8: Interleukin-8 precursor 0.115 0.028
CXCL5 CXCL5, ENA78, SCYB5: Small-inducible cytokine B5 precursor 0.115 0.028
PF4 PF4, CXCL4, SCYB4: Platelet factor 4 precursor 0.115 0.028
PDGFA PDGFA, PDGF1: Platelet-derived growth factor A chain precursor 0.115 0.028
CCL21 CCL21, SCYA21, UNQ784/PRO1600: Small-inducible cytokine A21 precursor 0.115 0.028
ELA2 ELA2: Leukocyte elastase precursor 0.115 0.028
TG TG: Thyroglobulin precursor 0.115 0.028
XCL1 XCL1, LTN, SCYC1: Lymphotactin precursor 0.115 0.028
CCL5 CCL5, D17S136E, SCYA5: Small-inducible cytokine A5 precursor 0.115 0.028
TACSTD1 TACSTD1, GA733-2, M1S2, M4S1, MIC18, TROP1: Tumor-associated calcium signal tran 0.115 0.028
COL17A1 COL17A1, BP180, BPAG2: Collagen alpha-1(XVII) chain 0.115 0.165
CXCL1 CXCL1, GRO, GRO1, GROA, MGSA, SCYB1: Growth-regulated protein alpha precursor 0.115 0.028
SPINK1 SPINK1, PSTI: Pancreatic secretory trypsin inhibitor precursor 0.115 0.028
CCL22 CCL22, A-152E5.1, MDC, SCYA22: Small-inducible cytokine A22 precursor 0.115 0.028
REG1B REG1A, PSPS, REG: Lithostathine 1 alpha precursor 0.115 0.028
LOX LOX: Protein-lysine 6-oxidase precursor 0.114 0.028
IL1RN IL1RN, IL1F3, IL1RA: Interleukin-1 receptor antagonist protein precursor 0.114 0.028
SFTPB SFTPB, SFTP3: Pulmonary surfactant-associated protein B precursor 0.114 0.028
CORT CORT, UNQ307/PRO350: Cortistatin precursor [Contains: Cortistatin-29; Cortistati 0.114 0.028
AOC3 AOC3, VAP1: Membrane copper amine oxidase 0.114 0.028
BDNF BDNF: Brain-derived neurotrophic factor precursor 0.114 0.028
IFNW1 IFNW1: Interferon omega-1 precursor 0.114 0.028
NPPC NPPC, CNP2: C-type natriuretic peptide precursor [Contains: CNP-22; CNP-29; CNP- 0.114 0.028
NPY NPY: Neuropeptide Y precursor [Contains: Neuropeptide Y 0.114 0.028
THBS2 N/A 0.114 0.028
ZP2 ZP2, ZPA: Zona pellucida sperm-binding protein 2 precursor 0.114 0.028
AGRP AGRP, AGRT, ART: Agouti-related protein precursor 0.114 0.028
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.113 0.049
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.113 0.049
TGFB1 TGFB1, TGFB: Transforming growth factor beta-1 precursor 0.111 0.028
ALK ALK: ALK tyrosine kinase receptor precursor 0.110 0.028
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.110 0.028
EFNB1 EFNB1, EFL-3, EPLG2, LERK2: Ephrin-B1 precursor 0.110 0.028
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.109 0.049
COL16A1 COL16A1: Collagen alpha-1(XVI) chain precursor 0.109 0.165
IL15RA IL15RA: Interleukin-15 receptor alpha chain precursor 0.109 0.028
LGALS1 LGALS1: Galectin-1 0.109 0.165
LGALS3 LGALS3, MAC2: Galectin-3 0.103 0.165
CFP CFP, PFC: Properdin precursor 0.103 0.028
SPINT2 SPINT2, HAI2, KOP: Kunitz-type protease inhibitor 2 precursor 0.103 0.028
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.103 0.028
KLK6 KLK6, PRSS18, PRSS9: Kallikrein-6 precursor 0.103 0.028
PNLIP PNLIP: Pancreatic triacylglycerol lipase precursor 0.103 0.028
SLIT2 SLIT2, SLIL3: Slit homolog 2 protein precursor 0.103 0.165
FAT2 FAT2, CDHF8, KIAA0811, MEGF1: Protocadherin Fat 2 precursor 0.103 0.083
CPB1 CPB1, CPB, PCPB: Carboxypeptidase B precursor 0.103 0.028
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.103 0.028
VWF VWF, F8VWF: von Willebrand factor precursor 0.103 0.028
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.103 0.028
SFTPD SFTPD, PSPD, SFTP4: Pulmonary surfactant-associated protein D precursor 0.103 0.165
WNT3 WNT3, INT4: Proto-oncogene protein Wnt-3 precursor 0.103 0.028
KLK1 KLK1: Kallikrein-1 precursor 0.103 0.028
CPA2 CPA2: Carboxypeptidase A2 precursor 0.103 0.028
MMP11 MMP11, STMY3: Stromelysin-3 precursor 0.103 0.028
CHI3L1 CHI3L1: Chitinase-3-like protein 1 precursor 0.102 0.028
TCN1 TCN1, TC1: Transcobalamin-1 precursor 0.100 0.028
CA6 CA6: Carbonic anhydrase 6 precursor 0.100 0.028
CST5 CST5: Cystatin-D precursor 0.100 0.028
INHA INHA: Inhibin alpha chain precursor 0.100 0.028
RNASE1 RNASE1, RIB1, RNS1: Ribonuclease pancreatic precursor 0.100 0.028
GNRH1 GNRH1, GNRH, GRH, LHRH: Progonadoliberin-1 precursor 0.100 0.028
IAPP IAPP: Islet amyloid polypeptide precursor 0.100 0.028
NPPA NPPA, ANP, PND: Atrial natriuretic factor precursor 0.100 0.028
IL18 IL18, IGIF, IL1F4: Interleukin-18 precursor 0.100 0.028
RNASE2 RNASE2, EDN, RNS2: Non-secretory ribonuclease precursor 0.100 0.028
PAPPA PAPPA, RP11-45A16.1-001: Pregnancy-associated plasma protein A, pappalysin 1 (Fr 0.100 0.028
PRB4 PRB4: Basic salivary proline-rich protein 4 precursor 0.100 0.028
CST7 CST7: Cystatin-F precursor 0.100 0.028
INS INS: Insulin precursor [Contains: Insulin B chain; Insulin A chain] 0.100 0.028
GAA GAA: Uncharacterized protein GAA 0.100 0.028
LGALS3BP LGALS3BP, M2BP: Galectin-3-binding protein precursor 0.100 0.028
MEP1B MEP1B: Meprin A subunit beta precursor 0.099 0.049
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.098 0.049
FNTB FNTB: Protein farnesyltransferase subunit beta 0.097 0.028
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.097 0.028
DLK1 DLK1, DLK: Delta-like protein precursor 0.096 0.109
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.096 0.109
EDA N/A 0.096 0.109
FGL2 FGL2: Fibroleukin precursor 0.093 0.028
CPE CPE: Carboxypeptidase E precursor 0.093 0.028
CPD CPD: Carboxypeptidase D precursor 0.093 0.028
PSAP PSAP, GLBA, SAP1: Proactivator polypeptide precursor [Contains: Saposin-A 0.090 0.028
CST3 CST3: Cystatin-C precursor 0.090 0.028
HLA-DRA 0.090 0.028
LTF GIG12: Growth-inhibiting protein 12 0.0898 0.028
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.088 0.049
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.086 0.028
ATRN N/A 0.086 0.049
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.086 0.049
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.083 0.028
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.083 0.028
SELE SELE, ELAM1: E-selectin precursor 0.081 0.049
VNN2 VNN2: Vascular non-inflammatory molecule 2 precursor 0.081 0.028
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.073 0.049
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.073 0.049
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.073 0.049
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.072 0.049
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.072 0.049
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.071 0.049
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.069 0.028
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.064 0.049
LDLR LDLR: Low-density lipoprotein receptor precursor 0.064 0.109
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.064 0.049
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.064 0.109
MEP1A MEP1A: Meprin A subunit alpha precursor 0.064 0.049
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.064 0.049
EGF EGF: Pro-epidermal growth factor precursor 0.063 0.109
AREG AREG, SDGF: Amphiregulin precursor 0.063 0.049
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.063 0.049
SORL1 SORL1: Sortilin-related receptor precursor 0.063 0.049
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.063 0.049
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.063 0.049
ITGB4 N/A 0.063 0.049
ITGB7 ITGB7: Integrin beta-7 precursor 0.058 0.049
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.057 0.049
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.056 0.109
DSP DSP: Desmoplakin 0.052 0.028
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.051 0.049
CRLF3 N/A 0.049 0.028
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.049 0.028
DLG2 DLG2: Disks large homolog 2 0.049 0.028
LMAN1 LMAN1, ERGIC53, F5F8D: Protein ERGIC-53 precursor 0.046 0.0688
FUBP1 N/A 0.046 0.0688
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.044 0.028
STAB2 STAB2, FEEL2, FELL, FEX2, HARE: Stabilin-2 precursor 0.041 0.027
EMILIN2 EMILIN2: EMILIN-2 precursor 0.041 0.027
MASP1 MASP1, CRARF, CRARF1, PRSS5: Complement-activating component of Ra-reactive fact 0.041 0.027
CIC CIC, KIAA0306: Protein capicua homolog 0.039 0.028
CANX CANX: Calnexin precursor 0.037 0.0688
LAMA4 LAMA4: Laminin subunit alpha-4 precursor 0.0308 0.027
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.029 0.028
LNX1 N/A 0.028 0.028
TUBGCP6 TUBGCP6, GCP6, KIAA1669: Gamma-tubulin complex component 6 0.028 0.028
PCGF6 N/A 0.028 0.028
CGN N/A 0.028 0.028
IRF2BP2 IRF2BP2, RP4-781K5.1-002: Interferon regulatory factor 2-binding protein 2. 0.028 0.028
RAD18 RAD18, RNF73: E3 ubiquitin-protein ligase RAD18 0.028 0.028
PBEF1 NAMPT, PBEF, PBEF1: Nicotinamide phosphoribosyltransferase 0.028 0.028
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.028 0.028
LGALS4 LGALS4: Galectin-4 0.028 0.027
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.027 0.051
MMRN1 MMRN1, ECM, EMILIN4, MMRN: Multimerin-1 precursor 0.027 0.051
PAPPA PAPPA: Pappalysin-1 precursor 0.027 0.051
LTBP1 LTBP1: Latent-transforming growth factor beta-binding protein, isoform 1S precur 0.027 0.051
COL4A2 COL4A2: Collagen alpha-2(IV) chain precursor [Contains: Canstatin] 0.027 0.051
COL1A2 COL1A2: Collagen alpha-2(I) chain precursor 0.027 0.051
COL2A1 N/A 0.027 0.051
COL5A2 COL5A2: Collagen alpha-2(V) chain precursor 0.027 0.051
ELTD1 ELTD1, RP11-143H12.1-002: EGF, latrophilin and seven transmembrane domain contai 0.027 0.051
CLEC14A CLEC14A, C14orf27, UNQ236/PRO269, EGFR5: C-type lectin domain family 14 member A 0.027 0.027
CBLN2 CBLN2: Cerebellin-2 0.027 0.027
CSPG3 CSPG3, NCAN, NEUR: Neurocan core protein precursor 0.027 0.027
COL11A2 COL11A2: Collagen alpha-2(XI) chain precursor 0.027 0.027
C1QTNF5 C1QTNF5, CTRP5, UNQ303/PRO344: Complement C1q tumor necrosis factor-related prot 0.027 0.027
C1QTNF7 N/A 0.027 0.027
MASP2 MASP2: Mannan-binding lectin serine protease 2 precursor 0.027 0.027
C1QL1 C1QL1, C1QRF, CRF: C1q-related factor precursor 0.027 0.027
COL13A1 COL13A1: Collagen alpha-1(XIII) chain 0.027 0.027
EMID2 EMID2, COL26A1, EMU2: Collagen alpha-1(XXVI) chain precursor 0.027 0.027
COL6A2 COL6A2: Collagen alpha-2(VI) chain precursor 0.027 0.027
C1QTNF2 C1QTNF2, CTRP2, UNQ6349/PRO21054: Complement C1q tumor necrosis factor-related p 0.027 0.027
COL13A1 N/A 0.027 0.027
NELL2 NELL2, NRP2: Protein kinase C-binding protein NELL2 precursor 0.027 0.027
CBLN4 CBLN4, CBLNL1, UNQ718/PRO1382: Cerebellin-4 precursor 0.027 0.027
STC2 STC2: Stanniocalcin-2 precursor 0.026 0.028
UNC5D N/A 0.025 0.028
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.025 0.028
SCRIB N/A 0.025 0.028
0.572
Total Score 37.80