PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between SMARCA5 and SIN3A

The interaction score between SMARCA5 and SIN3A is 27.60.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

N/A

Orthology

Organism	SMARCA5 Orthologue		SIN3A Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
bakers yeast	YBR245C	0.062	YOL004W	1	Other AffinityCaptureMS Get References From PubMed
bakers yeast	YOR304W	1	YOL004W	1
worm	P41877	0.551	O01319	1
fly	Q24368	1	Q8ML44	0.209

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.119

Domains

No domains were used in calculating likelihood of interaction

4.85E-3

Post-translational Modifications

Protein: SMARCA5

PTM	Residue	Reference
Phosphorylation	66	PubMed, HPRD
Phosphorylation	137	PubMed, HPRD
Phosphoserine	66	HPRD

Protein: SIN3A

PTM	Residue	Reference
Phosphorylation	832	PubMed, HPRD
Phosphoserine	832	HPRD
Phosphoserine	860	HPRD
Phosphoserine	1112	HPRD

Localisation

Protein: SMARCA5

Localisation	Reference
Nucleus	HPRD
Nucleolus	HPRD

Protein: SIN3A

Localisation	Reference
Nucleus	HPRD
Nucleolus	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between SMARCA5 and SIN3A that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SMARCA5 andSIN3A. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SMARCA5 has 1153 interactors and SIN3A has 133 interactors of which there are 103 common interactors.

Common Interactor	Name of Common Interactor	Score for SMARCA5-Interactor (?)	Score for SIN3A-Interactor (?)
H2AFX	H2AFX, H2AX: Histone H2A.x	3.35	1.15
SMARCC2	SMARCC2, BAF170: SWI/SNF-related matrix-associated actin-dependent regulator of	1.27	0.593
HIST1H4A	HIST1H4A, H4/A, HIST1H4B, H4/I, H4/G, HIST1H4D, H4/B, H4/J, HIST1H4F, HIST4H4, H	0.995	1.15
HDAC3	HDAC3: Histone deacetylase 3	0.763	0.046
HDAC1	HDAC1, RPD3L1: Histone deacetylase 1	0.763	2.45
HIST2H2AC	HIST2H2AC, H2AFQ: Histone H2A type 2-C	0.714	0.232
HIST3H2A	HIST3H2A: Histone H2A type 3	0.714	0.232
ADPRT	PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1	0.486	0.026
HDAC2	HDAC2: Histone deacetylase 2	0.461	12.20
ZNF318	ZNF318, HRIHFB2436: Zinc finger protein 318	0.430	0.051
MATR3	MATR3, KIAA0723: Matrin-3	0.430	0.051
SUZ12	SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12	0.385	0.046
BAZ2A	BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A	0.372	0.046
ZNF148	ZNF148, ZBP89: Zinc finger protein 148	0.260	0.051
SP3	SP3: Transcription factor Sp3	0.233	0.046
YY1	YY1: Transcriptional repressor protein YY1	0.233	0.046
AKAP8	AKAP8, AKAP95: A-kinase anchor protein 8	0.233	0.046
MBD3	MBD3: Methyl-CpG-binding domain protein 3	0.225	0.046
ZNF267	ZNF267: Zinc finger protein 267	0.210	0.051
ZNF24	ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24	0.188	0.046
HDAC8	N/A	0.165	0.051
MECP2	MECP2: Methyl-CpG-binding protein 2	0.152	0.051
TRERF1	TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1	0.148	0.046
HDAC7A	N/A	0.148	0.046
HIF1A	HIF1A, MOP1: Hypoxia-inducible factor 1 alpha	0.139	0.046
MTF1	MTF1: Metal regulatory transcription factor 1	0.139	0.046
KLF13	KLF13, BTEB3, NSLP1: Krueppel-like factor 13	0.139	0.046
ZNF217	ZNF217, ZABC1: Zinc finger protein 217	0.139	0.046
SNRP70	SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa	0.139	1.15
HDAC4	HDAC4, KIAA0288: Histone deacetylase 4	0.136	0.046
CSNK2A1	CSNK2A1: CSNK2A1 protein	0.129	1.15
HIVEP1	N/A	0.127	0.051
ZFX	ZFX: Zinc finger X-chromosomal protein	0.127	0.051
LSM4	LSM4: U6 snRNA-associated Sm-like protein LSm4	0.123	0.593
ZNF335	ZNF335: Zinc finger protein 335	0.114	0.046
BRPF1	BRPF1, BR140: Peregrin	0.114	0.046
ZNF76	ZNF76, D6S229E: Zinc finger protein 76	0.114	0.046
AKAP8L	AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like	0.114	0.046
DPF2	DPF2, REQ, UBID4: Zinc finger protein ubi-d4	0.111	0.046
HDAC6	HDAC6, JM21: Histone deacetylase 6	0.110	0.046
SH3BP3		0.096	0.051
REST	REST, NRSF, XBR: RE1-silencing transcription factor	0.096	0.051
HDAC5	HDAC5, KIAA0600: Histone deacetylase 5	0.088	0.046
KLF1	KLF1, EKLF: Krueppel-like factor 1	0.086	0.046
ZBTB40	ZBTB40, KIAA0478: Zinc finger and BTB domain-containing protein 40	0.086	0.046
EEA1	EEA1, ZFYVE2: Early endosome antigen 1	0.086	0.046
TCF8	ZEB1, AREB6, TCF8: Zinc finger E-box-binding homeobox 1	0.086	0.046
ZNF224	ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27: Zinc finger protein 224	0.086	0.046
ZFP91	ZFP91, FKSG11: Zinc finger protein 91 homolog	0.083	0.051
ZNF644	ZNF644, KIAA1221, ZEP2: Zinc finger protein 644	0.083	0.051
POGZ	POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain	0.083	0.051
ARNT	ARNT: Aryl hydrocarbon receptor nuclear translocator	0.083	0.051
ZNF579	ZNF579: Zinc finger protein 579	0.083	0.051
ZHX1	ZHX1: Zinc fingers and homeoboxes protein 1	0.083	0.051
ZNF295	ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295	0.083	0.051
ID2	ID2: DNA-binding protein inhibitor ID-2	0.080	0.051
TCF3	TCF3, E2A, ITF1: Transcription factor E2-alpha	0.078	0.046
SND1	SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1	0.078	0.046
ZBTB33	KAISO, ZBTB33, ZNF348: Transcriptional regulator Kaiso	0.077	0.051
RBM10	RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10	0.075	0.046
ZFPM1	ZFPM1, FOG1: Zinc finger protein ZFPM1	0.075	0.046
PRDM2	PRDM2, RIZ: PR domain zinc finger protein 2	0.075	0.046
ZNF174	ZNF174, ZSCAN8: Zinc finger protein 174	0.075	0.046
OSR1	OSR1, ODD: Protein odd-skipped-related 1	0.075	0.046
NCOA3	NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3	0.075	0.046
SP1	SP1, TSFP1: Transcription factor Sp1	0.069	0.046
ZNF551	N/A	0.069	0.046
AHR	AHR: Aryl hydrocarbon receptor precursor	0.069	0.046
SNAI1	SNAI1, SNAH: Zinc finger protein SNAI1	0.069	0.046
HIST1H2AC	HIST1H2AC, H2AFL: Histone H2A type 1-C	0.065	0.593
H2AFJ	H2A histone family member J.	0.064	0.119
SMARCC1	N/A	0.064	0.119
SF3A3	SF3A3, SAP61: Splicing factor 3A subunit 3	0.061	0.046
ZBTB7A	ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A	0.056	0.046
ZBTB16	ZBTB16, PLZF, ZNF145: Zinc finger and BTB domain-containing protein 16	0.050	0.046
SALL1	SALL1, SAL1: Sal-like protein 1	0.050	0.046
ZHX3	ZHX3, KIAA0395, TIX1: Zinc fingers and homeoboxes protein 3	0.049	0.051
EGR1	EGR1, ZNF225: Early growth response protein 1	0.049	0.046
TAL2	TAL2: T-cell acute lymphocytic leukemia protein 2	0.047	0.046
TFAP4	TFAP4: Transcription factor AP-4	0.047	0.046
KLF5	KLF5, BTEB2, CKLF, IKLF: Krueppel-like factor 5	0.044	0.046
BNC1	BNC1, BNC: Zinc finger protein basonuclin-1	0.044	0.046
HIST1H2AG	HIST1H2AG, H2AFP, HIST1H2AI, H2AFC, HIST1H2AK, H2AFD, HIST1H2AL, H2AFI, HIST1H2A	0.044	0.119
HIST1H2AB	N/A	0.044	0.119
MYCN	MYCN, NMYC: N-myc proto-oncogene protein	0.043	0.046
TAL1	TAL1, SCL, TCL5: T-cell acute lymphocytic leukemia protein 1	0.043	0.046
CCT4	CCT4, CCTD, SRB: T-complex protein 1 subunit delta	0.040	1.15
ID3	ID3, 1R21, HEIR-1: DNA-binding protein inhibitor ID-3	0.039	0.051
HIST2H2AA	HIST2H2AA3, H2AFO, HIST2H2AA: Histone H2A type 2-A	0.038	0.119
HIST2H2AB	HIST2H2AB: Histone H2A type 2-B	0.038	0.119
HIST1H2AK	HIST1H2AJ, H2AFE: Histone H2A type 1-J	0.038	0.119
HIST1H2AA	HIST1H2AA: Histone H2A type 1-A	0.038	0.119
HIST1H2AG	HIST1H2AH, HIST1H2AI: Histone H2A type 1-H	0.038	0.119
JMJD2B	JMJD2B, JHDM3B, KIAA0876: JmjC domain-containing histone demethylation protein 3	0.036	0.046
MYF5	MYF5: Myogenic factor 5	0.035	0.046
ATXN7	ATXN7, SCA7: Ataxin-7	0.033	0.051
HES6	HES6: Transcription cofactor HES-6	0.028	0.051
HAND1	HAND1, EHAND: Heart- and neural crest derivatives-expressed protein 1	0.028	0.046
HES1	HES1, HL, HRY: Transcription factor HES-1	0.028	0.046
SMN2	SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein	0.025	0.046
MLXIPL	MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein	0.025	0.046
ARID4A	ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A	0.025	0.046
MAX	MAX: Protein max	0.025	0.046

0.299

Total Score

27.60