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Evidence of Interaction Between PTPN1 and SOCS3

The interaction score between PTPN1 and SOCS3 is 11.40.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PTPN1 and SOCS3 = 0.21

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.88E-3
Orthology N/A N/A
Domains Domains present in PTPN1 and SOCS3:
Domains in PTPN1Domains in SOCS3
IPR000242 Tyrosine specific protein phosphatase
IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase
IPR003595 Protein tyrosine phosphatase, catalytic region
IPR002035 von Willebrand factor, type A
IPR012265 Tyr_Ptase_nr1_2.
IPR000980 SH2 motif
IPR001496 SOCS protein, C-terminal

The Chi square scores for co-occurrence of domains that are present in PTPN1 and SOCS3 are listed below.

Domain 1Domain 2Chi Square
IPR000242 Tyrosine specific protein phosphatase IPR000980 SH2 motif 17.0624
IPR002035 von Willebrand factor, type A IPR000980 SH2 motif 8.67735
IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase IPR000980 SH2 motif 8.21089
IPR012265 Tyr_Ptase_nr1_2. IPR000980 SH2 motif 3.11373
IPR003595 Protein tyrosine phosphatase, catalytic region IPR000980 SH2 motif 0.240348

The background colour of the table refers to:

  • Blue Domain is only present in PTPN1
  • Yellow Domain is only present in SOCS3
  • Green Domain is present in both PTPN1 and SOCS3

 0.109
Post-translational Modifications

Protein: PTPN1

PTMResidueReference
Acetylation 1 PubMed, HPRD
Glutathionylation 215 PubMed, HPRD
N-acetylmethionine 1 HPRD
Phosphorylation 50 PubMed, HPRD
Phosphorylation 66 PubMed, HPRD
Phosphorylation 152 PubMed, HPRD
Phosphorylation 153 PubMed, HPRD
Phosphorylation 242 PubMed, HPRD
Phosphorylation 243 PubMed, HPRD
Phosphorylation 352 PubMed, HPRD
Phosphorylation 378 PubMed, HPRD
Phosphorylation 386 PubMed, HPRD
Phosphoserine 50 PubMed, HPRD
Phosphoserine 352 HPRD
Phosphoserine 378 PubMed, HPRD
Phosphoserine 386 PubMed, HPRD
Phosphotyrosine 20 HPRD

Protein: SOCS3

PTMResidueReference
Ubiquitination 6 PubMed, HPRD
Localisation

Protein: PTPN1

LocalisationReference
ER HPRD
Nucleus HPRD
Cytoplasm HPRD

Protein: SOCS3

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between PTPN1 and SOCS3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PTPN1 andSOCS3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PTPN1 has 1180 interactors and SOCS3 has 1169 interactors of which there are 651 common interactors.

Common InteractorName of Common InteractorScore for PTPN1-Interactor (?)Score for SOCS3-Interactor (?)
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.515 0.100
VIL2 N/A 0.503 0.123
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.416 0.0407
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.416 0.0407
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.416 0.051
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.416 0.0407
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.416 0.100
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.307 0.0407
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.307 0.033
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.307 0.100
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.307 0.126
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.307 0.100
CRLF3 N/A 0.307 0.100
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.307 0.051
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.307 0.081
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.304 0.123
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.274 0.152
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.251 0.100
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.251 0.029
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.251 0.100
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.251 0.033
CXorf9 N/A 0.246 0.152
CSK CSK: Tyrosine-protein kinase CSK 0.246 1.20
VAV1 VAV1, VAV: Proto-oncogene vav 0.246 0.152
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.225 0.081
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.210 0.075
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.202 0.152
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.202 0.123
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.202 0.152
LYN LYN: Tyrosine-protein kinase Lyn 0.202 1.20
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.202 0.191
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.202 0.152
CD7 CD7: T-cell antigen CD7 precursor 0.191 0.029
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.191 0.067
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.191 0.072
GPA33 GPA33: Cell surface A33 antigen precursor 0.191 0.0407
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.191 0.082
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.191 0.072
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.191 0.100
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.191 0.166
IL9R IL9R: Interleukin-9 receptor precursor 0.191 0.202
SORL1 SORL1: Sortilin-related receptor precursor 0.191 0.081
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.191 0.051
STAT6 STAT6: Signal transducer and activator of transcription 6 0.181 0.152
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.181 0.109
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.181 0.251
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.181 0.251
NCK2 NCK2: Cytoplasmic protein NCK2 0.181 0.109
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.181 0.051
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.171 0.581
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.166 0.123
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.166 0.123
ROCK1 ROCK1: Rho-associated protein kinase 1 0.166 0.191
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.166 0.123
FUBP1 N/A 0.166 0.077
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.166 0.859
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.166 0.191
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.165 0.109
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.044
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.109
FN1 N/A 0.165 0.044
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.109
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.165 0.044
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.109
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.044
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.165 0.044
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.044
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.165 0.165
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.980
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.980
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.165 0.109
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.165 0.109
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.109
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.165 0.044
KIR3DL1 N/A 0.165 0.109
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.980
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.152 0.072
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.152 1.13
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.152 0.051
LILRB1 N/A 0.152 0.126
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.152 0.072
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.152 0.100
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.152 0.126
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.152 0.029
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.152 0.081
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.152 0.100
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.152 0.033
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.152 0.902
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.152 0.0407
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.152 0.0407
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.148 0.123
JAK1 0.148 0.975
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.148 1.50
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.148 0.063
MSN MSN: Moesin 0.148 0.123
ATM ATM: Serine-protein kinase ATM 0.148 0.123
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.148 0.152
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.148 0.152
SYK SYK: Tyrosine-protein kinase SYK 0.148 1.20
STK10 STK10: Uncharacterized protein STK10 0.148 0.152
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.148 0.123
RPS6KB1 N/A 0.148 0.152
APS SH2B2, APS: SH2B adapter protein 2 0.148 0.191
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.148 1.50
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.148 0.251
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.148 1.50
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.148 0.109
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.148 0.109
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.148 0.980
BSG N/A 0.148 0.044
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.148 0.109
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.148 0.980
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.148 0.980
CNTN1 CNTN1: Contactin-1 precursor 0.148 0.044
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.148 0.980
CNTN4 CNTN4: Contactin-4 precursor 0.148 0.044
ATRN N/A 0.148 0.049
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.136 1.13
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.136 0.100
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.136 0.191
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.136 1.13
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.136 0.152
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.136 0.644
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.136 0.731
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.136 0.126
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.136 0.902
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.136 0.644
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.136 0.123
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.130 0.031
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.127 0.100
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.126 0.152
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.126 0.0416
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.126 0.123
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.126 1.98
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.126 1.20
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.126 0.152
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.126 0.123
STK16 N/A 0.126 0.051
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.126 0.123
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.126 0.123
PRKAA1 N/A 0.126 0.109
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.126 0.152
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.126 1.98
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.126 0.152
GHR GHR: Growth hormone receptor precursor 0.123 0.072
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.123 0.065
PVR PVR, PVS: Poliovirus receptor precursor 0.123 0.067
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.123 0.644
ITGB4 N/A 0.123 0.065
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.123 0.126
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.123 0.100
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.123 0.126
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.123 0.100
MET MET: Hepatocyte growth factor receptor precursor 0.123 0.731
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.123 0.067
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.123 0.026
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.123 0.0407
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.123 0.902
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.123 0.902
PRLR PRLR: Prolactin receptor precursor 0.123 0.100
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.114 0.081
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.114 0.075
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.113 0.191
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.113 0.123
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.113 0.152
CDK2 CDK2: Cell division protein kinase 2 0.113 0.152
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.113 0.123
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.113 0.152
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.113 0.152
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.113 0.975
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.113 0.859
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.113 0.152
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.113 0.123
CRKL CRKL: Crk-like protein 0.113 0.152
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.113 0.123
DAB2 DAB2, DOC2: Disabled homolog 2 0.113 0.123
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.113 0.123
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.113 0.152
TLN1 TLN1: Uncharacterized protein TLN1 0.113 0.251
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.113 0.152
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.113 0.191
DOK1 DOK1: Docking protein 1 0.113 0.251
EEF1G EEF1G, EF1G, PRO1608: Elongation factor 1-gamma 0.111 0.026
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.111 0.048
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.110 0.581
DCC DCC: Netrin receptor DCC precursor 0.110 0.166
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.110 1.48
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.110 1.13
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.110 0.202
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.110 0.0407
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.110 0.100
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.110 0.902
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.110 0.029
KIT KIT: Mast/stem cell growth factor receptor precursor 0.110 0.731
EPOR EPOR: Erythropoietin receptor precursor 0.110 0.081
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.110 0.065
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.109 0.165
MAP2K5 N/A 0.109 0.165
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 1.30
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 0.056
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.109 0.165
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.109 0.165
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.109 0.165
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.109 0.028
MAPK15 N/A 0.109 0.165
PKP4 PKP4: Plakophilin-4 0.109 0.028
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.109 0.027
DNAJC13 DNAJC13, KIAA0678, RME8: DnaJ homolog subfamily C member 13 0.109 0.028
STAT3 0.109 0.165
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 1.30
MAPKAPK5 N/A 0.109 0.165
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 0.165
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.109 0.165
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.109 0.165
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.109 0.165
CDC2 CDC2: Cell division control protein 2 homolog 0.109 0.165
NF2 NF2, SCH: Merlin 0.109 0.165
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.109 0.165
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.109 0.165
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.109 0.165
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.109 0.165
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.109 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 0.165
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.109 0.165
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 1.30
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.109 0.165
EEF2K EEF2K: Elongation factor 2 kinase 0.109 0.165
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.109 0.033
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.109 0.166
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.100 0.859
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.100 0.307
LIMK2 LIMK2: LIM domain kinase 2 0.100 0.109
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.100 0.123
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.100 0.859
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.100 0.191
JUP JUP, CTNNG, DP3: Junction plakoglobin 0.100 0.034
DAPK2 DAPK2: Death-associated protein kinase 2 0.100 0.191
HCK N/A 0.100 1.20
IRS1 IRS1: Insulin receptor substrate 1 0.100 0.109
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.100 0.191
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.100 0.152
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.099 0.029
PTPRZ1 N/A 0.099 0.029
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.099 0.644
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.098 0.100
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.098 0.644
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.098 0.026
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.098 0.081
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.098 0.902
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.098 0.165
COTL1 COTL1, CLP: Coactosin-like protein 0.098 0.028
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.098 0.165
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.098 0.540
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.098 1.30
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.098 0.165
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.098 0.165
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.098 0.165
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.098 0.165
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.098 0.165
CFL2 CFL2: Cofilin-2 0.098 0.028
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.098 0.165
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.098 0.165
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.098 0.165
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.098 0.165
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.098 1.30
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.098 0.165
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.098 0.165
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.098 0.165
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.098 0.165
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.098 0.165
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.098 0.0688
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.098 0.165
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.098 0.165
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.097 0.072
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.097 0.902
NEO1 NEO1, NGN: Neogenin precursor 0.097 0.029
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.097 0.029
TNC TNC, HXB: Tenascin precursor 0.097 0.029
INSR INSR: Insulin receptor precursor 0.097 0.731
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.096 0.100
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.096 0.123
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.096 0.072
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.094 0.100
SOS1 SOS1: Son of sevenless homolog 1 0.094 0.100
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.094 0.126
CDK4 CDK4: Cell division protein kinase 4 0.090 0.152
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.090 0.109
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.090 0.152
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.090 0.251
WEE1 WEE1: Wee1-like protein kinase 0.090 0.152
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.090 0.191
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.090 0.098
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.090 0.191
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.090 0.191
CDK7 CDK7, MO15: Cell division protein kinase 7 0.090 0.109
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.090 0.109
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.090 0.128
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.090 0.152
ALK ALK: ALK tyrosine kinase receptor precursor 0.090 0.623
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.090 0.191
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.090 0.123
VWF VWF, F8VWF: von Willebrand factor precursor 0.090 0.041
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.088 0.644
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.088 0.123
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.088 0.100
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.088 0.123
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.088 0.026
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.087 0.081
CXCR4 CXCR4: C-X-C chemokine receptor type 4 0.087 0.0407
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.086 0.100
TBC1D1 TBC1D1, KIAA1108: TBC1 domain family member 1 0.086 0.038
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.083 0.049
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.083 0.109
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.083 0.109
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.083 0.109
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.083 0.109
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.0818 0.152
FNBP1 N/A 0.0818 0.123
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.0818 0.152
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.081 0.123
BMX N/A 0.081 1.50
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.081 0.109
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.081 0.109
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.081 0.109
CDKL5 N/A 0.081 0.109
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.081 0.123
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.081 0.191
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.081 0.051
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.081 0.123
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.081 0.859
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.081 0.191
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.081 0.191
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.081 0.152
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.081 0.123
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.081 0.109
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.081 0.109
STAT2 STAT2: Signal transducer and activator of transcription 2 0.0794 0.202
STAT4 STAT4: Signal transducer and activator of transcription 4 0.0794 0.081
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.0794 0.081
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.075 0.152
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.075 0.191
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.075 0.123
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.075 0.109
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.075 0.044
CIITA CIITA, MHC2TA: MHC class II transactivator 0.074 0.0425
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.073 1.50
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.073 0.105
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.073 0.975
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.073 0.191
TTN N/A 0.073 0.152
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.073 0.123
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.073 0.191
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.073 0.152
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.073 0.098
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.073 0.123
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.073 0.152
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.073 0.191
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.073 0.152
RAB32 RAB32: Ras-related protein Rab-32 0.073 0.123
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.073 0.109
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.073 0.123
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.073 0.109
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.073 0.251
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.0727 0.098
RIN1 RIN1: Ras and Rab interactor 1 0.072 0.191
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.072 0.045
CSPG2 N/A 0.072 0.0794
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.072 0.152
IRS2 IRS2: Insulin receptor substrate 2 0.072 0.152
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.072 0.152
ARVCF ARVCF: Armadillo repeat protein deleted in velo-cardio-facial syndrome 0.072 0.032
TP53 TP53, P53: Cellular tumor antigen p53 0.071 0.031
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.0688 0.109
KIAA1012 KIAA1012: Protein TRS85 homolog 0.067 0.026
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.067 0.152
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.067 0.191
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.067 0.026
LCP1 LCP1, PLS2: Plastin-2 0.067 0.048
C20orf4 C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4 0.067 0.026
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.067 0.152
PSCD4 PSCD4, CYT4: Cytohesin-4 0.067 0.191
ACTR3 ACTR3, ARP3: Actin-related protein 3 0.067 0.026
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.067 0.026
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.067 0.026
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.067 0.026
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.067 0.123
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.065 0.152
CDK5 CDK5: Cell division protein kinase 5 0.065 0.109
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.065 0.975
TLN2 TLN2: Uncharacterized protein TLN2 0.065 0.123
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.065 0.152
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.065 0.109
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.065 0.123
RDX RDX: Radixin 0.065 0.109
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.065 0.859
CDK6 CDK6: Cell division protein kinase 6 0.064 0.191
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.064 0.123
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.064 0.123
MYO3A MYO3A: Myosin IIIA 0.064 0.191
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.064 0.123
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.064 0.152
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.064 0.098
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.064 0.152
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.064 0.152
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.064 0.109
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.064 0.152
DAB1 DAB1: Disabled homolog 1 0.064 0.152
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.064 0.063
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.063 0.081
EGF EGF: Pro-epidermal growth factor precursor 0.062 0.072
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.062 0.109
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.062 0.109
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.062 0.109
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.062 0.109
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.061 0.077
PECAM1 PECAM1: Platelet endothelial cell adhesion molecule precursor 0.059 0.047
PRKCB1 PRKCB1, PKCB, PRKCB: Protein kinase C beta type 0.059 0.038
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.058 0.109
DYRK3 N/A 0.058 0.109
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.058 0.152
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.058 0.098
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.058 0.191
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.058 0.098
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.058 1.50
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.058 0.109
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.058 0.109
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.058 0.109
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.058 0.152
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.057 0.126
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.057 0.152
CD2AP CD2AP: CD2-associated protein 0.057 0.123
VASP VASP: Vasodilator-stimulated phosphoprotein 0.057 0.123
DRIM UTP20, DRIM: Small subunit processome component 20 homolog 0.057 0.032
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.057 0.152
HD HD, IT15: Huntingtin 0.057 0.032
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.056 0.100
F3 F3: Tissue factor precursor 0.055 0.065
FLII FLII, FLIL: Protein flightless-1 homolog 0.054 0.026
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.054 0.026
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.052 0.034
ANXA6 ANXA6, ANX6: Annexin A6 0.052 0.030
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.052 0.109
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 1.53
GSK3B GSK3B: Glycogen synthase kinase-3 beta 0.051 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.617
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 1.53
PTPNS1 SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP: Tyrosine-protein phosphatase non-rec 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
MARK2 N/A 0.051 0.051
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
GRB10 N/A 0.051 0.051
MAPK11 MAPK11, PRKM11, SAPK2: Mitogen-activated protein kinase 11 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.051
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
MARK1 MARK1, KIAA1477, MARK: Serine/threonine-protein kinase MARK1 0.051 0.051
MAP4K4 N/A 0.051 0.051
PRKCD PRKCD: Protein kinase C delta type 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
TLK2 TLK2: Serine/threonine-protein kinase tousled-like 2 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.617
CHUK CHUK, IKKA, TCF16: Inhibitor of nuclear factor kappa-B kinase subunit alpha 0.051 0.051
UNC5D UNC5D, KIAA1777, UNQ6012/PRO34692, UNC5H4: Netrin receptor UNC5D precursor 0.051 0.051
C6orf25 G6B, C6orf25: Protein G6b precursor 0.051 0.051
MAPK7 MAPK7, ERK4, ERK5, PRKM7: Mitogen-activated protein kinase 7 0.051 0.051
C6orf21 LY6G6F, C6orf21, G6F, LY6G6D, NG32: Lymphocyte antigen 6 complex locus protein G 0.051 0.051
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
DBNL DBNL, CMAP, PP5423, SH3P7: Drebrin-like protein 0.051 0.051
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.051 0.072
ETS2 ETS2: Protein C-ets-2 0.051 0.100
PLEK PLEK, P47: Pleckstrin 0.0513 0.100
PPID PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase 0.051 0.026
ACTG1 ACTB: Actin, cytoplasmic 1 0.051 0.032
RASA3 RASA3: Ras GTPase-activating protein 3 0.051 0.152
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.051 0.191
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.051 0.152
CLIC1 CLIC1, NCC27: Chloride intracellular channel protein 1 0.051 0.026
PLD1 PLD1: Phospholipase D1 0.051 0.191
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.051 0.109
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.051 0.109
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.051 0.152
HLA-DOA HLA-DOA, HLA-DNA, HLA-DZA: HLA class II histocompatibility antigen, DO alpha cha 0.050 0.032
DNM3 DNM3: Uncharacterized protein DNM3 0.049 0.165
AMPH AMPH, AMPH1: Amphiphysin 0.049 0.165
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.049 0.083
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.049 0.052
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.049 0.052
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.049 0.165
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.049 0.165
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.049 0.165
PSCD2 N/A 0.049 0.165
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.049 0.165
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.049 0.165
PPEF1 N/A 0.049 0.052
S100A16 S100A16, AAG13: Protein S100-A16 0.049 0.052
NASP NASP: Nuclear autoantigenic sperm protein 0.049 0.028
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.049 0.037
PHC3 PHC3, EDR3, PH3: Polyhomeotic-like protein 3 0.046 0.051
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.046 0.617
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.046 0.051
IKBKE IKBKE, IKKE, IKKI, KIAA0151: Inhibitor of nuclear factor kappa-B kinase subunit 0.046 0.051
EPB41 EPB41, E41P: Protein 4.1 0.046 0.051
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.046 0.051
FLT4 VEGFR3 long form 0.046 1.53
TBC1D4 TBC1D4: TBC1D4 protein 0.046 0.051
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.046 0.051
SRPK1 SRPK1: Serine/threonine-protein kinase SRPK1 0.046 0.051
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.046 0.081
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.046 0.100
KPNB1 KPNB1, NTF97: Importin subunit beta-1 0.046 0.026
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.045 0.062
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.0453 0.123
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.0453 0.051
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.0453 0.045
GLRX GLRX, GRX: Glutaredoxin-1 0.0453 0.026
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.0453 0.034
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.0453 0.032
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.0453 0.026
SCML2 SCML2: Sex comb on midleg-like protein 2 0.045 0.072
TP73 TP73, P73: Tumor protein p73 0.045 0.126
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.044 0.027
NIPBL N/A 0.044 0.028
ELMO1 N/A 0.044 0.165
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.044 0.165
ARHGEF7 N/A 0.044 0.165
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.044 0.052
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.044 0.165
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.044 0.165
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.044 0.165
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.044 0.028
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.044 0.165
TSC2 TSC2, TSC4: Tuberin 0.044 0.028
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.044 0.052
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.044 0.028
ACTN4 ACTN4: Alpha-actinin-4 0.044 0.052
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.044 0.165
CD44 N/A 0.0425 0.037
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.0425 0.037
CCR5 CCR5: CCR5 receptor (Fragment) 0.0425 0.100
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.042 0.0338
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.041 0.062
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.041 0.072
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.041 0.123
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.041 0.026
CDC23 CDC23: Cell division cycle protein 23 homolog 0.041 0.026
PLD2 PLD2: Phospholipase D2 0.041 0.307
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.041 0.251
MDN1 MDN1, KIAA0301: Midasin 0.041 0.026
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.041 0.060
NAPG NAPG, SNAPG: Gamma-soluble NSF attachment protein 0.041 0.026
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.041 0.026
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.041 0.123
PPP2CA PPP2CA: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 0.041 0.026
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.041 0.062
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.041 0.039
CD84 N/A 0.041 0.039
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.04 0.028
PDZD2 CDNA FLJ46853 fis, clone UTERU3009775, moderately similar to Rattus norvegicus P 0.04 0.028
CNN2 CNN2: Calponin-2 0.04 0.165
GRAP GRAP: GRB2-related adapter protein 0.039 0.0308
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.038 0.0782
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.037 0.045
IPO7 IPO7: Uncharacterized protein IPO7 0.037 0.026
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.037 0.060
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.037 0.045
GAB1 GAB1: GRB2-associated-binding protein 1 0.037 0.251
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.037 0.048
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.037 0.045
MCF2 MCF2, DBL: Proto-oncogene DBL 0.037 0.152
LTK LTK, TYK1: Leukocyte tyrosine kinase receptor precursor 0.036 0.330
UBE2A UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A 0.036 0.028
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.036 0.028
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.036 0.028
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.036 0.028
MYO18A 0.036 0.028
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.036 0.028
TMPRSS2 TMPRSS2, PRSS10: Transmembrane protease, serine 2 precursor 0.035 0.032
HPN HPN, TMPRSS1: Serine protease hepsin 0.035 0.037
VAV3 VAV3: Protein vav-3 0.035 0.0308
CTLA4 CTLA4, CD152: Cytotoxic T-lymphocyte protein 4 precursor 0.0338 0.047
TNIK TNIK, KIAA0551: TRAF2 and NCK-interacting protein kinase 0.0338 0.047
STAM2 STAM2: Signal transducing adapter molecule 2 0.033 0.152
FKBP4 FKBP4: FK506-binding protein 4 0.033 0.026
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 0.033 0.031
KIAA0690 N/A 0.033 0.0425
TXN TXN, TRDX, TRX, TRX1: Thioredoxin 0.033 0.026
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.033 0.152
ACTN1 ACTN1: Alpha-actinin-1 0.033 0.034
MYL3 MYL3: Myosin light polypeptide 3 0.033 0.039
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.033 0.039
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.033 0.039
SPTAN1 N/A 0.033 0.098
CTTN CTTN, EMS1: Src substrate cortactin 0.033 0.123
S100A3 S100A3, S100E: Protein S100-A3 0.032 0.039
GAB2 N/A 0.032 0.123
SORBS3 SORBS3, SCAM1: Vinexin 0.032 0.123
CD5 CD5, LEU1: T-cell surface glycoprotein CD5 precursor 0.032 0.100
RPS10 RPS10: 40S ribosomal protein S10 0.032 0.026
IRAK4 IRAK4: Interleukin-1 receptor-associated kinase 4 0.032 0.050
RIPK2 RIPK2, CARDIAK, UNQ277/PRO314/PRO34092, RICK, RIP2: Receptor-interacting serine/ 0.032 0.0308
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.031 0.100
RYK RYK, JTK5A: Tyrosine-protein kinase RYK precursor 0.0308 0.162
LETM1 LETM1: Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial 0.030 0.04
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.030 0.109
CETN1 CETN1, CEN1, CETN: Centrin-1 0.030 0.04
NOS1 NOS1: Nitric-oxide synthase, brain 0.030 0.0425
APBA3 APBA3, MINT3, X11L2: Amyloid beta A4 precursor protein-binding family A member 3 0.030 0.032
PSD TYL: TYL protein 0.029 0.109
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.109
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.029 0.123
S100B S100B: Protein S100-B 0.029 0.034
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.029 0.123
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.029 0.026
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.029 0.123
AKT2 AKT2: RAC-beta serine/threonine-protein kinase 0.029 0.041
ADRBK2 ADRBK2, BARK2, GRK3: Beta-adrenergic receptor kinase 2 0.029 0.0308
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.028 0.109
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.028 0.109
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.028 0.049
LAT LAT: Linker for activation of T-cells family member 1 0.028 0.109
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.028 0.109
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.027 0.026
TBCE TBCE: Tubulin-specific chaperone E 0.027 0.026
FGFR2 N/A 0.027 0.217
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.265
DDR1 DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE: Epithelial discoidin domain-con 0.027 0.217
WASPIP N/A 0.027 0.152
LPXN LPXN, LDLP: Leupaxin 0.027 0.026
DAPP1 N/A 0.027 0.032
DEF6 DEF6, IBP: Differentially expressed in FDCP 6 0.027 0.032
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.027 0.032
IFI35 N/A 0.027 0.026
EIF2S3 EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3 0.027 0.026
CNN3 CNN3: Calponin-3 0.0263 0.098
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.026 0.109
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.026 0.039
ANXA5 ANXA5, ANX5, ENX2, PP4: Annexin A5 0.026 0.037
TNF TNF, TNFA, TNFSF2: Tumor necrosis factor precursor 0.026 0.057
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.026 0.039
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.026 0.037
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.026 0.051
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.025 0.049
STOM STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein 0.025 0.04
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.025 0.049
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.025 0.049
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.025 0.049
0.228
Total Score 11.40