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Evidence of Interaction Between PTPN1 and YWHAB

The interaction score between PTPN1 and YWHAB is 1.34.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PTPN1 and YWHAB = 0.25

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.88E-3
Orthology
OrganismPTPN1 OrthologueYWHAB OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
fly Q9W0G1 1 P29310 0.275

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains No domains were used in calculating likelihood of interaction 0.014
Post-translational Modifications

Protein: PTPN1

PTMResidueReference
Acetylation 1 PubMed, HPRD
Glutathionylation 215 PubMed, HPRD
N-acetylmethionine 1 HPRD
Phosphorylation 50 PubMed, HPRD
Phosphorylation 66 PubMed, HPRD
Phosphorylation 152 PubMed, HPRD
Phosphorylation 153 PubMed, HPRD
Phosphorylation 242 PubMed, HPRD
Phosphorylation 243 PubMed, HPRD
Phosphorylation 352 PubMed, HPRD
Phosphorylation 378 PubMed, HPRD
Phosphorylation 386 PubMed, HPRD
Phosphoserine 50 PubMed, HPRD
Phosphoserine 352 HPRD
Phosphoserine 378 PubMed, HPRD
Phosphoserine 386 PubMed, HPRD
Phosphotyrosine 20 HPRD

Protein: YWHAB

PTMResidueReference
Acetylation 3 PubMed, HPRD
Phosphorylation 60 PubMed, HPRD
Phosphorylation 132 PubMed, HPRD
Phosphorylation 143 PubMed, HPRD
Phosphorylation 186 PubMed, HPRD
Localisation

Protein: PTPN1

LocalisationReference
ER HPRD
Nucleus HPRD
Cytoplasm HPRD

Protein: YWHAB

LocalisationReference
Golgi HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between PTPN1 and YWHAB that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PTPN1 andYWHAB. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PTPN1 has 1180 interactors and YWHAB has 1061 interactors of which there are 439 common interactors.

Common InteractorName of Common InteractorScore for PTPN1-Interactor (?)Score for YWHAB-Interactor (?)
VIL2 N/A 0.503 0.139
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.416 0.0446
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.416 0.036
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.416 0.036
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.416 0.036
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.307 0.0446
ITGAE ITGAE: Integrin alpha-E precursor 0.307 0.0446
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.307 0.027
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.307 0.0446
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.307 0.074
CRLF3 N/A 0.307 0.0446
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.304 0.188
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.274 0.070
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.251 0.0446
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.251 0.036
CXorf9 N/A 0.246 0.078
CSK CSK: Tyrosine-protein kinase CSK 0.246 0.078
VAV1 VAV1, VAV: Proto-oncogene vav 0.246 0.233
CD69 CD69: Early activation antigen CD69 0.210 0.027
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.202 0.163
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.202 0.0425
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.202 0.0425
LYN LYN: Tyrosine-protein kinase Lyn 0.202 0.129
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.202 0.260
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.202 0.087
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.191 0.0446
SORL1 SORL1: Sortilin-related receptor precursor 0.191 0.0446
STAT6 STAT6: Signal transducer and activator of transcription 6 0.181 0.129
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.181 0.038
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.181 0.087
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.181 0.046
NCK2 NCK2: Cytoplasmic protein NCK2 0.181 0.063
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.181 0.063
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.166 0.087
ROCK1 ROCK1: Rho-associated protein kinase 1 0.166 0.210
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.166 0.0425
FUBP1 N/A 0.166 0.070
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.166 0.0425
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.166 0.0425
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.165 0.025
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.155 0.074
LILRB1 N/A 0.152 0.0446
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.152 0.027
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.148 0.063
JAK1 0.148 0.078
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.148 0.0308
MSN MSN: Moesin 0.148 0.233
ATM ATM: Serine-protein kinase ATM 0.148 0.139
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.148 0.078
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.148 0.078
SYK SYK: Tyrosine-protein kinase SYK 0.148 0.078
STK10 STK10: Uncharacterized protein STK10 0.148 0.078
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.148 0.063
RPS6KB1 N/A 0.148 0.063
APS SH2B2, APS: SH2B adapter protein 2 0.148 0.043
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.148 0.129
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.148 0.029
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.148 0.118
ATRN N/A 0.148 0.044
ITGB7 ITGB7: Integrin beta-7 precursor 0.139 0.032
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.136 0.063
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.136 0.056
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.136 0.046
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.130 0.045
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.127 0.074
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.126 0.078
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.126 0.070
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.126 0.026
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.126 0.026
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.126 0.078
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.126 0.188
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.126 0.060
STK16 N/A 0.126 0.032
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.126 0.038
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.126 0.032
PRKAA1 N/A 0.126 0.026
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.126 0.0425
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.123 0.036
MET MET: Hepatocyte growth factor receptor precursor 0.123 0.033
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.123 0.036
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.123 0.026
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.114 6.99
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.114 0.032
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.113 0.029
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.113 0.046
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.113 0.276
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.113 0.087
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.113 221.00
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.113 0.046
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.113 0.029
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.113 0.038
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.113 0.078
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.113 0.078
CRKL CRKL: Crk-like protein 0.113 0.046
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.113 0.063
DAB2 DAB2, DOC2: Disabled homolog 2 0.113 0.0308
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.113 0.129
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.113 0.078
TLN1 TLN1: Uncharacterized protein TLN1 0.113 0.087
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.113 0.038
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.113 0.078
DOK1 DOK1: Docking protein 1 0.113 0.188
EEF1G EEF1G, EF1G, PRO1608: Elongation factor 1-gamma 0.111 0.118
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.111 0.063
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.110 0.029
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.109 0.028
MAP2K5 N/A 0.109 0.165
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 0.025
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.109 0.028
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.109 0.028
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.109 0.025
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.109 0.028
MAPK15 N/A 0.109 0.028
PKP4 PKP4: Plakophilin-4 0.109 0.028
DNAJC13 DNAJC13, KIAA0678, RME8: DnaJ homolog subfamily C member 13 0.109 0.028
STAT3 0.109 0.025
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 0.028
MAPKAPK5 N/A 0.109 0.028
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 0.028
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.109 0.028
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.109 0.025
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.109 0.025
CDC2 CDC2: Cell division control protein 2 homolog 0.109 0.025
NF2 NF2, SCH: Merlin 0.109 0.083
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.109 0.028
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.109 0.028
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.109 0.028
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.109 0.025
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.109 0.028
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 0.052
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.109 0.028
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 0.028
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.109 0.028
EEF2K EEF2K: Elongation factor 2 kinase 0.109 0.025
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.100 0.026
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.100 0.056
LIMK2 LIMK2: LIM domain kinase 2 0.100 0.048
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.100 0.038
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.100 0.026
HCK N/A 0.100 0.063
IRS1 IRS1: Insulin receptor substrate 1 0.100 0.062
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.100 0.055
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.100 0.0971
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.098 0.025
COTL1 COTL1, CLP: Coactosin-like protein 0.098 0.025
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.098 0.025
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.098 0.047
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.098 0.047
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.098 0.025
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.098 0.025
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.098 0.075
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.098 0.025
CFL2 CFL2: Cofilin-2 0.098 12.00
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.098 0.025
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.098 0.025
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.098 0.075
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.098 71.20
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.098 0.047
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.098 0.025
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.098 0.047
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.098 0.047
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.098 0.025
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.098 0.025
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.098 0.025
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.098 0.075
INSR INSR: Insulin receptor precursor 0.097 12.50
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.096 0.0446
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.096 0.048
SOS1 SOS1: Son of sevenless homolog 1 0.094 0.067
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.094 0.032
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.090 0.029
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.090 0.046
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.090 0.040
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.090 0.038
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.090 0.043
CFL1 CFL1, CFL: Cofilin-1 0.090 0.046
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.090 0.046
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.090 0.046
CDK7 CDK7, MO15: Cell division protein kinase 7 0.090 0.029
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.090 0.038
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.090 0.063
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.090 0.046
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.088 0.029
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.088 0.040
CXCR4 CXCR4: C-X-C chemokine receptor type 4 0.087 0.027
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.086 0.032
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.086 0.040
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.086 0.032
SEMA4B SEMA4B: Sema domain, immunoglobulin domain 0.083 0.049
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.0818 0.129
FNBP1 N/A 0.0818 0.129
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.0818 0.241
AIP AIP, XAP2: AH receptor-interacting protein 0.0818 0.038
BMX N/A 0.081 0.031
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.081 0.052
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.081 0.0425
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.081 0.163
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.081 0.078
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.081 0.046
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.081 0.026
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.081 0.062
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.081 0.070
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.081 0.026
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.0794 0.036
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.077 0.074
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.075 0.028
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.075 0.052
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.075 0.307
CIITA CIITA, MHC2TA: MHC class II transactivator 0.074 0.052
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.073 0.078
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.073 0.078
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.073 0.056
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.073 0.046
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.073 0.029
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.073 0.029
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.073 0.029
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.073 0.275
DBN1 DBN1, D0S117E: Drebrin 0.072 0.032
RIN1 RIN1: Ras and Rab interactor 1 0.072 0.136
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.072 0.026
IRS2 IRS2: Insulin receptor substrate 2 0.072 0.210
VDP DKFZp451D234: Putative uncharacterized protein DKFZp451D234 0.071 3.41
HLA-DRA 0.070 0.036
KIAA1012 KIAA1012: Protein TRS85 homolog 0.067 0.129
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.067 0.078
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.067 0.129
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.067 0.078
LCP1 LCP1, PLS2: Plastin-2 0.067 0.078
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.067 0.087
PSCD4 PSCD4, CYT4: Cytohesin-4 0.067 0.146
ACTR3 ACTR3, ARP3: Actin-related protein 3 0.067 0.129
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.067 0.078
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.067 0.188
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.067 0.038
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.067 0.078
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.067 0.063
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.065 0.049
CDK5 CDK5: Cell division protein kinase 5 0.065 0.046
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.065 0.035
TLN2 TLN2: Uncharacterized protein TLN2 0.065 0.028
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.065 0.139
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.065 0.0308
RDX RDX: Radixin 0.065 0.056
GMFB GMFB: Glia maturation factor beta 0.064 0.046
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.064 0.043
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.064 0.031
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.064 0.046
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.064 0.171
DAB1 DAB1: Disabled homolog 1 0.064 0.028
MVP MVP, LRP: Major vault protein 0.061 0.070
SLC9A3R1 SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50 0.061 0.0971
PDLIM1 PDLIM1, CLIM1, CLP36: PDZ and LIM domain protein 1 0.061 0.039
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.061 0.241
PRKCB1 PRKCB1, PKCB, PRKCB: Protein kinase C beta type 0.059 0.068
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.058 0.043
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.058 0.046
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.058 0.086
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.058 0.031
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.058 0.136
DSTN DSTN, ACTDP, DSN: Destrin 0.058 8.99
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.058 33.10
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.058 0.086
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.058 46.80
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.058 0.029
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.057 0.132
CD2AP CD2AP: CD2-associated protein 0.057 0.046
FLNA FLNA, FLN, FLN1: Filamin-A 0.057 0.070
VASP VASP: Vasodilator-stimulated phosphoprotein 0.057 0.0971
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.057 0.032
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.057 0.087
HD HD, IT15: Huntingtin 0.057 0.210
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.056 0.0453
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.055 0.075
FLII FLII, FLIL: Protein flightless-1 homolog 0.054 0.078
MICAL-L1 MICALL1, KIAA1668, MIRAB13: MICAL-like protein 1 0.054 0.029
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.054 0.078
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.052 0.063
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.052 0.136
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.051 0.032
PLEK PLEK, P47: Pleckstrin 0.0513 0.125
PPID PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase 0.051 0.078
PPP2R5A PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha 0.051 0.078
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.051 0.063
ACTG1 ACTB: Actin, cytoplasmic 1 0.051 0.129
RASA3 RASA3: Ras GTPase-activating protein 3 0.051 0.054
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.051 0.146
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.051 0.241
CLIC1 CLIC1, NCC27: Chloride intracellular channel protein 1 0.051 31.20
PLD1 PLD1: Phospholipase D1 0.051 0.035
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.051 0.029
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.051 0.146
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.051 0.035
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.051 0.233
DNM3 DNM3: Uncharacterized protein DNM3 0.049 0.052
AMPH AMPH, AMPH1: Amphiphysin 0.049 0.028
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.049 0.075
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.049 0.025
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.049 0.052
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.049 0.025
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.049 0.028
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.049 0.052
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.049 0.075
PSCD2 N/A 0.049 0.052
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.049 0.148
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.049 0.052
PPEF1 N/A 0.049 0.028
S100A16 S100A16, AAG13: Protein S100-A16 0.049 0.028
NASP NASP: Nuclear autoantigenic sperm protein 0.049 0.028
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.049 0.026
TNFRSF1B TNFRSF1B, TNFBR, TNFR2: Tumor necrosis factor receptor superfamily member 1B pre 0.048 0.0446
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.046 0.080
EPB41 EPB41, E41P: Protein 4.1 0.046 22.10
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.046 4.41
MYH9 MYH9: Myosin-9 0.046 0.032
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.046 0.111
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.045 0.078
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.0453 0.063
GLRX GLRX, GRX: Glutaredoxin-1 0.0453 0.039
STIP1 STIP1: Stress-induced-phosphoprotein 1 0.0453 0.052
GSTP1 GSTP1, FAEES3, GST3: Glutathione S-transferase P 0.0453 0.071
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.0453 0.0425
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.0453 0.0425
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.0453 0.096
NIPBL N/A 0.044 0.025
ELMO1 N/A 0.044 0.047
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.044 0.047
ARHGEF7 N/A 0.044 0.047
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.044 0.025
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.044 0.025
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.044 0.148
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.044 0.025
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.044 0.025
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.044 0.047
TSC2 TSC2, TSC4: Tuberin 0.044 0.148
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.044 0.025
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.044 0.025
ACTN4 ACTN4: Alpha-actinin-4 0.044 0.025
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.044 0.025
CD44 N/A 0.0425 0.0446
FADD FADD, MORT1: Protein FADD 0.0425 0.027
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.041 0.139
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.041 0.041
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.041 0.054
PPP1CB PPP1CB: Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0.041 0.078
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.041 0.038
CDC23 CDC23: Cell division cycle protein 23 homolog 0.041 3.97
PLD2 PLD2: Phospholipase D2 0.041 0.043
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.041 0.071
MDN1 MDN1, KIAA0301: Midasin 0.041 0.038
COPE COPE: Coatomer subunit epsilon 0.041 0.046
NAPG NAPG, SNAPG: Gamma-soluble NSF attachment protein 0.041 0.046
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.041 0.046
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 0.041 0.063
XPO1 XPO1, CRM1: Exportin-1 0.041 0.063
FLNB FLNB, FLN1L, FLN3, TABP, TAP: Filamin-B 0.041 0.029
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.041 0.054
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.041 0.066
PPP2CA PPP2CA: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 0.041 0.063
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.041 0.063
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.041 0.146
SYMPK SYMPK, SPK: Symplekin 0.041 0.029
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.04 0.047
PDZD2 CDNA FLJ46853 fis, clone UTERU3009775, moderately similar to Rattus norvegicus P 0.04 0.052
CNN2 CNN2: Calponin-2 0.04 0.028
GNB2L1 Lung cancer oncogene 7 0.039 0.036
CD14 CD14: Monocyte differentiation antigen CD14 precursor 0.039 0.027
XRCC1 XRCC1: DNA-repair protein XRCC1 0.039 0.027
NBN NBN, NBS, NBS1, P95: Nibrin 0.039 0.0446
GNAI2 Galphai2 protein 0.038 0.066
IPO7 IPO7: Uncharacterized protein IPO7 0.037 0.0425
GAB1 GAB1: GRB2-associated-binding protein 1 0.037 0.048
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.037 0.052
MCF2 MCF2, DBL: Proto-oncogene DBL 0.037 0.034
UBE2A UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A 0.036 0.025
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.036 0.148
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.036 0.047
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.036 0.025
MYO18A 0.036 0.047
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.036 0.025
TLR2 TLR2, TIL4: Toll-like receptor 2 precursor 0.035 0.032
ARAF ARAF, ARAF1, PKS, PKS2: A-Raf proto-oncogene serine/threonine-protein kinase 0.035 0.036
PDIA3 PDIA3, ERP57, ERP60, GRP58: Protein disulfide-isomerase A3 precursor 0.035 0.026
TXNDC TXNDC1, TMX, PSEC0085, TXNDC, UNQ235/PRO268: Thioredoxin domain-containing prote 0.035 0.035
ARFGEF2 ARFGEF2, ARFGEP2, BIG2: Brefeldin A-inhibited guanine nucleotide-exchange protei 0.035 0.032
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.033 0.038
PRDX1 PRDX1, PAGA, PAGB, TDPX2: Peroxiredoxin-1 0.033 0.054
KIAA0690 N/A 0.033 0.038
TXN TXN, TRDX, TRX, TRX1: Thioredoxin 0.033 0.054
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.033 0.118
ACTN1 ACTN1: Alpha-actinin-1 0.033 0.029
STUB1 STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1 0.033 0.038
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.033 0.071
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.033 0.038
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.033 0.046
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.033 0.078
SPTAN1 N/A 0.033 0.026
GAB2 N/A 0.032 0.0971
LTB4R LTB4R, BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7: Leukotriene B4 receptor 1 0.032 0.027
RPS10 RPS10: 40S ribosomal protein S10 0.032 0.063
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.031 0.304
CETN1 CETN1, CEN1, CETN: Centrin-1 0.030 0.044
HELZ HELZ, KIAA0054: Probable helicase with zinc finger domain 0.030 0.116
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.030 0.0425
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.030 0.275
PPP2CB PPP2CB: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0.029 0.029
PSD TYL: TYL protein 0.029 0.043
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.035
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.029 0.031
PRDX6 PRDX6, AOP2, KIAA0106: Peroxiredoxin-6 0.029 0.043
DNAJC7 DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7 0.029 0.038
CHP CHP: Calcium-binding protein p22 0.029 0.046
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.029 0.038
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.029 0.038
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.029 0.028
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 0.029 0.040
NCSTN NCSTN, KIAA0253, UNQ1874/PRO4317: Nicastrin precursor 0.029 0.040
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
TOPBP1 TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1 0.028 0.032
COL1A2 COL1A2: Collagen alpha-2(I) chain precursor 0.027 0.029
COL5A2 COL5A2: Collagen alpha-2(V) chain precursor 0.027 0.029
PARD3 N/A 0.027 0.0308
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.027 0.046
TBCE TBCE: Tubulin-specific chaperone E 0.027 0.038
UBE2E3 UBE2E3, UBCE4, UBCH9: Ubiquitin-conjugating enzyme E2 E3 0.027 0.063
WASPIP N/A 0.027 0.078
LPXN LPXN, LDLP: Leupaxin 0.027 0.063
DAPP1 N/A 0.027 0.070
DEF6 DEF6, IBP: Differentially expressed in FDCP 6 0.027 0.070
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.027 0.070
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.027 0.087
IFI35 N/A 0.027 0.070
EIF2S3 EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3 0.027 0.063
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.026 0.038
KLC2 KLC2: Kinesin light chain 2 0.026 0.110
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.026 0.026
TNFSF12 TNFSF12, APO3L, UNQ181/PRO207, DR3LG: Tumor necrosis factor ligand superfamily m 0.026 0.036
FCGR2A FCGR2A: Fc of IgG, low affinity IIa, receptor 0.026 0.027
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.026 0.032
0.228
Total Score 1.34