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Evidence of Interaction Between PTPN1 and TEC

The interaction score between PTPN1 and TEC is 33.90.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PTPN1 and TEC = 0.33

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 3.80E-3
Orthology
OrganismPTPN1 OrthologueTEC OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
fly Q9W0G1 1 P08630 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains Domains present in PTPN1 and TEC:
Domains in PTPN1Domains in TEC
IPR000242 Tyrosine specific protein phosphatase
IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase
IPR003595 Protein tyrosine phosphatase, catalytic region
IPR002035 von Willebrand factor, type A
IPR012265 Tyr_Ptase_nr1_2.
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR001849 Pleckstrin-like
IPR001452 SH3
IPR000980 SH2 motif
IPR001562 Tec/Btk domain
IPR011993 PH_type.

The Chi square scores for co-occurrence of domains that are present in PTPN1 and TEC are listed below.

Domain 1Domain 2Chi Square
IPR000242 Tyrosine specific protein phosphatase IPR008266 Tyrosine protein kinase, active site 21.1632
IPR000242 Tyrosine specific protein phosphatase IPR000980 SH2 motif 17.0624
IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase IPR000719 Protein kinase 14.0817
IPR000242 Tyrosine specific protein phosphatase IPR001245 Tyrosine protein kinase 13.4746
IPR003595 Protein tyrosine phosphatase, catalytic region IPR008266 Tyrosine protein kinase, active site 12.7546
IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase IPR008266 Tyrosine protein kinase, active site 11.3483
IPR003595 Protein tyrosine phosphatase, catalytic region IPR001245 Tyrosine protein kinase 10.8125
IPR012265 Tyr_Ptase_nr1_2. IPR001245 Tyrosine protein kinase 10.8006
IPR002035 von Willebrand factor, type A IPR000719 Protein kinase 9.66837
IPR012265 Tyr_Ptase_nr1_2. IPR008266 Tyrosine protein kinase, active site 9.42864
IPR002035 von Willebrand factor, type A IPR000980 SH2 motif 8.67735
IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase IPR000980 SH2 motif 8.21089
IPR000242 Tyrosine specific protein phosphatase IPR001849 Pleckstrin-like 7.2885
IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase IPR011009 Protein kinase-like 6.38835
IPR002035 von Willebrand factor, type A IPR011009 Protein kinase-like 6.08917
IPR000242 Tyrosine specific protein phosphatase IPR001452 SH3 6.02157
IPR003595 Protein tyrosine phosphatase, catalytic region IPR001452 SH3 5.9163
IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase IPR001245 Tyrosine protein kinase 5.8189
IPR003595 Protein tyrosine phosphatase, catalytic region IPR001849 Pleckstrin-like 4.809
IPR012265 Tyr_Ptase_nr1_2. IPR011009 Protein kinase-like 4.19561
IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase IPR001452 SH3 3.6459
IPR012265 Tyr_Ptase_nr1_2. IPR000719 Protein kinase 3.50984
IPR002035 von Willebrand factor, type A IPR001245 Tyrosine protein kinase 3.4643
IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase IPR001849 Pleckstrin-like 3.43279
IPR012265 Tyr_Ptase_nr1_2. IPR000980 SH2 motif 3.11373
IPR002035 von Willebrand factor, type A IPR008266 Tyrosine protein kinase, active site 2.51834
IPR003595 Protein tyrosine phosphatase, catalytic region IPR000719 Protein kinase 2.41962
IPR003595 Protein tyrosine phosphatase, catalytic region IPR011009 Protein kinase-like 2.23556
IPR000242 Tyrosine specific protein phosphatase IPR000719 Protein kinase 1.75342
IPR000242 Tyrosine specific protein phosphatase IPR011993 PH_type. 1.73843
IPR003595 Protein tyrosine phosphatase, catalytic region IPR011993 PH_type. 1.4276
IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase IPR011993 PH_type. 1.15025
IPR002035 von Willebrand factor, type A IPR001849 Pleckstrin-like 0.540107
IPR000242 Tyrosine specific protein phosphatase IPR011009 Protein kinase-like 0.527708
IPR002035 von Willebrand factor, type A IPR011993 PH_type. 0.41056
IPR003595 Protein tyrosine phosphatase, catalytic region IPR000980 SH2 motif 0.240348

The background colour of the table refers to:

  • Blue Domain is only present in PTPN1
  • Yellow Domain is only present in TEC
  • Green Domain is present in both PTPN1 and TEC

 0.109
Post-translational Modifications

Protein: PTPN1

PTMResidueReference
Acetylation 1 PubMed, HPRD
Glutathionylation 215 PubMed, HPRD
N-acetylmethionine 1 HPRD
Phosphorylation 50 PubMed, HPRD
Phosphorylation 66 PubMed, HPRD
Phosphorylation 152 PubMed, HPRD
Phosphorylation 153 PubMed, HPRD
Phosphorylation 242 PubMed, HPRD
Phosphorylation 243 PubMed, HPRD
Phosphorylation 352 PubMed, HPRD
Phosphorylation 378 PubMed, HPRD
Phosphorylation 386 PubMed, HPRD
Phosphoserine 50 PubMed, HPRD
Phosphoserine 352 HPRD
Phosphoserine 378 PubMed, HPRD
Phosphoserine 386 PubMed, HPRD
Phosphotyrosine 20 HPRD

Protein: TEC

PTMResidueReference
Phosphorylation 206 PubMed, HPRD
Localisation

Protein: PTPN1

LocalisationReference
ER HPRD
Nucleus HPRD
Cytoplasm HPRD

Protein: TEC

LocalisationReference
Cytoplasm HPRD
Transitive Score

The common interactors between PTPN1 and TEC that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PTPN1 andTEC. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PTPN1 has 1180 interactors and TEC has 1520 interactors of which there are 820 common interactors.

Common InteractorName of Common InteractorScore for PTPN1-Interactor (?)Score for TEC-Interactor (?)
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.515 0.166
VIL2 N/A 0.503 0.136
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.416 0.081
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.416 0.100
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.416 0.100
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.416 0.126
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.416 0.166
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.307 0.081
ITGAE ITGAE: Integrin alpha-E precursor 0.307 0.057
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.307 0.081
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.307 0.081
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.307 0.202
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.307 0.081
CRLF3 N/A 0.307 0.081
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.307 0.274
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.307 0.100
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.304 0.136
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.274 0.191
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.251 0.081
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.251 0.072
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.251 0.081
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.251 0.081
CXorf9 N/A 0.246 0.136
CSK CSK: Tyrosine-protein kinase CSK 0.246 1.07
VAV1 VAV1, VAV: Proto-oncogene vav 0.246 0.874
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.225 0.073
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.210 0.166
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.202 1.20
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.202 0.152
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.202 0.975
LYN LYN: Tyrosine-protein kinase Lyn 0.202 1.20
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.202 0.152
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.202 0.109
CD7 CD7: T-cell antigen CD7 precursor 0.191 0.072
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.191 0.100
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.191 0.072
GPA33 GPA33: Cell surface A33 antigen precursor 0.191 0.081
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.191 0.166
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.191 0.081
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.191 0.072
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.191 0.100
IL9R IL9R: Interleukin-9 receptor precursor 0.191 0.202
SORL1 SORL1: Sortilin-related receptor precursor 0.191 0.081
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.191 0.202
STAT6 STAT6: Signal transducer and activator of transcription 6 0.181 420.00
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.181 0.110
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.181 0.136
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.181 0.171
NCK2 NCK2: Cytoplasmic protein NCK2 0.181 0.874
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.181 0.110
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.171 0.655
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.166 0.136
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.166 0.152
ROCK1 ROCK1: Rho-associated protein kinase 1 0.166 0.152
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.166 0.191
FUBP1 N/A 0.166 0.055
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.166 0.859
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.166 0.123
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.165 0.109
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.109
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.109
EDA N/A 0.165 0.049
FN1 N/A 0.165 0.109
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.109
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.165 0.109
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.109
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.109
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.165 0.109
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.109
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.165 0.148
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.980
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.980
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.165 0.109
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.165 0.109
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.109
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.165 0.109
KIR3DL1 N/A 0.165 0.109
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.980
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.155 0.037
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.152 0.081
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.152 0.731
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.152 0.100
LILRB1 N/A 0.152 0.072
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.152 0.072
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.152 0.072
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.152 0.100
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.152 0.081
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.152 0.081
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.152 0.126
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.152 0.126
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.152 0.577
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.152 0.072
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.152 0.081
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.148 0.110
JAK1 0.148 0.770
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.148 0.046
MSN MSN: Moesin 0.148 0.097
ATM ATM: Serine-protein kinase ATM 0.148 0.110
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.148 0.097
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.148 0.110
SYK SYK: Tyrosine-protein kinase SYK 0.148 0.874
STK10 STK10: Uncharacterized protein STK10 0.148 0.097
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.148 0.770
RPS6KB1 N/A 0.148 0.110
APS SH2B2, APS: SH2B adapter protein 2 0.148 1.78
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.148 0.874
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.148 0.136
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.148 1.07
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.148 0.098
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.148 46.90
JAG2 JAG2: Jagged-2 precursor 0.148 0.044
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.148 0.878
BSG N/A 0.148 0.098
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.148 0.098
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.148 0.878
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.148 0.878
CNTN1 CNTN1: Contactin-1 precursor 0.148 0.098
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.148 0.878
CNTN4 CNTN4: Contactin-4 precursor 0.148 0.098
ATRN N/A 0.148 0.098
ITGB7 ITGB7: Integrin beta-7 precursor 0.139 0.073
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.136 0.808
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.136 0.073
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.136 0.110
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.136 0.808
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.136 0.136
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.136 1.01
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.136 0.577
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.136 0.073
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.136 1.01
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.136 0.577
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.136 0.110
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.130 0.027
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.127 0.072
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.126 0.097
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.126 0.975
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.126 1.50
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.126 0.975
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.126 1.50
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.126 0.874
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.126 0.097
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.126 0.975
STK16 N/A 0.126 0.152
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.126 0.770
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.126 0.123
PRKAA1 N/A 0.126 0.109
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.126 0.136
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.126 1.98
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.126 0.098
GHR GHR: Growth hormone receptor precursor 0.123 0.100
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.123 0.081
PVR PVR, PVS: Poliovirus receptor precursor 0.123 0.126
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.123 277.00
ITGB4 N/A 0.123 0.072
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.123 0.072
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.123 0.081
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.123 0.081
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.123 0.126
MET MET: Hepatocyte growth factor receptor precursor 0.123 0.902
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.123 0.166
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.123 0.072
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.123 0.081
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.123 0.902
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.123 1.13
PRLR PRLR: Prolactin receptor precursor 0.123 0.126
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.114 0.655
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.114 0.073
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.113 0.136
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.113 0.110
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.113 0.097
CDK2 CDK2: Cell division protein kinase 2 0.113 0.110
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.113 0.110
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.113 0.097
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.113 0.874
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.113 0.874
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.113 370.00
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.113 0.097
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.113 0.110
CRKL CRKL: Crk-like protein 0.113 1.07
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.113 0.097
DAB2 DAB2, DOC2: Disabled homolog 2 0.113 0.097
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.113 0.097
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.113 0.097
TLN1 TLN1: Uncharacterized protein TLN1 0.113 0.136
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.113 0.110
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.113 0.110
DOK1 DOK1: Docking protein 1 0.113 0.136
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.111 0.136
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.110 0.520
DCC DCC: Netrin receptor DCC precursor 0.110 0.090
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.110 0.808
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.110 0.808
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.110 0.090
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.110 0.148
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.110 0.073
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.110 0.655
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.110 0.072
KIT KIT: Mast/stem cell growth factor receptor precursor 0.110 0.520
EPOR EPOR: Erythropoietin receptor precursor 0.110 0.072
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.110 0.065
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.109 0.165
MAP2K5 N/A 0.109 0.165
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 563.00
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 1.30
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.109 0.165
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.109 0.165
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.109 0.165
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.109 0.028
MAPK15 N/A 0.109 0.165
PKP4 PKP4: Plakophilin-4 0.109 0.028
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.109 0.056
DNAJC13 DNAJC13, KIAA0678, RME8: DnaJ homolog subfamily C member 13 0.109 0.028
STAT3 0.109 1.30
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 1.30
MAPKAPK5 N/A 0.109 0.165
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 1.30
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 0.0688
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.109 0.165
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.109 0.148
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.109 0.165
CDC2 CDC2: Cell division control protein 2 homolog 0.109 0.165
NF2 NF2, SCH: Merlin 0.109 0.165
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.109 0.165
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.109 0.165
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.109 0.165
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.109 0.0688
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.109 0.165
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.109 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 1.30
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.109 0.165
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 1.30
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.109 0.165
EEF2K EEF2K: Elongation factor 2 kinase 0.109 0.165
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.109 0.072
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.109 0.100
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.100 0.975
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.100 0.171
LIMK2 LIMK2: LIM domain kinase 2 0.100 0.123
PKP3 PKP3: Plakophilin-3 0.100 0.026
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.100 0.098
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.100 0.859
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.100 0.171
JUP JUP, CTNNG, DP3: Junction plakoglobin 0.100 0.056
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.100 0.105
DAPK2 DAPK2: Death-associated protein kinase 2 0.100 0.152
HCK N/A 0.100 0.770
IRS1 IRS1: Insulin receptor substrate 1 0.100 0.152
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.100 0.251
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.100 0.123
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.099 0.064
PTPRZ1 N/A 0.099 0.064
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.099 0.577
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.098 0.081
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.098 0.520
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.098 0.065
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.098 0.081
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.098 0.731
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.098 0.148
COTL1 COTL1, CLP: Coactosin-like protein 0.098 0.047
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.098 0.148
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.098 0.484
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.098 1.17
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.098 0.148
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.098 0.148
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.098 0.148
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.098 0.148
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.098 0.148
CFL2 CFL2: Cofilin-2 0.098 0.047
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.098 1.17
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.098 0.148
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.098 0.148
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.098 0.148
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.098 1.17
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.098 0.148
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.098 0.148
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.098 1.17
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.098 0.148
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.098 0.148
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.098 0.062
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.098 0.148
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.098 0.148
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.097 0.064
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.097 0.808
NEO1 NEO1, NGN: Neogenin precursor 0.097 0.090
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.097 0.064
TNC TNC, HXB: Tenascin precursor 0.097 0.058
INSR INSR: Insulin receptor precursor 0.097 0.577
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.096 0.072
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.096 0.123
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.096 0.072
FCN3 FCN3, FCNH, HAKA1: Ficolin-3 precursor 0.096 0.030
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.094 0.808
SOS1 SOS1: Son of sevenless homolog 1 0.094 0.064
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.094 0.073
CDK4 CDK4: Cell division protein kinase 4 0.090 0.136
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.090 0.110
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.090 0.097
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.090 108.00
WEE1 WEE1: Wee1-like protein kinase 0.090 0.136
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.090 0.136
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.090 0.088
CFL1 CFL1, CFL: Cofilin-1 0.090 0.0308
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.090 0.136
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.090 0.097
CDK7 CDK7, MO15: Cell division protein kinase 7 0.090 0.110
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.090 0.110
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.090 0.094
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.090 0.110
ALK ALK: ALK tyrosine kinase receptor precursor 0.090 0.445
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.090 0.225
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.090 0.097
VWF VWF, F8VWF: von Willebrand factor precursor 0.090 0.041
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.088 0.577
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.088 0.088
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.088 0.073
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.088 0.110
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.088 0.065
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.087 0.126
CXCR4 CXCR4: C-X-C chemokine receptor type 4 0.087 0.100
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.086 0.113
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.086 0.064
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.086 0.029
TBC1D1 TBC1D1, KIAA1108: TBC1 domain family member 1 0.086 0.042
OPTC OPTC, OPT: Opticin precursor 0.083 0.049
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.083 0.109
DLK1 DLK1, DLK: Delta-like protein precursor 0.083 0.049
SEMA4B SEMA4B: Sema domain, immunoglobulin domain 0.083 0.109
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.083 0.109
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.083 0.109
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.083 0.109
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.083 0.109
RTN4R RTN4R, NOGOR, UNQ330/PRO526: Reticulon-4 receptor precursor 0.083 0.049
HLA-DOB HLA-DOB: HLA class II histocompatibility antigen, DO beta chain precursor 0.083 0.032
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.0818 0.110
FNBP1 N/A 0.0818 0.110
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.0818 0.110
AIP AIP, XAP2: AH receptor-interacting protein 0.0818 0.029
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.081 0.191
MUC2 MUC2, SMUC: Mucin-2 precursor 0.081 0.039
BMX N/A 0.081 1.50
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.081 0.109
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.081 0.109
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.081 0.123
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.081 0.034
CDKL5 N/A 0.081 0.123
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.081 0.088
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.081 0.051
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.081 0.088
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.081 0.063
FSTL1 FSTL1, FRP: Follistatin-related protein 1 precursor 0.081 0.045
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.081 0.123
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.081 1.20
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.081 0.152
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.081 0.152
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.081 0.109
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.081 0.109
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.081 0.088
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.081 0.191
STAT2 STAT2: Signal transducer and activator of transcription 2 0.0794 0.902
STAT4 STAT4: Signal transducer and activator of transcription 4 0.0794 0.644
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.0794 0.644
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.077 0.032
GP9 GP9: Platelet glycoprotein IX precursor 0.077 0.037
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.077 0.032
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.075 0.171
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.075 0.191
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.075 0.123
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.075 0.098
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.075 0.044
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.075 0.098
CIITA CIITA, MHC2TA: MHC class II transactivator 0.074 0.096
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.073 370.00
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.073 0.046
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.073 0.770
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.073 0.136
TTN N/A 0.073 0.171
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.073 0.088
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.073 0.041
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.073 0.136
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.073 0.110
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.073 0.097
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.073 0.097
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.073 0.225
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.073 0.110
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.073 0.097
KPNA2 KPNA2, RCH1, SRP1: Importin subunit alpha-2 0.073 19.00
RAB32 RAB32: Ras-related protein Rab-32 0.073 0.033
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.073 0.110
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.073 0.097
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.073 0.097
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.073 0.225
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.0727 0.098
DBN1 DBN1, D0S117E: Drebrin 0.072 0.031
RIN1 RIN1: Ras and Rab interactor 1 0.072 0.874
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.072 0.045
CSPG2 N/A 0.072 0.045
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.072 0.123
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.072 0.051
IRS2 IRS2: Insulin receptor substrate 2 0.072 0.098
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.072 0.123
TP53 TP53, P53: Cellular tumor antigen p53 0.071 0.027
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.0688 422.00
VPREB3 VPREB3, UNQ355/PRO619: Pre-B lymphocyte protein 3 precursor 0.067 0.032
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.067 0.110
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.067 0.110
LCP1 LCP1, PLS2: Plastin-2 0.067 0.110
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.067 0.110
PSCD4 PSCD4, CYT4: Cytohesin-4 0.067 0.097
ACTR3 ACTR3, ARP3: Actin-related protein 3 0.067 0.049
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.067 0.056
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.067 0.136
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.065 0.110
CDK5 CDK5: Cell division protein kinase 5 0.065 0.097
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.065 0.694
TLN2 TLN2: Uncharacterized protein TLN2 0.065 0.097
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.065 0.110
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.065 0.097
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.065 0.097
RDX RDX: Radixin 0.065 0.097
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.065 0.775
CDK6 CDK6: Cell division protein kinase 6 0.064 0.110
GMFB GMFB: Glia maturation factor beta 0.064 0.0308
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.064 0.110
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.064 0.110
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.064 0.041
MYO3A MYO3A: Myosin IIIA 0.064 0.171
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.064 0.136
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.064 0.171
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.064 0.097
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.064 0.110
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.064 46.80
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.064 0.097
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.064 0.136
DAB1 DAB1: Disabled homolog 1 0.064 0.110
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.064 0.041
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.063 0.072
MARCO MARCO, SCARA2: Macrophage receptor MARCO 0.063 0.025
ITIH1 ITIH1, IGHEP1: Inter-alpha-trypsin inhibitor heavy chain H1 precursor 0.062 0.057
EGF EGF: Pro-epidermal growth factor precursor 0.062 0.081
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.062 0.100
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.062 0.072
AREG AREG, SDGF: Amphiregulin precursor 0.062 0.037
HGFAC HGFAC: Hepatocyte growth factor activator precursor 0.062 0.057
UMOD UMOD: Uromodulin precursor 0.062 0.037
NOTCH3 NOTCH3: Neurogenic locus notch homolog protein 3 precursor 0.062 0.032
NOTCH4 N/A 0.062 0.0453
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.062 0.098
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.062 0.098
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.062 0.098
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.062 0.098
PDLIM1 PDLIM1, CLIM1, CLP36: PDZ and LIM domain protein 1 0.061 0.026
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.061 0.097
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.060 8.58
PECAM1 PECAM1: Platelet endothelial cell adhesion molecule precursor 0.059 0.0338
PRKCB1 PRKCB1, PKCB, PRKCB: Protein kinase C beta type 0.059 0.038
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.058 0.097
DYRK3 N/A 0.058 0.097
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.058 0.097
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.058 0.097
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.058 1.07
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.058 0.088
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.058 0.770
DSTN DSTN, ACTDP, DSN: Destrin 0.058 0.028
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.058 0.046
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.058 46.80
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.058 42.20
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.058 0.088
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.058 0.097
FUT3 FUT3, FT3B, LE: Galactoside 3(4)-L-fucosyltransferase 0.057 0.041
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.057 0.090
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.057 0.123
CD2AP CD2AP: CD2-associated protein 0.057 0.097
FLNA FLNA, FLN, FLN1: Filamin-A 0.057 0.049
VASP VASP: Vasodilator-stimulated phosphoprotein 0.057 0.123
DRIM UTP20, DRIM: Small subunit processome component 20 homolog 0.057 0.026
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.057 0.123
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.057 0.123
HD HD, IT15: Huntingtin 0.057 0.077
F10 F10: Coagulation factor X precursor 0.056 0.051
LDLR LDLR: Low-density lipoprotein receptor precursor 0.056 0.033
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.056 0.041
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.056 0.041
FAT2 FAT2, CDHF8, KIAA0811, MEGF1: Protocadherin Fat 2 precursor 0.056 0.033
MEP1B MEP1B: Meprin A subunit beta precursor 0.056 0.067
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.056 0.065
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.056 0.081
SLITRK5 SLITRK5, KIAA0918, LRRC11: SLIT and NTRK-like protein 5 precursor 0.056 0.029
SELE SELE, ELAM1: E-selectin precursor 0.055 0.0453
GP1BA N/A 0.055 0.057
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.055 0.081
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.055 0.032
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.055 0.065
F3 F3: Tissue factor precursor 0.055 0.072
TPBG TPBG, 5T4: Trophoblast glycoprotein precursor 0.055 0.032
FLII FLII, FLIL: Protein flightless-1 homolog 0.054 0.056
MICAL-L1 MICALL1, KIAA1668, MIRAB13: MICAL-like protein 1 0.054 0.035
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.054 0.0308
ST14 ST14, PRSS14, SNC19, TADG15: Suppressor of tumorigenicity protein 14 0.054 0.033
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.052 0.049
TMPRSS9 N/A 0.052 0.049
LRG1 LRG1, LRG: Leucine-rich alpha-2-glycoprotein precursor 0.052 0.049
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.052 0.099
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.052 0.088
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.617
GSK3B GSK3B: Glycogen synthase kinase-3 beta 0.051 0.051
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.617
HLA-DRA HLA-DRA, HLA-DRA1: HLA class II histocompatibility antigen, DR alpha chain precu 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.617
PTPNS1 SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP: Tyrosine-protein phosphatase non-rec 0.051 0.051
NULL Ig heavy chain V-III region WEA 0.051 0.051
TRB@ TCRB: T-cell receptor beta chain V region CTL-L17 precursor 0.051 0.051
STIM1 STIM1, GOK: Stromal interaction molecule 1 precursor 0.051 0.051
NULL Ig kappa chain V region EV15 precursor 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.617
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
MARK2 N/A 0.051 0.051
NCAM1 N/A 0.051 0.051
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
NULL Ig heavy chain V-III region BUR 0.051 0.051
GRB10 N/A 0.051 0.617
NULL TCRA: T-cell receptor alpha chain V region CTL-L17 precursor 0.051 0.051
MAPK11 MAPK11, PRKM11, SAPK2: Mitogen-activated protein kinase 11 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.617
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
HLA-DRB2 HLA class II histocompatibility antigen, DW2.2/DR2.2 beta chain (Fragment) 0.051 0.051
MARK1 MARK1, KIAA1477, MARK: Serine/threonine-protein kinase MARK1 0.051 0.051
MAP4K4 N/A 0.051 0.051
IGHM N/A 0.051 0.051
PRKCD PRKCD: Protein kinase C delta type 0.051 0.051
IGHG3 N/A 0.051 0.051
IGHD N/A 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
FCGR2A FCGR2A, CD32, FCG2, FCGR2A1, IGFR2: Low affinity immunoglobulin gamma Fc region 0.051 0.051
TLK2 TLK2: Serine/threonine-protein kinase tousled-like 2 0.051 0.046
DOK2 DOK2: Docking protein 2 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.617
NULL Ig kappa chain V-I region CAR 0.051 0.051
IGHA1 N/A 0.051 0.051
LOC649805 Ig heavy chain V-II region COR 0.051 0.051
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-27 alpha chain precursor 0.051 0.051
IGHA2 IGHA2: Ig alpha-2 chain C region 0.051 0.051
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.617
CHUK CHUK, IKKA, TCF16: Inhibitor of nuclear factor kappa-B kinase subunit alpha 0.051 0.051
UNC5D UNC5D, KIAA1777, UNQ6012/PRO34692, UNC5H4: Netrin receptor UNC5D precursor 0.051 0.051
HLA-A N/A 0.051 0.051
C6orf25 G6B, C6orf25: Protein G6b precursor 0.051 0.051
NULL Ig lambda chain V-II region NEI 0.051 0.051
MAPK7 MAPK7, ERK4, ERK5, PRKM7: Mitogen-activated protein kinase 7 0.051 0.051
HLA-DQB1 HLA-DQB1: HLA class II histocompatibility antigen, DQB1*0602 beta chain precurso 0.051 0.051
IGHG1 N/A 0.051 0.051
C6orf21 LY6G6F, C6orf21, G6F, LY6G6D, NG32: Lymphocyte antigen 6 complex locus protein G 0.051 0.051
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-68 alpha chain precursor 0.051 0.051
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
IGHE IGHE: Ig epsilon chain C region 0.051 0.051
NULL Ig lambda chain V-I region EPS 0.051 0.051
DBNL DBNL, CMAP, PP5423, SH3P7: Drebrin-like protein 0.051 0.051
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.051 0.731
ETS2 ETS2: Protein C-ets-2 0.051 0.072
PLEK PLEK, P47: Pleckstrin 0.0513 0.081
ACTG1 ACTB: Actin, cytoplasmic 1 0.051 0.049
RASA3 RASA3: Ras GTPase-activating protein 3 0.051 0.110
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.051 0.097
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.051 0.110
PLD1 PLD1: Phospholipase D1 0.051 0.171
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.051 0.088
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.051 127.00
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.051 0.097
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.050 0.033
HLA-DOA HLA-DOA, HLA-DNA, HLA-DZA: HLA class II histocompatibility antigen, DO alpha cha 0.050 0.053
DNM3 DNM3: Uncharacterized protein DNM3 0.049 0.165
AMPH AMPH, AMPH1: Amphiphysin 0.049 0.165
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.049 0.148
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.049 0.165
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.049 0.165
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.049 0.148
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.049 0.165
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.049 0.165
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.049 0.165
PSCD2 N/A 0.049 0.165
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.049 0.148
DCN DCN: Decorin precursor 0.049 0.034
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.049 0.165
PPEF1 N/A 0.049 0.165
S100A16 S100A16, AAG13: Protein S100-A16 0.049 0.165
NASP NASP: Nuclear autoantigenic sperm protein 0.049 0.028
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.049 0.058
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.049 0.029
TNFRSF10C TNFRSF10C, DCR1, UNQ321/PRO366, LIT, TRAILR3, TRID: Tumor necrosis factor recept 0.048 0.0453
TNFRSF1B TNFRSF1B, TNFBR, TNFR2: Tumor necrosis factor receptor superfamily member 1B pre 0.048 0.032
STK17A STK17A, DRAK1: Serine/threonine-protein kinase 17A 0.047 0.028
PIK3C2B PIK3C2B: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta pol 0.047 0.028
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.046 0.077
PHC3 PHC3, EDR3, PH3: Polyhomeotic-like protein 3 0.046 0.046
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.046 0.553
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.046 0.046
IKBKE IKBKE, IKKE, IKKI, KIAA0151: Inhibitor of nuclear factor kappa-B kinase subunit 0.046 0.046
EPB41 EPB41, E41P: Protein 4.1 0.046 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 0.553
AGC1 AGC1, CSPG1, MSK16: Aggrecan core protein precursor 0.046 0.046
VAV2 VAV2: Uncharacterized protein VAV2 0.046 0.553
FLT4 VEGFR3 long form 0.046 0.553
TBC1D4 TBC1D4: TBC1D4 protein 0.046 0.046
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.046 0.046
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.046 0.046
SRPK1 SRPK1: Serine/threonine-protein kinase SRPK1 0.046 0.046
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.046 0.577
MYH9 MYH9: Myosin-9 0.046 0.029
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.046 0.113
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.045 0.056
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.0453 0.097
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.0453 0.051
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.0453 0.045
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.0453 0.109
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.0453 0.062
SCML2 SCML2: Sex comb on midleg-like protein 2 0.045 0.072
TP73 TP73, P73: Tumor protein p73 0.045 0.081
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.044 0.029
MEP1A MEP1A: Meprin A subunit alpha precursor 0.044 0.033
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.044 0.056
NIPBL N/A 0.044 0.025
BMP1 N/A 0.044 0.030
ELMO1 N/A 0.044 0.148
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.044 0.148
ARHGEF7 N/A 0.044 0.148
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.044 0.148
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.044 0.148
PLAT PLAT: Tissue-type plasminogen activator precursor 0.044 0.030
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.044 0.148
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.044 0.148
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.044 0.075
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.044 0.148
TSC2 TSC2, TSC4: Tuberin 0.044 0.075
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.044 0.148
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.044 0.025
ACTN4 ACTN4: Alpha-actinin-4 0.044 0.148
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.044 0.148
F7 F7: Coagulation factor VII precursor 0.044 0.030
CD44 N/A 0.0425 0.032
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.0425 0.033
CCR5 CCR5: CCR5 receptor (Fragment) 0.0425 0.081
FADD FADD, MORT1: Protein FADD 0.0425 0.0453
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.042 0.030
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.041 0.110
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.041 0.058
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.041 0.097
PLD2 PLD2: Phospholipase D2 0.041 0.171
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.041 0.171
MDN1 MDN1, KIAA0301: Midasin 0.041 0.049
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.041 0.225
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.041 0.056
XPO1 XPO1, CRM1: Exportin-1 0.041 0.049
FLNB FLNB, FLN1L, FLN3, TABP, TAP: Filamin-B 0.041 0.049
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.041 0.097
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.041 0.029
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.041 0.049
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.041 0.097
CD84 N/A 0.041 0.032
KIR2DL4 N/A 0.041 0.032
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.04 0.028
PDZD2 CDNA FLJ46853 fis, clone UTERU3009775, moderately similar to Rattus norvegicus P 0.04 0.028
CNN2 CNN2: Calponin-2 0.04 0.165
CASR CASR, GPRC2A, PCAR1: Extracellular calcium-sensing receptor precursor 0.039 0.0453
CD14 CD14: Monocyte differentiation antigen CD14 precursor 0.039 0.037
GRAP GRAP: GRB2-related adapter protein 0.039 0.274
MAP4K2 MAP4K2, GCK, RAB8IP: Mitogen-activated protein kinase kinase kinase kinase 2 0.039 0.0308
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.038 0.047
GNAI2 Galphai2 protein 0.038 0.029
GNA13 GNA13: Guanine nucleotide-binding protein alpha-13 subunit 0.038 0.041
ITIH4 ITIH4, IHRP, PRO1851, ITIHL1, PK120: Inter-alpha-trypsin inhibitor heavy chain H 0.037 0.039
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.037 0.051
PROZ PROZ: Vitamin K-dependent protein Z precursor 0.037 0.039
IPO7 IPO7: Uncharacterized protein IPO7 0.037 0.062
F12 F12: Coagulation factor XII precursor 0.037 0.039
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.037 0.191
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.037 0.045
C2 C2: Complement C2 precursor 0.037 0.039
F5 F5: Coagulation factor V precursor 0.037 0.063
KERA KERA: Keratocan precursor 0.037 0.0513
CFB CFB, BF, BFD: Complement factor B precursor 0.037 0.031
GAB1 GAB1: GRB2-associated-binding protein 1 0.037 0.191
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.037 0.109
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.037 0.045
C1R C1R: Complement C1r subcomponent precursor 0.037 0.025
MCF2 MCF2, DBL: Proto-oncogene DBL 0.037 0.191
S100A7 S100A7, PSOR1: Protein S100-A7 0.037 0.123
C8A C8A: Complement component C8 alpha chain precursor 0.037 0.039
LTK LTK, TYK1: Leukocyte tyrosine kinase receptor precursor 0.036 0.145
UBE2A UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A 0.036 0.025
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.036 0.075
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.036 0.075
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.036 0.075
MYO18A 0.036 0.025
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.036 0.075
TLR4 TLR4: Toll-like receptor 4 precursor 0.035 0.090
GP5 GP5: Platelet glycoprotein V precursor 0.035 0.051
TMPRSS2 TMPRSS2, PRSS10: Transmembrane protease, serine 2 precursor 0.035 0.029
HPN HPN, TMPRSS1: Serine protease hepsin 0.035 0.051
TLR2 TLR2, TIL4: Toll-like receptor 2 precursor 0.035 0.064
VAV3 VAV3: Protein vav-3 0.035 0.218
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.035 0.026
TNN TNN: Tenascin-N precursor 0.034 0.053
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.0338 0.0338
CTLA4 CTLA4, CD152: Cytotoxic T-lymphocyte protein 4 precursor 0.0338 0.059
TNIK TNIK, KIAA0551: TRAF2 and NCK-interacting protein kinase 0.0338 0.047
PTGS1 PTGS1, COX1: Prostaglandin G/H synthase 1 precursor 0.034 0.034
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.033 0.029
STAM2 STAM2: Signal transducing adapter molecule 2 0.033 0.136
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 0.033 0.097
FGB FGB: Fibrinogen beta chain precursor [Contains: Fibrinopeptide B] 0.033 0.028
C8B C8B: Complement component C8 beta chain precursor 0.033 0.035
C6 C6: Complement component C6 precursor 0.033 0.035
PROC PROC: Vitamin K-dependent protein C precursor 0.033 0.035
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.033 0.110
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.033 0.041
IGFALS IGFALS, ALS: Insulin-like growth factor-binding protein complex acid labile chai 0.033 0.035
ACTN1 ACTN1: Alpha-actinin-1 0.033 0.097
MYL3 MYL3: Myosin light polypeptide 3 0.033 0.110
C9 C9: Complement component C9 precursor [Contains: Complement component C9a; Compl 0.033 0.035
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.033 0.097
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.033 0.097
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.033 0.097
F9 F9: Coagulation factor IX precursor 0.033 0.046
SPAG1 SPAG1: Sperm-associated antigen 1 0.033 0.029
SPTAN1 N/A 0.033 0.098
CTTN CTTN, EMS1: Src substrate cortactin 0.033 0.109
S100A3 S100A3, S100E: Protein S100-A3 0.032 0.123
ANGPTL3 ANGPTL3, ANGPT5, UNQ153/PRO179: Angiopoietin-related protein 3 precursor 0.032 0.031
GAB2 N/A 0.032 0.098
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.032 0.045
SORBS3 SORBS3, SCAM1: Vinexin 0.032 0.136
CD5 CD5, LEU1: T-cell surface glycoprotein CD5 precursor 0.032 0.100
RPS10 RPS10: 40S ribosomal protein S10 0.032 0.069
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.031 0.064
SI SI: Sucrase-isomaltase, intestinal [Contains: Sucrase 0.031 0.025
GRM1 GRM1, GPRC1A, MGLUR1: Metabotropic glutamate receptor 1 precursor 0.031 0.037
TSHR N/A 0.0308 0.029
PTPRH N/A 0.0308 0.032
RYK RYK, JTK5A: Tyrosine-protein kinase RYK precursor 0.0308 0.162
LETM1 LETM1: Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial 0.030 0.098
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.030 0.098
CETN1 CETN1, CEN1, CETN: Centrin-1 0.030 0.098
GAS2 GAS2: Growth arrest-specific protein 2 0.030 0.039
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.030 0.055
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.030 0.055
NOS1 NOS1: Nitric-oxide synthase, brain 0.030 0.071
CFI CFI, IF: Complement factor I precursor 0.030 0.031
PSD TYL: TYL protein 0.029 0.088
HPCA HPCA, BDR2: Neuron-specific calcium-binding protein hippocalcin 0.029 0.097
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.097
DLG2 DLG2: Disks large homolog 2 0.029 0.046
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.029 0.109
S100B S100B: Protein S100-B 0.029 0.109
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.029 0.109
CHP CHP: Calcium-binding protein p22 0.029 0.097
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.029 0.110
SPARC SPARC, ON: SPARC precursor 0.029 0.041
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 0.029 13.90
CD82 CD82, KAI1, SAR2, ST6, TSPAN27: CD82 antigen 0.029 0.054
SLC4A7 SLC4A7: Uncharacterized protein SLC4A7 0.029 0.033
AKT2 AKT2: RAC-beta serine/threonine-protein kinase 0.029 0.060
PRKCH PRKCH, PKCL, PRKCL: Protein kinase C eta type 0.029 7.56
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.028 0.049
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.028 0.109
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.028 0.049
PCDHA2 PCDHA2: Protocadherin alpha 2 precursor 0.028 0.049
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.028 0.109
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.028 0.049
MUCDHL MUPCDH, MUCDHL, UNQ2781/PRO7168: Mucin and cadherin-like protein precursor 0.028 0.049
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.028 0.049
GPR126 DREG: Developmentally regulated G-protein-coupled receptor alpha 1 0.028 0.049
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.028 0.049
LAT LAT: Linker for activation of T-cells family member 1 0.028 0.109
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.028 0.109
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.028 0.04
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.028 0.049
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
TBXA2R TBXA2R: Thromboxane A2 receptor 0.028 0.04
CDH6 CDH6: Cadherin-6 precursor 0.028 0.049
DRD2 DRD2: D(2) dopamine receptor 0.028 0.049
GRIN2B GRIN2B, NMDAR2B: Glutamate [NMDA] receptor subunit epsilon-2 precursor 0.028 0.046
EGFL4 MEGF8, C19orf49, EGFL4, KIAA0817: Multiple epidermal growth factor-like domains 0.0273 0.042
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.027 0.0308
TBCE TBCE: Tubulin-specific chaperone E 0.027 0.049
FGFR2 N/A 0.027 0.217
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.265
DDR1 DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE: Epithelial discoidin domain-con 0.027 0.195
WASPIP N/A 0.027 0.136
DAPP1 N/A 0.027 0.026
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.027 0.062
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.027 0.062
CNN3 CNN3: Calponin-3 0.0263 0.098
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.026 0.097
KLC2 KLC2: Kinesin light chain 2 0.026 0.0308
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.026 0.110
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.026 0.098
TNFSF12 TNFSF12, APO3L, UNQ181/PRO207, DR3LG: Tumor necrosis factor ligand superfamily m 0.026 0.032
SPINT2 SPINT2, HAI2, KOP: Kunitz-type protease inhibitor 2 precursor 0.026 0.032
DSG3 DSG3: Desmoglein-3 precursor 0.026 0.037
SDC1 SDC1, SDC: Syndecan-1 precursor 0.026 0.037
LTA LTA, TNFB, TNFSF1: Lymphotoxin-alpha precursor 0.026 0.037
TNF TNF, TNFA, TNFSF2: Tumor necrosis factor precursor 0.026 0.029
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.026 0.062
CDH5 CDH5: Cadherin-5 precursor 0.026 0.032
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.026 0.0453
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.026 0.100
CD40LG CD40LG, CD40L, TNFSF5, TRAP: CD40 ligand 0.026 0.037
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.026 0.100
RYR1 0.025 0.063
APP APP, A4, AD1: Amyloid beta A4 protein precursor 0.025 0.098
ADCY6 ADCY6, KIAA0422: Adenylate cyclase type 6 0.025 0.044
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.025 0.098
STOM STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein 0.025 0.044
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.025 0.098
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.025 0.098
AQP4 AQP4: Aquaporin-4 0.025 0.036
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.025 0.044
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.025 0.044
0.572
Total Score 33.90