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Evidence of Interaction Between PBK and CDC6

The interaction score between PBK and CDC6 is 17.90.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PBK and CDC6 = 0.71

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology
OrganismPBK OrthologueCDC6 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
fly Q9VX24 1 Q9VSM9 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains Domains present in PBK and CDC6:
Domains in PBKDomains in CDC6
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR002290 Serine/threonine protein kinase
IPR008271 Serine/threonine protein kinase, active site
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR011991 Wing_hlx_DNA_bd.

The Chi square scores for co-occurrence of domains that are present in PBK and CDC6 are listed below.

Domain 1Domain 2Chi Square
IPR000719 Protein kinase IPR011991 Wing_hlx_DNA_bd. 16.884
IPR001245 Tyrosine protein kinase IPR011991 Wing_hlx_DNA_bd. 15.5948
IPR000719 Protein kinase IPR003593 AAA ATPase 12.6046
IPR000719 Protein kinase IPR003959 AAA ATPase, central region 6.2595
IPR002290 Serine/threonine protein kinase IPR003593 AAA ATPase 3.98716
IPR008271 Serine/threonine protein kinase, active site IPR003593 AAA ATPase 3.41163
IPR008271 Serine/threonine protein kinase, active site IPR011991 Wing_hlx_DNA_bd. 2.3775
IPR008271 Serine/threonine protein kinase, active site IPR003959 AAA ATPase, central region 1.79861
IPR002290 Serine/threonine protein kinase IPR011991 Wing_hlx_DNA_bd. 0.686914

The background colour of the table refers to:

  • Blue Domain is only present in PBK
  • Yellow Domain is only present in CDC6
  • Green Domain is present in both PBK and CDC6

 0.028
Post-translational Modifications

Protein: PBK

PTMResidueReference
Phosphorylation 9 PubMed, HPRD

Protein: CDC6

PTMResidueReference
Phosphorylation 54 PubMed, HPRD
Phosphorylation 74 PubMed, HPRD
Phosphorylation 106 PubMed, HPRD
Localisation

Protein: PBK

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: CDC6

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between PBK and CDC6 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PBK andCDC6. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PBK has 1538 interactors and CDC6 has 931 interactors of which there are 701 common interactors.

Common InteractorName of Common InteractorScore for PBK-Interactor (?)Score for CDC6-Interactor (?)
CDC20 CDC20: Cell division cycle protein 20 homolog 0.822 0.276
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.763 0.063
CCNB1 Cyclin B1 0.763 86.60
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.575 0.157
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.430 0.308
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.416 0.027
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.416 0.087
MLH1 MLH1, COCA2: DNA mismatch repair protein Mlh1 0.385 0.066
CTPS CTPS: CTP synthase 1 0.385 0.066
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.372 0.032
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.372 0.040
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.372 0.040
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.372 0.040
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.344 0.471
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.307 0.070
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.276 0.066
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.276 0.503
STMN1 STMN1, LAP18, OP18: Stathmin 0.275 0.032
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.275 0.033
CRKL CRKL: Crk-like protein 0.275 0.032
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.275 0.032
STAM2 STAM2: Signal transducing adapter molecule 2 0.275 0.033
MKI67 MKI67: Antigen KI-67 0.269 0.917
CCNB2 CCNB2: G2/mitotic-specific cyclin-B2 0.263 69.60
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.260 0.430
ROCK1 ROCK1: Rho-associated protein kinase 1 0.251 0.032
RAN RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran 0.241 0.066
TUBB TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain 0.233 0.129
NPM1 NPM1, NPM: Nucleophosmin 0.233 0.129
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.225 0.029
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.191 0.0425
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.191 0.225
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.188 0.066
HSP90AA1 Hsp89-alpha-delta-N 0.188 0.032
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 0.188 0.066
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.171 0.114
CCNH CCNH: Cyclin-H 0.171 0.136
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.171 0.029
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.171 0.0818
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.171 0.038
EEF2K EEF2K: Elongation factor 2 kinase 0.165 0.025
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.165 0.028
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.165 0.075
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.165 0.049
NSBP1 NSBP1: Nucleosome-binding protein 1 0.165 0.028
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.165 0.025
STAT3 0.165 0.044
CREB1 CREB1: cAMP response element-binding protein 0.165 0.148
NF2 NF2, SCH: Merlin 0.165 0.028
DBF4 DBF4, ASK: Protein DBF4 homolog 0.160 0.025
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.155 0.063
RB1 RB1: Retinoblastoma-associated protein 0.155 0.416
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.155 0.515
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.155 0.0446
PLEK PLEK, P47: Pleckstrin 0.152 0.026
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.152 0.029
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.152 0.026
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.025
CDC25A CDC25A: M-phase inducer phosphatase 1 0.148 0.025
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.148 0.025
ELMO1 N/A 0.148 0.047
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.148 0.025
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.148 0.148
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.148 0.025
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.148 0.025
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.148 0.025
CCNT2 CCNT2: Cyclin-T2 0.148 0.148
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.025
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.148 0.148
CDC25C CDC25C: M-phase inducer phosphatase 3 0.148 0.025
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.146 431.00
MCM3 MCM3: DNA replication licensing factor MCM3 0.146 1.62
BRCA1 BRCA1, RNF53: Breast cancer type 1 susceptibility protein 0.144 0.385
ESPL1 N/A 0.144 0.308
CENPA CENPA: Histone H3-like centromeric protein A 0.144 0.308
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.144 0.503
TRAP1 TRAP1, HSP75: Heat shock protein 75 kDa, mitochondrial precursor 0.139 0.032
THOC1 THOC1, HPR1: THO complex subunit 1 0.139 0.032
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 0.139 0.063
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.139 0.086
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.136 0.041
FNBP1 N/A 0.136 0.029
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.136 0.086
KIF11 N/A 0.129 0.276
PCNA PCNA: Proliferating cell nuclear antigen 0.129 1.62
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.129 0.246
MSH6 MSH6, GTBP: DNA mismatch repair protein MSH6 0.129 0.129
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.129 1.62
RACGAP1 RACGAP1, KIAA1478, MGCRACGAP: Rac GTPase-activating protein 1 0.129 0.066
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.129 0.276
MAD2L1 MAD2L1, MAD2: Mitotic spindle assembly checkpoint protein MAD2A 0.129 0.276
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.129 0.276
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.129 0.461
KPNA2 KPNA2, RCH1, SRP1: Importin subunit alpha-2 0.129 0.111
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.0425
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.127 0.038
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.127 0.086
GRLF1 N/A 0.127 0.026
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.127 0.114
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.127 0.063
EIF4G1 EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1 0.127 0.052
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.127 0.091
STAT2 STAT2: Signal transducer and activator of transcription 2 0.123 0.077
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.123 0.026
HMGA2 HMGA2, HMGIC: High mobility group protein HMGI-C 0.123 0.032
CCNA2 CCNA2, CCN1, CCNA: Cyclin-A2 0.123 0.263
DAXX DAXX, BING2, DAP6: Death domain-associated protein 6 0.114 0.029
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.114 0.046
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.114 0.372
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.114 0.225
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.110 0.035
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.110 0.136
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.110 0.035
DOK1 DOK1: Docking protein 1 0.110 0.029
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.110 0.041
STAT6 STAT6: Signal transducer and activator of transcription 6 0.110 0.033
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.110 0.029
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.110 0.041
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.110 0.028
STAT4 STAT4: Signal transducer and activator of transcription 4 0.109 0.044
GAB1 GAB1: GRB2-associated-binding protein 1 0.109 0.026
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.098 0.037
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.097 0.028
CCND1 CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1 0.097 0.136
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.096 0.077
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.096
BATF BATF: Basic leucine zipper transcriptional factor ATF-like 0.096 0.191
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.096 0.033
ARFGAP1 N/A 0.096 0.0425
MYB MYB: Myb proto-oncogene protein 0.096 0.210
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.088 0.028
AOF2 AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1 0.087 0.070
TK1 TK1: Thymidine kinase, cytosolic 0.087 0.066
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.087 0.917
NME1 NME1, NDPKA, NM23: Nucleoside diphosphate kinase A 0.087 0.0446
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.087 0.385
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.087 0.515
KIF23 N/A 0.087 0.144
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.087 0.515
FANCA FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein 0.087 0.144
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.086 0.043
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.086 0.114
GTF2A1 GTF2A1, TF2A1: Transcription initiation factor IIA subunit 1 0.086 0.086
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.086 0.038
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.083 0.083
PPEF1 N/A 0.083 0.028
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.028
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.083 0.165
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.083 0.049
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.083 0.049
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.083 0.025
BID BID: BH3-interacting domain death agonist 0.083 0.028
MAPK15 N/A 0.083 0.052
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.083
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.083 0.165
CCNF CCNF: G2/mitotic-specific cyclin-F 0.083 0.137
NBN NBN, NBS, NBS1, P95: Nibrin 0.080 0.155
PTMA N/A 0.080 0.070
SNRPC SNRPC: U1 small nuclear ribonucleoprotein C 0.078 0.078
MYBL2 MYBL2, BMYB: Myb-related protein B 0.078 0.385
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.078 0.078
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.078 0.129
EIF2S2 EIF2S2, EIF2B: Eukaryotic translation initiation factor 2 subunit 2 0.078 0.078
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.078 0.461
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 0.078 0.129
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.078 0.129
CCT4 CCT4, CCTD, SRB: T-complex protein 1 subunit delta 0.078 0.040
TIMELESS TIMELESS, TIM, TIM1, TIMELESS1: Protein timeless homolog 0.078 0.129
H2AFX H2AFX, H2AX: Histone H2A.x 0.078 0.129
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.078 0.763
CDK2 CDK2: Cell division protein kinase 2 0.078 6.86
EIF3S9 EIF3S9: Eukaryotic translation initiation factor 3 subunit 9 0.078 0.078
BLM BLM, RECQ2, RECQL3: Bloom syndrome protein 0.078 0.129
CDK4 CDK4: Cell division protein kinase 4 0.078 0.129
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.078 0.078
WEE1 WEE1: Wee1-like protein kinase 0.078 0.078
RRM2 RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2 0.078 0.066
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.078 0.129
CCT8 CCT8: Uncharacterized protein CCT8 0.078 0.040
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.078 0.385
LIG1 LIG1: DNA ligase 1 0.078 0.129
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.078 0.385
ELF1 ELF1: ETS-related transcription factor Elf-1 0.077 0.077
ELK1 ELK1: ETS domain-containing protein Elk-1 0.077 0.069
CETN1 CETN1, CEN1, CETN: Centrin-1 0.075 0.025
GIT2 N/A 0.075 0.047
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.075 0.075
TSC2 TSC2, TSC4: Tuberin 0.075 0.036
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.025
RBL1 RBL1: Retinoblastoma-like protein 1 0.075 0.148
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.075 0.075
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.071 0.087
PPP1R8 N/A 0.071 0.139
STIP1 STIP1: Stress-induced-phosphoprotein 1 0.070 0.036
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.070 0.070
ABCF1 N/A 0.070 0.070
DNMT1 DNMT1, AIM, DNMT: DNA 0.070 0.087
COIL COIL, CLN80: Coilin 0.070 0.032
UNG N/A 0.070 0.078
RDBP RDBP, NELFE, RD: Negative elongation factor E 0.070 0.052
SET SET: Protein SET 0.070 0.070
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.070 0.416
THOP1 THOP1: Thimet oligopeptidase 0.070 0.032
KIF22 KIF22, KID, KNSL4: Kinesin-like protein KIF22 0.070 0.087
TCOF1 N/A 0.070 0.070
UBAP2 N/A 0.070 0.070
ZNF318 ZNF318, HRIHFB2436: Zinc finger protein 318 0.070 0.155
BAZ1B BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain 0.070 0.515
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.070 0.070
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.070 0.087
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.070 0.036
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.070 0.0446
HIST1H1B HIST1H1B, H1F5: Histone H1.5 0.069 0.069
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.069 0.069
RELA RELA, NFKB3: Transcription factor p65 0.069 0.069
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.069 0.041
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.069 0.069
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.069 0.043
EIF4G3 EIF4G3: Eukaryotic translation initiation factor 4 gamma 3 0.069 0.056
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.069 0.029
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.029
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.063 0.078
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.063 0.246
RANBP9 RANBP9, RANBPM: Ran-binding protein 9 0.063 0.029
HSPD1 0.063 0.066
CPSF1 CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1 0.063 0.046
NOL1 N/A 0.063 0.078
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.063 0.078
NUP153 N/A 0.063 0.078
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.063 0.461
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 0.063 0.078
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.063 0.040
PABPC4 PABPC4, APP1, PABP4: Polyadenylate-binding protein 4 0.063 0.078
HDAC2 HDAC2: Histone deacetylase 2 0.063 0.118
CSPG6 SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3 0.063 0.078
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.063 0.233
TP53 TP53, P53: Cellular tumor antigen p53 0.063 0.146
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 0.063 0.063
SNRPB2 SNRPB2: U2 small nuclear ribonucleoprotein B'' 0.063 0.063
POLA2 POLA2: DNA polymerase subunit alpha B 0.063 0.129
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.063 0.040
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.063 0.118
MTHFD1 MTHFD1, MTHFC, MTHFD: C-1-tetrahydrofolate synthase, cytoplasmic 0.063 0.040
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.063 0.032
WRN WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase 0.063 0.129
SUZ12 SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12 0.063 0.233
UBA2 SAE2, UBA2, HRIHFB2115, UBLE1B: SUMO-activating enzyme subunit 2 0.063 0.063
CDC23 CDC23: Cell division cycle protein 23 homolog 0.063 0.040
SSB SSB: Lupus La protein 0.063 0.078
XPO1 XPO1, CRM1: Exportin-1 0.063 0.137
TCF3 TCF3, E2A, ITF1: Transcription factor E2-alpha 0.063 0.146
TAF6 TAF6, TAF2E, TAFII70: Transcription initiation factor TFIID subunit 6 0.063 0.063
SKIIP SNW1, SKIIP, SKIP: SNW domain-containing protein 1 0.063 0.063
CCT6A CCT6A, CCT6, CCTZ: T-complex protein 1 subunit zeta 0.063 0.066
CBX3 CBX3: Chromobox protein homolog 3 0.063 0.078
G3BP G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1 0.063 0.040
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.063 0.063
ELAVL1 ELAVL1, HUR: ELAV-like protein 1 0.063 0.078
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 0.063 0.032
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.063 0.078
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.063 0.118
TOPBP1 TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1 0.063 0.233
CDK7 CDK7, MO15: Cell division protein kinase 7 0.063 0.046
LMNB1 LMNB1, LMN2, LMNB: Lamin-B1 0.063 0.129
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.063 0.063
MDM4 MDM4, MDMX: Mdm4 protein 0.062 0.039
NFE2L2 NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2 0.062 0.110
ERG ERG: Transcriptional regulator ERG 0.062 0.127
BACH1 BACH1: Transcription regulator protein BACH1 0.062 0.109
NFATC1 N/A 0.062 0.152
ERF ERF: ETS domain-containing transcription factor ERF 0.062 0.096
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.062 0.037
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.062 0.043
H1FX H1FX: Histone H1x 0.062 0.077
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.062 0.039
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.056 0.033
ATM ATM: Serine-protein kinase ATM 0.056 0.056
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.056 0.056
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.056 0.114
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.055 0.027
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.055 0.026
SLC4A1AP SLC4A1AP: Uncharacterized protein SLC4A1AP 0.054 0.056
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.054 0.054
MAFG MAFG: Transcription factor MafG 0.054 0.225
RAB4A N/A 0.052 0.028
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.052 0.049
GSR GSR, GLUR, GRD1: Glutathione reductase, mitochondrial precursor 0.052 0.032
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.052 0.052
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.052 0.074
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.052 0.118
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.052 0.052
EIF2S3 EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3 0.052 0.032
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.052 0.052
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.052 0.132
PPIA PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A 0.052 0.032
RBM14 RBM14, SIP: RNA-binding protein 14 0.052 0.052
PHB2 PHB2, BAP, REA: Prohibitin-2 0.052 0.036
DDX21 DDX21: Nucleolar RNA helicase 2 0.052 0.070
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.050 0.044
ETV1 ETV1, ER81: ETS translocation variant 1 0.049 0.055
ETS2 ETS2: Protein C-ets-2 0.049 0.062
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.049 0.109
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.049 0.035
JUND JUND: Transcription factor jun-D 0.049 0.097
HIST1H1A HIST1H1A, H1F1: Histone H1.1 0.049 0.056
ETS1 ETS1, EWSR2: Protein C-ets-1 0.049 0.056
MYST4 MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4 0.049 0.056
ATF6 ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha 0.049 0.097
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.049 0.097
DDIT3 DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3 0.048 0.152
TRAF1 TRAF1, EBI6: TNF receptor-associated factor 1 0.048 0.041
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.047 0.075
NOC2L NOC2L: Nucleolar complex protein 2 homolog 0.046 0.063
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.046 0.139
TIAL1 TIAL1: Nucleolysin TIAR 0.046 0.063
ZCCHC8 ZCCHC8: Zinc finger CCHC domain-containing protein 8 0.046 0.063
MDN1 MDN1, KIAA0301: Midasin 0.046 0.275
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.046 0.046
WDR79 N/A 0.046 0.063
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.046 0.078
CSDA CSDA, DBPA: DNA-binding protein A 0.046 0.114
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 0.046 1.03
HDGF HDGF, HMG1L2: Hepatoma-derived growth factor 0.046 0.063
SND1 SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1 0.046 0.046
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.046 0.063
PAK1IP1 PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1 0.046 0.046
HSPH1 HSPH1, HSP105, HSP110, KIAA0201: Heat shock protein 105 kDa 0.046 0.032
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.046 0.063
POLR2A POLR2A: Uncharacterized protein POLR2A 0.046 0.038
APEX1 APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase 0.046 0.233
SF3B4 SF3B4, SAP49: Splicing factor 3B subunit 4 0.046 0.046
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.046 0.078
MTA1 MTA1: Metastasis-associated protein MTA1 0.046 0.188
TDG TDG: G/T mismatch-specific thymine DNA glycosylase 0.046 0.063
NME2 NME2, NM23B: Nucleoside diphosphate kinase B 0.046 0.032
LDHB LDHB: L-lactate dehydrogenase B chain 0.046 0.032
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.046 0.063
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.046 0.038
WDHD1 WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1 0.046 0.233
REXO2 REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor 0.046 0.063
ZNF330 ZNF330, NOA36: Zinc finger protein 330 0.046 0.063
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.046 65.00
HDAC3 HDAC3: Histone deacetylase 3 0.046 0.118
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.046 0.063
CCNC CCNC: Cyclin-C 0.044 0.044
CCNG1 CCNG1, CCNG, CYCG1: Cyclin-G1 0.044 0.060
CDK5R1 CDK5R1, CDK5R, NCK5A: Cyclin-dependent kinase 5 activator 1 precursor 0.044 0.088
JUN JUN: Transcription factor AP-1 0.044 0.088
JUNB JUNB: Transcription factor jun-B 0.044 0.088
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.044 0.062
UBTF UBTF, UBF, UBF1: Nucleolar transcription factor 1 0.0425 0.127
NAT1 NAT1, AAC1: Arylamine N-acetyltransferase 1 0.0425 0.027
GTF2F2 N/A 0.0425 0.155
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.0425 0.0425
FUBP1 N/A 0.0425 0.027
SNAPC4 SNAPC4, SNAP190: snRNA-activating protein complex subunit 4 0.0425 0.127
TRRAP N/A 0.0425 0.052
STK16 N/A 0.0425 0.0425
SREBF2 N/A 0.0425 0.052
JMJD1A JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr 0.0425 0.032
RBM6 RBM6, DEF3: RNA-binding protein 6 0.0425 0.032
API5 N/A 0.0425 0.052
MATR3 MATR3, KIAA0723: Matrin-3 0.0425 0.155
JUP JUP, CTNNG, DP3: Junction plakoglobin 0.039 0.041
TP73 TP73, P73: Tumor protein p73 0.039 0.026
WBSCR20A N/A 0.038 0.038
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.038 0.029
MRE11A MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A 0.038 0.046
YY1 YY1: Transcriptional repressor protein YY1 0.038 0.114
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.038 0.063
PABPC1 PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1 0.038 0.038
SFRS4 SFRS4, SRP75: Splicing factor, arginine/serine-rich 4 0.038 0.046
GMCL1L GMCL1L, GCL: Germ cell-less protein-like 1-like 0.038 0.029
COPB2 COPB2: Coatomer subunit beta' 0.038 0.046
TOP3A TOP3A, TOP3: DNA topoisomerase 3-alpha 0.038 0.038
VCP VCP: Transitional endoplasmic reticulum ATPase 0.038 0.181
SAFB SAFB, HAP, HET, SAFB1: Scaffold attachment factor B 0.038 0.038
RBM15 RBM15, OTT: Putative RNA-binding protein 15 0.038 0.046
PHF10 N/A 0.038 0.046
CLTC CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1 0.038 0.046
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.038 0.038
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 0.038 0.087
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.038 0.038
PAPOLA PAPOLA, PAP: Poly(A) polymerase alpha 0.038 0.038
AKAP8L AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like 0.038 0.114
FKBP4 FKBP4: FK506-binding protein 4 0.038 0.046
RBM7 0.038 0.038
TAF10 TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10 0.038 0.029
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.038 0.063
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.038 0.067
MBD3 MBD3: Methyl-CpG-binding domain protein 3 0.038 0.046
SRF SRF: Serum response factor 0.038 0.114
TAL1 TAL1, SCL, TCL5: T-cell acute lymphocytic leukemia protein 1 0.038 0.139
CRSP2 MED14, ARC150, CRSP2, CXorf4, DRIP150, EXLM1, RGR1, TRAP170: Mediator of RNA pol 0.038 0.046
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.038 0.046
ACIN1 ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus 0.038 0.038
WBSCR1 EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H 0.038 0.046
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.038 0.046
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.038 0.029
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.038 0.086
KLF1 KLF1, EKLF: Krueppel-like factor 1 0.038 0.139
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.038 0.275
CEBPE CEBPE: CCAAT/enhancer-binding protein epsilon 0.035 0.136
ABCB9 ABCB9, KIAA1520: ATP-binding cassette sub-family B member 9 precursor 0.034 0.062
SLC2A1 SLC2A1, GLUT1: Solute carrier family 2, facilitated glucose transporter member 1 0.033 0.046
NR3C1 NR3C1, GRL: Glucocorticoid receptor 0.032 0.060
BAZ2A BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A 0.032 0.225
EMD EMD, EDMD, STA: Emerin 0.032 0.032
USP24 USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24 0.032 0.052
MTF1 MTF1: Metal regulatory transcription factor 1 0.032 0.086
IKBKG IKBKG, FIP3, NEMO: NF-kappa-B essential modulator 0.032 0.0425
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.032 0.0425
BRIP1 BRIP1, BACH1, FANCJ: Fanconi anemia group J protein 0.032 0.038
PHF3 PHF3, KIAA0244: PHD finger protein 3 0.032 0.032
CHUK N/A 0.032 0.052
ZNF638 ZNF638, NP220, ZFML: Zinc finger protein 638 0.032 0.0425
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.032 0.0425
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.032 0.052
DRIM UTP20, DRIM: Small subunit processome component 20 homolog 0.032 0.155
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.032 0.032
PHF8 PHF8, KIAA1111, ZNF422: PHD finger protein 8 0.032 0.026
MYBBP1A MYBBP1A, P160: Myb-binding protein 1A 0.032 0.052
HD HD, IT15: Huntingtin 0.032 0.075
XRCC4 N/A 0.032 0.032
ZNF267 ZNF267: Zinc finger protein 267 0.032 0.096
GNB2L1 Lung cancer oncogene 7 0.032 0.0425
IFI16 N/A 0.032 0.032
KIAA0853 N/A 0.032 0.052
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.032 0.0425
IPO7 IPO7: Uncharacterized protein IPO7 0.032 0.124
TERF2 TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2 0.032 0.127
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.032 0.032
FNBP4 FNBP4, FBP30, KIAA1014: Formin-binding protein 4 0.032 0.0425
TOP2B N/A 0.032 0.052
TP53BP1 TP53BP1: Tumor suppressor p53-binding protein 1 0.032 0.096
SCML2 SCML2: Sex comb on midleg-like protein 2 0.032 0.026
PER2 PER2, KIAA0347: Period circadian protein homolog 2 0.032 0.026
TGIF2 TGIF2: Homeobox protein TGIF2 0.032 0.155
XRCC1 XRCC1: DNA-repair protein XRCC1 0.032 0.127
FOSL2 FOSL2, FRA2: Fos-related antigen 2 0.031 0.088
BRD2 BRD2, KIAA9001, RING3: Bromodomain-containing protein 2 0.029 0.136
C20orf4 C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4 0.029 0.029
SEC31L1 N/A 0.029 0.029
SP3 SP3: Transcription factor Sp3 0.029 0.086
SIRT1 SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1 0.029 0.136
FZR1 N/A 0.029 0.038
ARMET ARMET, ARP: Protein ARMET precursor 0.029 0.029
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.029 0.029
NCOR1 NCOR1, KIAA1047: Nuclear receptor corepressor 1 0.029 0.114
SAPS3 N/A 0.029 0.038
AKAP8 AKAP8, AKAP95: A-kinase anchor protein 8 0.029 0.114
SFRS6 SFRS6, SRP55: Splicing factor, arginine/serine-rich 6 0.029 0.038
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.029 0.051
YEATS2 KIAA1197, YEATS2: YEATS domain-containing protein 2 0.029 0.046
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.029 0.086
METTL1 METTL1, C12orf1: tRNA 0.029 0.038
SYMPK SYMPK, SPK: Symplekin 0.029 0.114
RBMX2 RBMX2, CGI-79: RNA-binding motif protein, X-linked 2 0.029 0.038
EP300 N/A 0.029 0.029
KIAA0683 DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized 0.029 0.038
SPEN SPEN, KIAA0929, MINT, SHARP: Msx2-interacting protein 0.029 0.038
CORO1C CORO1C, CRNN4: Coronin-1C 0.029 0.029
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.029 0.051
CSTF2T CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant 0.029 0.038
DDX51 DDX51: ATP-dependent RNA helicase DDX51 0.029 0.029
USP34 USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34 0.029 0.029
ERCC3 ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit 0.029 0.038
TCEB3 TCEB3, MSTP059: Transcription elongation factor B polypeptide 3 0.029 0.029
BRPF1 BRPF1, BR140: Peregrin 0.029 0.136
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.029 0.114
DIAPH1 Diaphanous 1 0.029 0.029
CUL4B N/A 0.029 0.029
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.029 0.038
TOPORS TOPORS, LUN, TP53BPL: E3 ubiquitin-protein ligase Topors 0.029 0.029
SKIV2L SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti 0.029 0.038
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.029 0.046
KLHDC4 N/A 0.029 0.029
LIG4 LIG4: DNA ligase 4 0.029 0.069
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.029 0.038
RPS6KB1 N/A 0.029 0.038
DUSP15 N/A 0.028 0.028
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
TRERF1 TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1 0.028 0.075
CORO6 N/A 0.028 0.028
TFAP4 TFAP4: Transcription factor AP-4 0.028 0.075
HNRPC HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2 0.028 0.028
ZC3HAV1 ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1 0.028 0.028
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.028 0.083
ZNF644 ZNF644, KIAA1221, ZEP2: Zinc finger protein 644 0.028 0.083
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.028 0.052
MITF MITF: Microphthalmia-associated transcription factor 0.028 0.028
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.028 0.025
ZHX1 ZHX1: Zinc fingers and homeoboxes protein 1 0.028 0.083
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.028
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.028 0.025
UHRF1 0.028 0.028
HDAC7A N/A 0.028 0.047
POGZ POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain 0.028 0.083
SFRS9 SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9 0.028 0.025
TCF20 TCF20, KIAA0292, SPBP: Transcription factor 20 0.028 0.028
ZNF295 ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295 0.028 0.083
C13orf8 N/A 0.028 0.028
ZFP91 ZFP91, FKSG11: Zinc finger protein 91 homolog 0.028 0.083
AR AR, DHTR, NR3C4: Androgen receptor 0.028 0.028
FLJ21816 PALB2, FANCN: Partner and localizer of BRCA2 0.028 0.028
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.028 0.028
MLL2 MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2 0.028 0.028
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.028 0.025
TMPO TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha 0.028 0.028
RAVER1 RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1 0.028 0.028
CAMKK1 N/A 0.028 0.025
PRDM2 PRDM2, RIZ: PR domain zinc finger protein 2 0.028 0.075
ZCCHC3 ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3 0.028 0.028
IRF7 N/A 0.028 0.028
NFIA NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A 0.028 0.028
MLL4 WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7 0.028 0.025
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
ARNT ARNT: Aryl hydrocarbon receptor nuclear translocator 0.028 0.052
NES N/A 0.028 0.025
FLJ23436 N/A 0.028 0.025
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.028 0.083
CDC2 CDC2: Cell division control protein 2 homolog 0.028 0.025
HDAC8 N/A 0.028 0.052
CUTL1 CUTL1: Homeobox protein cut-like 1 0.028 0.083
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.028 0.028
MAPKAPK5 N/A 0.028 0.028
CABLES1 N/A 0.028 0.028
DNAJC13 DNAJC13, KIAA0678, RME8: DnaJ homolog subfamily C member 13 0.028 0.04
ZNF265 N/A 0.028 0.028
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.028 0.028
HES6 HES6: Transcription cofactor HES-6 0.028 0.052
AXIN1 0.028 0.04
PKP4 PKP4: Plakophilin-4 0.028 0.04
SYTL4 Endocrine transmitter regulatory protein 0.028 0.028
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.028 0.025
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.028 0.025
PTBP1 PTBP1: Polypyrimidine tract binding protein 1 0.028 0.028
PHLDB2 N/A 0.028 0.028
CBFA2T2 CBFA2T2, EHT, MTGR1: Protein CBFA2T2 0.028 0.028
WDR54 N/A 0.028 0.028
ZNF579 ZNF579: Zinc finger protein 579 0.028 0.083
DSP DSP: Desmoplakin 0.028 0.028
LOC642558 FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1 0.028 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.028 0.028
ATXN2L ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein 0.028 0.028
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.028 0.04
C20orf18 N/A 0.028 0.052
KIF1B N/A 0.028 0.028
JDP2 jdp2, JDP2: Jun dimerization protein 2 0.028 0.028
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
BCOR N/A 0.028 0.025
NIPA1 NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1 0.028 0.028
DKFZp434K1815 DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815 0.028 0.028
KIAA1443 HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez 0.028 0.083
SNRPB N/A 0.028 0.028
ILF3 ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3 0.028 0.028
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.028 0.028
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.028 0.028
CEBPB CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta 0.028 0.088
FOS FOS, G0S7: Proto-oncogene protein c-fos 0.028 0.097
CCND2 CCND2: G1/S-specific cyclin-D2 0.028 0.028
CREM hCREM-1: HCREM 1alpha protein 0.027 0.027
CREM CREM, RP11-324I22.1-005: cAMP responsive element modulator 0.027 0.027
IRF3 IRF3: Interferon regulatory factor 3 0.026 0.077
RFXDC2 RFXDC2: Regulatory factor X domain-containing protein 2. 0.026 0.032
SRPR SRPR: Uncharacterized protein SRPR 0.026 0.126
AANAT AANAT, SNAT: Serotonin N-acetyltransferase 0.026 0.096
ID3 ID3, 1R21, HEIR-1: DNA-binding protein inhibitor ID-3 0.026 0.062
POU2F1 POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1 0.026 0.077
AFF1 N/A 0.026 0.032
SP100 N/A 0.026 0.077
HIST1H3A HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, 0.026 0.029
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.026 0.0425
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.026 0.086
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.026 0.032
STRN3 STRN3, GS2NA, SG2NA: Striatin-3 0.026 0.026
ZFX ZFX: Zinc finger X-chromosomal protein 0.026 0.096
WDR1 N/A 0.026 0.026
HIVEP1 N/A 0.026 0.096
SMARCC2 N/A 0.026 0.032
GTF3C4 GTF3C4: General transcription factor 3C polypeptide 4 0.026 0.026
PGR PGR, NR3C3: Progesterone receptor 0.026 0.039
NCOA3 N/A 0.026 0.026
TERF2IP TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1 0.026 0.077
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.026 0.032
ZNF335 ZNF335: Zinc finger protein 335 0.026 0.069
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.026 0.032
ZNF217 ZNF217, ZABC1: Zinc finger protein 217 0.026 0.069
SFRS15 SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15 0.026 0.0425
TRIM25 TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25 0.026 0.029
RBM10 RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10 0.025 0.075
KCTD1 0.025 0.025
RBBP6 RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6 0.025 0.025
NIPBL N/A 0.025 0.075
SSBP4 SSBP4: Single-stranded DNA-binding protein 4 0.025 0.025
WWTR1 WWTR1, TAZ: WW domain-containing transcription regulator protein 1 0.025 0.025
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.025 0.025
NEDD4 NEDD4: Uncharacterized protein NEDD4 0.025 0.025
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.025
FAF1 FAF1, CGI-03: FAS-associated factor 1 0.025 0.025
UBE2R2 UBE2R2, CDC34B, UBC3B: Ubiquitin-conjugating enzyme E2 R2 0.025 3.39
MAX MAX: Protein max 0.025 0.047
HOXA10 HOXA10, HOX1H: Homeobox protein Hox-A10 0.025 0.075
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.025 0.025
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.025 0.047
ZNF598 ZNF598: Zinc finger protein 598 0.025 0.025
POLR1C POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1 0.025 0.025
MLXIPL MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein 0.025 0.047
DLX3 DLX3: Homeobox protein DLX-3 0.025 0.075
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.025 0.047
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.025 0.025
TCEA1 N/A 0.025 0.025
REXO1 REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog 0.025 0.025
PURB PURB: Transcriptional activator protein Pur-beta 0.025 0.025
IWS1 IWS1, IWS1L: IWS1 homolog 0.025 0.025
SEC13L1 N/A 0.025 0.025
SMN2 SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein 0.025 0.025
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.025 0.025
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.025
PSIP1 PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein 0.025 0.025
SPAST SPAST, KIAA1083, SPG4: Spastin 0.025 0.098
ISL2 ISL2: Insulin gene enhancer protein ISL-2 0.025 0.075
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.025 0.025
NFYA NFYA: Nuclear transcription factor Y subunit alpha 0.025 0.025
RNF20 0.025 0.075
FARSLA FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain 0.025 0.075
ADK ADK: Adenosine kinase 0.025 0.025
HNRPM HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M 0.025 0.025
TIA1 TIA1: Nucleolysin TIA-1 isoform p40 0.025 0.025
ZFPM1 ZFPM1, FOG1: Zinc finger protein ZFPM1 0.025 0.075
HEXIM2 HEXIM2, L3: Protein HEXIM2 0.025 0.025
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.025 0.025
MSL3L1 MSL3L1: Male-specific lethal 3-like 1 0.025 0.025
GRK6 N/A 0.025 0.025
DDX20 DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20 0.025 0.025
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.025
SYAP1 SYAP1, PRO3113: Synapse-associated protein 1 0.025 0.025
DHX8 DHX8, DDX8: ATP-dependent RNA helicase DHX8 0.025 0.148
CAMK2A N/A 0.025 0.025
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.025 0.025
SETD3 SETD3, C14orf154: SET domain-containing protein 3 0.025 0.025
NCOA3 NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3 0.025 0.047
SMAD1 SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1 0.025 0.075
MIER1 MIER1, KIAA1610: Mesoderm induction early response protein 1 0.025 0.025
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.025 0.025
EDF1 EDF1: Endothelial differentiation-related factor 1 0.025 0.025
RFFL RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin 0.025 0.025
HTATIP N/A 0.025 0.025
HNRPD HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0 0.025 0.025
SAP14 SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14 0.025 0.025
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.025 0.025
ZNF174 ZNF174, ZSCAN8: Zinc finger protein 174 0.025 0.075
NHN1 NHN1: Conserved nuclear protein NHN1 0.025 0.025
TAL2 TAL2: T-cell acute lymphocytic leukemia protein 2 0.025 0.075
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.025 0.025
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.025 0.075
OSR1 OSR1, ODD: Protein odd-skipped-related 1 0.025 0.075
C20orf77 N/A 0.025 0.025
GEMIN5 GEMIN5: Gem-associated protein 5 0.025 0.025
BRD4 N/A 0.025 0.148
GATAD2B GATAD2B, KIAA1150: Transcriptional repressor p66 beta 0.025 0.075
PHF16 PHF16, JADE3, KIAA0215: Protein Jade-3 0.025 0.025
SMARCA2 SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2 0.025 0.025
LMNA LMNA, LMN1: Lamin-A/C 0.025 0.025
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.148
ARID4A ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A 0.025 0.025
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.025
SON 0.025 0.025
MAPK8IP3 N/A 0.025 0.025
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.025 0.025
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.025 0.025
HNRPUL1 HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1 0.025 0.025
MKI67IP MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein 0.025 0.025
HIST3H2A HIST3H2A: Histone H2A type 3 0.025 0.025
C14orf4 C14orf4, KIAA1865, My039: RING finger protein C14orf4 0.025 0.025
MAP2K3 N/A 0.025 0.025
RAD50 RAD50: DNA repair protein RAD50 0.025 0.044
NUP98 N/A 0.025 0.025
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.047
SOX8 SOX8: Transcription factor SOX-8 0.025 0.075
PRKCB1 N/A 0.025 0.025
NSUN2 NSUN2, SAKI, TRM4: tRNA 0.025 0.025
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.047
FLJ40432 FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227 0.025 0.025
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.148
RNF113A RNF113A, RNF113, ZNF183: RING finger protein 113A 0.025 0.025
DIDO1 N/A 0.025 0.025
BUB3 BUB3: Mitotic checkpoint protein BUB3 0.025 0.025
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.075
ATXN2L N/A 0.025 0.025
HNRPA2B1 HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1 0.025 0.025
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.025 0.025
DLG7 DLG7, KIAA0008: Disks large-associated protein DLG7 0.025 0.025
GMNN GMNN: Geminin 0.025 0.053
PTTG1 PTTG1, EAP1, PTTG, TUTR1: Securin 0.025 0.025
TPX2 TPX2, C20orf1, C20orf2, DIL2, HCA519: Targeting protein for Xklp2 0.025 0.053
KNTC2 KNTC2, HEC, HEC1: Kinetochore protein Hec1 0.025 0.0479
0.347
Total Score 17.90