Home
Advanced Search
Help
Update History
Statistics
Downloads
The Barton Group
<<< Back to DDX46

Evidence of Interaction Between DDX46 and MCM7

The interaction score between DDX46 and MCM7 is 1.06.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between DDX46 and MCM7 = 0.68

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 7.78E-3
Orthology N/A N/A
Domains No domains were used in calculating likelihood of interaction 1.48E-3
Post-translational Modifications

Protein: DDX46

PTMResidueReference
Phosphorylation 804 PubMed, HPRD
Phosphoserine 804 HPRD

Protein: MCM7

PTMResidueReference
Localisation

Protein: DDX46

LocalisationReference
Nucleus HPRD

Protein: MCM7

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between DDX46 and MCM7 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between DDX46 andMCM7. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , DDX46 has 1244 interactors and MCM7 has 165 interactors of which there are 76 common interactors.

Common InteractorName of Common InteractorScore for DDX46-Interactor (?)Score for MCM7-Interactor (?)
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.917 0.123
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.515 0.060
MCM3 MCM3: DNA replication licensing factor MCM3 0.430 209.00
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.416 0.044
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.308 0.060
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.260 0.074
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.260 209.00
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.260 0.053
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.260 0.123
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.253 0.059
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.231 0.108
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.210 69.60
MTA1 MTA1: Metastasis-associated protein MTA1 0.210 0.074
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.155 0.044
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.155 0.067
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.155 0.067
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.144 0.038
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.144 0.060
ELF1 ELF1: ETS-related transcription factor Elf-1 0.144 0.050
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.144 0.074
RPA1 RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit 0.137 0.123
DARS DARS, PIG40: Aspartyl-tRNA synthetase, cytoplasmic 0.108 0.059
RPS23 RPS23: 40S ribosomal protein S23 0.090 0.060
SCYE1 SCYE1, EMAP2: Multisynthetase complex auxiliary component p43 [Contains: Endothe 0.090 0.060
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.090 0.137
PCNA PCNA: Proliferating cell nuclear antigen 0.087 0.789
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.087 0.028
DNMT1 DNMT1, AIM, DNMT: DNA 0.087 0.137
RB1 RB1: Retinoblastoma-associated protein 0.087 0.083
CSDA CSDA, DBPA: DNA-binding protein A 0.077 0.044
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.074 0.059
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.074 0.059
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.070 0.028
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.070 0.028
H1FX H1FX: Histone H1x 0.070 0.050
MDN1 MDN1, KIAA0301: Midasin 0.070 0.060
IRF3 IRF3: Interferon regulatory factor 3 0.070 0.041
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.070 1.82
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.070 0.044
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.070 0.123
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.070 0.049
OBFC1 OBFC1: Oligonucleotide/oligosaccharide-binding fold-containing protein 1 0.067 0.041
NARS NARS, ASNS: Asparaginyl-tRNA synthetase, cytoplasmic 0.065 0.035
PSMC6 PSMC6, SUG2: 26S protease regulatory subunit S10B 0.057 0.059
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.052 0.294
CCNB1 Cyclin B1 0.052 0.263
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.052 0.036
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.052 69.60
POLR2H POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3 0.051 0.123
XRCC3 XRCC3: DNA-repair protein XRCC3 0.050 0.074
SSBP1 SSBP1, SSBP: Single-stranded DNA-binding protein, mitochondrial precursor 0.048 0.055
SRPR SRPR: Uncharacterized protein SRPR 0.0446 0.032
CCNH CCNH: Cyclin-H 0.0425 0.028
GTF2F2 N/A 0.0425 0.041
MCM5 MCM5, CDC46: DNA replication licensing factor MCM5 0.042 69.60
POLR2G POLR2G: DNA-directed RNA polymerase II subunit RPB7 0.042 0.060
POT1 POT1: Protection of telomeres protein 1 0.042 0.083
VCP VCP: Transitional endoplasmic reticulum ATPase 0.036 0.047
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.036 0.0968
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.032 0.0308
ERG ERG: Transcriptional regulator ERG 0.032 0.041
ERF ERF: ETS domain-containing transcription factor ERF 0.032 0.0308
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.032 0.036
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.028 0.027
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.028 0.027
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.028 0.027
TPRKB TPRKB, CGI-121, My019: TP53RK-binding protein 0.027 0.027
ILF2 ILF2, NF45, PRO3063: Interleukin enhancer-binding factor 2 0.027 0.027
ZCCHC17 ZCCHC17, PS1D, HSPC243, HSPC251, LDC4: Nucleolar protein of 40 kDa 0.027 0.027
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.027 0.059
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.026 0.028
MCM6 MCM6: DNA replication licensing factor MCM6 0.0255 0.789
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.0255 0.060
MRPS28 MRPS28, MRPS35, HSPC007: Mitochondrial 28S ribosomal protein S28 0.0255 0.074
EIF1AX EIF1AX, EIF1A, EIF4C: Eukaryotic translation initiation factor 1A, X-chromosomal 0.0255 0.060
CUL2 CUL2: Cullin-2 0.025 0.044
0.572
Total Score 1.06