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Evidence of Interaction Between DDX46 and MCM6

The interaction score between DDX46 and MCM6 is 3.54.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between DDX46 and MCM6 = 0.64

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 7.78E-3
Orthology N/A N/A
Domains No domains were used in calculating likelihood of interaction 8.18E-3
Post-translational Modifications

Protein: DDX46

PTMResidueReference
Phosphorylation 804 PubMed, HPRD
Phosphoserine 804 HPRD

Protein: MCM6

PTMResidueReference
Localisation

Protein: DDX46

LocalisationReference
Nucleus HPRD

Protein: MCM6

LocalisationReference
Nucleoplasm HPRD
Transitive Score

The common interactors between DDX46 and MCM6 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between DDX46 andMCM6. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , DDX46 has 1244 interactors and MCM6 has 177 interactors of which there are 87 common interactors.

Common InteractorName of Common InteractorScore for DDX46-Interactor (?)Score for MCM6-Interactor (?)
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.917 0.123
DDX21 DDX21: Nucleolar RNA helicase 2 0.917 0.0255
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.917 0.0278
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.515 0.060
MCM3 MCM3: DNA replication licensing factor MCM3 0.430 209.00
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.430 0.042
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.416 0.044
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.308 0.044
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.260 0.123
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.260 69.60
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.260 0.123
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.253 0.059
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.231 0.065
EXOSC8 EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43 0.231 0.065
WRN WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase 0.210 0.074
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.210 69.60
MTA1 MTA1: Metastasis-associated protein MTA1 0.210 0.060
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.210 0.042
BLM BLM, RECQ2, RECQL3: Bloom syndrome protein 0.210 0.123
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.155 0.060
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.155 0.067
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.155 0.067
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.144 0.044
ELF1 ELF1: ETS-related transcription factor Elf-1 0.144 0.041
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.144 0.060
RPA1 RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit 0.137 0.123
DARS DARS, PIG40: Aspartyl-tRNA synthetase, cytoplasmic 0.108 0.047
RPS23 RPS23: 40S ribosomal protein S23 0.090 0.044
SCYE1 SCYE1, EMAP2: Multisynthetase complex auxiliary component p43 [Contains: Endothe 0.090 0.060
RECQL RECQL, RECQL1: ATP-dependent DNA helicase Q1 0.090 0.044
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.090 0.137
KIF11 N/A 0.087 0.044
PCNA PCNA: Proliferating cell nuclear antigen 0.087 0.044
DNMT1 DNMT1, AIM, DNMT: DNA 0.087 0.137
EIF2S2 EIF2S2, EIF2B: Eukaryotic translation initiation factor 2 subunit 2 0.087 0.074
RB1 RB1: Retinoblastoma-associated protein 0.087 0.083
SNRPA SNRPA: U1 small nuclear ribonucleoprotein A 0.084 0.053
CSDA CSDA, DBPA: DNA-binding protein A 0.077 0.036
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.074 0.047
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.074 0.612
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.074 0.059
H1FX H1FX: Histone H1x 0.070 0.041
MDN1 MDN1, KIAA0301: Midasin 0.070 0.060
TIMELESS TIMELESS, TIM, TIM1, TIMELESS1: Protein timeless homolog 0.070 3.89
IRF3 IRF3: Interferon regulatory factor 3 0.070 0.041
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.070 1.82
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.070 0.036
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.070 0.123
ESPL1 N/A 0.070 0.049
OBFC1 OBFC1: Oligonucleotide/oligosaccharide-binding fold-containing protein 1 0.067 0.041
MUTYH N/A 0.067 0.137
NARS NARS, ASNS: Asparaginyl-tRNA synthetase, cytoplasmic 0.065 0.035
EXOSC7 EXOSC7, KIAA0116, RRP42: Exosome complex exonuclease RRP42 0.065 0.059
PSMC6 PSMC6, SUG2: 26S protease regulatory subunit S10B 0.057 0.047
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.052 0.294
CCNB1 Cyclin B1 0.052 0.123
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.052 0.036
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.052 0.263
EXOSC4 EXOSC4, RRP41, SKI6: Exosome complex exonuclease RRP41 0.051 0.029
POLR2H POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3 0.051 0.123
XRCC3 XRCC3: DNA-repair protein XRCC3 0.050 0.060
SSBP1 SSBP1, SSBP: Single-stranded DNA-binding protein, mitochondrial precursor 0.048 0.055
SRPR SRPR: Uncharacterized protein SRPR 0.0446 0.032
CCNH CCNH: Cyclin-H 0.0425 0.028
GTF2F2 N/A 0.0425 0.041
PES1 PES1: Pescadillo homolog 1 0.042 1.10
MCM5 MCM5, CDC46: DNA replication licensing factor MCM5 0.042 69.60
POLR2G POLR2G: DNA-directed RNA polymerase II subunit RPB7 0.042 0.060
POT1 POT1: Protection of telomeres protein 1 0.042 0.083
HRB2 KRR1, HRB2: KRR1 small subunit processome component homolog 0.037 3.08
VCP VCP: Transitional endoplasmic reticulum ATPase 0.036 0.035
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.036 0.207
ERG ERG: Transcriptional regulator ERG 0.032 0.041
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.032 0.028
EXOSC5 EXOSC5, CML28, RRP46: Exosome complex exonuclease RRP46 0.032 0.047
NTHL1 NTHL1, NTH1, OCTS3: Endonuclease III-like protein 1 0.0308 0.036
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.028 0.027
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.028 0.027
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.028 0.027
OGG1 N/A 0.027 0.027
ZCCHC17 ZCCHC17, PS1D, HSPC243, HSPC251, LDC4: Nucleolar protein of 40 kDa 0.027 0.027
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.027 0.0968
DDX39 DDX39: ATP-dependent RNA helicase DDX39 0.0255 0.038
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.0255 0.060
MRPS28 MRPS28, MRPS35, HSPC007: Mitochondrial 28S ribosomal protein S28 0.0255 0.074
EIF1AX EIF1AX, EIF1A, EIF4C: Eukaryotic translation initiation factor 1A, X-chromosomal 0.0255 0.060
CUL2 CUL2: Cullin-2 0.025 0.044
0.347
Total Score 3.54