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Evidence of Interaction Between SHC3 and KIT

The interaction score between SHC3 and KIT is 6.36E3.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SHC3 and KIT = 0.01

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology
OrganismSHC3 OrthologueKIT OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00217895 0.171 IPI00018335 0.132
human IPI00217895 0.171 IPI00021396 0.132
human IPI00643176 0.34 IPI00018335 0.132
  • Y2H
  • InVitro
  • InVivo

Get References From PubMed
human IPI00643176 0.34 IPI00021396 0.132
  • Y2H

Get References From PubMed
worm Q9TYT3 0.34 O76698 0.132
worm Q9TYT3 0.34 Q21038 0.132
worm Q9TYT3 0.34 Q21041 0.132

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 1.07
Domains Domains present in SHC3 and KIT:
Domains in SHC3Domains in KIT
IPR000980 SH2 motif
IPR006019 Phosphotyrosine interaction (PID or PI)
IPR006020 Phosphotyrosine interaction domain
IPR011993 PH_type.
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR003598 Immunoglobulin C-2 type
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR001824 Receptor tyrosine kinase, class III
IPR009134 Vascular endothelial growth factor receptor, VEGFR
IPR013151 Immunoglobulin.

The Chi square scores for co-occurrence of domains that are present in SHC3 and KIT are listed below.

Domain 1Domain 2Chi Square
IPR000980 SH2 motif IPR008266 Tyrosine protein kinase, active site 383.26
IPR000980 SH2 motif IPR001245 Tyrosine protein kinase 238.73
IPR000980 SH2 motif IPR001824 Receptor tyrosine kinase, class III 101.074
IPR000980 SH2 motif IPR007110 Immunoglobulin-like 94.9752
IPR011993 PH_type. IPR001245 Tyrosine protein kinase 88.2896
IPR011993 PH_type. IPR008266 Tyrosine protein kinase, active site 85.0032
IPR000980 SH2 motif IPR000719 Protein kinase 82.1364
IPR000980 SH2 motif IPR003599 Immunoglobulin subtype 66.4833
IPR000980 SH2 motif IPR003598 Immunoglobulin C-2 type 64.7072
IPR000980 SH2 motif IPR011009 Protein kinase-like 59.6059
IPR000980 SH2 motif IPR009134 Vascular endothelial growth factor receptor, VEGFR 49.095
IPR011993 PH_type. IPR000719 Protein kinase 37.108
IPR000980 SH2 motif IPR013151 Immunoglobulin. 36.9251
IPR011993 PH_type. IPR011009 Protein kinase-like 21.3114
IPR011993 PH_type. IPR009134 Vascular endothelial growth factor receptor, VEGFR 3.65681
IPR011993 PH_type. IPR001824 Receptor tyrosine kinase, class III 3.54397
IPR011993 PH_type. IPR003599 Immunoglobulin subtype 2.87015
IPR011993 PH_type. IPR007110 Immunoglobulin-like 1.73192
IPR011993 PH_type. IPR013151 Immunoglobulin. 0.399518
IPR006020 Phosphotyrosine interaction domain IPR011009 Protein kinase-like 0.203907
IPR011993 PH_type. IPR003598 Immunoglobulin C-2 type 0.0205778
IPR006020 Phosphotyrosine interaction domain IPR008266 Tyrosine protein kinase, active site 0.0178144
IPR006020 Phosphotyrosine interaction domain IPR001245 Tyrosine protein kinase 0.0104833
IPR006020 Phosphotyrosine interaction domain IPR000719 Protein kinase 0.00379833

The background colour of the table refers to:

  • Blue Domain is only present in SHC3
  • Yellow Domain is only present in KIT
  • Green Domain is present in both SHC3 and KIT

 0.217
Post-translational Modifications

Protein: SHC3

PTMResidueReference

Protein: KIT

PTMResidueReference
Dephosphorylation 570 PubMed, HPRD
N-linked 130 PubMed, HPRD
Phosphorylation 545 PubMed, HPRD
Phosphorylation 547 PubMed, HPRD
Phosphorylation 553 PubMed, HPRD
Phosphorylation 568 PubMed, HPRD
Phosphorylation 570 PubMed, HPRD
Phosphorylation 703 PubMed, HPRD
Phosphorylation 721 PubMed, HPRD
Phosphorylation 730 PubMed, HPRD
Phosphorylation 741 PubMed, HPRD
Phosphorylation 746 PubMed, HPRD
Phosphorylation 747 PubMed, HPRD
Phosphorylation 821 PubMed, HPRD
Phosphorylation 900 PubMed, HPRD
Phosphorylation 936 PubMed, HPRD
Phosphorylation 959 PubMed, HPRD
Localisation

Protein: SHC3

LocalisationReference
Cytoplasm HPRD

Protein: KIT

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Transitive Score

The common interactors between SHC3 and KIT that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SHC3 andKIT. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SHC3 has 346 interactors and KIT has 1344 interactors of which there are 154 common interactors.

Common InteractorName of Common InteractorScore for SHC3-Interactor (?)Score for KIT-Interactor (?)
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 207.00 127.00
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 173.00 43.20
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 147.00 112.00
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 114.00 422.00
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 93.60 0.148
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 74.90 0.808
HCK N/A 67.50 0.577
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 67.50 0.577
ZAP70 ZAP70: Uncharacterized protein ZAP70 67.50 0.577
INSR INSR: Insulin receptor precursor 61.50 0.110
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 61.50 46.80
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 61.50 0.171
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 55.50 46.80
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 55.50 0.110
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 17.40 0.041
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 16.30 487.00
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 11.50 0.878
PRKCG PRKCG, PKCG: Protein kinase C gamma type 10.50 0.041
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 9.04 0.484
VAV1 VAV1, VAV: Proto-oncogene vav 7.67 0.655
STAT6 STAT6: Signal transducer and activator of transcription 6 7.67 0.577
CRKL CRKL: Crk-like protein 7.56 388.00
NCK2 NCK2: Cytoplasmic protein NCK2 7.56 315.00
GRAP GRAP: GRB2-related adapter protein 7.56 61.50
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 6.81 0.577
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 6.81 0.808
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 5.94 0.318
SOS1 SOS1: Son of sevenless homolog 1 5.35 0.094
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.490 0.110
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.362 0.123
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.265 0.980
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.265 0.265
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.265 0.980
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.251 0.123
BMX N/A 0.244 0.654
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.237 0.980
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.237 0.098
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.217 0.165
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.217 0.165
FGFR2 N/A 0.217 0.027
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.217 0.165
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.200 0.123
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.197 0.644
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.197 0.731
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.197 0.081
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.197 0.200
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.195 0.165
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.195 0.148
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.195 0.148
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.177 0.520
FYN N/A 0.174 0.162
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.174 0.581
MET MET: Hepatocyte growth factor receptor precursor 0.162 0.109
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.157 0.644
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.157 0.902
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.156 0.644
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.156 0.808
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.156 0.0308
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.156 0.808
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.156 0.655
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.145 0.097
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.145 0.097
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.145 0.097
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.145 0.088
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.145 0.110
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.145 0.097
LYN LYN: Tyrosine-protein kinase Lyn 0.140 0.577
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.140 0.902
CSK CSK: Tyrosine-protein kinase CSK 0.140 0.655
SYK SYK: Tyrosine-protein kinase SYK 0.140 0.902
JAK1 0.140 0.731
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.140 0.902
TIE1 TIE1, TIE: Tyrosine-protein kinase receptor Tie-1 precursor 0.129 0.0308
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.128 0.275
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.128 0.097
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.128 0.097
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.128 0.097
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.126 0.098
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.115 0.110
ALK ALK: ALK tyrosine kinase receptor precursor 0.094 0.064
MT3 MT3: Metallothionein-3 0.083 0.062
CHN1 CHN1, ARHGAP2, CHN: N-chimaerin 0.074 0.145
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.074 0.073
SPTAN1 N/A 0.067 0.081
CDK5 CDK5: Cell division protein kinase 5 0.060 0.041
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.060 0.073
PSD TYL: TYL protein 0.060 0.073
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.053 0.123
COBL N/A 0.050 0.0453
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.047 0.046
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.044 0.073
TLN2 TLN2: Uncharacterized protein TLN2 0.044 0.064
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.044 0.033
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.044 0.033
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.044 0.033
BZRAP1 BZRAP1, KIAA0612, RBP1: Peripheral-type benzodiazepine receptor-associated prote 0.041 0.053
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.039 0.152
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.039 0.062
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.039 0.191
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.036 0.041
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.036 0.073
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.036 0.073
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.036 0.033
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.036 0.041
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.036 0.090
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.035 0.110
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.032 0.077
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.032 0.063
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.0308 0.081
GAB1 GAB1: GRB2-associated-binding protein 1 0.0308 0.081
MCF2 MCF2, DBL: Proto-oncogene DBL 0.0308 0.072
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.0288 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.0288 0.051
FES FES, FPS: Proto-oncogene tyrosine-protein kinase Fes/Fps 0.0288 0.0288
FES Proto-oncogene c-fes variant 4 0.0288 0.0288
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.0288 0.051
BLK BLK: Tyrosine-protein kinase BLK 0.0288 0.0288
FES Proto-oncogene c-fes variant 3 0.0288 0.0288
BTK BTK kinase deficient isoform 6: Dominant-negative kinase-deficient Brutons tyros 0.0288 0.0288
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.0288 0.051
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.029 0.057
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.028 0.058
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.028 0.113
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.028 0.041
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.028 0.090
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.028 0.029
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.028 0.113
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.028 0.090
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.028 0.033
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.028 0.090
CNN2 CNN2: Calponin-2 0.027 0.109
MAP2K5 N/A 0.027 0.049
AMPH AMPH, AMPH1: Amphiphysin 0.027 0.109
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.217
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.027 0.049
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.027 0.980
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.217
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.027 0.109
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.027 0.109
NF2 NF2, SCH: Merlin 0.027 0.109
LNK SH2B3, LNK: SH2B adapter protein 3 0.027 0.980
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.217
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.217
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.027 0.109
MAPK15 N/A 0.027 0.049
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.027 0.980
PSCD2 N/A 0.027 0.109
DNM3 DNM3: Uncharacterized protein DNM3 0.027 0.109
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.027 0.049
FLT4 VEGFR3 long form 0.0258 0.046
FES N/A 0.0258 0.0258
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.0258 0.046
0.228
Total Score 6.36E3