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Evidence of Interaction Between SHC3 and FER

The interaction score between SHC3 and FER is 21.60.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SHC3 and FER = -0.08

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.62E-3
Orthology
OrganismSHC3 OrthologueFER OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00217895 0.171 IPI00556627 0.393
human IPI00643176 0.34 IPI00556627 0.393
worm Q9TYT3 0.34 O02064 0.208
worm Q9TYT3 0.34 Q19726 0.272
worm Q9TYT3 0.34 Q22146 1
fly Q24080 0.171 P18106 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains Domains present in SHC3 and FER:
Domains in SHC3Domains in FER
IPR000980 SH2 motif
IPR006019 Phosphotyrosine interaction (PID or PI)
IPR006020 Phosphotyrosine interaction domain
IPR011993 PH_type.
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR001060 Cdc15/Fes/CIP4
IPR000980 SH2 motif

The Chi square scores for co-occurrence of domains that are present in SHC3 and FER are listed below.

Domain 1Domain 2Chi Square
IPR000980 SH2 motif IPR008266 Tyrosine protein kinase, active site 383.26
IPR000980 SH2 motif IPR001245 Tyrosine protein kinase 238.73
IPR011993 PH_type. IPR001245 Tyrosine protein kinase 88.2896
IPR011993 PH_type. IPR008266 Tyrosine protein kinase, active site 85.0032
IPR000980 SH2 motif IPR000719 Protein kinase 82.1364
IPR000980 SH2 motif IPR011009 Protein kinase-like 59.6059
IPR011993 PH_type. IPR000719 Protein kinase 37.108
IPR000980 SH2 motif IPR000980 SH2 motif 36.445
IPR011993 PH_type. IPR000980 SH2 motif 33.2172
IPR011993 PH_type. IPR011009 Protein kinase-like 21.3114
IPR011993 PH_type. IPR001060 Cdc15/Fes/CIP4 1.71423
IPR006020 Phosphotyrosine interaction domain IPR000980 SH2 motif 1.20067
IPR006020 Phosphotyrosine interaction domain IPR011009 Protein kinase-like 0.203907
IPR006020 Phosphotyrosine interaction domain IPR008266 Tyrosine protein kinase, active site 0.0178144
IPR006020 Phosphotyrosine interaction domain IPR001245 Tyrosine protein kinase 0.0104833
IPR006020 Phosphotyrosine interaction domain IPR000719 Protein kinase 0.00379833

The background colour of the table refers to:

  • Blue Domain is only present in SHC3
  • Yellow Domain is only present in FER
  • Green Domain is present in both SHC3 and FER

 0.265
Post-translational Modifications

Protein: SHC3

PTMResidueReference

Protein: FER

PTMResidueReference
Phosphorylation 714 PubMed, HPRD
Localisation

Protein: SHC3

LocalisationReference
Cytoplasm HPRD

Protein: FER

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between SHC3 and FER that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SHC3 andFER. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SHC3 has 346 interactors and FER has 1332 interactors of which there are 241 common interactors.

Common InteractorName of Common InteractorScore for SHC3-Interactor (?)Score for FER-Interactor (?)
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 207.00 0.655
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 173.00 0.874
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 147.00 0.655
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 114.00 1.17
DDR1 DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE: Epithelial discoidin domain-con 93.60 0.195
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 93.60 0.878
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 74.90 0.770
KIT KIT: Mast/stem cell growth factor receptor precursor 69.80 0.655
HCK N/A 67.50 0.770
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 67.50 0.770
ZAP70 ZAP70: Uncharacterized protein ZAP70 67.50 0.770
LTK LTK, TYK1: Leukocyte tyrosine kinase receptor precursor 61.50 0.128
INSR INSR: Insulin receptor precursor 61.50 0.577
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 61.50 0.577
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 61.50 0.577
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 55.50 0.520
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 55.50 0.520
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 17.40 0.097
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 16.30 0.770
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 11.50 1.17
PRKCG PRKCG, PKCG: Protein kinase C gamma type 10.50 0.097
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 9.04 0.878
VAV1 VAV1, VAV: Proto-oncogene vav 7.67 0.874
STAT6 STAT6: Signal transducer and activator of transcription 6 7.67 0.770
CRKL CRKL: Crk-like protein 7.56 1.07
NCK2 NCK2: Cytoplasmic protein NCK2 7.56 0.874
GRAP GRAP: GRB2-related adapter protein 7.56 0.177
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 6.81 0.770
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 6.81 1.07
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 5.94 1.01
SOS1 SOS1: Son of sevenless homolog 1 5.35 0.113
TYRO3 TYRO3, BYK, DTK, RSE, SKY: Tyrosine-protein kinase receptor TYRO3 precursor 0.677 0.143
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.490 0.577
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.362 0.577
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.265 1.30
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.265 0.265
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.265 1.30
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.251 0.731
BMX N/A 0.244 0.975
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.237 1.17
TNK1 TNK1: Non-receptor tyrosine-protein kinase TNK1 0.237 0.237
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.237 1.17
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.217 0.980
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.217 0.980
FGFR2 N/A 0.217 0.217
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.217 0.980
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.200 0.581
RET urf-ret: Urf-ret protein 0.200 0.129
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.197 0.975
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.197 1.20
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.197 1.50
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.197 0.174
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.195 0.878
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.195 0.878
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.195 0.878
MUSK MUSK: Muscle, skeletal receptor tyrosine protein kinase precursor 0.179 0.145
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.177 0.770
FYN N/A 0.174 0.174
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.174 0.975
AMHR2 AMHR2, AMHR: Anti-Muellerian hormone type-2 receptor precursor 0.162 0.162
STYK1 STYK1, NOK: Tyrosine protein-kinase STYK1 0.162 0.162
MET MET: Hepatocyte growth factor receptor precursor 0.162 0.731
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.157 0.859
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.157 1.20
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.156 0.770
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.156 0.770
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.156 0.274
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.156 1.07
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.145 0.655
INSRR INSRR, IRR: Insulin receptor-related protein precursor 0.145 0.145
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.145 0.655
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.145 0.655
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.145 0.655
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.145 0.577
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.145 0.655
ROR1 ROR1, NTRKR1: Tyrosine-protein kinase transmembrane receptor ROR1 precursor 0.145 0.145
RYK RYK, JTK5A: Tyrosine-protein kinase RYK precursor 0.145 0.200
LYN LYN: Tyrosine-protein kinase Lyn 0.140 0.770
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.140 0.874
CSK CSK: Tyrosine-protein kinase CSK 0.140 0.874
SYK SYK: Tyrosine-protein kinase SYK 0.140 0.874
JAK1 0.140 0.874
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.140 1.07
TIE1 TIE1, TIE: Tyrosine-protein kinase receptor Tie-1 precursor 0.129 0.143
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.128 0.655
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.128 0.577
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.128 0.577
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.128 0.520
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.126 0.484
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.115 0.808
ROR2 ROR2, NTRKR2: Tyrosine-protein kinase transmembrane receptor ROR2 precursor 0.115 0.179
ALK ALK: ALK tyrosine kinase receptor precursor 0.094 0.445
MT3 MT3: Metallothionein-3 0.083 0.033
CHN1 CHN1, ARHGAP2, CHN: N-chimaerin 0.074 0.156
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.074 0.088
SPTAN1 N/A 0.067 0.109
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.060 0.088
CDK5 CDK5: Cell division protein kinase 5 0.060 0.097
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.060 0.088
PSD TYL: TYL protein 0.060 0.097
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.053 0.065
COBL N/A 0.050 0.098
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.047 0.064
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.044 0.110
TLN2 TLN2: Uncharacterized protein TLN2 0.044 0.097
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.044 0.097
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.044 0.110
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.044 0.110
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.039 0.072
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.039 0.072
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.039 0.072
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.036 0.110
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.036 0.088
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.036 0.097
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.036 0.097
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.036 0.097
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.036 0.097
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.035 0.058
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.032 0.032
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.032 0.072
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.0308 0.191
ULK2 ULK2, KIAA0623: Serine/threonine-protein kinase ULK2 0.0308 0.0308
GAB1 GAB1: GRB2-associated-binding protein 1 0.0308 0.109
MCF2 MCF2, DBL: Proto-oncogene DBL 0.0308 0.152
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.0288 0.617
NULL N/A 0.0288 0.0288
NTRK3 N/A 0.0288 0.0288
ROS1 ROS1: Proto-oncogene tyrosine-protein kinase ROS precursor 0.0288 0.0288
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.0288 0.617
FES FES, FPS: Proto-oncogene tyrosine-protein kinase Fes/Fps 0.0288 0.0288
DDR2 DDR2, NTRKR3, TKT, TYRO10: Discoidin domain-containing receptor 2 precursor 0.0288 0.0288
FES Proto-oncogene c-fes variant 4 0.0288 0.0288
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.0288 0.617
BLK BLK: Tyrosine-protein kinase BLK 0.0288 0.0288
FES Proto-oncogene c-fes variant 3 0.0288 0.0288
AATK apoptosis-associated tyrosine kinase 0.0288 0.0288
NULL N/A 0.0288 0.0288
MUSK MUSK: MUSK protein 0.0288 0.0288
TESK2 TESK2: Dual specificity testis-specific protein kinase 2 0.0288 0.0288
NTRK3 NTRK3, TRKC: NT-3 growth factor receptor precursor 0.0288 0.0288
NULL Tyrosine kinase 0.0288 0.0288
BTK BTK kinase deficient isoform 6: Dominant-negative kinase-deficient Brutons tyros 0.0288 0.0288
TTN TTN: Uncharacterized protein TTN (Fragment) 0.0288 0.0288
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.0288 0.617
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.029 0.064
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.028 0.136
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.028 0.097
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.028 0.136
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.028 0.110
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.028 0.110
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.028 0.088
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.028 0.110
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.028 0.097
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.028 0.136
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.028 0.088
CNN2 CNN2: Calponin-2 0.027 0.165
TRIM9 TRIM9, KIAA0282, RNF91: Tripartite motif-containing protein 9 0.027 0.027
NEK4 NEK4, STK2: Serine/threonine-protein kinase Nek4 0.027 0.027
ABI3 ABI3, NESH: ABI gene family member 3 0.027 0.027
MAP2K5 N/A 0.027 0.165
PPP1R9A PPP1R9A, KIAA1222: Neurabin-1 0.027 0.027
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.027 0.165
PXK PXK: PX domain-containing protein kinase-like protein 0.027 0.027
ASB14 ASB14: Ankyrin repeat and SOCS box protein 14 0.027 0.027
STAC STAC: SH3 and cysteine-rich domain-containing protein 0.027 0.027
PLEKHA3 PLEKHA3, FAPP1: Pleckstrin homology domain-containing family A member 3 0.027 0.027
CDC2L2 N/A 0.027 0.027
WSB1 WSB1, SWIP1: WD repeat and SOCS box-containing protein 1 0.027 0.027
ASB3 ASB3: ASB3 protein 0.027 0.027
CADPS2 CADPS2, CAPS2, KIAA1591: Calcium-dependent secretion activator 2 0.027 0.027
FAM43A N/A 0.027 0.027
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.027 0.056
ASB12 ASB12: Ankyrin repeat and SOCS box protein 12 0.027 0.027
UBL7 UBL7, BMSCUBP, SB132: Ubiquitin-like protein 7 0.027 0.027
ASB2 ASB2: Ankyrin repeat and SOCS box protein 2 0.027 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.027 0.165
AMPH AMPH, AMPH1: Amphiphysin 0.027 0.165
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.027 0.165
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.027 0.165
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.265
CADPS CADPS, CAPS, CAPS1, KIAA1121: Calcium-dependent secretion activator 1 0.027 0.027
RASGRF1 RASGRF1, CDC25: Guanine nucleotide-releasing protein 0.027 0.027
DUSP10 DUSP10, MKP5: Dual specificity protein phosphatase 10 0.027 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.027 0.165
APBB1 APBB1, FE65, RIR: Amyloid beta A4 precursor protein-binding family B member 1 0.027 0.027
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.027 1.30
EFS EFS: Embryonal Fyn-associated substrate 0.027 0.027
NEBL N/A 0.027 0.027
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.265
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.027 0.165
SORBS2 N/A 0.027 0.027
MAPKAPK5 N/A 0.027 0.165
CAMKK1 CAMKK1, CAMKKA: Calcium/calmodulin-dependent protein kinase kinase 1 0.027 0.027
CASKIN1 N/A 0.027 0.027
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.027 0.165
NF2 NF2, SCH: Merlin 0.027 0.165
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.027 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.027 1.30
NOXA1 NOXA1, RP13-927H1.1-001: NADPH oxidase activator 1 0.027 0.027
ANKK1 ANKK1, PKK2, SGK288: Ankyrin repeat and protein kinase domain-containing protein 0.027 0.027
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.265
ALS2CR7 ALS2CR7: Serine/threonine-protein kinase ALS2CR7 0.027 0.027
RIPK5 RIPK5, KIAA0472, HDCMD38P, RIP5, SGK496: Receptor-interacting serine/threonine-p 0.027 0.027
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.265
ARHGEF1 ARHGEF1: Rho guanine nucleotide exchange factor 1 0.027 0.027
CENTB5 KIAA1716, CENTB5: Centaurin-beta 5 0.027 0.027
ASB6 ASB6: Ankyrin repeat and SOCS box protein 6 0.027 0.027
DOK5 DOK5, C20orf180: Docking protein 5 0.027 0.027
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.027 0.165
DOK6 DOK6: Uncharacterized protein DOK6 0.027 0.027
MAPK15 N/A 0.027 0.165
NEK11 NEK11: Serine/threonine-protein kinase Nek11 0.027 0.027
PSD3 N/A 0.027 0.027
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.027 0.165
PLEKHA4 PLEKHA4, PEPP1: Pleckstrin homology domain-containing family A member 4 0.027 0.027
PTPN13 N/A 0.027 0.027
SHANK1 SHANK1: SH3 and multiple ankyrin repeat domains protein 1 0.027 0.027
VEPH1 VEPH1, KIAA1692, VEPH: Ventricular zone-expressed PH domain-containing protein h 0.027 0.027
FANK1 FANK1, HSD13, UNQ6504/PRO21382: Fibronectin type 3 and ankyrin repeat domains pr 0.027 0.027
OSBPL9 N/A 0.027 0.027
ASB10 ASB10: Ankyrin repeat and SOCS box protein 10 0.027 0.027
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.027 0.056
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.027 1.30
PSCD2 N/A 0.027 0.165
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.027 0.165
OSBPL6 OSBPL6, ORP6: Oxysterol-binding protein-related protein 6 0.027 0.027
ASB7 ASB7: Ankyrin repeat and SOCS box protein 7 0.027 0.027
MID2 N/A 0.027 0.027
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.027 0.165
DNM3 DNM3: Uncharacterized protein DNM3 0.027 0.165
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.027 0.165
PDIK1L PDIK1L, CLIK1L: Serine/threonine-protein kinase PDIK1L 0.027 0.027
STK35 STK35, CLIK1, PDIK1: Serine/threonine-protein kinase 35 0.027 0.027
ASB17 ASB17: Ankyrin repeat and SOCS box protein 17 0.027 0.027
RASGRF2 RASGRF2: Ras protein-specific guanine nucleotide-releasing factor 2 (Fragment) 0.027 0.027
SRA1 APBB3, FE65L2: Amyloid beta A4 precursor protein-binding family B member 3 0.027 0.027
FLT4 VEGFR3 long form 0.0258 0.553
FES N/A 0.0258 0.0258
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.0258 0.553
0.347
Total Score 21.60