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Evidence of Interaction Between SHC3 and EPHA2

The interaction score between SHC3 and EPHA2 is 17.70.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SHC3 and EPHA2 = -0.07

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.62E-3
Orthology
OrganismSHC3 OrthologueEPHA2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00217895 0.171 IPI00008315 0.315
human IPI00217895 0.171 IPI00016645 0.312
human IPI00643176 0.34 IPI00008315 0.315
human IPI00643176 0.34 IPI00016645 0.312
worm Q9TYT3 0.34 O61460 0.312
fly Q24080 0.171 O96435 0.315

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains Domains present in SHC3 and EPHA2:
Domains in SHC3Domains in EPHA2
IPR000980 SH2 motif
IPR006019 Phosphotyrosine interaction (PID or PI)
IPR006020 Phosphotyrosine interaction domain
IPR011993 PH_type.
IPR006209 EGF-like domain
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR001090 Ephrin receptor, ligand binding
IPR001426 Receptor tyrosine kinase, class V
IPR001660 Sterile alpha motif SAM
IPR003961 Fibronectin, type III
IPR008957 Fibronectin, type III-like fold
IPR008979 Galactose-binding like
IPR013032 IPR006209.
IPR013761 Sterile alpha motif-type

The Chi square scores for co-occurrence of domains that are present in SHC3 and EPHA2 are listed below.

Domain 1Domain 2Chi Square
IPR000980 SH2 motif IPR008266 Tyrosine protein kinase, active site 383.26
IPR000980 SH2 motif IPR001245 Tyrosine protein kinase 238.73
IPR000980 SH2 motif IPR003961 Fibronectin, type III 184.508
IPR011993 PH_type. IPR001245 Tyrosine protein kinase 88.2896
IPR011993 PH_type. IPR008266 Tyrosine protein kinase, active site 85.0032
IPR000980 SH2 motif IPR000719 Protein kinase 82.1364
IPR000980 SH2 motif IPR011009 Protein kinase-like 59.6059
IPR011993 PH_type. IPR000719 Protein kinase 37.108
IPR006020 Phosphotyrosine interaction domain IPR013032 IPR006209. 34.846
IPR006020 Phosphotyrosine interaction domain IPR006209 EGF-like domain 31.1032
IPR000980 SH2 motif IPR008957 Fibronectin, type III-like fold 27.8744
IPR011993 PH_type. IPR011009 Protein kinase-like 21.3114
IPR000980 SH2 motif IPR006209 EGF-like domain 19.373
IPR000980 SH2 motif IPR001090 Ephrin receptor, ligand binding 15.3359
IPR000980 SH2 motif IPR001426 Receptor tyrosine kinase, class V 15.3359
IPR000980 SH2 motif IPR013032 IPR006209. 10.3113
IPR000980 SH2 motif IPR001660 Sterile alpha motif SAM 7.84781
IPR011993 PH_type. IPR006209 EGF-like domain 5.24203
IPR011993 PH_type. IPR003961 Fibronectin, type III 3.27464
IPR000980 SH2 motif IPR008979 Galactose-binding like 2.33753
IPR011993 PH_type. IPR013032 IPR006209. 2.18154
IPR000980 SH2 motif IPR013761 Sterile alpha motif-type 1.71776
IPR011993 PH_type. IPR008957 Fibronectin, type III-like fold 0.662857
IPR011993 PH_type. IPR001090 Ephrin receptor, ligand binding 0.536291
IPR011993 PH_type. IPR001426 Receptor tyrosine kinase, class V 0.536291
IPR011993 PH_type. IPR001660 Sterile alpha motif SAM 0.412672
IPR006020 Phosphotyrosine interaction domain IPR011009 Protein kinase-like 0.203907
IPR006020 Phosphotyrosine interaction domain IPR008266 Tyrosine protein kinase, active site 0.0178144
IPR006020 Phosphotyrosine interaction domain IPR001245 Tyrosine protein kinase 0.0104833
IPR011993 PH_type. IPR013761 Sterile alpha motif-type 0.00618012
IPR006020 Phosphotyrosine interaction domain IPR000719 Protein kinase 0.00379833

The background colour of the table refers to:

  • Blue Domain is only present in SHC3
  • Yellow Domain is only present in EPHA2
  • Green Domain is present in both SHC3 and EPHA2

 0.217
Post-translational Modifications

Protein: SHC3

PTMResidueReference

Protein: EPHA2

PTMResidueReference
Phosphorylation 588 PubMed, HPRD
Phosphorylation 594 PubMed, HPRD
Phosphorylation 772 PubMed, HPRD
Phosphotyrosine 588 PubMed, HPRD
Phosphotyrosine 594 PubMed, HPRD
Phosphotyrosine 772 PubMed, HPRD
Phosphotyrosine 921 PubMed, HPRD
Localisation

Protein: SHC3

LocalisationReference
Cytoplasm HPRD

Protein: EPHA2

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between SHC3 and EPHA2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SHC3 andEPHA2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SHC3 has 346 interactors and EPHA2 has 1476 interactors of which there are 145 common interactors.

Common InteractorName of Common InteractorScore for SHC3-Interactor (?)Score for EPHA2-Interactor (?)
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 207.00 0.110
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 173.00 0.073
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 147.00 0.097
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 114.00 0.878
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 93.60 0.148
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 74.90 0.577
KIT KIT: Mast/stem cell growth factor receptor precursor 69.80 0.097
HCK N/A 67.50 0.655
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 67.50 0.577
ZAP70 ZAP70: Uncharacterized protein ZAP70 67.50 0.520
LTK LTK, TYK1: Leukocyte tyrosine kinase receptor precursor 61.50 0.036
INSR INSR: Insulin receptor precursor 61.50 0.088
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 61.50 0.097
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 61.50 0.110
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 55.50 53.10
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 55.50 0.225
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 16.30 0.577
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 11.50 0.878
PRKCG PRKCG, PKCG: Protein kinase C gamma type 10.50 0.029
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 9.04 0.484
VAV1 VAV1, VAV: Proto-oncogene vav 7.67 0.655
STAT6 STAT6: Signal transducer and activator of transcription 6 7.67 0.655
CRKL CRKL: Crk-like protein 7.56 0.577
NCK2 NCK2: Cytoplasmic protein NCK2 7.56 315.00
GRAP GRAP: GRB2-related adapter protein 7.56 0.128
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 6.81 0.520
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 6.81 0.655
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 5.94 0.445
SOS1 SOS1: Son of sevenless homolog 1 5.35 0.041
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.490 46.80
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.362 0.088
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.265 0.980
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.265 0.265
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.265 0.980
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.251 0.098
BMX N/A 0.244 0.581
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.237 0.878
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.237 0.098
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.217 0.165
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.217 0.165
FGFR2 N/A 0.217 0.027
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.217 0.165
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.200 0.123
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.197 0.644
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.197 0.902
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.197 0.081
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.197 0.143
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.195 0.148
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.195 0.148
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.195 71.20
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.177 0.577
FYN N/A 0.174 0.143
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.174 2.46
MET MET: Hepatocyte growth factor receptor precursor 0.162 0.307
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.157 0.644
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.157 0.902
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.156 0.520
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.156 0.655
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.156 1.01
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.156 0.577
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.145 65.60
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.145 46.80
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.145 0.275
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.145 65.60
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.145 0.110
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.145 53.10
LYN LYN: Tyrosine-protein kinase Lyn 0.140 0.808
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.140 0.655
CSK CSK: Tyrosine-protein kinase CSK 0.140 0.655
SYK SYK: Tyrosine-protein kinase SYK 0.140 1.01
JAK1 0.140 0.577
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.140 0.655
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.128 0.225
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.128 108.00
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.128 0.136
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.126 46.90
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.115 82.20
ALK ALK: ALK tyrosine kinase receptor precursor 0.094 0.073
CHN1 CHN1, ARHGAP2, CHN: N-chimaerin 0.074 0.115
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.074 0.065
SPTAN1 N/A 0.067 0.072
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.060 0.058
PSD TYL: TYL protein 0.060 0.065
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.053 0.098
COBL N/A 0.050 0.032
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.047 0.041
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.044 0.058
TLN2 TLN2: Uncharacterized protein TLN2 0.044 0.058
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.044 0.058
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.044 0.026
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.044 0.026
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.039 0.098
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.039 0.098
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.039 0.109
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.036 0.058
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.036 0.073
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.036 0.064
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.036 0.058
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.035 0.088
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.032 0.062
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.032 0.063
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.0308 0.065
GAB1 GAB1: GRB2-associated-binding protein 1 0.0308 0.072
MCF2 MCF2, DBL: Proto-oncogene DBL 0.0308 0.065
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.0288 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.0288 0.051
FES FES, FPS: Proto-oncogene tyrosine-protein kinase Fes/Fps 0.0288 0.0288
FES Proto-oncogene c-fes variant 4 0.0288 0.0288
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.0288 0.051
BLK BLK: Tyrosine-protein kinase BLK 0.0288 0.0288
FES Proto-oncogene c-fes variant 3 0.0288 0.0288
BTK BTK kinase deficient isoform 6: Dominant-negative kinase-deficient Brutons tyros 0.0288 0.0288
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.0288 0.051
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.029 0.037
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.028 0.073
DUSP7 DUSP7, PYST2: Dual specificity protein phosphatase 7 0.028 0.029
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.028 0.073
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.028 0.058
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.028 0.064
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.028 0.058
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.028 0.064
CNN2 CNN2: Calponin-2 0.027 0.109
MAP2K5 N/A 0.027 0.049
AMPH AMPH, AMPH1: Amphiphysin 0.027 0.109
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.217
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.027 0.049
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.027 0.980
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.217
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.027 0.109
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.027 0.109
NF2 NF2, SCH: Merlin 0.027 0.109
LNK SH2B3, LNK: SH2B adapter protein 3 0.027 0.980
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.217
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.217
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.027 0.109
MAPK15 N/A 0.027 0.109
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.027 0.980
PSCD2 N/A 0.027 0.109
DNM3 DNM3: Uncharacterized protein DNM3 0.027 0.109
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.027 0.049
FLT4 VEGFR3 long form 0.0258 0.046
FES N/A 0.0258 0.0258
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.0258 0.046
0.347
Total Score 17.70