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Evidence of Interaction Between SHC3 and MAPK12

The interaction score between SHC3 and MAPK12 is 2.13.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SHC3 and MAPK12 = 0.10

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology
OrganismSHC3 OrthologueMAPK12 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00217895 0.171 IPI00002857 0.301
human IPI00643176 0.34 IPI00002857 0.301

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains Domains present in SHC3 and MAPK12:
Domains in SHC3Domains in MAPK12
IPR000980 SH2 motif
IPR006019 Phosphotyrosine interaction (PID or PI)
IPR006020 Phosphotyrosine interaction domain
IPR011993 PH_type.
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008351 JNK MAP kinase
IPR008352 p38 MAP kinase

The Chi square scores for co-occurrence of domains that are present in SHC3 and MAPK12 are listed below.

Domain 1Domain 2Chi Square
IPR000980 SH2 motif IPR000719 Protein kinase 82.1364
IPR000980 SH2 motif IPR011009 Protein kinase-like 59.6059
IPR000980 SH2 motif IPR008271 Serine/threonine protein kinase, active site 41.4368
IPR011993 PH_type. IPR000719 Protein kinase 37.108
IPR011993 PH_type. IPR011009 Protein kinase-like 21.3114
IPR000980 SH2 motif IPR002290 Serine/threonine protein kinase 18.5445
IPR006020 Phosphotyrosine interaction domain IPR008351 JNK MAP kinase 4.49279
IPR000980 SH2 motif IPR003527 MAP kinase 3.65309
IPR006020 Phosphotyrosine interaction domain IPR003527 MAP kinase 1.95712
IPR011993 PH_type. IPR008271 Serine/threonine protein kinase, active site 0.535834
IPR011993 PH_type. IPR008351 JNK MAP kinase 0.270016
IPR006020 Phosphotyrosine interaction domain IPR011009 Protein kinase-like 0.203907
IPR006020 Phosphotyrosine interaction domain IPR002290 Serine/threonine protein kinase 0.195004
IPR011993 PH_type. IPR002290 Serine/threonine protein kinase 0.0555974
IPR011993 PH_type. IPR003527 MAP kinase 0.0276008
IPR006020 Phosphotyrosine interaction domain IPR000719 Protein kinase 0.00379833
IPR006020 Phosphotyrosine interaction domain IPR008271 Serine/threonine protein kinase, active site 0.00100301

The background colour of the table refers to:

  • Blue Domain is only present in SHC3
  • Yellow Domain is only present in MAPK12
  • Green Domain is present in both SHC3 and MAPK12

 0.027
Post-translational Modifications

Protein: SHC3

PTMResidueReference

Protein: MAPK12

PTMResidueReference
Phosphorylation 3 PubMed, HPRD
Phosphorylation 183 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphothreonine 183 PubMed, HPRD
Phosphotyrosine 185 PubMed, HPRD
Localisation

Protein: SHC3

LocalisationReference
Cytoplasm HPRD

Protein: MAPK12

LocalisationReference
Mitochondrion HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between SHC3 and MAPK12 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SHC3 andMAPK12. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SHC3 has 346 interactors and MAPK12 has 1410 interactors of which there are 173 common interactors.

Common InteractorName of Common InteractorScore for SHC3-Interactor (?)Score for MAPK12-Interactor (?)
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 207.00 0.041
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 173.00 0.044
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 147.00 0.026
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 114.00 0.148
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 93.60 0.044
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 74.90 0.110
KIT KIT: Mast/stem cell growth factor receptor precursor 69.80 0.033
HCK N/A 67.50 0.088
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 67.50 0.110
ZAP70 ZAP70: Uncharacterized protein ZAP70 67.50 0.088
INSR INSR: Insulin receptor precursor 61.50 0.026
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 61.50 0.026
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 61.50 0.029
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 55.50 0.026
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 55.50 0.033
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 17.40 0.044
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 16.30 0.088
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 11.50 0.148
PRKCG PRKCG, PKCG: Protein kinase C gamma type 10.50 0.056
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 9.04 0.148
VAV1 VAV1, VAV: Proto-oncogene vav 7.67 0.110
STAT6 STAT6: Signal transducer and activator of transcription 6 7.67 0.097
CRKL CRKL: Crk-like protein 7.56 0.110
NCK2 NCK2: Cytoplasmic protein NCK2 7.56 0.088
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 6.81 0.088
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 6.81 0.110
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 5.94 0.110
SOS1 SOS1: Son of sevenless homolog 1 5.35 0.110
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.490 0.029
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.362 0.037
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.265 0.165
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.265 0.027
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.265 0.165
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.251 0.037
BMX N/A 0.244 0.191
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.237 0.165
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.237 0.083
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.217 0.049
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.217 0.049
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.217 0.049
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.200 0.037
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.197 0.251
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.197 0.251
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.197 0.077
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.195 0.049
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.195 0.044
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.195 0.044
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.177 0.171
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.174 0.152
MET MET: Hepatocyte growth factor receptor precursor 0.162 0.0453
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.157 0.098
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.157 0.123
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.156 0.109
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.156 0.088
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.156 0.097
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.156 0.171
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.145 0.041
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.145 0.041
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.145 0.075
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.145 0.041
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.145 0.026
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.145 0.051
LYN LYN: Tyrosine-protein kinase Lyn 0.140 0.109
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.140 0.123
CSK CSK: Tyrosine-protein kinase CSK 0.140 0.171
SYK SYK: Tyrosine-protein kinase SYK 0.140 0.123
JAK1 0.140 0.098
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.140 0.251
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.128 0.0453
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.128 0.033
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.128 0.033
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.128 0.033
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.126 0.030
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.115 0.041
ALK ALK: ALK tyrosine kinase receptor precursor 0.094 0.039
DUSP8 DUSP8, VH5: Dual specificity protein phosphatase 8 0.074 0.156
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.074 0.097
SPTAN1 N/A 0.067 0.055
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.060 0.056
CDK5 CDK5: Cell division protein kinase 5 0.060 0.062
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.060 0.110
PSD TYL: TYL protein 0.060 0.109
COBL N/A 0.050 0.049
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.047 0.088
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.044 0.110
SNTG1 SNTG1: Gamma-1-syntrophin 0.044 0.036
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.044 0.049
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.044 0.055
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.044 0.055
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.039 0.100
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.036 0.055
TSC1 TSC1, KIAA0243, TSC: Hamartin 0.036 0.026
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.036 0.097
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.036 0.171
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.036 0.049
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.036 0.098
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.036 0.136
RASAL1 RASAL1, RASAL: RasGAP-activating-like protein 1 0.036 0.028
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.032 0.859
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.0308 0.191
GAB1 GAB1: GRB2-associated-binding protein 1 0.0308 0.152
MCF2 MCF2, DBL: Proto-oncogene DBL 0.0308 0.191
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.029 0.028
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.028 0.086
DUSP7 DUSP7, PYST2: Dual specificity protein phosphatase 7 0.028 0.156
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.028 0.044
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.028 0.086
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.028 0.062
EPB41L5 EPB41L5: Erythrocyte membrane protein band 4.1 like 5 0.028 0.041
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.028 0.097
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.028 0.069
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.028 0.049
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.028 0.098
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.028 0.096
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.028 0.049
CNN2 CNN2: Calponin-2 0.027 0.075
MAP2K5 N/A 0.027 0.165
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.027 0.083
ASB14 ASB14: Ankyrin repeat and SOCS box protein 14 0.027 0.027
PLEKHA3 PLEKHA3, FAPP1: Pleckstrin homology domain-containing family A member 3 0.027 0.027
WSB1 WSB1, SWIP1: WD repeat and SOCS box-containing protein 1 0.027 0.027
ASB3 ASB3: ASB3 protein 0.027 0.027
CADPS2 CADPS2, CAPS2, KIAA1591: Calcium-dependent secretion activator 2 0.027 0.027
FAM43A N/A 0.027 0.027
ASB12 ASB12: Ankyrin repeat and SOCS box protein 12 0.027 0.027
ASB2 ASB2: Ankyrin repeat and SOCS box protein 2 0.027 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.027 0.083
AMPH AMPH, AMPH1: Amphiphysin 0.027 0.083
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.027 0.083
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.027 0.075
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.027
CADPS CADPS, CAPS, CAPS1, KIAA1121: Calcium-dependent secretion activator 1 0.027 0.027
RASGRF1 RASGRF1, CDC25: Guanine nucleotide-releasing protein 0.027 0.027
DUSP10 DUSP10, MKP5: Dual specificity protein phosphatase 10 0.027 0.237
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.027 0.083
APBB1 APBB1, FE65, RIR: Amyloid beta A4 precursor protein-binding family B member 1 0.027 0.027
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.027 0.165
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.027
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.027 0.165
MAPKAPK5 N/A 0.027 0.083
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.027 0.083
NF2 NF2, SCH: Merlin 0.027 0.165
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.027 0.083
LNK SH2B3, LNK: SH2B adapter protein 3 0.027 0.165
NOXA1 NOXA1, RP13-927H1.1-001: NADPH oxidase activator 1 0.027 0.027
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.027
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.027
ARHGEF1 ARHGEF1: Rho guanine nucleotide exchange factor 1 0.027 0.027
CENTB5 KIAA1716, CENTB5: Centaurin-beta 5 0.027 0.027
ASB6 ASB6: Ankyrin repeat and SOCS box protein 6 0.027 0.027
DOK5 DOK5, C20orf180: Docking protein 5 0.027 0.027
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.027 0.165
DOK6 DOK6: Uncharacterized protein DOK6 0.027 0.027
MAPK15 N/A 0.027 0.083
PSD3 N/A 0.027 0.027
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.027 0.083
PLEKHA4 PLEKHA4, PEPP1: Pleckstrin homology domain-containing family A member 4 0.027 0.027
PTPN13 N/A 0.027 0.027
VEPH1 VEPH1, KIAA1692, VEPH: Ventricular zone-expressed PH domain-containing protein h 0.027 0.027
OSBPL9 N/A 0.027 0.027
ASB10 ASB10: Ankyrin repeat and SOCS box protein 10 0.027 0.027
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.027 0.165
PSCD2 N/A 0.027 0.165
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.027 0.083
OSBPL6 OSBPL6, ORP6: Oxysterol-binding protein-related protein 6 0.027 0.027
ASB7 ASB7: Ankyrin repeat and SOCS box protein 7 0.027 0.027
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.027 0.083
DNM3 DNM3: Uncharacterized protein DNM3 0.027 0.165
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.027 0.083
ASB17 ASB17: Ankyrin repeat and SOCS box protein 17 0.027 0.027
RASGRF2 RASGRF2: Ras protein-specific guanine nucleotide-releasing factor 2 (Fragment) 0.027 0.027
SRA1 APBB3, FE65L2: Amyloid beta A4 precursor protein-binding family B member 3 0.027 0.027
0.299
Total Score 2.13