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Evidence of Interaction Between SHC3 and GRB2

The interaction score between SHC3 and GRB2 is 1.37E3.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismSHC3 OrthologueGRB2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00217895 0.171 IPI00013864 0.559
human IPI00643176 0.34 IPI00013864 0.559
  • InVitro
  • InVivo

Get References From PubMed
worm Q9TYT3 0.34 P29355 1
fly Q24080 0.171 Q08012 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 1.07
Domains Domains present in SHC3 and GRB2:
Domains in SHC3Domains in GRB2
IPR000980 SH2 motif
IPR006019 Phosphotyrosine interaction (PID or PI)
IPR006020 Phosphotyrosine interaction domain
IPR011993 PH_type.
IPR001452 SH3
IPR000108 Neutrophil cytosol factor 2
IPR000980 SH2 motif

The Chi square scores for co-occurrence of domains that are present in SHC3 and GRB2 are listed below.

Domain 1Domain 2Chi Square
IPR000980 SH2 motif IPR001452 SH3 59.5667
IPR000980 SH2 motif IPR000980 SH2 motif 36.445
IPR011993 PH_type. IPR000980 SH2 motif 33.2172
IPR011993 PH_type. IPR001452 SH3 29.6332
IPR000980 SH2 motif IPR000108 Neutrophil cytosol factor 2 21.5484
IPR011993 PH_type. IPR000108 Neutrophil cytosol factor 2 15.9415
IPR006020 Phosphotyrosine interaction domain IPR000980 SH2 motif 1.20067
IPR006020 Phosphotyrosine interaction domain IPR001452 SH3 0.00727939

The background colour of the table refers to:

  • Blue Domain is only present in SHC3
  • Yellow Domain is only present in GRB2
  • Green Domain is present in both SHC3 and GRB2

 0.027
Post-translational Modifications

Protein: SHC3

PTMResidueReference

Protein: GRB2

PTMResidueReference
Phosphorylation 160 PubMed, HPRD
Localisation

Protein: SHC3

LocalisationReference
Cytoplasm HPRD

Protein: GRB2

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between SHC3 and GRB2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SHC3 andGRB2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SHC3 has 346 interactors and GRB2 has 1488 interactors of which there are 256 common interactors.

Common InteractorName of Common InteractorScore for SHC3-Interactor (?)Score for GRB2-Interactor (?)
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 207.00 0.878
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 173.00 1.17
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 147.00 422.00
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 114.00 1.17
DDR1 DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE: Epithelial discoidin domain-con 93.60 0.195
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 93.60 0.878
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 74.90 1.17
KIT KIT: Mast/stem cell growth factor receptor precursor 69.80 0.878
HCK N/A 67.50 1.17
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 67.50 1.17
ZAP70 ZAP70: Uncharacterized protein ZAP70 67.50 1.17
LTK LTK, TYK1: Leukocyte tyrosine kinase receptor precursor 61.50 0.195
INSR INSR: Insulin receptor precursor 61.50 0.878
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 61.50 0.878
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 61.50 0.878
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 55.50 0.878
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 55.50 0.878
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 17.40 0.148
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 16.30 0.148
PRKCG PRKCG, PKCG: Protein kinase C gamma type 10.50 0.148
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 9.04 0.098
VAV1 VAV1, VAV: Proto-oncogene vav 7.67 0.148
STAT6 STAT6: Signal transducer and activator of transcription 6 7.67 0.148
CRKL CRKL: Crk-like protein 7.56 0.148
NCK2 NCK2: Cytoplasmic protein NCK2 7.56 0.148
GRAP GRAP: GRB2-related adapter protein 7.56 2.04
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 6.81 0.148
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 6.81 0.148
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 5.94 8.34
SOS1 SOS1: Son of sevenless homolog 1 5.35 18.00
TYRO3 TYRO3, BYK, DTK, RSE, SKY: Tyrosine-protein kinase receptor TYRO3 precursor 0.677 0.217
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.490 0.878
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.362 0.878
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.265 1.30
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.265 0.265
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.265 1.30
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.251 0.980
BMX N/A 0.244 1.30
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.237 1.17
TNK1 TNK1: Non-receptor tyrosine-protein kinase TNK1 0.237 0.237
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.237 1.17
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.217 0.980
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.217 0.980
FGFR2 N/A 0.217 0.217
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.217 0.980
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.200 0.980
RET urf-ret: Urf-ret protein 0.200 0.217
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.197 1.30
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.197 1.30
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.197 1.30
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.197 0.265
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.195 0.878
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.195 0.878
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.195 0.878
MUSK MUSK: Muscle, skeletal receptor tyrosine protein kinase precursor 0.179 0.195
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.177 1.17
FYN N/A 0.174 0.265
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.174 1.30
AMHR2 AMHR2, AMHR: Anti-Muellerian hormone type-2 receptor precursor 0.162 0.217
STYK1 STYK1, NOK: Tyrosine protein-kinase STYK1 0.162 0.217
MET MET: Hepatocyte growth factor receptor precursor 0.162 0.980
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.157 1.30
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.157 1.30
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.156 1.17
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.156 1.17
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.156 0.237
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.156 1.17
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.156 1.17
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.145 0.878
INSRR INSRR, IRR: Insulin receptor-related protein precursor 0.145 0.195
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.145 0.878
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.145 0.878
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.145 0.878
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.145 0.878
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.145 0.878
ROR1 ROR1, NTRKR1: Tyrosine-protein kinase transmembrane receptor ROR1 precursor 0.145 0.195
RYK RYK, JTK5A: Tyrosine-protein kinase RYK precursor 0.145 0.217
LYN LYN: Tyrosine-protein kinase Lyn 0.140 1.17
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.140 1.17
CSK CSK: Tyrosine-protein kinase CSK 0.140 1.17
SYK SYK: Tyrosine-protein kinase SYK 0.140 1.17
JAK1 0.140 1.17
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.140 1.17
CAMK2A CAMK2A, CAMKA, KIAA0968: Calcium/calmodulin-dependent protein kinase type II alp 0.137 0.027
TIE1 TIE1, TIE: Tyrosine-protein kinase receptor Tie-1 precursor 0.129 0.217
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.128 0.878
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.128 0.878
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.128 0.878
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.128 0.878
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.126 0.484
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.115 0.878
ROR2 ROR2, NTRKR2: Tyrosine-protein kinase transmembrane receptor ROR2 precursor 0.115 0.195
ALK ALK: ALK tyrosine kinase receptor precursor 0.094 0.484
MT3 MT3: Metallothionein-3 0.083 0.056
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.074 0.148
SPTAN1 N/A 0.067 0.165
CENTG1 N/A 0.067 0.027
CACNB3 CACNB3, CACNLB3: Voltage-dependent L-type calcium channel subunit beta-3 0.067 0.027
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.060 0.148
CDK5 CDK5: Cell division protein kinase 5 0.060 0.148
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.060 0.148
PSD TYL: TYL protein 0.060 0.148
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.053 0.109
SPTBN4 SPTBN4, KIAA1642, SPTBN3: Spectrin beta chain, brain 3 0.050 0.027
COBL N/A 0.050 0.165
PHLPP PHLPP, KIAA0606, PLEKHE1, SCOP: PH domain leucine-rich repeat-containing protein 0.050 0.027
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.047 0.098
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.044 0.148
TLN2 TLN2: Uncharacterized protein TLN2 0.044 0.148
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.044 0.148
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.044 0.148
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.044 0.148
SH3GLB2 SH3GLB2, KIAA1848, PP578: SH3 domain GRB2-like protein B2 0.041 0.027
PTPRR N/A 0.041 0.027
NOS1AP NOS1AP, CAPON, KIAA0464: Carboxyl-terminal PDZ ligand of neuronal nitric oxide s 0.041 0.027
BZRAP1 BZRAP1, KIAA0612, RBP1: Peripheral-type benzodiazepine receptor-associated prote 0.041 0.027
MYO10 MYO10: Myosin-X 0.041 0.027
CAMK2G Calcium/calmodulin-dependent protein kinase isoform A (Fragment) 0.041 0.027
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.039 0.109
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.039 0.109
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.039 0.109
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.036 0.148
WIRE WIPF2, WICH, PP10631, WIRE: WAS/WASL-interacting protein family member 2 0.036 0.682
TSC1 TSC1, KIAA0243, TSC: Hamartin 0.036 0.025
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.036 0.148
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.036 0.148
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.036 0.148
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.036 0.148
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.036 0.148
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.035 0.098
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.032 0.049
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.032 0.109
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.0308 0.165
PLEKHB1 PLEKHB1, KPL1, PHR1, PHRET1: Pleckstrin homology domain-containing family B memb 0.0308 0.027
ULK2 ULK2, KIAA0623: Serine/threonine-protein kinase ULK2 0.0308 0.027
GAB1 GAB1: GRB2-associated-binding protein 1 0.0308 0.165
AHI1 N/A 0.0308 0.027
MCF2 MCF2, DBL: Proto-oncogene DBL 0.0308 0.165
CDC42BPB CDC42BPB, KIAA1124: Serine/threonine-protein kinase MRCK beta 0.0308 0.027
ASB1 ASB1: Uncharacterized protein ASB1 0.0308 0.027
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.0288 0.617
NULL N/A 0.0288 0.0288
NTRK3 N/A 0.0288 0.0288
ROS1 ROS1: Proto-oncogene tyrosine-protein kinase ROS precursor 0.0288 0.0288
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.0288 0.617
FES FES, FPS: Proto-oncogene tyrosine-protein kinase Fes/Fps 0.0288 0.0288
DDR2 DDR2, NTRKR3, TKT, TYRO10: Discoidin domain-containing receptor 2 precursor 0.0288 0.0288
FES Proto-oncogene c-fes variant 4 0.0288 0.0288
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.0288 0.617
BLK BLK: Tyrosine-protein kinase BLK 0.0288 0.0288
FES Proto-oncogene c-fes variant 3 0.0288 0.0288
AATK apoptosis-associated tyrosine kinase 0.0288 0.0288
NULL N/A 0.0288 0.0288
MUSK MUSK: MUSK protein 0.0288 0.0288
TESK2 TESK2: Dual specificity testis-specific protein kinase 2 0.0288 0.0288
NTRK3 NTRK3, TRKC: NT-3 growth factor receptor precursor 0.0288 0.0288
NULL Tyrosine kinase 0.0288 0.0288
BTK BTK kinase deficient isoform 6: Dominant-negative kinase-deficient Brutons tyros 0.0288 0.0288
TTN TTN: Uncharacterized protein TTN (Fragment) 0.0288 0.0288
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.0288 0.617
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.029 0.098
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.028 0.148
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.028 0.148
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.028 0.148
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.028 0.148
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.028 0.148
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.028 0.148
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.028 0.148
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.028 0.148
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.028 0.148
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.028 0.148
CNN2 CNN2: Calponin-2 0.027 0.148
TRIM9 TRIM9, KIAA0282, RNF91: Tripartite motif-containing protein 9 0.027 0.027
NEK4 NEK4, STK2: Serine/threonine-protein kinase Nek4 0.027 0.027
ABI3 ABI3, NESH: ABI gene family member 3 0.027 0.027
MAP2K5 N/A 0.027 0.165
PPP1R9A PPP1R9A, KIAA1222: Neurabin-1 0.027 0.027
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.027 0.165
PXK PXK: PX domain-containing protein kinase-like protein 0.027 0.027
ASB14 ASB14: Ankyrin repeat and SOCS box protein 14 0.027 0.027
STAC STAC: SH3 and cysteine-rich domain-containing protein 0.027 0.027
PLEKHA3 PLEKHA3, FAPP1: Pleckstrin homology domain-containing family A member 3 0.027 0.027
CDC2L2 N/A 0.027 0.027
WSB1 WSB1, SWIP1: WD repeat and SOCS box-containing protein 1 0.027 0.027
ASB3 ASB3: ASB3 protein 0.027 0.027
CADPS2 CADPS2, CAPS2, KIAA1591: Calcium-dependent secretion activator 2 0.027 0.027
FAM43A N/A 0.027 0.027
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.027 0.056
ASB12 ASB12: Ankyrin repeat and SOCS box protein 12 0.027 0.027
UBL7 UBL7, BMSCUBP, SB132: Ubiquitin-like protein 7 0.027 0.027
ASB2 ASB2: Ankyrin repeat and SOCS box protein 2 0.027 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.027 0.165
AMPH AMPH, AMPH1: Amphiphysin 0.027 0.165
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.027 0.165
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.027 0.148
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.027
CADPS CADPS, CAPS, CAPS1, KIAA1121: Calcium-dependent secretion activator 1 0.027 0.027
RASGRF1 RASGRF1, CDC25: Guanine nucleotide-releasing protein 0.027 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.027 0.165
APBB1 APBB1, FE65, RIR: Amyloid beta A4 precursor protein-binding family B member 1 0.027 0.027
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.027 0.165
EFS EFS: Embryonal Fyn-associated substrate 0.027 0.027
NEBL N/A 0.027 0.027
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.027
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.027 0.165
SORBS2 N/A 0.027 0.027
MAPKAPK5 N/A 0.027 0.165
CAMKK1 CAMKK1, CAMKKA: Calcium/calmodulin-dependent protein kinase kinase 1 0.027 0.027
CASKIN1 N/A 0.027 0.027
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.027 0.165
NF2 NF2, SCH: Merlin 0.027 0.165
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.027 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.027 0.165
NOXA1 NOXA1, RP13-927H1.1-001: NADPH oxidase activator 1 0.027 0.027
ANKK1 ANKK1, PKK2, SGK288: Ankyrin repeat and protein kinase domain-containing protein 0.027 0.027
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.027
ALS2CR7 ALS2CR7: Serine/threonine-protein kinase ALS2CR7 0.027 0.027
RIPK5 RIPK5, KIAA0472, HDCMD38P, RIP5, SGK496: Receptor-interacting serine/threonine-p 0.027 0.027
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.027
ARHGEF1 ARHGEF1: Rho guanine nucleotide exchange factor 1 0.027 0.027
CENTB5 KIAA1716, CENTB5: Centaurin-beta 5 0.027 0.027
ASB6 ASB6: Ankyrin repeat and SOCS box protein 6 0.027 0.027
DOK5 DOK5, C20orf180: Docking protein 5 0.027 0.027
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.027 0.165
DOK6 DOK6: Uncharacterized protein DOK6 0.027 0.027
MAPK15 N/A 0.027 0.165
NEK11 NEK11: Serine/threonine-protein kinase Nek11 0.027 0.027
PSD3 N/A 0.027 0.027
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.027 0.165
PLEKHA4 PLEKHA4, PEPP1: Pleckstrin homology domain-containing family A member 4 0.027 0.027
PTPN13 N/A 0.027 0.027
SHANK1 SHANK1: SH3 and multiple ankyrin repeat domains protein 1 0.027 0.027
VEPH1 VEPH1, KIAA1692, VEPH: Ventricular zone-expressed PH domain-containing protein h 0.027 0.027
FANK1 FANK1, HSD13, UNQ6504/PRO21382: Fibronectin type 3 and ankyrin repeat domains pr 0.027 0.027
OSBPL9 N/A 0.027 0.027
ASB10 ASB10: Ankyrin repeat and SOCS box protein 10 0.027 0.027
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.027 0.056
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.027 0.165
PSCD2 N/A 0.027 0.165
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.027 0.165
OSBPL6 OSBPL6, ORP6: Oxysterol-binding protein-related protein 6 0.027 0.027
ASB7 ASB7: Ankyrin repeat and SOCS box protein 7 0.027 0.027
MID2 N/A 0.027 0.027
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.027 0.165
DNM3 DNM3: Uncharacterized protein DNM3 0.027 0.165
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.027 0.165
PDIK1L PDIK1L, CLIK1L: Serine/threonine-protein kinase PDIK1L 0.027 0.027
STK35 STK35, CLIK1, PDIK1: Serine/threonine-protein kinase 35 0.027 0.027
ASB17 ASB17: Ankyrin repeat and SOCS box protein 17 0.027 0.027
RASGRF2 RASGRF2: Ras protein-specific guanine nucleotide-releasing factor 2 (Fragment) 0.027 0.027
SRA1 APBB3, FE65L2: Amyloid beta A4 precursor protein-binding family B member 3 0.027 0.027
FLT4 VEGFR3 long form 0.0258 0.553
FES N/A 0.0258 0.0258
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.0258 0.553
0.299
Total Score 1.37E3