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Evidence of Interaction Between CD2AP and PSMA7

The interaction score between CD2AP and PSMA7 is 252.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between CD2AP and PSMA7 = 0.64

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 7.78E-3
Orthology
OrganismCD2AP OrthologuePSMA7 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00477876 1 IPI00154509 0.607
bakers yeast YGR136W 1 YOL038W 1
bakers yeast YPR154W 1 YOL038W 1
  • Y2H
  • Other

Get References From PubMed
worm Q6A573 0.216 Q95005 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains No domains were used in calculating likelihood of interaction 1.48E-3
Post-translational Modifications

Protein: CD2AP

PTMResidueReference
Phosphotyrosine 88 HPRD

Protein: PSMA7

PTMResidueReference
Localisation

Protein: CD2AP

LocalisationReference
Plasma membrane HPRD
Nucleolus HPRD
Cytoplasm HPRD

Protein: PSMA7

LocalisationReference
Cytoplasm HPRD
Transitive Score

The common interactors between CD2AP and PSMA7 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between CD2AP andPSMA7. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , CD2AP has 1210 interactors and PSMA7 has 222 interactors of which there are 105 common interactors.

Common InteractorName of Common InteractorScore for CD2AP-Interactor (?)Score for PSMA7-Interactor (?)
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.763 0.123
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.515 0.067
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.515 0.038
RPS6KB1 N/A 0.461 0.074
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.461 0.263
CSK CSK: Tyrosine-protein kinase CSK 0.461 0.038
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.416 0.067
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.385 0.263
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.372 0.044
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.372 0.074
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.372 0.060
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.050
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.307 0.036
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.251 0.041
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.251 0.041
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.233 0.074
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.233 0.060
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.225 0.044
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.225 0.074
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.210 0.050
STK16 N/A 0.191 0.041
CDK2 CDK2: Cell division protein kinase 2 0.188 0.060
CDK4 CDK4: Cell division protein kinase 4 0.188 0.074
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.188 0.074
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.188 0.060
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.188 0.060
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.171 0.060
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.171 0.044
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.171 0.036
MAPK15 N/A 0.165 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.165 0.027
WEE1 WEE1: Wee1-like protein kinase 0.155 0.036
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.152 0.0308
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.144 0.060
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.139 0.123
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.139 0.060
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.139 0.060
CDK7 CDK7, MO15: Cell division protein kinase 7 0.139 0.060
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.139 0.044
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.139 0.044
STK10 STK10: Uncharacterized protein STK10 0.139 0.060
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.129 323.00
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.126 0.044
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.114 0.036
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.114 0.044
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.114 0.060
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.114 0.036
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.111 2.15
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.109 0.036
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.104 0.036
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.087 0.050
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.086 0.036
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.027
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.078 1.64E3
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.078 691.00
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.078 1.64E3
CDK6 CDK6: Cell division protein kinase 6 0.077 0.028
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.076 0.060
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.075 0.032
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.075 0.354
PSMA8 PSMA8, PSMA7L: Proteasome subunit alpha type-7-like 0.071 12.60
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.069 0.028
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.069 0.028
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.069 0.036
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.067 0.596
CSNK1G3 CSNK1G3: Casein kinase I isoform gamma-3 0.067 0.083
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.066 0.059
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.063 0.074
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.063 0.263
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.063 0.074
MELK MELK, KIAA0175: Maternal embryonic leucine zipper kinase 0.060 0.060
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.060 0.060
CDK9 CDK9, CDC2L4: Cell division protein kinase 9 0.059 0.0968
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.056 0.036
CDK5 CDK5: Cell division protein kinase 5 0.056 0.028
SORBS3 SORBS3, SCAM1: Vinexin 0.049 0.065
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.046 0.123
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.046 0.890
MAP4K5 MAP4K5: Mitogen-activated protein kinase kinase kinase kinase 5 0.044 0.036
MAP4K2 MAP4K2, GCK, RAB8IP: Mitogen-activated protein kinase kinase kinase kinase 2 0.044 0.060
PRKX PRKX, PKX1: Serine/threonine-protein kinase PRKX 0.044 0.044
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.044 0.195
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0425 0.041
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.0425 0.0308
DYRK4 DYRK4: Dual specificity tyrosine-phosphorylation-regulated kinase 4 0.041 0.044
PPP2CA PPP2CA: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 0.038 0.132
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.038 0.028
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.038 0.028
ARAF ARAF, ARAF1, PKS, PKS2: A-Raf proto-oncogene serine/threonine-protein kinase 0.036 0.060
ADRBK2 ADRBK2, BARK2, GRK3: Beta-adrenergic receptor kinase 2 0.036 0.044
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.032 0.041
KIF3A KIF3A, KIF3: Kinesin-like protein KIF3A 0.029 0.129
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.028 0.027
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.028 0.027
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.028 0.027
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.028 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.028 0.027
MAPKAPK5 N/A 0.028 0.027
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.028 0.027
PCTK2 PCTK2: Serine/threonine-protein kinase PCTAIRE-2 0.028 0.028
CAMKK1 CAMKK1, CAMKKA: Calcium/calmodulin-dependent protein kinase kinase 1 0.027 0.027
PDIK1L PDIK1L, CLIK1L: Serine/threonine-protein kinase PDIK1L 0.027 0.027
ANKK1 ANKK1, PKK2, SGK288: Ankyrin repeat and protein kinase domain-containing protein 0.027 0.027
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.025 0.027
C11orf58 SMAP, C11orf58: Small acidic protein 0.025 0.027
0.572
Total Score 252.00