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Evidence of Interaction Between HMGB1 and SUPT16H

The interaction score between HMGB1 and SUPT16H is 5.64.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between HMGB1 and SUPT16H = 0.84

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismHMGB1 OrthologueSUPT16H OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YBR089C-A 1 YGL207W 1
bakers yeast YPR052C 1 YGL207W 1
  • SyntheticLethal
  • SyntheticGrowthDefect
  • AffinityCaptureWestern
  • DosageRescue

Get References From PubMed
worm Q09390 0.746 Q9N5R9 1
fly Q24537 1 Q9W071 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains No domains were used in calculating likelihood of interaction N/A
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation No localisation data was used in calculating likelihood of interaction
Transitive Score

The common interactors between HMGB1 and SUPT16H that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between HMGB1 andSUPT16H. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , HMGB1 has 200 interactors and SUPT16H has 152 interactors of which there are 44 common interactors.

Common InteractorName of Common InteractorScore for HMGB1-Interactor (?)Score for SUPT16H-Interactor (?)
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 9.26 1.10
SMARCC2 SMARCC2, BAF170: SWI/SNF-related matrix-associated actin-dependent regulator of 6.33 0.593
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 3.89 6.52
HIST1H3A HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, 2.73 0.181
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.782 0.614
SUPT5H SUPT5H: Uncharacterized protein SUPT5H 0.593 0.593
TOX TOX, KIAA0808: Thymus high mobility group box protein TOX 0.593 0.593
C14orf92 TOX4, C14orf92, KIAA0737: TOX high mobility group box family member 4 0.371 0.300
TNRC9 TOX3, CAGF9, TNRC9: TOX high mobility group box family member 3 0.233 0.390
LOC644380 HMG1L10: High mobility group protein 1-like 10 0.119 0.119
LOC646993 similar to high-mobility group box 3 0.119 0.119
HMGB4 HMG2-like protein 0.119 0.119
NULL Uncharacterized protein ENSP00000328286 (Fragment) 0.119 0.119
SMARCC1 N/A 0.119 0.119
HMG4L HMG4L: High mobility group protein B3-like 0.119 0.119
NULL Uncharacterized protein ENSP00000332650 0.119 0.119
LOC441795 Uncharacterized protein ENSP00000332888 (Fragment) 0.119 0.119
NULL N/A 0.119 0.119
HMG1L1 HMG1L1, RP4-579F20.2-001: High-mobility group protein 1-like 1. 0.119 0.119
C20orf100 N/A 0.119 0.119
LOC440093 Histone H3-like 0.119 0.119
NULL 0.119 0.119
NULL N/A 0.119 0.119
LOC644914 H3L-like histone (Fragment) 0.119 0.119
NULL WUGSC:H_NH0244E06.1: WUGSC:H_NH0244E06.1 protein 0.119 0.119
HIST3H3 HIST3H3, H3FT: Histone H3.1t 0.108 0.110
HMGB3 HMGB3, HMG2A, HMG4: High mobility group protein B3 0.108 0.181
DUT DUT: Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor 0.082 0.027
HIST2H3C HIST2H3A, HIST2H3C, H3F2, H3FM: Histone H3.2 0.071 0.119
LOC203510 N/A 0.053 0.110
HNRPAB N/A 0.049 0.027
CPSF6 CPSF6, CFIM68: Cleavage and polyadenylation specificity factor subunit 6 0.049 0.027
HNRPD N/A 0.027 0.027
DKFZP586L0724 NOL11, L14: Nucleolar protein 11 0.027 0.027
NOLC1 NOLC1, KIAA0035: Nucleolar phosphoprotein p130 0.027 0.027
KIAA0101 PAF, KIAA0101, L5, NS5ATP9: PCNA-associated factor 0.027 0.027
POLD3 POLD3, KIAA0039: DNA polymerase subunit delta-3 0.027 0.027
SMC4L1 N/A 0.027 0.027
ILF2 ILF2, NF45, PRO3063: Interleukin enhancer-binding factor 2 0.027 0.027
C18orf56 N/A 0.027 0.027
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.027 0.027
DEK DEK: Protein DEK 0.027 0.027
EXOSC8 EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43 0.027 0.027
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.0255 0.027
2.15E-3
Total Score 5.64