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Evidence of Interaction Between SSR2 and NEU1

The interaction score between SSR2 and NEU1 is 0.038.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SSR2 and NEU1 = 0.37

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 3.80E-3
Orthology N/A N/A
Domains No domains were used in calculating likelihood of interaction 0.028
Post-translational Modifications

Protein: SSR2

PTMResidueReference
N-linked 88 PubMed, HPRD
N-linked 104 PubMed, HPRD

Protein: NEU1

PTMResidueReference
Phosphorylation 242 PubMed, HPRD
Phosphorylation 244 PubMed, HPRD
Phosphorylation 251 PubMed, HPRD
Localisation

Protein: SSR2

LocalisationReference
ER HPRD

Protein: NEU1

LocalisationReference
ER HPRD
Plasma membrane HPRD
Lysosome HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between SSR2 and NEU1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SSR2 andNEU1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SSR2 has 121 interactors and NEU1 has 170 interactors of which there are 67 common interactors.

Common InteractorName of Common InteractorScore for SSR2-Interactor (?)Score for NEU1-Interactor (?)
SSR1 SSR1, TRAPA, PSEC0262: Translocon-associated protein subunit alpha precursor 0.276 0.0425
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.157 0.027
TMED9 TMED9, GP25L2: Transmembrane emp24 domain-containing protein 9 precursor 0.129 0.070
TOR1A TOR1A, DQ2, DYT1: Torsin-1A precursor 0.129 0.0425
TXNDC TXNDC1, TMX, PSEC0085, TXNDC, UNQ235/PRO268: Thioredoxin domain-containing prote 0.129 0.032
BCAP31 BCAP31, BAP31, DXS1357E: B-cell receptor-associated protein 31 0.129 0.052
GANAB GANAB, G2AN, KIAA0088: Neutral alpha-glucosidase AB precursor 0.087 0.070
TFIP11 TFIP11, HSPC006: Tuftelin-interacting protein 11 0.078 0.026
SUMO2 SUMO2, SMT3B, SMT3H2: Small ubiquitin-related modifier 2 precursor 0.078 0.032
PDIA6 PDIA6, TXNDC7: Protein disulfide-isomerase A6 precursor 0.078 0.070
LMAN2 LMAN2, C5orf8: Vesicular integral-membrane protein VIP36 precursor 0.078 0.052
SF3A1 SF3A1, SAP114: Splicing factor 3 subunit 1 0.078 0.032
SEC61B SEC61B: Protein transport protein Sec61 subunit beta 0.078 0.032
NEDD8 NEDD8: NEDD8 precursor 0.078 0.0425
NCSTN NCSTN, KIAA0253, UNQ1874/PRO4317: Nicastrin precursor 0.078 0.052
VIM VIM: Vimentin 0.070 0.052
SORL1 SORL1: Sortilin-related receptor precursor 0.070 0.032
PRKAR1A PRKAR1A, PKR1, PRKAR1, TSE1: cAMP-dependent protein kinase type I-alpha regulato 0.063 0.052
CANX CANX: Calnexin precursor 0.063 0.052
COASY COASY, PSEC0106: Bifunctional coenzyme A synthase 0.063 0.0425
C5orf14 TXNDC15, C5orf14, UNQ335/PRO534: Thioredoxin domain-containing protein 15 precur 0.063 0.052
LARP1 LARP1, KIAA0731, LARP: La-related protein 1 0.052 0.026
P4HB P4HB, ERBA2L, PDI, PDIA1, PO4DB: Protein disulfide-isomerase precursor 0.046 0.070
HMOX2 HMOX2, HO2: Heme oxygenase 2 0.046 0.026
HYOU1 HYOU1, ORP150: Hypoxia up-regulated protein 1 precursor 0.046 0.0425
PCYT1A N/A 0.046 0.026
GCS1 GCS1: Mannosyl-oligosaccharide glucosidase 0.046 0.052
MAN2B1 MAN2B1, LAMAN, MANB: Lysosomal alpha-mannosidase precursor 0.040 0.0425
GOLGA5 GOLGA5, RETII, RFG5: Golgin subfamily A member 5 0.040 0.027
LMAN2L N/A 0.038 0.032
NTE N/A 0.038 0.026
HMOX1 HMOX1, HO, HO1: Heme oxygenase 1 0.038 0.0425
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.038 0.191
RRBP1 N/A 0.032 0.052
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.032 0.202
F13A1 F13A1, F13A: Coagulation factor XIII A chain precursor 0.029 0.0425
HMGCR HMGCR: 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.029 0.032
FKBP10 FKBP10, FKBP65, PSEC0056: FK506-binding protein 10 precursor 0.029 0.032
RTN2 RTN2, NSPL1: Reticulon-2 0.028 0.028
DNASE1 DNASE1, DNL1, DRNI: Deoxyribonuclease-1 precursor 0.028 0.028
HM13 HM13, H13, MSTP086, IMP1, PSL3, SPP: Minor histocompatibility antigen H13 0.028 0.028
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.028 0.028
SORCS1 SORCS1, SORCS: VPS10 domain-containing receptor SorCS1 precursor 0.028 0.028
BACE1 BACE1, BACE: Beta-secretase 1 precursor 0.028 0.028
SUMF2 SUMF2, PSEC0171, UNQ1968/PRO4500: Sulfatase-modifying factor 2 precursor 0.028 0.028
TAPBP N/A 0.028 0.028
BCL2L1 BCL2L1, BCL2L, BCLX: Apoptosis regulator Bcl-X 0.028 0.028
PCSK9 PCSK9, NARC1, PSEC0052: Proprotein convertase subtilisin/kexin type 9 precursor 0.028 0.028
MAL2 MAL2: Protein MAL2 0.028 0.028
PTGS1 PTGS1, COX1: Prostaglandin G/H synthase 1 precursor 0.028 0.028
KCNQ2 N/A 0.028 0.028
MCL1 MCL1: Induced myeloid leukemia cell differentiation protein Mcl-1 0.028 0.028
COL17A1 COL17A1, BP180, BPAG2: Collagen alpha-1(XVII) chain 0.026 0.026
BACE2 BACE2, AEPLC, UNQ418/PRO852, ALP56, ASP21: Beta-secretase 2 precursor 0.026 0.0425
SRPR SRPR: Uncharacterized protein SRPR 0.025 0.052
MBTPS1 MBTPS1, KIAA0091, S1P, SKI1: Membrane-bound transcription factor site-1 protease 0.025 0.028
OPRM1 OPRM1, MOR1: Mu-type opioid receptor 0.025 0.028
QSCN6 QSOX1, QSCN6, UNQ2520/PRO6013: Sulfhydryl oxidase 1 precursor 0.025 0.028
BAT3 BAT3, G3: Large proline-rich protein BAT3 0.025 0.028
PSEN1 PSEN1, AD3, PS1, PSNL1: Presenilin-1 0.025 0.028
KCNH2 KCNH2, ERG, ERG1, HERG, HERG1: Potassium voltage-gated channel subfamily H membe 0.025 0.028
CREG2 CREG2: Protein CREG2 precursor 0.025 0.028
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.025 0.028
UGT2B10 UGT2B10: UDP-glucuronosyltransferase 2B10 precursor 0.025 0.028
SUMF1 SUMF1, FGE, PSEC0152, UNQ3037/PRO9852: Sulfatase-modifying factor 1 precursor 0.025 0.028
ENPP7 ENPP7, UNQ3077/PRO9912: Ectonucleotide pyrophosphatase/phosphodiesterase family 0.025 0.028
RTN1 RTN1, NSP: Reticulon-1 0.025 0.028
2.15E-3
Total Score 0.038