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Evidence of Interaction Between ARHGEF18 and ZAP70

The interaction score between ARHGEF18 and ZAP70 is 6.11.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between ARHGEF18 and ZAP70 = 0.51

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 6.27E-3
Orthology N/A N/A
Domains Domains present in ARHGEF18 and ZAP70:
Domains in ARHGEF18Domains in ZAP70
IPR000219 DH domain
IPR001849 Pleckstrin-like
IPR011993 PH_type.
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR000980 SH2 motif
IPR012234 TyrPK_SYK.

The Chi square scores for co-occurrence of domains that are present in ARHGEF18 and ZAP70 are listed below.

Domain 1Domain 2Chi Square
IPR001849 Pleckstrin-like IPR001245 Tyrosine protein kinase 125.014
IPR001849 Pleckstrin-like IPR008266 Tyrosine protein kinase, active site 119.16
IPR011993 PH_type. IPR001245 Tyrosine protein kinase 88.2896
IPR011993 PH_type. IPR008266 Tyrosine protein kinase, active site 85.0032
IPR001849 Pleckstrin-like IPR000719 Protein kinase 66.4046
IPR001849 Pleckstrin-like IPR000980 SH2 motif 51.2962
IPR001849 Pleckstrin-like IPR011009 Protein kinase-like 42.4143
IPR011993 PH_type. IPR000719 Protein kinase 37.108
IPR011993 PH_type. IPR000980 SH2 motif 33.2172
IPR000219 DH domain IPR008266 Tyrosine protein kinase, active site 27.839
IPR011993 PH_type. IPR011009 Protein kinase-like 21.3114
IPR000219 DH domain IPR000980 SH2 motif 18.9157
IPR000219 DH domain IPR001245 Tyrosine protein kinase 18.2882
IPR000219 DH domain IPR012234 TyrPK_SYK. 7.86015
IPR000219 DH domain IPR000719 Protein kinase 7.7624
IPR000219 DH domain IPR011009 Protein kinase-like 6.13238
IPR001849 Pleckstrin-like IPR012234 TyrPK_SYK. 4.36354
IPR011993 PH_type. IPR012234 TyrPK_SYK. 1.50425

The background colour of the table refers to:

  • Blue Domain is only present in ARHGEF18
  • Yellow Domain is only present in ZAP70
  • Green Domain is present in both ARHGEF18 and ZAP70

 0.027
Post-translational Modifications

Protein: ARHGEF18

PTMResidueReference

Protein: ZAP70

PTMResidueReference
Dephosphorylation 292 PubMed, HPRD
Phosphorylation 69 PubMed, HPRD
Phosphorylation 126 PubMed, HPRD
Phosphorylation 178 PubMed, HPRD
Phosphorylation 289 PubMed, HPRD
Phosphorylation 292 PubMed, HPRD
Phosphorylation 293 PubMed, HPRD
Phosphorylation 315 PubMed, HPRD
Phosphorylation 319 PubMed, HPRD
Phosphorylation 474 PubMed, HPRD
Phosphorylation 492 PubMed, HPRD
Phosphorylation 493 PubMed, HPRD
Phosphorylation 494 PubMed, HPRD
Phosphoserine 289 HPRD
Phosphotyrosine 248 HPRD
Phosphotyrosine 292 HPRD
Phosphotyrosine 315 HPRD
Phosphotyrosine 319 HPRD
Phosphotyrosine 492 PubMed, HPRD
Phosphotyrosine 493 HPRD
Localisation No localisation data was used in calculating likelihood of interaction

Protein: ZAP70

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between ARHGEF18 and ZAP70 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between ARHGEF18 andZAP70. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , ARHGEF18 has 463 interactors and ZAP70 has 1506 interactors of which there are 299 common interactors.

Common InteractorName of Common InteractorScore for ARHGEF18-Interactor (?)Score for ZAP70-Interactor (?)
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.294 0.461
CSK CSK: Tyrosine-protein kinase CSK 0.294 2.17
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.137 0.416
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.137 0.416
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.137 0.275
NCK2 NCK2: Cytoplasmic protein NCK2 0.137 1.78
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.137 0.191
STAT6 STAT6: Signal transducer and activator of transcription 6 0.137 856.00
FNBP1 N/A 0.137 0.372
DYRK2 DYRK2: Dual specificity tyrosine-phosphorylation-regulated kinase 2 0.137 0.294
VAV1 VAV1, VAV: Proto-oncogene vav 0.137 2.94
CDK9 CDK9, CDC2L4: Cell division protein kinase 9 0.137 0.047
STK17A STK17A, DRAK1: Serine/threonine-protein kinase 17A 0.137 0.074
ARHGAP4 ARHGAP4, KIAA0131, RGC1, RHOGAP4: Rho GTPase-activating protein 4 0.137 0.067
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.137 17.40
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.137 132.00
WASPIP N/A 0.137 0.461
CSNK1G2 CSNK1G2: Casein kinase I isoform gamma-2 0.137 0.060
IL27RA N/A 0.108 0.053
GAK GAK: Cyclin G-associated kinase 0.108 0.047
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.108 0.274
ITGB7 ITGB7: Integrin beta-7 precursor 0.108 0.227
IL2RG IL2RG: Cytokine receptor common gamma chain precursor 0.108 0.108
CRLF3 N/A 0.108 0.274
SEMA4D SEMA4D, CD100, SEMAJ: Semaphorin-4D precursor 0.108 0.108
CENTB1 CENTB1, KIAA0050: Centaurin-beta 1 0.090 0.074
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.090 0.461
ATM ATM: Serine-protein kinase ATM 0.083 0.763
OSTF1 N/A 0.083 0.083
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.083 2.17
RP6-213H19.1 MST4, MASK: Serine/threonine-protein kinase MST4 0.083 0.074
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.083 0.129
LYN LYN: Tyrosine-protein kinase Lyn 0.083 1.50
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.083 0.275
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.083 0.148
TRIB2 TRIB2, TRB2: Tribbles homolog 2 0.083 0.074
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.083 0.372
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.083 0.275
PRKX PRKX, PKX1: Serine/threonine-protein kinase PRKX 0.083 0.074
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.083 0.251
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.083 0.171
CXorf9 N/A 0.083 0.372
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.083 0.032
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.083 0.372
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.083 0.225
CSNK1D CSNK1D: Casein kinase I isoform delta 0.083 0.044
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.083 0.225
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.083 5.04
JAK1 0.083 12.80
CSNK1G3 CSNK1G3: Casein kinase I isoform gamma-3 0.083 0.041
WASF2 WASF2, WAVE2: Wiskott-Aldrich syndrome protein family member 2 0.083 0.036
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.083 0.275
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.083 14.30
STK10 STK10: Uncharacterized protein STK10 0.083 0.763
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.083 0.763
RASA4 RASA4, CAPRI, GAPL, KIAA0538: Ras GTPase-activating protein 4 0.083 0.028
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.083 3.64
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.083 0.171
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.083 9.65
RPS6KB1 N/A 0.083 0.275
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.067 0.416
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.067 0.225
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.067 0.136
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.067 6.03
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.067 4.07
PRMT2 PRMT2, HMT1, HRMT1L1: Protein arginine N-methyltransferase 2 0.067 0.137
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.067 0.038
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.067 0.275
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.067 0.225
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.067 0.191
IRAK4 IRAK4: Interleukin-1 receptor-associated kinase 4 0.067 0.050
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.067 0.874
ARAF ARAF, ARAF1, PKS, PKS2: A-Raf proto-oncogene serine/threonine-protein kinase 0.067 0.036
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.067 0.461
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.067 0.171
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.067 0.171
FYB FYB, SLAP130: FYN-binding protein 0.067 0.083
SYK SYK: Tyrosine-protein kinase SYK 0.067 1.07
SOS1 SOS1: Son of sevenless homolog 1 0.067 0.181
CLK3 CLK3: Dual specificity protein kinase CLK3 0.067 0.036
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.067 0.416
SH2D1A SH2D1A, DSHP, SAP: SH2 domain-containing protein 1A 0.067 8.73
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.067 0.307
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.067 1.98
RIN3 N/A 0.067 0.596
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.067 2.42
GRAP GRAP: GRB2-related adapter protein 0.067 0.360
FYN N/A 0.067 2.91
RASA2 RASA2, GAP1M, RASGAP: Ras GTPase-activating protein 2 0.067 0.074
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.067 0.225
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.067 0.123
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.067 784.00
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.065 0.202
ADAM8 ADAM8, MS2: ADAM 8 precursor 0.053 0.059
IL21R IL21R, NILR, UNQ3121/PRO10273: Interleukin-21 receptor precursor 0.053 0.032
SORL1 SORL1: Sortilin-related receptor precursor 0.053 0.202
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.050 0.171
PRKCH PRKCH, PKCL, PRKCL: Protein kinase C eta type 0.050 0.263
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.050 0.225
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.050 0.251
CAMK2G Calcium/calmodulin-dependent protein kinase isoform A (Fragment) 0.050 0.0308
CSNK1A1 CSNK1A1: Casein kinase I isoform alpha 0.050 0.028
VAV3 VAV3: Protein vav-3 0.050 0.274
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.050 0.171
ROCK1 ROCK1: Rho-associated protein kinase 1 0.050 0.251
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.050 0.171
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.050 650.00
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.050 0.275
PIK3R4 PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4 0.050 0.036
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.050 856.00
MTSS1 N/A 0.050 0.036
ARHGEF7 ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB: Rho guanine nucleotide exchange 0.050 0.0308
STAT4 STAT4: Signal transducer and activator of transcription 4 0.050 10.70
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.050 0.123
NRAS NRAS, HRAS1: GTPase NRas precursor 0.050 0.029
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.050 0.275
MYO1F MYO1F: Myosin-If 0.050 0.044
WIRE WIPF2, WICH, PP10631, WIRE: WAS/WASL-interacting protein family member 2 0.050 0.0308
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.050 0.372
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.050 0.152
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.050 2.91
VRK3 N/A 0.050 0.041
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.050 0.171
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.050 1.78
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.050 12.80
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.050 0.225
CD2AP CD2AP: CD2-associated protein 0.050 0.171
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.050 0.859
CRKL CRKL: Crk-like protein 0.050 1.35
CXCR4 CXCR4: C-X-C chemokine receptor type 4 0.0471 0.274
TNKS2 TNKS2, PARP5B, TANK2, TNKL: Tankyrase-2 0.042 0.047
ZZEF1 ZZEF1, KIAA0399: Zinc finger ZZ-type and EF-hand domain-containing protein 1 0.042 0.053
APBA3 APBA3, MINT3, X11L2: Amyloid beta A4 precursor protein-binding family A member 3 0.042 0.053
VIL2 N/A 0.042 65.60
ARHGDIB ARHGDIB, GDIA2, GDID4, RAP1GN1: Rho GDP-dissociation inhibitor 2 0.042 0.063
SNX6 SNX6: Sorting nexin-6 0.042 0.060
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.041 0.110
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.041 0.171
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.041 0.136
SH3GLB1 SH3GLB1, CGI-61: SH3 domain GRB2-like protein B1 0.041 0.0308
RASA3 RASA3: Ras GTPase-activating protein 3 0.041 0.461
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.041 0.110
MAST3 MAST3, KIAA0561: Microtubule-associated serine/threonine-protein kinase 3 0.041 0.036
TSC1 TSC1, KIAA0243, TSC: Hamartin 0.041 0.029
ASB8 ASB8, PP14212: Ankyrin repeat and SOCS box protein 8 0.041 0.041
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.041 0.136
DAPK3 DAPK3, ZIPK: Death-associated protein kinase 3 0.041 0.0308
WNK1 WNK1, KDP, KIAA0344, PRKWNK1: Serine/threonine-protein kinase WNK1 0.041 0.028
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.041 0.029
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.041 0.225
STAT2 STAT2: Signal transducer and activator of transcription 2 0.041 0.902
APS SH2B2, APS: SH2B adapter protein 2 0.041 0.770
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.041 0.152
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.041 0.225
PCTK2 PCTK2: Serine/threonine-protein kinase PCTAIRE-2 0.041 0.060
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.041 0.416
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.041 0.136
ARHGAP26 ARHGAP26, GRAF, KIAA0621, OPHN1L: Rho GTPase-activating protein 26 0.041 0.036
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.041 0.251
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.041 0.136
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.041 0.136
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.041 0.110
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.039 0.181
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.032 1.19
IL11RA IL11RA: Interleukin-11 receptor alpha chain precursor 0.032 0.039
LTK LTK, TYK1: Leukocyte tyrosine kinase receptor precursor 0.032 0.225
RYK RYK, JTK5A: Tyrosine-protein kinase RYK precursor 0.032 0.251
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.0308 0.225
STK16 N/A 0.0308 0.123
PIM1 N/A 0.0308 0.036
CDK2 CDK2: Cell division protein kinase 2 0.0308 0.136
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.0308 6.73
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.0308 0.110
CDK4 CDK4: Cell division protein kinase 4 0.0308 0.110
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.0308 0.100
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.0308 0.461
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.0308 1.50
CDK7 CDK7, MO15: Cell division protein kinase 7 0.0308 0.110
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.0308 0.109
HCK N/A 0.0308 0.874
PRKAA1 N/A 0.0308 0.251
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.0308 0.136
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.0308 370.00
SOCS1 SOCS1, SSI1, TIP3: Suppressor of cytokine signaling 1 0.0308 0.156
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.0308 0.123
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.0308 0.136
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.030 55.00
ASB3 ASB3: ASB3 protein 0.027 0.027
NOXA1 NOXA1, RP13-927H1.1-001: NADPH oxidase activator 1 0.027 0.027
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.027 0.165
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.027 0.165
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.027 0.148
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.027 1.30
FANK1 FANK1, HSD13, UNQ6504/PRO21382: Fibronectin type 3 and ankyrin repeat domains pr 0.027 0.027
ASB7 ASB7: Ankyrin repeat and SOCS box protein 7 0.027 0.027
AMPH AMPH, AMPH1: Amphiphysin 0.027 0.165
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.027 0.165
MID2 N/A 0.027 0.027
RAB5B RAB5B: Ras-related protein Rab-5B 0.027 0.025
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.027 0.025
MAPK15 N/A 0.027 0.165
KIAA0031 EFTUD2, KIAA0031, SNRP116: 116 kDa U5 small nuclear ribonucleoprotein component 0.027 0.025
EEF2K EEF2K: Elongation factor 2 kinase 0.027 0.165
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.027 71.20
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.027 0.148
EFS EFS: Embryonal Fyn-associated substrate 0.027 0.027
PDIK1L PDIK1L, CLIK1L: Serine/threonine-protein kinase PDIK1L 0.027 0.027
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.027 0.148
CASKIN1 N/A 0.027 0.027
TSSK3 TSSK3, SPOGA3, STK22C: Testis-specific serine/threonine-protein kinase 3 0.027 0.027
STAC STAC: SH3 and cysteine-rich domain-containing protein 0.027 0.027
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.027 0.148
TRIM9 TRIM9, KIAA0282, RNF91: Tripartite motif-containing protein 9 0.027 0.027
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.027 422.00
ASB6 ASB6: Ankyrin repeat and SOCS box protein 6 0.027 0.027
ABI3 ABI3, NESH: ABI gene family member 3 0.027 0.027
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.027 0.165
CDC2 CDC2: Cell division control protein 2 homolog 0.027 0.165
ALS2CR7 ALS2CR7: Serine/threonine-protein kinase ALS2CR7 0.027 0.027
MLCK MYLK3, MLCK: Putative myosin light chain kinase 3 0.027 0.027
RIPK5 RIPK5, KIAA0472, HDCMD38P, RIP5, SGK496: Receptor-interacting serine/threonine-p 0.027 0.027
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.027 0.148
PXK PXK: PX domain-containing protein kinase-like protein 0.027 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.027 0.165
STK35 STK35, CLIK1, PDIK1: Serine/threonine-protein kinase 35 0.027 0.027
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.027 0.098
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.265
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.027 563.00
PSKH2 PSKH2: Serine/threonine-protein kinase H2 0.027 0.027
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.265
NEK4 NEK4, STK2: Serine/threonine-protein kinase Nek4 0.027 0.027
CDC2L2 N/A 0.027 0.027
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.027 1.17
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.027 0.148
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.027 0.098
CAMKK1 CAMKK1, CAMKKA: Calcium/calmodulin-dependent protein kinase kinase 1 0.027 0.027
NEBL N/A 0.027 0.027
ASB10 ASB10: Ankyrin repeat and SOCS box protein 10 0.027 0.027
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.027 0.148
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.027 0.165
WSB1 WSB1, SWIP1: WD repeat and SOCS box-containing protein 1 0.027 0.027
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.027 0.148
TNK1 TNK1: Non-receptor tyrosine-protein kinase TNK1 0.027 0.237
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.027 0.148
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.027 0.148
ASB17 ASB17: Ankyrin repeat and SOCS box protein 17 0.027 0.027
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.027 0.148
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.027 1.30
LNK SH2B3, LNK: SH2B adapter protein 3 0.027 1.30
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.027 0.056
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.027 1.17
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.027 0.165
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.027 0.148
ANKK1 ANKK1, PKK2, SGK288: Ankyrin repeat and protein kinase domain-containing protein 0.027 0.027
ASB14 ASB14: Ankyrin repeat and SOCS box protein 14 0.027 0.027
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.027 1.17
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.027 0.165
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.027 0.148
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.027 0.098
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.265
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.027 0.148
SHANK1 SHANK1: SH3 and multiple ankyrin repeat domains protein 1 0.027 0.027
SORBS2 N/A 0.027 0.027
MAP2K5 N/A 0.027 0.165
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.027 0.165
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.027 0.148
NEK11 NEK11: Serine/threonine-protein kinase Nek11 0.027 0.027
ASB12 ASB12: Ankyrin repeat and SOCS box protein 12 0.027 0.027
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.027 0.148
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.027 0.165
CAMKK2 CAMKK2, CAMKKB, KIAA0787: Calcium/calmodulin-dependent protein kinase kinase 2 0.027 0.027
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.027 1.30
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.027 0.165
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.027 0.148
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.265
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.027 0.165
RASD1 RASD1, AGS1, DEXRAS1: Dexamethasone-induced Ras-related protein 1 precursor 0.027 0.025
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.027 1.17
STAT3 0.027 1.30
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.027 0.148
ASB2 ASB2: Ankyrin repeat and SOCS box protein 2 0.027 0.027
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.265
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.027 0.165
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.027 0.148
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.027 0.165
MAPKAPK5 N/A 0.027 0.165
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.027 0.148
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.027 0.056
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.027 1.30
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.027 0.165
MYLIP MYLIP, BZF1, BM-023, PP5242: E3 ubiquitin-protein ligase MYLIP 0.0255 0.041
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.0255 0.225
ACTG1 ACTB: Actin, cytoplasmic 1 0.0255 0.038
ACTR3 ACTR3, ARP3: Actin-related protein 3 0.0255 0.063
SAMD9 SAMD9, C7orf5, DRIF1, KIAA2004, OEF1: Sterile alpha motif domain-containing prot 0.0255 0.067
LCP1 LCP1, PLS2: Plastin-2 0.0255 0.275
KPNB1 KPNB1, NTF97: Importin subunit beta-1 0.0255 0.038
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.0255 0.067
0.228
Total Score 6.11