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Evidence of Interaction Between OPRM1 and IL8RB

The interaction score between OPRM1 and IL8RB is 3.07.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology N/A N/A
Domains Domains present in OPRM1 and IL8RB:
Domains in OPRM1Domains in IL8RB
IPR000276 Rhodopsin-like GPCR superfamily
IPR000105 Mu opioid receptor
IPR001418 Opioid receptor
IPR000276 Rhodopsin-like GPCR superfamily
IPR000057 Interleukin 8B receptor
IPR000174 Interleukin-8 receptor
IPR001277 C-X-C chemokine receptor, type 4

The Chi square scores for co-occurrence of domains that are present in OPRM1 and IL8RB are listed below.

Domain 1Domain 2Chi Square
IPR000276 Rhodopsin-like GPCR superfamily IPR000276 Rhodopsin-like GPCR superfamily 11.8987
IPR000276 Rhodopsin-like GPCR superfamily IPR001277 C-X-C chemokine receptor, type 4 1.40343

The background colour of the table refers to:

  • Blue Domain is only present in OPRM1
  • Yellow Domain is only present in IL8RB
  • Green Domain is present in both OPRM1 and IL8RB

 0.034
Post-translational Modifications

Protein: OPRM1

PTMResidueReference
Phosphorylation 244 PubMed, HPRD
Phosphorylation 418 PubMed, HPRD
Phosphorylation 420 PubMed, HPRD
Phosphorylation 427 PubMed, HPRD
Phosphorylation 434 PubMed, HPRD
Phosphorylation 439 PubMed, HPRD

Protein: IL8RB

PTMResidueReference
Phosphorylation 347 PubMed, HPRD
Phosphorylation 351 PubMed, HPRD
Phosphorylation 352 PubMed, HPRD
Phosphorylation 353 PubMed, HPRD
Localisation

Protein: OPRM1

LocalisationReference
ER HPRD
Golgi HPRD
Plasma membrane HPRD

Protein: IL8RB

LocalisationReference
Plasma membrane HPRD
Endosome HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between OPRM1 and IL8RB that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between OPRM1 andIL8RB. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , OPRM1 has 551 interactors and IL8RB has 587 interactors of which there are 324 common interactors.

Common InteractorName of Common InteractorScore for OPRM1-Interactor (?)Score for IL8RB-Interactor (?)
GNAL GNAL: Guanine nucleotide-binding protein G(olf) subunit alpha 1.53 0.692
GNAS GNAS, GNAS1, GSP: Guanine nucleotide-binding protein G(s) subunit alpha isoforms 1.53 1.05
CCL14 CCL14, NCC2, SCYA14: Small-inducible cytokine A14 precursor 1.53 0.357
CCL7 MCP-3: Monocyte chemotactic protein-3 1.53 0.357
GNA14 GNA14: Guanine nucleotide-binding protein alpha-14 subunit 1.37 0.624
CCL22 CCL22, A-152E5.1, MDC, SCYA22: Small-inducible cytokine A22 precursor 0.540 0.644
PF4V1 PF4V1, SCYB4V1: Platelet factor 4 variant precursor 0.540 3.05
CCL2 CCL2, MCP1, SCYA2: Small-inducible cytokine A2 precursor 0.540 0.644
CCL1 CCL1, SCYA1: Small-inducible cytokine A1 precursor 0.540 0.644
CCL24 CCL24, MPIF2, SCYA24: Small-inducible cytokine A24 precursor 0.540 0.731
PPBP PPBP, CTAP3, SCYB7, TGB1, THBGB1: Platelet basic protein precursor 0.540 10.70
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 0.540 1.50
CCL5 CCL5, D17S136E, SCYA5: Small-inducible cytokine A5 precursor 0.540 1.48
LOC643930 CCL3L1, D17S1718, G0S19-2, SCYA3L1: Small-inducible cytokine A3-like 1 precursor 0.540 0.980
CCL13 CCL13, MCP4, NCC1, SCYA13: Small-inducible cytokine A13 precursor 0.540 0.644
CXCL11 CXCL11, ITAC, SCYB11, SCYB9B: Small-inducible cytokine B11 precursor 0.540 0.644
GNAI1 GNAI1: Guanine nucleotide-binding protein G(i), alpha-1 subunit 0.540 0.775
PF4 PF4, CXCL4, SCYB4: Platelet factor 4 precursor 0.540 5.04
XCL1 XCL1, LTN, SCYC1: Lymphotactin precursor 0.540 0.902
CXCL9 CXCL9, CMK, MIG, SCYB9: Small-inducible cytokine B9 precursor 0.540 0.644
CXCL10 CXCL10, INP10, SCYB10: Small-inducible cytokine B10 precursor 0.540 0.644
CXCL1 CXCL1, GRO, GRO1, GROA, MGSA, SCYB1: Growth-regulated protein alpha precursor 0.540 0.644
IL8 IL8: Interleukin-8 precursor 0.540 0.731
GNAZ GNAZ: Guanine nucleotide-binding protein G(z) subunit alpha 0.540 0.975
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 2 0.540 0.859
GNAT1 GNAT1, GNATR: Guanine nucleotide-binding protein G(t), alpha-1 subunit 0.540 0.859
GNAT2 GNAT2, GNATC: Guanine nucleotide-binding protein G(t), alpha-2 subunit 0.540 0.859
GNA15 GNA15, GNA16: Guanine nucleotide-binding protein alpha-15 subunit 0.540 0.975
CXCL5 CXCL5, ENA78, SCYB5: Small-inducible cytokine B5 precursor 0.540 0.902
CXCL12 Stromal cell-derived factor 1 delta 0.540 0.644
CCL11 CCL11, SCYA11: Eotaxin precursor 0.540 0.644
CCL21 CCL21, SCYA21, UNQ784/PRO1600: Small-inducible cytokine A21 precursor 0.540 0.644
CCL26 CCL26, SCYA26, UNQ216/PRO242: Small-inducible cytokine A26 precursor 0.540 0.980
GNAI2 Galphai2 protein 0.540 1.50
CCL8 CCL8, MCP2, SCYA10, SCYA8: Small-inducible cytokine A8 precursor 0.540 0.644
CCL4 CCL4, CCL4L, LAG1, MIP1B, SCYA4, SCYA4L: Small-inducible cytokine A4 precursor 0.540 0.902
CCL15 CCL15, MIP5, NCC3, SCYA15: Small-inducible cytokine A15 precursor 0.540 0.980
GNAQ GNAQ, GAQ: Guanine nucleotide-binding protein G(q) subunit alpha 0.484 1.20
GNA12 GNA12: Guanine nucleotide-binding protein alpha-12 subunit 0.484 0.859
GNA11 GNA11, GA11: Guanine nucleotide-binding protein subunit alpha-11 0.484 0.775
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.484 1.30
GNA13 GNA13: Guanine nucleotide-binding protein alpha-13 subunit 0.484 0.975
CXCL6 CXCL6, GCP2, SCYB6: Small-inducible cytokine B6 precursor 0.140 0.143
CXCL3 CXCL3, GRO3, GROG, SCYB3: Macrophage inflammatory protein 2-beta precursor 0.140 0.143
CCL17 CCL17, SCYA17, TARC: Small-inducible cytokine A17 precursor 0.140 0.162
CCL28 CCL28, SCYA28: Small-inducible cytokine A28 precursor 0.140 0.217
CCL25 CCL25, SCYA25, TECK: Small-inducible cytokine A25 precursor 0.140 0.143
CCL23 MIP3, CCL23, MPIF1, SCYA23: Small-inducible cytokine A23 precursor 0.140 0.200
XCL2 XCL2, SCYC2: Cytokine SCM-1 beta precursor 0.140 0.217
CCL16 CCL16, ILINCK, NCC4, SCYA16: Small-inducible cytokine A16 precursor 0.140 0.143
CXCL13 CXCL13, BCA1, BLC, SCYB13: Small-inducible cytokine B13 precursor 0.140 0.143
CCL18 CCL18, AMAC1, DCCK1, MIP4, PARC, SCYA18: Small-inducible cytokine A18 precursor 0.140 0.143
CCL27 CCL27, ILC, SCYA27: Small-inducible cytokine A27 precursor 0.140 0.143
CCL3 CCL3, G0S19-1, MIP1A, SCYA3: Small-inducible cytokine A3 precursor 0.140 0.162
CX3CL1 CX3CL1, A-152E5.2, FKN, NTT, SCYD1: Fractalkine precursor 0.140 0.129
CCL19 CCL19, ELC, MIP3B, SCYA19: Small-inducible cytokine A19 precursor 0.140 0.143
CCL20 CCL20, LARC, MIP3A, SCYA20: Small-inducible cytokine A20 precursor 0.140 0.143
CXCL2 CXCL2, GRO2, GROB, MIP2A, SCYB2: Macrophage inflammatory protein 2-alpha precurs 0.140 0.143
ARL3 ARL3, ARFL3: ADP-ribosylation factor-like protein 3 0.126 0.129
NOS3 N/A 0.083 0.025
NOS2A NOS2A, NOS2: Nitric oxide synthase, inducible 0.083 0.034
HPN HPN, TMPRSS1: Serine protease hepsin 0.083 0.055
NOS1 NOS1: Nitric-oxide synthase, brain 0.083 0.032
AVPR2 AVPR2, ADHR, DIR, DIR3, V2R: Vasopressin V2 receptor 0.075 0.025
TSHB TSHB: Thyrotropin subunit beta precursor 0.0688 0.072
ORM1 ORM1, AGP1: Alpha-1-acid glycoprotein 1 precursor 0.0688 0.072
RLN2 RLN2: Prorelaxin H2 precursor [Contains: Relaxin B chain; Relaxin A chain] 0.0688 0.072
LCN2 LCN2, HNL, NGAL: Neutrophil gelatinase-associated lipocalin precursor 0.0688 0.081
FSHB FSHB: Follitropin subunit beta precursor 0.0688 0.081
C4A C4A: Complement C4-A precursor 0.0688 0.109
AXIN1 0.0688 0.109
AGRP AGRP, AGRT, ART: Agouti-related protein precursor 0.0688 0.081
LHB LHB: Lutropin subunit beta precursor 0.0688 0.072
RGS2 RGS2, G0S8: Regulator of G-protein signaling 2 0.0688 0.202
CGB CGB, CGB3, CGB5, CGB7, CGB8: Choriogonadotropin subunit beta precursor 0.0688 0.072
APOD APOD: Apolipoprotein D precursor 0.0688 0.072
EDN3 EDN3: Endothelin-3 precursor 0.0688 0.072
EDN2 EDN2: Endothelin-2 precursor 0.0688 0.072
RGS18 RGS18, RGS13: Regulator of G-protein signaling 18 0.0688 0.109
PTGDS PTGDS, PDS: Prostaglandin-H2 D-isomerase precursor 0.0688 0.072
RGS16 RGS16, RGSR: Regulator of G-protein signaling 16 0.0688 0.072
NPY NPY: Neuropeptide Y precursor [Contains: Neuropeptide Y 0.0688 0.072
PAEP PAEP: Glycodelin precursor 0.0688 0.072
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.0688 0.072
GHRL GHRL, MTLRP, UNQ524/PRO1066: Appetite-regulating hormone precursor 0.0688 0.109
RGS4 RGS4: Regulator of G-protein signaling 4 0.0688 0.072
CORT CORT, UNQ307/PRO350: Cortistatin precursor [Contains: Cortistatin-29; Cortistati 0.0688 0.065
INS INS: Insulin precursor [Contains: Insulin B chain; Insulin A chain] 0.0688 0.072
C8G C8G: Complement component C8 gamma chain precursor 0.0688 0.072
EDN1 EDN1: Endothelin-1 precursor 0.0688 0.072
ORM2 ORM2, AGP2: Alpha-1-acid glycoprotein 2 precursor 0.0688 0.072
APOM APOM, G3A, HSPC336, NG20: Apolipoprotein M 0.0688 0.072
C3 0.0688 0.072
AGT AGT, SERPINA8: Angiotensinogen precursor 0.0688 0.072
AMBP AMBP, HCP, ITIL: AMBP protein precursor [Contains: Alpha-1-microglobulin 0.0688 0.072
HTR2C HTR2C, HTR1C: 5-hydroxytryptamine receptor 2C 0.062 0.109
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.062 0.072
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.062 0.072
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.062 0.100
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.062 0.109
RGS19 RGS19, GAIP, GNAI3IP: Regulator of G-protein signaling 19 0.062 0.202
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.062 0.100
PMP2 PMP2: Myelin P2 protein 0.062 0.072
FRG1 FRG1: Protein FRG1 0.062 0.081
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.062 0.065
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.062 0.072
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.062 0.072
C5 C5: Complement C5 precursor [Contains: Complement C5 beta chain; Complement C5 a 0.051 0.051
C4B C4B: Complement C4-B precursor 0.051 0.051
OXT OXT, OT: Oxytocin-neurophysin 1 precursor 0.051 0.0338
AVP N/A 0.051 0.0338
POMC POMC: Corticotropin-lipotropin precursor 0.051 0.0338
PSCD2 N/A 0.049 0.04
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.049 0.04
ARRB1 ARRB1, ARR1: Beta-arrestin-1 0.046 0.051
ARRB2 N/A 0.046 0.160
EPB41 EPB41, E41P: Protein 4.1 0.046 0.051
RGS7 RGS7: Regulator of G-protein signaling 7 0.046 0.0338
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.044 0.046
PSCD4 PSCD4, CYT4: Cytohesin-4 0.044 0.061
PSD TYL: TYL protein 0.044 0.0263
MYCBP2 MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2 0.044 0.025
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.034 0.0453
CCR5 CCR5: CCR5 receptor (Fragment) 0.034 0.077
BMX N/A 0.034 0.0453
C1R C1R: Complement C1r subcomponent precursor 0.034 0.032
A2M A2M, FWP007: Alpha-2-macroglobulin precursor 0.034 0.029
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.034 0.030
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.034 0.049
RHO RHO, OPN2: Rhodopsin 0.034 0.055
F7 F7: Coagulation factor VII precursor 0.034 0.049
EDG1 EDG1: Sphingosine 1-phosphate receptor Edg-1 0.034 0.127
FPRL1 FPRL1, FPR2, FPRH1, LXA4R: FMLP-related receptor I 0.034 2.75
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.034 0.101
NF2 NF2, SCH: Merlin 0.034 0.049
APS SH2B2, APS: SH2B adapter protein 2 0.034 0.0453
TMPRSS2 TMPRSS2, PRSS10: Transmembrane protease, serine 2 precursor 0.034 0.055
HTR6 HTR6: 5-hydroxytryptamine receptor 6 0.034 0.055
F2RL1 F2RL1, GPR11, PAR2: Proteinase-activated receptor 2 precursor 0.034 0.155
F9 F9: Coagulation factor IX precursor 0.034 0.032
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.034 0.0453
C2 C2: Complement C2 precursor 0.034 0.032
PCOLCE PCOLCE, PCPE1: Procollagen C-endopeptidase enhancer 1 precursor 0.034 0.032
LTB4R LTB4R, BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7: Leukotriene B4 receptor 1 0.034 0.096
MCF2 MCF2, DBL: Proto-oncogene DBL 0.034 0.0263
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.034 0.028
AZU1 AZU1: Azurocidin precursor 0.034 0.037
FPR1 FPR1: fMet-Leu-Phe receptor 0.034 0.260
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.034 0.0453
PROZ PROZ: Vitamin K-dependent protein Z precursor 0.034 0.037
CTGF CTGF, CCN2, HCS24: Connective tissue growth factor precursor 0.034 0.032
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.034 0.028
DNM3 DNM3: Uncharacterized protein DNM3 0.034 0.04
VASP VASP: Vasodilator-stimulated phosphoprotein 0.034 0.440
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.034 0.072
IRS2 IRS2: Insulin receptor substrate 2 0.034 0.030
F10 F10: Coagulation factor X precursor 0.034 0.055
PROS1 PROS1, PROS: Vitamin K-dependent protein S precursor 0.034 0.032
ELA3B ELA3B: Elastase-3B precursor 0.034 0.032
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.034 0.04
PZP PZP: Pregnancy zone protein precursor 0.034 0.032
GPR23 LPA4, GPR23, P2RY9: Lysophosphatidic acid receptor 4 0.034 0.055
PTAFR PTAFR, PAFR: Platelet-activating factor receptor 0.034 0.083
PRSS22 PRSS22, BSSP4, SP001LA, PRSS26, UNQ302/PRO343: Brain-specific serine protease 4 0.034 0.037
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.034 0.100
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.034 0.055
MC4R MC4R: Melanocortin receptor 4 0.034 0.062
IRS1 IRS1: Insulin receptor substrate 1 0.034 0.0263
F2RL2 F2RL2, PAR3: Proteinase-activated receptor 3 precursor 0.034 0.055
GAB2 N/A 0.034 0.074
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.034 0.037
KLK1 KLK1: Kallikrein-1 precursor 0.034 0.032
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.034 0.075
TGFB1 TGFB1, TGFB: Transforming growth factor beta-1 precursor 0.034 0.091
MUC2 MUC2, SMUC: Mucin-2 precursor 0.034 0.032
ELA2 ELA2: Leukocyte elastase precursor 0.034 0.037
DRD1 DRD1: D(1A) dopamine receptor 0.034 0.055
CMA1 CMA1, CYH, CYM: Chymase precursor 0.034 0.032
F2R F2R, CF2R, PAR1, TR: Proteinase-activated receptor 1 precursor 0.034 0.062
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.034 0.030
KCNJ1 KCNJ1, ROMK1: ATP-sensitive inward rectifier potassium channel 1 0.034 0.055
P2RY4 P2RY4, NRU: P2Y purinoceptor 4 0.034 0.055
EDNRB EDNRB, ETRB: Endothelin B receptor precursor 0.034 0.083
F12 F12: Coagulation factor XII precursor 0.034 0.032
F11 F11: Coagulation factor XI precursor 0.034 0.049
ROCK1 ROCK1: Rho-associated protein kinase 1 0.034 0.057
KLK3 KLK3, APS: Prostate-specific antigen precursor 0.034 0.049
CTSG CTSG: Cathepsin G precursor 0.034 0.037
C5AR1 C5AR1, C5AR, C5R1: C5a anaphylatoxin chemotactic receptor 0.034 0.430
PRTN3 PRTN3, MBN: Myeloblastin precursor 0.034 0.037
DOK1 DOK1: Docking protein 1 0.034 0.046
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.034 0.049
LNK SH2B3, LNK: SH2B adapter protein 3 0.034 0.049
KCNJ3 KCNJ3, GIRK1: G protein-activated inward rectifier potassium channel 1 0.034 0.062
PLAT PLAT: Tissue-type plasminogen activator precursor 0.034 0.049
NDP NDP: Norrin precursor 0.034 0.029
HGFAC HGFAC: Hepatocyte growth factor activator precursor 0.034 0.055
CFI CFI, IF: Complement factor I precursor 0.034 0.032
GAB1 GAB1: GRB2-associated-binding protein 1 0.034 0.030
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.034 0.032
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.034 0.049
KLK6 KLK6, PRSS18, PRSS9: Kallikrein-6 precursor 0.034 0.032
TBXA2R TBXA2R: Thromboxane A2 receptor 0.034 0.083
F2RL3 F2RL3, PAR4: Proteinase-activated receptor 4 precursor 0.034 0.062
HP HP: Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta c 0.034 0.032
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.034 0.083
PTGIR PTGIR, PRIPR: Prostacyclin receptor 0.034 0.077
ST14 ST14, PRSS14, SNC19, TADG15: Suppressor of tumorigenicity protein 14 0.034 0.055
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.034 0.126
GZMB Endogenous granzyme B 0.034 0.0453
CXCR4 CXCR4: C-X-C chemokine receptor type 4 0.034 0.077
CFB CFB, BF, BFD: Complement factor B precursor 0.034 0.032
JAK1 0.034 0.126
PROC PROC: Vitamin K-dependent protein C precursor 0.034 0.032
PRSS1 PRSS1, TRP1, TRY1, TRYP1: Trypsin-1 precursor 0.034 0.032
DRD2 DRD2: D(2) dopamine receptor 0.034 0.083
FLNA FLNA, FLN, FLN1: Filamin-A 0.034 0.0453
GDF15 GDF15, MIC1, PDF, PLAB, PTGFB: Growth/differentiation factor 15 precursor 0.034 0.032
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.034 0.0263
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.034 0.030
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.034 0.055
F2 F2: Prothrombin precursor 0.034 0.032
CGA CGA: Glycoprotein hormones alpha chain precursor 0.034 0.032
PDGFA PDGFA, PDGF1: Platelet-derived growth factor A chain precursor 0.034 0.032
C1S C1S: Complement C1s subcomponent precursor 0.034 0.032
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.034 0.049
ELMO1 N/A 0.030 0.04
TACR2 TACR2, NK2R, NKNAR, TAC2R: Substance-K receptor 0.030 0.049
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.030 0.030
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.030 0.034
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.030 0.057
FNTB FNTB: Protein farnesyltransferase subunit beta 0.030 0.037
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.030 0.029
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.030 0.049
TSHR N/A 0.030 0.055
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.030 0.032
KCNJ12 KCNJ12, IRK2, KCNJN1: ATP-sensitive inward rectifier potassium channel 12 0.030 0.055
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.030 0.037
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.030 0.04
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.030 0.0263
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.030 0.0453
STAT6 STAT6: Signal transducer and activator of transcription 6 0.030 0.075
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.030 0.049
STAT3 0.030 0.049
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.030 0.032
CHRM2 CHRM2: Muscarinic acetylcholine receptor M2 0.030 0.062
RASA3 RASA3: Ras GTPase-activating protein 3 0.030 0.030
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.030 0.030
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.030 0.046
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.030 0.049
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.030 0.0453
TLN1 TLN1: Uncharacterized protein TLN1 0.030 0.075
TLN2 TLN2: Uncharacterized protein TLN2 0.030 0.029
DAB2 DAB2, DOC2: Disabled homolog 2 0.030 0.0263
TIMP1 TIMP1, CLGI, TIMP: Metalloproteinase inhibitor 1 precursor 0.030 0.037
PLD1 PLD1: Phospholipase D1 0.030 0.0263
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.030 0.034
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.030 0.029
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.030 0.037
RPS6KB1 N/A 0.030 0.037
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.030 0.032
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.030 0.0263
FLNB FLNB, FLN1L, FLN3, TABP, TAP: Filamin-B 0.030 0.032
SFRP1 CDNA FLJ45402 fis, clone BRHIP3029409, moderately similar to Homo sapiens secret 0.030 0.049
PLG PLG: Plasminogen precursor 0.030 0.032
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.030 0.077
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.030 0.0263
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.030 0.057
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.030 0.0263
SSTR3 SSTR3: Somatostatin receptor type 3 0.030 0.049
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.030 0.0453
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.030 0.049
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.030 0.074
RDX RDX: Radixin 0.030 0.029
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.030 0.032
ARHGEF7 N/A 0.030 0.04
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.030 0.049
HGF HGF, HPTA: Hepatocyte growth factor precursor 0.030 0.083
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.030 0.049
VIL2 N/A 0.030 0.037
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.030 0.0263
MSN MSN: Moesin 0.030 0.124
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.030 0.0263
PLD2 PLD2: Phospholipase D2 0.030 0.0263
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.030 0.04
OR10H3 OR10H3: Olfactory receptor 10H3 0.030 0.055
DAB1 DAB1: Disabled homolog 1 0.030 0.0263
STK10 STK10: Uncharacterized protein STK10 0.030 0.027
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.030 0.049
LPA LPA: Apolipoprotein(a) precursor 0.030 0.037
STAT4 STAT4: Signal transducer and activator of transcription 4 0.030 0.025
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.030 0.026
VAV1 VAV1, VAV: Proto-oncogene vav 0.030 0.075
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.030 0.032
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.030 0.049
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.030 0.063
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.030 0.075
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.030 0.04
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.030 0.029
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.030 0.037
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.030 0.124
TRHR TRHR: Thyrotropin-releasing hormone receptor 0.030 0.077
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.030 0.04
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.030 0.029
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.030 0.0453
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.030 0.127
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.030 0.101
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.030 0.032
TMPRSS9 N/A 0.030 0.083
NULL Neutrophil-activating protein 4 (Fragment) 0.0288 0.0288
GNAS N/A 0.0288 0.0288
CXCL14 CXCL14, NJAC, UNQ240/PRO273, SCYB14: Small-inducible cytokine B14 precursor 0.0288 0.0288
GNAS Mutant guanine nucleotide-binding protein G(S), alpha subunit 0.0288 0.0288
GNAS N/A 0.0288 0.0288
GNAS GSA: Alpha subunit of GsGTP binding protein (Fragment) 0.0288 0.0288
NULL N/A 0.0288 0.0288
GNAS N/A 0.0288 0.0288
GNAS Guanine nucleotide-binding protein Gs alpha subunit isoform L2 0.0288 0.0288
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.028 0.028
SORL1 SORL1: Sortilin-related receptor precursor 0.028 0.087
LILRB1 N/A 0.028 0.032
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.025 0.026
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.025 0.028
NCSTN NCSTN, KIAA0253, UNQ1874/PRO4317: Nicastrin precursor 0.025 0.032
0.228
Total Score 3.07