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Evidence of Interaction Between OPRM1 and RGS7

The interaction score between OPRM1 and RGS7 is 4.19.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismOPRM1 OrthologueRGS7 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm Q23033 0.164 P49809 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains Domains present in OPRM1 and RGS7:
Domains in OPRM1Domains in RGS7
IPR000276 Rhodopsin-like GPCR superfamily
IPR000105 Mu opioid receptor
IPR001418 Opioid receptor
IPR000591 Pleckstrin putative G-protein interacting domain
IPR000342 Regulator of G protein
IPR001770 G-protein, gamma subunit
IPR011991 Wing_hlx_DNA_bd.

The Chi square scores for co-occurrence of domains that are present in OPRM1 and RGS7 are listed below.

Domain 1Domain 2Chi Square
IPR000276 Rhodopsin-like GPCR superfamily IPR000342 Regulator of G protein 43.7004

The background colour of the table refers to:

  • Blue Domain is only present in OPRM1
  • Yellow Domain is only present in RGS7
  • Green Domain is present in both OPRM1 and RGS7

 0.051
Post-translational Modifications

Protein: OPRM1

PTMResidueReference
Phosphorylation 244 PubMed, HPRD
Phosphorylation 418 PubMed, HPRD
Phosphorylation 420 PubMed, HPRD
Phosphorylation 427 PubMed, HPRD
Phosphorylation 434 PubMed, HPRD
Phosphorylation 439 PubMed, HPRD

Protein: RGS7

PTMResidueReference
Phosphorylation 434 PubMed, HPRD
Phosphoserine 434 HPRD
Localisation

Protein: OPRM1

LocalisationReference
ER HPRD
Golgi HPRD
Plasma membrane HPRD

Protein: RGS7

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Secreted HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between OPRM1 and RGS7 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between OPRM1 andRGS7. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , OPRM1 has 551 interactors and RGS7 has 306 interactors of which there are 84 common interactors.

Common InteractorName of Common InteractorScore for OPRM1-Interactor (?)Score for RGS7-Interactor (?)
GNAL GNAL: Guanine nucleotide-binding protein G(olf) subunit alpha 1.53 3.85
GNAS GNAS, GNAS1, GSP: Guanine nucleotide-binding protein G(s) subunit alpha isoforms 1.53 1.53
GNA14 GNA14: Guanine nucleotide-binding protein alpha-14 subunit 1.37 1.02
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 0.540 0.369
GNAI1 GNAI1: Guanine nucleotide-binding protein G(i), alpha-1 subunit 0.540 1.39
GNAZ GNAZ: Guanine nucleotide-binding protein G(z) subunit alpha 0.540 1.72
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 2 0.540 6.78
GNAT1 GNAT1, GNATR: Guanine nucleotide-binding protein G(t), alpha-1 subunit 0.540 0.412
GNAT2 GNAT2, GNATC: Guanine nucleotide-binding protein G(t), alpha-2 subunit 0.540 0.412
GNA15 GNA15, GNA16: Guanine nucleotide-binding protein alpha-15 subunit 0.540 0.366
GNAI2 Galphai2 protein 0.540 0.328
GNAQ GNAQ, GAQ: Guanine nucleotide-binding protein G(q) subunit alpha 0.484 1.39
GNA12 GNA12: Guanine nucleotide-binding protein alpha-12 subunit 0.484 0.412
GNA11 GNA11, GA11: Guanine nucleotide-binding protein subunit alpha-11 0.484 0.638
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.484 0.553
GNA13 GNA13: Guanine nucleotide-binding protein alpha-13 subunit 0.484 0.363
ARL3 ARL3, ARFL3: ADP-ribosylation factor-like protein 3 0.126 0.039
BDKRB2 BDKRB2, BKR2: B2 bradykinin receptor 0.083 0.038
AVPR2 AVPR2, ADHR, DIR, DIR3, V2R: Vasopressin V2 receptor 0.075 0.030
AVPR1A AVPR1A, AVPR1: Vasopressin V1a receptor 0.075 0.034
OPRD1 OPRD1, OPRD: Delta-type opioid receptor 0.075 0.053
OXTR OXTR: Oxytocin receptor 0.075 0.034
AVPR1B AVPR1B, AVPR3, VPR3: Vasopressin V1b receptor 0.075 0.030
HTR2C HTR2C, HTR1C: 5-hydroxytryptamine receptor 2C 0.062 0.086
KCNH2 KCNH2, ERG, ERG1, HERG, HERG1: Potassium voltage-gated channel subfamily H membe 0.047 0.046
ARRB1 ARRB1, ARR1: Beta-arrestin-1 0.046 0.046
ARRB2 N/A 0.046 0.0273
IL8RB IL8RB, CXCR2: High affinity interleukin-8 receptor B 0.034 0.0338
CCR5 CCR5: CCR5 receptor (Fragment) 0.034 0.030
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.034 0.0273
RHO RHO, OPN2: Rhodopsin 0.034 0.0338
EDG1 EDG1: Sphingosine 1-phosphate receptor Edg-1 0.034 0.047
FPRL1 FPRL1, FPR2, FPRH1, LXA4R: FMLP-related receptor I 0.034 0.0338
HTR6 HTR6: 5-hydroxytryptamine receptor 6 0.034 0.038
CENTA1 CENTA1: Centaurin-alpha 1 0.034 0.129
F2RL1 F2RL1, GPR11, PAR2: Proteinase-activated receptor 2 precursor 0.034 0.030
LTB4R LTB4R, BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7: Leukotriene B4 receptor 1 0.034 0.030
FPR1 FPR1: fMet-Leu-Phe receptor 0.034 0.030
GPR23 LPA4, GPR23, P2RY9: Lysophosphatidic acid receptor 4 0.034 0.038
PTAFR PTAFR, PAFR: Platelet-activating factor receptor 0.034 0.051
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.034 0.034
MC4R MC4R: Melanocortin receptor 4 0.034 0.0338
F2RL2 F2RL2, PAR3: Proteinase-activated receptor 3 precursor 0.034 0.038
DRD1 DRD1: D(1A) dopamine receptor 0.034 0.070
F2R F2R, CF2R, PAR1, TR: Proteinase-activated receptor 1 precursor 0.034 0.0338
P2RY4 P2RY4, NRU: P2Y purinoceptor 4 0.034 0.038
EDNRB EDNRB, ETRB: Endothelin B receptor precursor 0.034 0.051
C5AR1 C5AR1, C5AR, C5R1: C5a anaphylatoxin chemotactic receptor 0.034 0.030
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.034 0.0338
TBXA2R TBXA2R: Thromboxane A2 receptor 0.034 0.051
F2RL3 F2RL3, PAR4: Proteinase-activated receptor 4 precursor 0.034 0.038
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.034 0.051
PTGIR PTGIR, PRIPR: Prostacyclin receptor 0.034 0.031
CXCR4 CXCR4: C-X-C chemokine receptor type 4 0.034 0.034
DRD2 DRD2: D(2) dopamine receptor 0.034 0.051
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.034 0.507
TACR2 TACR2, NK2R, NKNAR, TAC2R: Substance-K receptor 0.030 0.034
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.030 0.049
TSHR N/A 0.030 0.0273
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.030 0.061
CHRM2 CHRM2: Muscarinic acetylcholine receptor M2 0.030 0.042
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.030 0.061
SSTR3 SSTR3: Somatostatin receptor type 3 0.030 0.034
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.030 0.030
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.030 0.045
OR10H3 OR10H3: Olfactory receptor 10H3 0.030 0.030
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.030 0.045
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.030 0.036
TRHR TRHR: Thyrotropin-releasing hormone receptor 0.030 0.031
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.030 0.0273
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.030 0.0273
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.030 0.034
GNAS N/A 0.0288 0.0288
GNAS Mutant guanine nucleotide-binding protein G(S), alpha subunit 0.0288 0.0288
GNAS N/A 0.0288 0.0288
GNAS GSA: Alpha subunit of GsGTP binding protein (Fragment) 0.0288 0.0288
GNAS N/A 0.0288 0.0288
GNAS Guanine nucleotide-binding protein Gs alpha subunit isoform L2 0.0288 0.0288
PRKAR2B N/A 0.028 0.042
PRKAR2A PRKAR2A, PKR2, PRKAR2: cAMP-dependent protein kinase type II-alpha regulatory su 0.028 0.0273
RYR2 RYR2: Ryanodine receptor 2 0.028 0.068
GDI1 GDI1, GDIL, OPHN2, RABGDIA, XAP4: Rab GDP dissociation inhibitor alpha 0.028 0.053
NTE N/A 0.025 0.042
PRKAR1A PRKAR1A, PKR1, PRKAR1, TSE1: cAMP-dependent protein kinase type I-alpha regulato 0.025 0.042
0.228
Total Score 4.19