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Evidence of Interaction Between TPT1 and MAN2A1

The interaction score between TPT1 and MAN2A1 is 2.93.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between TPT1 and MAN2A1 = 0.60

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 6.27E-3
Orthology
OrganismTPT1 OrthologueMAN2A1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00012453 0.186 IPI00719182 0.247
human IPI00410496 0.448 IPI00719182 0.247
human IPI00456829 0.6 IPI00719182 0.247
human IPI00396478 0.538 IPI00719182 0.247
human IPI00413821 0.671 IPI00719182 0.247
worm Q93573 1 Q21010 1
fly Q9VGS2 1 Q24451 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.22E-3
Domains No domains were used in calculating likelihood of interaction 0.014
Post-translational Modifications

Protein: TPT1

PTMResidueReference
Phosphorylation 46 PubMed, HPRD
Phosphorylation 64 PubMed, HPRD
Phosphoserine 46 PubMed, HPRD
Phosphoserine 64 PubMed, HPRD

Protein: MAN2A1

PTMResidueReference
N-linked 78 PubMed, HPRD
N-linked 1125 PubMed, HPRD
Localisation

Protein: TPT1

LocalisationReference
Nucleus HPRD
Nucleolus HPRD
Secreted HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: MAN2A1

LocalisationReference
Golgi HPRD
Transitive Score

The common interactors between TPT1 and MAN2A1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TPT1 andMAN2A1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TPT1 has 796 interactors and MAN2A1 has 199 interactors of which there are 153 common interactors.

Common InteractorName of Common InteractorScore for TPT1-Interactor (?)Score for MAN2A1-Interactor (?)
CDC23 CDC23: Cell division cycle protein 23 homolog 8.61 0.032
EEF1A1 EEF1A1: Elongation factor 1-alpha 0.827 0.032
RPS3 RPS3, OK/SW-cl.26: 40S ribosomal protein S3 0.276 0.040
RPS10 RPS10: 40S ribosomal protein S10 0.276 0.032
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.144 0.087
STAT6 STAT6: Signal transducer and activator of transcription 6 0.129 0.040
ACTG1 ACTB: Actin, cytoplasmic 1 0.129 0.040
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.129 0.066
HNRPK N/A 0.129 0.066
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.129 0.066
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.129 0.078
EEF1B2 EEF1B2, EEF1B, EF1B: Elongation factor 1-beta 0.129 0.040
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.129 0.032
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.087 0.0446
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.087 0.036
LPXN LPXN, LDLP: Leupaxin 0.078 0.032
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.078 0.040
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.078 0.040
FLII FLII, FLIL: Protein flightless-1 homolog 0.078 0.032
SEC24B SEC24B: Protein transport protein Sec24B 0.078 0.066
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.078 0.032
SAPS3 N/A 0.078 0.032
GMIP GMIP: GEM-interacting protein 0.078 0.032
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.078 0.032
KIAA1012 KIAA1012: Protein TRS85 homolog 0.078 0.066
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.078 0.040
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.078 0.078
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.078 0.032
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.078 0.040
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.078 0.040
RPS6KB1 N/A 0.078 0.040
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.078 0.032
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.078 0.040
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.078 0.066
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.078 0.032
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.078 0.040
LYN LYN: Tyrosine-protein kinase Lyn 0.078 0.032
VAV1 VAV1, VAV: Proto-oncogene vav 0.078 0.032
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.078 0.040
MSN MSN: Moesin 0.078 0.032
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.078 0.040
CSK CSK: Tyrosine-protein kinase CSK 0.078 0.032
PPARBP N/A 0.078 0.040
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.078 0.032
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.078 0.040
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.078 0.032
MPG N/A 0.070 0.027
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.070 0.036
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.070 0.027
MARK2 N/A 0.070 0.036
DEF6 DEF6, IBP: Differentially expressed in FDCP 6 0.070 0.036
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.070 0.0446
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.070 0.027
CASP8 N/A 0.070 0.036
DNM2 N/A 0.070 0.027
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.070 0.036
SAT SAT1, SAT: Diamine acetyltransferase 1 0.070 0.027
DAPP1 N/A 0.070 0.027
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.070 0.0446
EIF3S8 EIF3S8: Eukaryotic translation initiation factor 3 subunit 8 0.063 0.032
LCP1 LCP1, PLS2: Plastin-2 0.063 0.032
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.063 0.040
USP34 USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34 0.063 0.032
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.063 0.040
PSCD4 PSCD4, CYT4: Cytohesin-4 0.063 0.078
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.063 0.032
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.063 0.040
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.063 0.032
FNBP1 N/A 0.063 0.032
USP10 USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10 0.063 0.040
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.063 0.040
GSK3B N/A 0.063 0.032
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.063 0.032
XPO1 XPO1, CRM1: Exportin-1 0.063 0.032
SYK SYK: Tyrosine-protein kinase SYK 0.063 0.040
KLHDC4 N/A 0.063 0.032
PPP1CB PPP1CB: Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0.063 0.066
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.063 0.032
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.063 0.066
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.063 0.040
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.063 0.032
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.063 0.032
VCP VCP: Transitional endoplasmic reticulum ATPase 0.063 0.032
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.063 0.032
YWHAZ YWHAZ: 14-3-3 protein zeta/delta 0.063 0.040
UBE4A N/A 0.063 0.066
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.063 0.066
JAK1 0.063 0.032
COPA COPA: Coatomer subunit alpha 0.063 0.066
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.063 0.032
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.063 0.040
STK10 STK10: Uncharacterized protein STK10 0.063 0.032
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.063 0.032
USP47 USP47: Ubiquitin carboxyl-terminal hydrolase 47 0.063 0.040
API5 N/A 0.052 0.036
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.052 0.027
FTH1 FTH1, FTH, OK/SW-cl.84, FTHL6, PIG15: Ferritin heavy chain 0.052 0.027
VAV2 VAV2, RP11-153P4.1-003: Vav 2 oncogene 0.052 0.027
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.052 0.027
CIITA CIITA, MHC2TA: MHC class II transactivator 0.052 0.027
CHUK N/A 0.052 0.036
RGS2 RGS2, G0S8: Regulator of G-protein signaling 2 0.052 0.027
AHNAK AHNAK: AHNAK protein 0.052 0.027
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.052 0.027
FLNA FLNA, FLN, FLN1: Filamin-A 0.052 0.027
ROCK1 ROCK1: Rho-associated protein kinase 1 0.052 0.027
ABCF1 N/A 0.052 0.027
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.046 0.040
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.046 0.032
THOC1 THOC1, HPR1: THO complex subunit 1 0.046 0.032
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.046 0.032
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.046 0.032
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.046 0.032
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.046 0.032
NRAS NRAS, HRAS1: GTPase NRas precursor 0.046 0.078
PREP PREP, PEP: Prolyl endopeptidase 0.046 0.032
YWHAQ YWHAQ: 14-3-3 protein theta 0.0425 0.036
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.0425 0.027
HD HD, IT15: Huntingtin 0.0425 0.036
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.0425 0.027
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.0425 0.036
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.0425 0.027
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.0425 0.027
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.040 0.038
VDP DKFZp451D234: Putative uncharacterized protein DKFZp451D234 0.040 0.129
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.040 0.038
EXOC2 N/A 0.038 0.032
PTPN11 N/A 0.038 0.040
HSP90AA1 Hsp89-alpha-delta-N 0.038 0.032
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.038 0.032
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.038 0.032
SSR2 SSR2, TRAPB, HSD25: Translocon-associated protein subunit beta precursor 0.038 0.066
ST8SIA4 ST8SIA4, PST, PST1, SIAT8D: CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransfe 0.036 0.0425
ST3GAL1 ST3GAL1, SIAT4, SIAT4A: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sia 0.036 0.052
GLG1 GLG1: Golgi apparatus protein 1 0.036 0.087
IRS2 IRS2: Insulin receptor substrate 2 0.032 0.027
MAN2B1 MAN2B1, LAMAN, MANB: Lysosomal alpha-mannosidase precursor 0.032 0.063
ST6GAL1 ST6GAL1, SIAT1: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltrans 0.032 0.046
GOLGA5 GOLGA5, RETII, RFG5: Golgin subfamily A member 5 0.032 0.063
NCSTN NCSTN, KIAA0253, UNQ1874/PRO4317: Nicastrin precursor 0.032 0.040
TMED9 TMED9, GP25L2: Transmembrane emp24 domain-containing protein 9 precursor 0.032 0.063
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.029 0.063
DYNC1LI1 DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1 0.029 0.032
PSCD2 N/A 0.028 0.028
CDC42 N/A 0.028 0.028
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.028 0.028
GOLGA4 GOLGA4: Golgin subfamily A member 4 0.027 0.052
GOLGA3 GOLGA3: Golgin subfamily A member 3 0.027 0.052
TSC2 TSC2, TSC4: Tuberin 0.025 0.025
RAB5B RAB5B: Ras-related protein Rab-5B 0.025 0.025
RAC1 N/A 0.025 0.025
C11orf58 SMAP, C11orf58: Small acidic protein 0.025 0.025
SFRS2IP SFRS2IP, CASP11, SIP1: SFRS2-interacting protein 0.025 0.025
0.228
Total Score 2.93