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Evidence of Interaction Between SRC and SHC3

The interaction score between SRC and SHC3 is 23.50.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SRC and SHC3 = 0.03

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology N/A N/A
Domains Domains present in SRC and SHC3:
Domains in SRCDomains in SHC3
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR001452 SH3
IPR000980 SH2 motif
IPR000980 SH2 motif
IPR006019 Phosphotyrosine interaction (PID or PI)
IPR006020 Phosphotyrosine interaction domain
IPR011993 PH_type.

The Chi square scores for co-occurrence of domains that are present in SRC and SHC3 are listed below.

Domain 1Domain 2Chi Square
IPR008266 Tyrosine protein kinase, active site IPR000980 SH2 motif 383.26
IPR001245 Tyrosine protein kinase IPR000980 SH2 motif 238.73
IPR001245 Tyrosine protein kinase IPR011993 PH_type. 88.2896
IPR008266 Tyrosine protein kinase, active site IPR011993 PH_type. 85.0032
IPR000719 Protein kinase IPR000980 SH2 motif 82.1364
IPR001452 SH3 IPR000980 SH2 motif 59.5667
IPR000719 Protein kinase IPR011993 PH_type. 37.108
IPR000980 SH2 motif IPR000980 SH2 motif 36.445
IPR000980 SH2 motif IPR011993 PH_type. 33.2172
IPR001452 SH3 IPR011993 PH_type. 29.6332
IPR000980 SH2 motif IPR006020 Phosphotyrosine interaction domain 1.20067
IPR008266 Tyrosine protein kinase, active site IPR006020 Phosphotyrosine interaction domain 0.0178144
IPR001245 Tyrosine protein kinase IPR006020 Phosphotyrosine interaction domain 0.0104833
IPR001452 SH3 IPR006020 Phosphotyrosine interaction domain 0.00727939
IPR000719 Protein kinase IPR006020 Phosphotyrosine interaction domain 0.00379833

The background colour of the table refers to:

  • Blue Domain is only present in SRC
  • Yellow Domain is only present in SHC3
  • Green Domain is present in both SRC and SHC3

 0.265
Post-translational Modifications

Protein: SRC

PTMResidueReference
Dephosphorylation 338 PubMed, HPRD
Dephosphorylation 419 PubMed, HPRD
Dephosphorylation 530 PubMed, HPRD
Myristoylation 2 PubMed, HPRD
Phosphorylation 12 PubMed, HPRD
Phosphorylation 17 PubMed, HPRD
Phosphorylation 75 PubMed, HPRD
Phosphorylation 97 PubMed, HPRD
Phosphorylation 216 PubMed, HPRD
Phosphorylation 419 PubMed, HPRD
Phosphorylation 530 PubMed, HPRD
Phosphotyrosine 418 PubMed, HPRD
Phosphotyrosine 529 PubMed, HPRD

Protein: SHC3

PTMResidueReference
Localisation

Protein: SRC

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD

Protein: SHC3

LocalisationReference
Cytoplasm HPRD
Transitive Score

The common interactors between SRC and SHC3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SRC andSHC3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SRC has 1642 interactors and SHC3 has 346 interactors of which there are 243 common interactors.

Common InteractorName of Common InteractorScore for SRC-Interactor (?)Score for SHC3-Interactor (?)
SYK SYK: Tyrosine-protein kinase SYK 1.98 0.140
LYN LYN: Tyrosine-protein kinase Lyn 1.98 0.140
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 1.98 0.140
STAT6 STAT6: Signal transducer and activator of transcription 6 1.98 7.67
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 1.98 0.140
CSK CSK: Tyrosine-protein kinase CSK 1.98 0.140
HCK N/A 1.50 67.50
JAK2 JAK2: Tyrosine-protein kinase JAK2 1.50 0.156
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 1.50 0.157
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 1.50 67.50
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 1.50 0.177
VAV1 VAV1, VAV: Proto-oncogene vav 1.50 7.67
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 1.30 0.027
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 1.30 0.027
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 1.30 0.265
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 1.30 114.00
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 1.30 0.237
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 1.30 0.265
LNK SH2B3, LNK: SH2B adapter protein 3 1.30 0.027
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 1.30 11.50
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 1.30 0.237
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 1.20 0.197
CRKL CRKL: Crk-like protein 1.20 7.56
INSL3 JAK3: Tyrosine-protein kinase JAK3 1.20 0.197
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 1.20 6.81
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 1.20 0.156
BMX N/A 1.20 0.244
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 1.20 0.156
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 1.20 0.174
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 1.20 16.30
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 1.13 5.94
FLT3 FLT3, STK1: FL cytokine receptor precursor 1.13 0.128
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.980 0.217
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.980 93.60
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.980 0.217
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.980 0.217
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.980 0.195
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.980 9.04
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.980 0.195
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.980 0.195
NCK2 NCK2: Cytoplasmic protein NCK2 0.975 7.56
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.975 74.90
JAK1 0.975 0.140
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.902 0.115
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.902 0.128
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.902 0.145
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.902 0.128
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.902 0.251
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.902 55.50
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.859 0.156
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.859 0.157
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.859 173.00
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.859 6.81
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.859 67.50
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.731 0.145
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.731 0.145
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.731 0.200
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.731 0.145
INSR INSR: Insulin receptor precursor 0.731 61.50
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.731 147.00
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.731 207.00
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.731 0.145
MET MET: Hepatocyte growth factor receptor precursor 0.731 0.162
KIT KIT: Mast/stem cell growth factor receptor precursor 0.731 69.80
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.644 61.50
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.644 0.128
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.644 0.490
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.644 0.145
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.644 61.50
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.644 55.50
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.617 0.0288
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.617 0.0288
FLT4 VEGFR3 long form 0.617 0.0258
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.617 0.0288
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.617 0.0288
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.617 0.0258
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.581 0.362
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.540 0.126
ALK ALK: ALK tyrosine kinase receptor precursor 0.497 0.094
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.305 0.156
TNK1 TNK1: Non-receptor tyrosine-protein kinase TNK1 0.265 0.237
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.265 0.027
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.265 0.027
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.265 0.027
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.265 0.265
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.265 0.027
AMHR2 AMHR2, AMHR: Anti-Muellerian hormone type-2 receptor precursor 0.251 0.162
GRAP GRAP: GRB2-related adapter protein 0.244 7.56
DDR1 DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE: Epithelial discoidin domain-con 0.217 93.60
FGFR2 N/A 0.217 0.217
LTK LTK, TYK1: Leukocyte tyrosine kinase receptor precursor 0.200 61.50
MUSK MUSK: Muscle, skeletal receptor tyrosine protein kinase precursor 0.200 0.179
RYK RYK, JTK5A: Tyrosine-protein kinase RYK precursor 0.200 0.145
FYN N/A 0.197 0.174
GAB1 GAB1: GRB2-associated-binding protein 1 0.191 0.0308
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.191 0.028
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.174 0.197
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.165 0.027
CNN2 CNN2: Calponin-2 0.165 0.027
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.027
NF2 NF2, SCH: Merlin 0.165 0.027
AMPH AMPH, AMPH1: Amphiphysin 0.165 0.027
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.165 0.027
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.165 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.165 0.027
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.165 0.027
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.165 0.027
MAP2K5 N/A 0.165 0.027
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.027
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.165 0.027
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.165 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.165 0.027
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.027
MAPKAPK5 N/A 0.165 0.027
PSCD2 N/A 0.165 0.027
MAPK15 N/A 0.165 0.027
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.165 0.027
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.165 0.027
RET urf-ret: Urf-ret protein 0.162 0.200
TIE1 TIE1, TIE: Tyrosine-protein kinase receptor Tie-1 precursor 0.162 0.129
STYK1 STYK1, NOK: Tyrosine protein-kinase STYK1 0.162 0.162
ROR1 ROR1, NTRKR1: Tyrosine-protein kinase transmembrane receptor ROR1 precursor 0.162 0.145
CHN1 CHN1, ARHGAP2, CHN: N-chimaerin 0.157 0.074
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.152 0.036
MCF2 MCF2, DBL: Proto-oncogene DBL 0.152 0.0308
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.152 0.028
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.152 0.028
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.152 0.060
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.152 0.028
INSRR INSRR, IRR: Insulin receptor-related protein precursor 0.143 0.145
ROR2 ROR2, NTRKR2: Tyrosine-protein kinase transmembrane receptor ROR2 precursor 0.143 0.115
TYRO3 TYRO3, BYK, DTK, RSE, SKY: Tyrosine-protein kinase receptor TYRO3 precursor 0.129 0.677
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.123 17.40
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.123 0.0308
CDK5 CDK5: Cell division protein kinase 5 0.123 0.060
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.123 0.028
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.123 0.028
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.123 0.036
COBL N/A 0.110 0.050
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.110 0.044
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.110 0.036
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.109 0.028
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.109 0.028
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.109 0.044
TLN2 TLN2: Uncharacterized protein TLN2 0.109 0.044
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.109 10.50
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.109 0.044
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.109 0.036
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.109 0.036
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.109 0.060
SOS1 SOS1: Son of sevenless homolog 1 0.100 5.35
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.098 0.028
MT3 MT3: Metallothionein-3 0.098 0.083
SPTAN1 N/A 0.098 0.067
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.098 0.036
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.098 0.044
PSD TYL: TYL protein 0.098 0.060
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.098 0.074
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.098 0.028
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.081 0.032
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.081 0.039
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.0727 0.047
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.0727 0.029
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.0727 0.053
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.065 0.039
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.065 0.035
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.065 0.039
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.056 0.027
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.056 0.027
DUSP7 DUSP7, PYST2: Dual specificity protein phosphatase 7 0.0308 0.028
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.029 0.032
NULL Tyrosine kinase 0.0288 0.0288
TTN TTN: Uncharacterized protein TTN (Fragment) 0.0288 0.0288
NTRK3 NTRK3, TRKC: NT-3 growth factor receptor precursor 0.0288 0.0288
FES Proto-oncogene c-fes variant 4 0.0288 0.0288
NTRK3 N/A 0.0288 0.0288
NULL N/A 0.0288 0.0288
FES Proto-oncogene c-fes variant 3 0.0288 0.0288
MUSK MUSK: MUSK protein 0.0288 0.0288
BLK BLK: Tyrosine-protein kinase BLK 0.0288 0.0288
ROS1 ROS1: Proto-oncogene tyrosine-protein kinase ROS precursor 0.0288 0.0288
DDR2 DDR2, NTRKR3, TKT, TYRO10: Discoidin domain-containing receptor 2 precursor 0.0288 0.0288
FES N/A 0.0288 0.0258
AATK apoptosis-associated tyrosine kinase 0.0288 0.0288
FES FES, FPS: Proto-oncogene tyrosine-protein kinase Fes/Fps 0.0288 0.0288
NULL N/A 0.0288 0.0288
TESK2 TESK2: Dual specificity testis-specific protein kinase 2 0.0288 0.0288
BTK BTK kinase deficient isoform 6: Dominant-negative kinase-deficient Brutons tyros 0.0288 0.0288
ASB17 ASB17: Ankyrin repeat and SOCS box protein 17 0.027 0.027
NEK4 NEK4, STK2: Serine/threonine-protein kinase Nek4 0.027 0.027
CENTB5 KIAA1716, CENTB5: Centaurin-beta 5 0.027 0.027
ASB3 ASB3: ASB3 protein 0.027 0.027
PTPN13 N/A 0.027 0.027
STK35 STK35, CLIK1, PDIK1: Serine/threonine-protein kinase 35 0.027 0.027
ASB14 ASB14: Ankyrin repeat and SOCS box protein 14 0.027 0.027
PPP1R9A PPP1R9A, KIAA1222: Neurabin-1 0.027 0.027
CDC2L2 N/A 0.027 0.027
RASGRF2 RASGRF2: Ras protein-specific guanine nucleotide-releasing factor 2 (Fragment) 0.027 0.027
VEPH1 VEPH1, KIAA1692, VEPH: Ventricular zone-expressed PH domain-containing protein h 0.027 0.027
DOK5 DOK5, C20orf180: Docking protein 5 0.027 0.027
CASKIN1 N/A 0.027 0.027
ASB12 ASB12: Ankyrin repeat and SOCS box protein 12 0.027 0.027
CADPS CADPS, CAPS, CAPS1, KIAA1121: Calcium-dependent secretion activator 1 0.027 0.027
ARHGEF1 ARHGEF1: Rho guanine nucleotide exchange factor 1 0.027 0.027
DUSP10 DUSP10, MKP5: Dual specificity protein phosphatase 10 0.027 0.027
STAC STAC: SH3 and cysteine-rich domain-containing protein 0.027 0.027
OSBPL6 OSBPL6, ORP6: Oxysterol-binding protein-related protein 6 0.027 0.027
PLEKHA4 PLEKHA4, PEPP1: Pleckstrin homology domain-containing family A member 4 0.027 0.027
PLEKHA3 PLEKHA3, FAPP1: Pleckstrin homology domain-containing family A member 3 0.027 0.027
MID2 N/A 0.027 0.027
PSD3 N/A 0.027 0.027
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
SORBS2 N/A 0.027 0.027
PXK PXK: PX domain-containing protein kinase-like protein 0.027 0.027
ASB6 ASB6: Ankyrin repeat and SOCS box protein 6 0.027 0.027
CAMKK1 CAMKK1, CAMKKA: Calcium/calmodulin-dependent protein kinase kinase 1 0.027 0.027
OSBPL9 N/A 0.027 0.027
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
SHANK1 SHANK1: SH3 and multiple ankyrin repeat domains protein 1 0.027 0.027
ASB2 ASB2: Ankyrin repeat and SOCS box protein 2 0.027 0.027
WSB1 WSB1, SWIP1: WD repeat and SOCS box-containing protein 1 0.027 0.027
ASB7 ASB7: Ankyrin repeat and SOCS box protein 7 0.027 0.027
CADPS2 CADPS2, CAPS2, KIAA1591: Calcium-dependent secretion activator 2 0.027 0.027
PDIK1L PDIK1L, CLIK1L: Serine/threonine-protein kinase PDIK1L 0.027 0.027
ANKK1 ANKK1, PKK2, SGK288: Ankyrin repeat and protein kinase domain-containing protein 0.027 0.027
FANK1 FANK1, HSD13, UNQ6504/PRO21382: Fibronectin type 3 and ankyrin repeat domains pr 0.027 0.027
FAM43A N/A 0.027 0.027
NEBL N/A 0.027 0.027
NEK11 NEK11: Serine/threonine-protein kinase Nek11 0.027 0.027
ALS2CR7 ALS2CR7: Serine/threonine-protein kinase ALS2CR7 0.027 0.027
RASGRF1 RASGRF1, CDC25: Guanine nucleotide-releasing protein 0.027 0.027
EFS EFS: Embryonal Fyn-associated substrate 0.027 0.027
TRIM9 TRIM9, KIAA0282, RNF91: Tripartite motif-containing protein 9 0.027 0.027
NOXA1 NOXA1, RP13-927H1.1-001: NADPH oxidase activator 1 0.027 0.027
ABI3 ABI3, NESH: ABI gene family member 3 0.027 0.027
SRA1 APBB3, FE65L2: Amyloid beta A4 precursor protein-binding family B member 3 0.027 0.027
ASB10 ASB10: Ankyrin repeat and SOCS box protein 10 0.027 0.027
UBL7 UBL7, BMSCUBP, SB132: Ubiquitin-like protein 7 0.027 0.027
RIPK5 RIPK5, KIAA0472, HDCMD38P, RIP5, SGK496: Receptor-interacting serine/threonine-p 0.027 0.027
DOK6 DOK6: Uncharacterized protein DOK6 0.027 0.027
APBB1 APBB1, FE65, RIR: Amyloid beta A4 precursor protein-binding family B member 1 0.027 0.027
ABR ABR: Active breakpoint cluster region-related protein 0.027 11.50
TSC1 TSC1, KIAA0243, TSC: Hamartin 0.026 0.036
0.299
Total Score 23.50