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The Barton Group

Predicted interactions involving protein INSR: Insulin receptor precursor (IPI00025803) that score above 12.5

Click on the protein name for more information about the protein.

The Score column is the predicted score of interaction between the two proteins

Click on the Evidence link to view a breakdown of the information about the predicted interaction.

Key
Module ScoreDatabases
Where interaction is observed in another database a link is provided:

Protein 1 (?)Protein 2 (?) Name of Protein 2 Module Scores (?) Scores (?) Evidence (?) Database (?)
INSR JAK2 JAK2: Tyrosine-protein kinase JAK2 6.35E4 Evidence
INSR CRKL CRKL: Crk-like protein 6.35E4 Evidence
INSR STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 6.35E4 Evidence
INSR PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 5.39E4 Evidence
INSR STAT5B STAT5B: Signal transducer and activator of transcription 5B 3.97E4 Evidence
INSR PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 1.63E4 Evidence
INSR YWHAB YWHAB: 14-3-3 protein beta/alpha 1.74E3 Evidence
INSR FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 200.0 Evidence
INSR STAT3 200.0 Evidence
INSR GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 200.0 Evidence
INSR INSL3 JAK3: Tyrosine-protein kinase JAK3 147.0 Evidence
INSR ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 147.0 Evidence
INSR GRB10 N/A 141.0 Evidence
INSR PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 135.0 Evidence
INSR TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 132.0 Evidence
INSR SYK SYK: Tyrosine-protein kinase SYK 132.0 Evidence
INSR LYN LYN: Tyrosine-protein kinase Lyn 132.0 Evidence
INSR BMX N/A 125.0 Evidence
INSR STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 110.0 Evidence
INSR SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 101.0 Evidence
INSR SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 101.0 Evidence
INSR BLNK BLNK, BASH, SLP65: B-cell linker protein 89.30 Evidence
INSR CRK CRK: Proto-oncogene C-crk 85.60 Evidence
INSR LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 80.50 Evidence
INSR APS SH2B2, APS: SH2B adapter protein 2 80.00 Evidence
INSR BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 80.00 Evidence
INSR TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 80.00 Evidence
INSR FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 80.00 Evidence
INSR YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 80.00 Evidence
INSR RASA1 RASA1, RASA: Ras GTPase-activating protein 1 79.90 Evidence
INSR CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 72.70 Evidence
INSR VAV1 VAV1, VAV: Proto-oncogene vav 72.10 Evidence
INSR ZAP70 ZAP70: Uncharacterized protein ZAP70 72.10 Evidence
INSR JAK1 72.10 Evidence
INSR NCK2 NCK2: Cytoplasmic protein NCK2 62.10 Evidence
INSR STAT2 STAT2: Signal transducer and activator of transcription 2 55.80 Evidence
INSR GRAP GRAP: GRB2-related adapter protein 53.20 Evidence
INSR SHC3 SHC3, NSHC, SHCC: SHC-transforming protein 3 53.20 Evidence
INSR RIN1 RIN1: Ras and Rab interactor 1 52.50 Evidence
INSR STAT6 STAT6: Signal transducer and activator of transcription 6 52.50 Evidence
INSR HCK N/A 52.50 Evidence
INSR GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 49.00 Evidence
INSR CSK CSK: Tyrosine-protein kinase CSK 47.30 Evidence
INSR CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 44.10 Evidence
INSR TEK TEK, TIE2: Angiopoietin-1 receptor precursor 43.60 Evidence
INSR EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 40.60 Evidence
INSR PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 39.10 Evidence
INSR CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 37.80 Evidence
INSR ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 33.90 Evidence
INSR EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 33.90 Evidence
INSR PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 31.20 Evidence
INSR GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 31.10 Evidence
INSR SOCS1 SOCS1, SSI1, TIP3: Suppressor of cytokine signaling 1 29.30 Evidence
INSR EPOR EPOR: Erythropoietin receptor precursor 28.20 Evidence
INSR GHR GHR: Growth hormone receptor precursor 28.20 Evidence
INSR IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 28.20 Evidence
INSR CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 28.20 Evidence
INSR IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 25.3 Evidence
INSR KIT KIT: Mast/stem cell growth factor receptor precursor 25.3 Evidence
INSR IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 24.80 Evidence
INSR GNAT1 GNAT1, GNATR: Guanine nucleotide-binding protein G(t), alpha-1 subunit 23.20 Evidence
INSR LEPR LEPR, DB, OBR: Leptin receptor precursor 22.90 Evidence
INSR PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 22.90 Evidence
INSR IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 22.90 Evidence
INSR CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 22.90 Evidence
INSR AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 22.30 Evidence
INSR MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 22.20 Evidence
INSR ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 22.20 Evidence
INSR PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 22.20 Evidence
INSR DAB2 DAB2, DOC2: Disabled homolog 2 21.60 Evidence
INSR PRLR PRLR: Prolactin receptor precursor 21.10 Evidence
INSR TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 20.50 Evidence
INSR PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 20.50 Evidence
INSR GNAI1 GNAI1: Guanine nucleotide-binding protein G(i), alpha-1 subunit 20.40 Evidence
INSR GNAZ GNAZ: Guanine nucleotide-binding protein G(z) subunit alpha 20.40 Evidence
INSR GNAT2 GNAT2, GNATC: Guanine nucleotide-binding protein G(t), alpha-2 subunit 20.40 Evidence
INSR CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 20.00 Evidence
INSR PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 19.70 Evidence
INSR AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 19.70 Evidence
INSR CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 19.10 Evidence
INSR KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 18.90 Evidence
INSR S100A3 S100A3, S100E: Protein S100-A3 18.60 Evidence
INSR SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 18.60 Evidence
INSR AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 17.60 Evidence
INSR IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 17.10 Evidence
INSR MPL MPL, TPOR: Thrombopoietin receptor precursor 17.10 Evidence
INSR STAM2 STAM2: Signal transducing adapter molecule 2 16.60 Evidence
INSR IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 16.40 Evidence
INSR CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 15.50 Evidence
INSR FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 15.30 Evidence
INSR ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 15.30 Evidence
INSR ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 15.10 Evidence
INSR IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 15.00 Evidence
INSR HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 15.00 Evidence
INSR CD1A CD1A: T-cell surface glycoprotein CD1a precursor 15.00 Evidence
INSR SELE SELE, ELAM1: E-selectin precursor 15.00 Evidence
INSR MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 14.60 Evidence
INSR IRS2 IRS2: Insulin receptor substrate 2 13.90 Evidence
INSR PRKCE PRKCE, PKCE: Protein kinase C epsilon type 13.60 Evidence
INSR CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 13.50 Evidence
INSR PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 13.50 Evidence
INSR NEDD9 NEDD9, CASL: Enhancer of filamentation 1 13.50 Evidence
INSR LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 13.50 Evidence
INSR DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 13.50 Evidence
INSR CDC25A CDC25A: M-phase inducer phosphatase 1 13.50 Evidence
INSR ACTN4 ACTN4: Alpha-actinin-4 13.50 Evidence
INSR RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 13.40 Evidence
INSR EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 13.20 Evidence