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The Barton Group

Predicted interactions involving protein MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 (IPI00219604) that score above 2.5

Click on the protein name for more information about the protein.

The Score column is the predicted score of interaction between the two proteins

Click on the Evidence link to view a breakdown of the information about the predicted interaction.

Key
Module ScoreDatabases
Where interaction is observed in another database a link is provided:

Protein 1 (?)Protein 2 (?) Name of Protein 2 Module Scores (?) Scores (?) Evidence (?) Database (?)
MAP2K1 BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 6.08E3 Evidence O
MAP2K1 RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 3.26E3 Evidence O
MAP2K1 AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 32.80 Evidence
MAP2K1 DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 31.20 Evidence
MAP2K1 SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 30.00 Evidence
MAP2K1 MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 27.80 Evidence O
MAP2K1 DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 27.80 Evidence
MAP2K1 JAK2 JAK2: Tyrosine-protein kinase JAK2 25.00 Evidence
MAP2K1 VAV1 VAV1, VAV: Proto-oncogene vav 25.00 Evidence
MAP2K1 STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 23.70 Evidence
MAP2K1 DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 20.50 Evidence
MAP2K1 JAK1 20.50 Evidence
MAP2K1 PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 20.40 Evidence
MAP2K1 NRAS NRAS, HRAS1: GTPase NRas precursor 20.20 Evidence
MAP2K1 YWHAB YWHAB: 14-3-3 protein beta/alpha 17.90 Evidence
MAP2K1 DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 17.60 Evidence
MAP2K1 PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 17.60 Evidence
MAP2K1 CDC25A CDC25A: M-phase inducer phosphatase 1 17.60 Evidence
MAP2K1 PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 17.60 Evidence
MAP2K1 SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 17.60 Evidence
MAP2K1 LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 17.30 Evidence
MAP2K1 SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 17.30 Evidence
MAP2K1 IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 16.50 Evidence
MAP2K1 HSP90AA1 Hsp89-alpha-delta-N 16.50 Evidence
MAP2K1 MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 15.70 Evidence O
MAP2K1 YWHAZ YWHAZ: 14-3-3 protein zeta/delta 15.40 Evidence
MAP2K1 FRS3 FRS3: Fibroblast growth factor receptor substrate 3 15.30 Evidence
MAP2K1 RB1 RB1: Retinoblastoma-associated protein 15.10 Evidence
MAP2K1 CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 15.10 Evidence
MAP2K1 DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 13.80 Evidence
MAP2K1 FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 13.40 Evidence
MAP2K1 RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 12.00 Evidence
MAP2K1 MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 10.60 Evidence
MAP2K1 PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 10.30 Evidence
MAP2K1 STK3 STK3, MST2: Serine/threonine-protein kinase 3 10.30 Evidence
MAP2K1 CDK5R1 CDK5R1, CDK5R, NCK5A: Cyclin-dependent kinase 5 activator 1 precursor 10.30 Evidence
MAP2K1 RBL2 RBL2, RB2: Retinoblastoma-like protein 2 10.30 Evidence
MAP2K1 JUN JUN: Transcription factor AP-1 10.30 Evidence
MAP2K1 ABI1 ABI1, SSH3BP1: Abl interactor 1 9.96 Evidence
MAP2K1 MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 9.96 Evidence
MAP2K1 SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 9.32 Evidence
MAP2K1 YWHAQ YWHAQ: 14-3-3 protein theta 8.40 Evidence
MAP2K1 NR3C1 NR3C1, GRL: Glucocorticoid receptor 8.40 Evidence
MAP2K1 HSF1 HSF1, HSTF1: Heat shock factor protein 1 8.22 Evidence
MAP2K1 CLTC CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1 7.52 Evidence
MAP2K1 YWHAH YWHAH, YWHA1: 14-3-3 protein eta 7.20 Evidence
MAP2K1 RAB5B RAB5B: Ras-related protein Rab-5B 6.50 Evidence
MAP2K1 NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 6.39 Evidence
MAP2K1 PEBP1 PEBP1, PBP, PEBP: Phosphatidylethanolamine-binding protein 1 6.35 Evidence O
MAP2K1 GRB10 N/A 6.14 Evidence
MAP2K1 IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 5.87 Evidence
MAP2K1 STK10 STK10: Uncharacterized protein STK10 5.55 Evidence
MAP2K1 YWHAE YWHAE: 14-3-3 protein epsilon 5.55 Evidence
MAP2K1 XPO1 XPO1, CRM1: Exportin-1 5.55 Evidence
MAP2K1 GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 5.55 Evidence
MAP2K1 NOL1 N/A 5.55 Evidence
MAP2K1 IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 5.41 Evidence
MAP2K1 DUSP2 DUSP2, PAC1: Dual specificity protein phosphatase 2 5.30 Evidence
MAP2K1 RAP1GA1 N/A 5.09 Evidence
MAP2K1 MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 5.08 Evidence
MAP2K1 TBXA2R TBXA2R: Thromboxane A2 receptor 4.78 Evidence
MAP2K1 PRKCE PRKCE, PKCE: Protein kinase C epsilon type 4.73 Evidence
MAP2K1 RAB5A RAB5A, RAB5: Ras-related protein Rab-5A 4.69 Evidence
MAP2K1 BCL2 BCL2: Apoptosis regulator Bcl-2 4.65 Evidence
MAP2K1 COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 4.55 Evidence
MAP2K1 ARRB2 N/A 4.35 Evidence
MAP2K1 BAD BAD, BBC6, BCL2L8: Bcl2 antagonist of cell death 3.98 Evidence
MAP2K1 AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 3.92 Evidence
MAP2K1 MAPK7 mitogen-activated protein kinase 7 isoform 1 3.85 Evidence
MAP2K1 IPO7 IPO7: Uncharacterized protein IPO7 3.85 Evidence
MAP2K1 PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 3.51 Evidence
MAP2K1 GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 3.51 Evidence
MAP2K1 GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 3.45 Evidence
MAP2K1 TBCE TBCE: Tubulin-specific chaperone E 3.45 Evidence
MAP2K1 PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 3.45 Evidence
MAP2K1 SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 3.45 Evidence
MAP2K1 RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 3.45 Evidence
MAP2K1 CDK4 CDK4: Cell division protein kinase 4 3.45 Evidence
MAP2K1 STAP2 Uncharacterized protein ENSP00000317912 3.34 Evidence
MAP2K1 YWHAG YWHAG: 14-3-3 protein gamma 3.34 Evidence
MAP2K1 PKP4 PKP4: Plakophilin-4 3.34 Evidence
MAP2K1 C9orf88 N/A 3.34 Evidence
MAP2K1 CENTB5 KIAA1716, CENTB5: Centaurin-beta 5 3.18 Evidence
MAP2K1 RASGRF2 RASGRF2: Ras protein-specific guanine nucleotide-releasing factor 2 (Fragment) 3.18 Evidence
MAP2K1 DOK5 DOK5, C20orf180: Docking protein 5 3.18 Evidence
MAP2K1 NRAS HRAS, HRAS1: GTPase HRas precursor 3.04 Evidence O
MAP2K1 PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 2.99 Evidence
MAP2K1 RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 2.99 Evidence
MAP2K1 MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 2.99 Evidence
MAP2K1 RSU1 RSU1, RSP1: Ras suppressor protein 1 2.99 Evidence
MAP2K1 DIP13B APPL2, DIP13B: DCC-interacting protein 13-beta 2.93 Evidence
MAP2K1 PARD6G PARD6G, PAR6G: Partitioning defective 6 homolog gamma 2.85 Evidence
MAP2K1 PI4KII PI4K2A: Phosphatidylinositol 4-kinase type 2-alpha 2.75 Evidence
MAP2K1 MTMR3 MTMR3, KIAA0371, ZFYVE10: Myotubularin-related protein 3 2.63 Evidence
MAP2K1 GYS1 GYS1, GYS: Glycogen [starch] synthase, muscle 2.51 Evidence