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Method 3 - a two segment scan of a two segment domain (Figure 6c)

Now consider a domain made up of two segments, consisting of residues to and to . The algorithm scans this domain for subdomains in the following way.

is made up of two segments and , formed by placing four boundaries at , , and . Note that one of the boundaries of both components of segment A must lie on the boundary of the parent domain. The split value between and must show them to be correlated when compared with MSV. B can consist of up to two segments. This split value is calculated for all possible segment 's formed by varying , , and . The maximum split value is stored, together with the corresponding values of , , and , called , , and , which define and . The maximum split value is compared with MSV and if and are not correlated, the parent domain is split at this point. goes on to form a two segment child domain.

For all three scans, if consists of only one segment, it is considered to form a single segment child domain. If consists of two segments, the split value between these two parts is calculated. If the two segments are correlated, they are placed together to form a single child domain made up of two segments, otherwise, they are considered to be two separate, child domains. If consists of three segments, the split values between all pairs are calculated. If none of the pairs are correlated the segments are considered to form three distinct child domains. If one of the pairs are correlated, the two segments are placed together to form a two segment child domain, the left over segment forming a single segment child domain on its own. If two or three of the pairs are correlated, the pair with the highest degree of correlation (i.e. lowest split value) are placed together to form a two segment child domain, the left over segment again forming a single segment child domain on its own.



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