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Evidence of Interaction Between MCM4 and MCM6

The interaction score between MCM4 and MCM6 is 1.59E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MCM4 and MCM6 = 0.88

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismMCM4 OrthologueMCM6 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YPR019W 1 YGL201C 1
  • CoLocalization
  • CoPurification

Get References From PubMed
worm Q95XQ8 1 P34647 1
fly Q26454 1 O96047 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in MCM4 and MCM6:
Domains in MCM4Domains in MCM6
IPR008994 Nucleic acid-binding OB-fold
IPR001208 MCM
IPR008047 MCM protein 4
IPR008994 Nucleic acid-binding OB-fold
IPR001208 MCM
IPR008049 MCM protein 6

The Chi square scores for co-occurrence of domains that are present in MCM4 and MCM6 are listed below.

Domain 1Domain 2Chi Square
IPR001208 MCM IPR001208 MCM 364.867
IPR001208 MCM IPR008049 MCM protein 6 348.635
IPR008994 Nucleic acid-binding OB-fold IPR001208 MCM 301.459
IPR008994 Nucleic acid-binding OB-fold IPR008994 Nucleic acid-binding OB-fold 191.222

The background colour of the table refers to:

  • Blue Domain is only present in MCM4
  • Yellow Domain is only present in MCM6
  • Green Domain is present in both MCM4 and MCM6

 0.027
Post-translational Modifications

Protein: MCM4

PTMResidueReference
Phosphorylation 7 PubMed, HPRD
Phosphorylation 19 PubMed, HPRD
Phosphorylation 32 PubMed, HPRD
Phosphorylation 54 PubMed, HPRD
Phosphorylation 110 PubMed, HPRD
Phosphorylation 326 PubMed, HPRD
Phosphoserine 326 HPRD

Protein: MCM6

PTMResidueReference
Localisation

Protein: MCM4

LocalisationReference
Nucleus HPRD
Nucleolus HPRD

Protein: MCM6

LocalisationReference
Nucleoplasm HPRD
Transitive Score

The common interactors between MCM4 and MCM6 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MCM4 andMCM6. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MCM4 has 882 interactors and MCM6 has 177 interactors of which there are 156 common interactors.

Common InteractorName of Common InteractorScore for MCM4-Interactor (?)Score for MCM6-Interactor (?)
MCM3 MCM3: DNA replication licensing factor MCM3 1.29E3 209.00
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 1.29E3 69.60
MCM7 MCM7, CDC47, MCM2: DNA replication licensing factor MCM7 69.60 0.789
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 34.20 1.82
CCNB1 Cyclin B1 1.62 0.123
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 1.62 0.263
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.852 0.293
PCNA PCNA: Proliferating cell nuclear antigen 0.827 0.044
CCNA2 CCNA2, CCN1, CCNA: Cyclin-A2 0.789 0.263
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.763 0.123
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.763 0.123
MCM10 MCM10, PRO2249: Protein MCM10 homolog 0.593 0.593
DNMT1 DNMT1, AIM, DNMT: DNA 0.515 0.137
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.515 0.067
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.503 0.0968
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.503 0.207
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.461 0.123
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.461 0.123
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.461 0.060
WRN WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase 0.461 0.074
BLM BLM, RECQ2, RECQL3: Bloom syndrome protein 0.461 0.123
EIF2S2 EIF2S2, EIF2B: Eukaryotic translation initiation factor 2 subunit 2 0.461 0.074
RB1 RB1: Retinoblastoma-associated protein 0.416 0.083
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.416 0.067
MTA1 MTA1: Metastasis-associated protein MTA1 0.372 0.060
ESPL1 N/A 0.307 0.049
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.304 0.059
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.304 0.047
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.304 0.059
KIF11 N/A 0.276 0.044
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.275 0.060
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.275 0.044
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.275 0.036
MDN1 MDN1, KIAA0301: Midasin 0.275 0.060
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.275 0.060
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.275 0.044
CSDA CSDA, DBPA: DNA-binding protein A 0.275 0.036
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.269 0.0278
CCNB2 CCNB2: G2/mitotic-specific cyclin-B2 0.263 0.263
MCM5 MCM5, CDC46: DNA replication licensing factor MCM5 0.263 69.60
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.260 0.042
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.260 0.042
DDX21 DDX21: Nucleolar RNA helicase 2 0.260 0.0255
ELF1 ELF1: ETS-related transcription factor Elf-1 0.251 0.041
GTF2F2 N/A 0.251 0.041
VCP VCP: Transitional endoplasmic reticulum ATPase 0.245 0.035
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.225 0.044
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.225 0.028
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.225 0.036
CCNH CCNH: Cyclin-H 0.225 0.028
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.210 0.0255
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.207 0.207
RFC3 RFC3: Replication factor C subunit 3 0.207 0.207
RFC4 RFC4: Replication factor C subunit 4 0.207 0.620
RFC5 RFC5: Replication factor C subunit 5 0.207 0.207
ERG ERG: Transcriptional regulator ERG 0.191 0.041
IRF3 IRF3: Interferon regulatory factor 3 0.191 0.041
SRPR SRPR: Uncharacterized protein SRPR 0.166 0.032
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.165 0.027
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.165 0.027
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.165 0.027
GMNN GMNN: Geminin 0.160 0.027
POLR2H POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3 0.156 0.123
H1FX H1FX: Histone H1x 0.152 0.041
CCNF CCNF: G2/mitotic-specific cyclin-F 0.137 0.137
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.137 0.137
TIMELESS TIMELESS, TIM, TIM1, TIMELESS1: Protein timeless homolog 0.129 3.89
RPA1 RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit 0.123 0.123
ORC2L ORC2L, ORC2: Origin recognition complex subunit 2 0.123 0.074
ABCE1 ABCE1, RLI, OK/SW-cl.40, RNASEL1, RNASELI, RNS4I: ATP-binding cassette sub-famil 0.123 0.123
MRPS28 MRPS28, MRPS35, HSPC007: Mitochondrial 28S ribosomal protein S28 0.123 0.074
ORC6L ORC6L: Origin recognition complex subunit 6 0.123 0.123
EXOSC8 EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43 0.108 0.065
TAF9 AK6, AD-004, CGI-137: Adenylate kinase isoenzyme 6 0.108 0.108
PSMC3 PSMC3, TBP1: 26S protease regulatory subunit 6A 0.0968 0.059
EXOSC7 EXOSC7, KIAA0116, RRP42: Exosome complex exonuclease RRP42 0.0968 0.059
ATAD3A ATAD3A: ATPase family AAA domain-containing protein 3A 0.0968 0.059
CUL2 CUL2: Cullin-2 0.093 0.044
MUTYH N/A 0.083 0.137
CDCA8 CDCA8, PESCRG3: Borealin 0.082 0.027
SMC4L1 N/A 0.082 0.027
HMMR HMMR: Hyaluronan-mediated motility receptor 0.082 0.027
C18orf56 N/A 0.082 0.027
ZWINT N/A 0.082 0.027
C22orf18 N/A 0.082 0.027
RAD54L RAD54L, RAD54A: DNA repair and recombination protein RAD54-like 0.081 0.081
HELLS HELLS, PASG, Nbla10143, SMARCA6: Lymphoid-specific helicase 0.081 0.081
CCNG1 CCNG1, CCNG, CYCG1: Cyclin-G1 0.074 0.074
RECQL4 RECQL4, RECQ4: ATP-dependent DNA helicase Q4 0.074 0.060
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.074 0.060
XRCC3 XRCC3: DNA-repair protein XRCC3 0.074 0.060
EIF1AX EIF1AX, EIF1A, EIF4C: Eukaryotic translation initiation factor 1A, X-chromosomal 0.074 0.060
EXOSC4 EXOSC4, RRP41, SKI6: Exosome complex exonuclease RRP41 0.0735 0.029
RFX5 RFX5: DNA-binding protein RFX5 0.067 0.083
IRF4 IRF4, MUM1: Interferon regulatory factor 4 0.067 0.050
POT1 POT1: Protection of telomeres protein 1 0.067 0.083
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.065 0.065
SNRPA SNRPA: U1 small nuclear ribonucleoprotein A 0.065 0.053
SCYE1 SCYE1, EMAP2: Multisynthetase complex auxiliary component p43 [Contains: Endothe 0.060 0.060
CCND2 CCND2: G1/S-specific cyclin-D2 0.060 0.036
TFDP1 TFDP1, DP1: Transcription factor Dp-1 0.060 0.060
PSMC6 PSMC6, SUG2: 26S protease regulatory subunit S10B 0.059 0.047
DARS DARS, PIG40: Aspartyl-tRNA synthetase, cytoplasmic 0.059 0.047
RUVBL1 RUVBL1, NMP238, TIP49, TIP49A: RuvB-like 1 0.059 0.059
SRP54 SRP54: Signal recognition particle 54 kDa protein 0.059 0.047
H1F0 H1F0, H1FV: Histone H1.0 0.058 0.028
SSBP1 SSBP1, SSBP: Single-stranded DNA-binding protein, mitochondrial precursor 0.055 0.055
TPX2 TPX2, C20orf1, C20orf2, DIL2, HCA519: Targeting protein for Xklp2 0.053 0.027
RUVBL2 RUVBL2, TIP48, CGI-46, TIP49B: RuvB-like 2 0.047 0.047
EXOSC5 EXOSC5, CML28, RRP46: Exosome complex exonuclease RRP46 0.047 0.047
DVL2 DVL2: Segment polarity protein dishevelled homolog DVL-2 0.047 0.059
POLR2G POLR2G: DNA-directed RNA polymerase II subunit RPB7 0.044 0.060
GCLC GCLC, GLCL, GLCLC: Glutamate--cysteine ligase catalytic subunit 0.044 0.036
CCNC CCNC: Cyclin-C 0.044 0.060
RPS23 RPS23: 40S ribosomal protein S23 0.044 0.044
GTF2E2 GTF2E2, TF2E2: Transcription initiation factor IIE subunit beta 0.044 0.060
EIF1AY EIF1AY: Eukaryotic translation initiation factor 1A, Y-chromosomal 0.044 0.036
IRF5 IRF5: Interferon regulatory factor 5 0.041 0.041
E2F2 E2F2: Transcription factor E2F2 0.041 0.0308
ADAR ADAR, ADAR1, DSRAD, G1P1, IFI4: Double-stranded RNA-specific adenosine deaminase 0.041 0.050
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.040 0.612
RECQL RECQL, RECQL1: ATP-dependent DNA helicase Q1 0.036 0.044
NTHL1 NTHL1, NTH1, OCTS3: Endonuclease III-like protein 1 0.036 0.036
E2F3 E2F3, KIAA0075: Transcription factor E2F3 0.036 0.044
GABPA GABPA, E4TF1A: GA-binding protein alpha chain 0.036 0.036
NARS NARS, ASNS: Asparaginyl-tRNA synthetase, cytoplasmic 0.035 0.035
OBFC1 OBFC1: Oligonucleotide/oligosaccharide-binding fold-containing protein 1 0.0308 0.041
ELF4 ELF4, ELFR, MEF: ETS-related transcription factor Elf-4 0.0308 0.0308
IRF2 IRF2: Interferon regulatory factor 2 0.0308 0.0308
NUBP1 NUBP1, NBP, NBP1: Nucleotide-binding protein 1 0.029 0.029
BCS1L BCS1L, BCS1: Mitochondrial chaperone BCS1 0.029 0.035
DVL1 DVL1: Segment polarity protein dishevelled homolog DVL-1 0.028 0.028
CCND3 CCND3: G1/S-specific cyclin-D3 0.028 0.044
MYST3 MYST3, MOZ, RUNXBP2, ZNF220: Histone acetyltransferase MYST3 0.028 0.036
DVL3 DVL3, KIAA0208: Segment polarity protein dishevelled homolog DVL-3 0.028 0.028
PAX5 PAX5: Paired box protein Pax-5 0.028 0.028
E2F5 E2F5: Transcription factor E2F5 0.028 0.036
RAD51AP1 N/A 0.027 0.027
MCM10 N/A 0.027 0.027
KIAA0101 PAF, KIAA0101, L5, NS5ATP9: PCNA-associated factor 0.027 0.027
TMPO N/A 0.027 0.027
XAB1 XAB1, MBDIN, HUSSY-23: XPA-binding protein 1 0.027 0.0331
PRSS15 LONP1, PRSS15: Lon protease homolog, mitochondrial precursor 0.027 0.027
ABCF2 ABCF2, HUSSY-18: ATP-binding cassette sub-family F member 2 0.027 0.027
HSFY1 HSFY1, HSF2L, HSFY: Heat shock transcription factor, Y-linked 0.027 0.027
DNAH11 N/A 0.027 0.027
PAX3 PAX3, HUP2: Paired box protein Pax-3 0.027 0.027
C20orf116 C20orf116: Uncharacterized protein C20orf116 precursor 0.027 0.027
OGG1 N/A 0.027 0.027
HILS1 HILS1: Spermatid-specific linker histone H1-like protein 0.027 0.027
FOXQ1 FOXQ1, HFH1: Forkhead box protein Q1 0.027 0.027
ZCCHC17 ZCCHC17, PS1D, HSPC243, HSPC251, LDC4: Nucleolar protein of 40 kDa 0.027 0.027
RPA3 RPA3, REPA3, RPA14: Replication protein A 14 kDa subunit 0.027 0.027
SPIC SPIC: Transcription factor Spi-C 0.027 0.027
IRF7 IRF7: Interferon regulatory factor 7 0.027 0.027
HRB2 KRR1, HRB2: KRR1 small subunit processome component homolog 0.026 3.08
0.572
Total Score 1.59E4