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Evidence of Interaction Between TRADD and TNFRSF1A

The interaction score between TRADD and TNFRSF1A is 165.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between TRADD and TNFRSF1A = 0.46

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 4.62E-3
Orthology N/A N/A
Domains Domains present in TRADD and TNFRSF1A:
Domains in TRADDDomains in TNFRSF1A
IPR011029 DEATH-like
IPR000488 Death domain
IPR009095 TRADD, N-terminal
IPR001368 TNFR/CD27/30/40/95 cysteine-rich region
IPR011029 DEATH-like
IPR000488 Death domain
IPR013032 IPR006209.

The Chi square scores for co-occurrence of domains that are present in TRADD and TNFRSF1A are listed below.

Domain 1Domain 2Chi Square
IPR011029 DEATH-like IPR011029 DEATH-like 869.796
IPR011029 DEATH-like IPR000488 Death domain 434.384
IPR000488 Death domain IPR000488 Death domain 281.479
IPR009095 TRADD, N-terminal IPR011029 DEATH-like 222.64
IPR009095 TRADD, N-terminal IPR000488 Death domain 219.455
IPR009095 TRADD, N-terminal IPR001368 TNFR/CD27/30/40/95 cysteine-rich region 93.1693
IPR000488 Death domain IPR001368 TNFR/CD27/30/40/95 cysteine-rich region 91.0201
IPR011029 DEATH-like IPR001368 TNFR/CD27/30/40/95 cysteine-rich region 74.0903
IPR011029 DEATH-like IPR013032 IPR006209. 1.79204
IPR000488 Death domain IPR013032 IPR006209. 0.43011

The background colour of the table refers to:

  • Blue Domain is only present in TRADD
  • Yellow Domain is only present in TNFRSF1A
  • Green Domain is present in both TRADD and TNFRSF1A

 0.980
Post-translational Modifications

Protein: TRADD

PTMResidueReference
Acetylation 225 PubMed, HPRD

Protein: TNFRSF1A

PTMResidueReference
Phosphorylation 274 PubMed, HPRD
Phosphorylation 280 PubMed, HPRD
Proteolytic Cleavage 260 PubMed, HPRD
Localisation

Protein: TRADD

LocalisationReference
ER HPRD
Golgi HPRD
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: TNFRSF1A

LocalisationReference
Golgi HPRD
Plasma membrane HPRD
Secreted HPRD
Transitive Score

The common interactors between TRADD and TNFRSF1A that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TRADD andTNFRSF1A. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TRADD has 1077 interactors and TNFRSF1A has 1259 interactors of which there are 554 common interactors.

Common InteractorName of Common InteractorScore for TRADD-Interactor (?)Score for TNFRSF1A-Interactor (?)
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 5.42 3.05
RPS10 RPS10: 40S ribosomal protein S10 4.07 1.48
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 3.28 1.48
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 3.28 1.48
CIITA CIITA, MHC2TA: MHC class II transactivator 2.42 0.731
THOC1 THOC1, HPR1: THO complex subunit 1 1.98 0.644
FADD FADD, MORT1: Protein FADD 1.81 2.42
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 1.50 1.48
CARD8 CARD8, KIAA0955, NDPP1: Caspase recruitment domain-containing protein 8 1.36 0.404
CASP9 CASP9, MCH6: Caspase-9 precursor 1.30 0.980
CASP1 CASP1, IL1BC, IL1BCE: Caspase-1 precursor 1.30 0.980
CASP8 CASP8, MCH5: Caspase-8 precursor 1.05 0.980
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.980 1.30
CASP2 CASP2, ICH1, NEDD2: Caspase-2 precursor 0.970 0.731
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.917 0.075
PEA15 PEA15: Astrocytic phosphoprotein PEA-15 0.872 0.581
BIRC2 BIRC2, API1, IAP2, MIHB, RNF48: Baculoviral IAP repeat-containing protein 2 0.824 0.251
CASP4 CASP4, ICH2: Caspase-4 precursor 0.824 0.677
PSMD12 PSMD12: 26S proteasome non-ATPase regulatory subunit 12 0.692 0.357
DDX58 DDX58: Probable ATP-dependent RNA helicase DDX58 0.677 0.214
MYD88 0.677 0.824
IRAK4 IRAK4: Interleukin-1 receptor-associated kinase 4 0.666 0.251
QRICH1 N/A 0.666 0.251
NFKB2 N/A 0.617 0.617
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.581 0.859
IFIH1 IFIH1, MDA5, RH116: Interferon-induced helicase C domain-containing protein 1 0.547 0.162
FLII FLII, FLIL: Protein flightless-1 homolog 0.515 0.340
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.430 0.075
ATM ATM: Serine-protein kinase ATM 0.430 0.037
STAT6 STAT6: Signal transducer and activator of transcription 6 0.430 0.153
STK10 STK10: Uncharacterized protein STK10 0.430 0.091
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.430 0.091
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.430 0.075
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.416 0.202
BIRC1 BIRC1, NAIP: Baculoviral IAP repeat-containing protein 1 0.402 0.404
RIPK2 RIPK2, CARDIAK, UNQ277/PRO314/PRO34092, RICK, RIP2: Receptor-interacting serine/ 0.402 0.330
CARD15 NOD2, CARD15, IBD1: Nucleotide-binding oligomerization domain-containing protein 0.402 0.677
MYCBP2 MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2 0.340 0.063
MAD1L1 MAD1L1, MAD1, TXBP181: Mitotic spindle assembly checkpoint protein MAD1 0.307 0.027
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.307 0.166
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.307 0.100
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.307 0.902
CARD4 NOD1, CARD4: Nucleotide-binding oligomerization domain-containing protein 1 0.305 0.200
DEDD DEDD, DEDPRO1, KE05, DEFT: Death effector domain-containing protein 0.305 0.330
TNFRSF1B TNFRSF1B, TNFBR, TNFR2: Tumor necrosis factor receptor superfamily member 1B pre 0.274 0.515
CARD14 CARD14, CARMA2: Caspase recruitment domain-containing protein 14 0.265 0.217
NALP5 NLRP5, MATER, NALP5: NACHT, LRR and PYD domains-containing protein 5 0.265 0.217
NALP10 NLRP10, NALP10, NOD8, PYNOD: NACHT, LRR and PYD domains-containing protein 10 0.265 0.217
BIRC3 BIRC3, API2, IAP1, MIHC, RNF49: Baculoviral IAP repeat-containing protein 3 0.265 0.217
NALP4 N/A 0.265 0.217
CARD11 CARD11, CARMA1: Caspase recruitment domain-containing protein 11 0.265 0.217
PYCARD PYCARD, ASC, CARD5, TMS1: Apoptosis-associated speck-like protein containing a C 0.265 0.217
NALP1 NLRP1, CARD7, DEFCAP, KIAA0926, NAC, NALP1: NACHT, LRR and PYD domains-containin 0.265 0.217
CARD12 NLRC4, CARD12, UNQ6189/PRO20215, CLAN, CLAN1, IPAF: NLR family CARD domain-conta 0.265 0.217
APAF1 N/A 0.265 0.217
ICEBERG ICEBERG, UNQ5804/PRO19611: Caspase-1 inhibitor Iceberg 0.265 0.217
NALP6 NLRP6, NALP6, PYPAF5: NACHT, LRR and PYD domains-containing protein 6 0.265 0.217
DEDD2 DEDD2, FLAME3, PSEC0004: DNA-binding death effector domain-containing protein 2 0.265 0.217
BCL10 BCL10, CIPER, CLAP: B-cell lymphoma/leukemia 10 0.265 0.217
NALP11 NLRP11, NALP11, NOD17, PYPAF6: NACHT, LRR and PYD domains-containing protein 11 0.265 0.217
NALP14 NLRP14, NALP14, NOD5: NACHT, LRR and PYD domains-containing protein 14 0.265 0.217
C9orf89 C9orf89: Bcl10-interacting CARD protein 0.265 0.217
NALP12 NLRP12, NALP12, PYPAF7, RNO: NACHT, LRR and PYD domains-containing protein 12 0.265 0.217
NALP13 NLRP13, NALP13, NOD14: NACHT, LRR and PYD domains-containing protein 13 0.265 0.217
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.260 0.057
CSK CSK: Tyrosine-protein kinase CSK 0.260 0.057
JAK1 0.260 0.075
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.260 0.057
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.260 0.057
RPS6KB1 N/A 0.260 0.0453
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.260 0.091
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.260 0.075
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.251 0.731
IRAK3 IRAK3: Interleukin-1 receptor-associated kinase 3 0.251 0.491
NALP2 NLRP2, NALP2, NBS1, PAN1, PYPAF2: NACHT, LRR and PYD domains-containing protein 0.244 0.162
CASP10 N/A 0.244 0.143
TEP1 TEP1, TLP1, TP1: Telomerase protein component 1 0.244 0.143
LRCH4 LRCH4, LRN, LRRN1, LRRN4: Leucine-rich repeat and calponin homology domain-conta 0.231 0.041
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.228 0.063
TNFRSF25 TNFRSF25, APO3, UNQ455/PRO779, DDR3, DR3, TNFRSF12, WSL, WSL1: Tumor necrosis fa 0.217 0.265
TNFRSF10A TNFRSF10A, APO2, DR4, TRAILR1: Tumor necrosis factor receptor superfamily member 0.217 0.265
TNFRSF10B TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9: Tumor necrosis factor receptor 0.217 0.265
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.210 0.124
EEF1A1 EEF1A1: Elongation factor 1-alpha 0.210 0.075
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.210 0.057
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.210 0.0453
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.210 0.091
EIF2S3 EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3 0.210 0.0453
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.210 0.037
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.210 0.124
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.210 0.124
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.210 0.037
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.210 0.091
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.210 0.075
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.210 0.037
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.210 0.032
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.210 0.075
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.210 0.124
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.210 0.0453
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.210 0.091
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.202 0.063
TNFRSF21 TNFRSF21, DR6, UNQ437/PRO868: Tumor necrosis factor receptor superfamily member 0.200 0.197
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.191 0.072
CASP3 CASP3, CPP32: Caspase-3 precursor 0.191 0.100
TBCE TBCE: Tubulin-specific chaperone E 0.191 0.100
CASP5 CASP5, ICH3: Caspase-5 precursor 0.174 0.200
CRADD CRADD, RAIDD: Death domain-containing protein CRADD 0.174 0.143
CARD10 CARD10, CARMA3: Caspase recruitment domain-containing protein 10 0.174 0.200
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.166 0.100
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.166 0.063
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.165 0.109
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.165 0.109
CASP6 CASP6, MCH2: Caspase-6 precursor 0.165 0.109
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.165 0.109
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.165 0.109
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.157 0.070
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.157 0.070
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.155 0.124
EEF2 EEF2, EF2: Elongation factor 2 0.155 0.075
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.155 0.0453
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.155 0.057
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.155 0.057
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.155 0.124
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.155 0.0453
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.155 0.253
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.155 0.091
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.155 0.057
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.155 0.057
ROCK1 ROCK1: Rho-associated protein kinase 1 0.155 0.057
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.155 0.075
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.155 0.057
IFI35 N/A 0.144 0.027
MARK2 N/A 0.144 0.027
PSCD4 PSCD4, CYT4: Cytohesin-4 0.144 0.036
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.144 0.027
VAV1 VAV1, VAV: Proto-oncogene vav 0.144 0.027
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.144 0.091
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.144 0.036
FAS Tumor necrosis factor receptor superfamily, member 6 isoform 1 variant (Fragment 0.141 0.217
FBXL11 FBXL11, FBL7, JHDM1A, KIAA1004: JmjC domain-containing histone demethylation pro 0.137 0.032
TRIM38 TRIM38, RNF15, RORET: Tripartite motif-containing protein 38 0.137 0.039
SYK SYK: Tyrosine-protein kinase SYK 0.132 0.061
LYN LYN: Tyrosine-protein kinase Lyn 0.132 0.101
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.132 0.074
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.132 0.037
RNF7 RNF7, RBX2, ROC2, SAG: RING-box protein 2 0.129 0.0782
UNC5B N/A 0.129 0.174
UNC5C UNC5C, UNC5H3: Netrin receptor UNC5C precursor 0.129 0.157
COASY COASY, PSEC0106: Bifunctional coenzyme A synthase 0.128 0.0794
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.127 0.075
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.127 0.075
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.0453
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.127 0.057
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.127 0.0453
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.127 0.126
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.127 0.153
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.127 0.037
UBE2E3 UBE2E3, UBCE4, UBCH9: Ubiquitin-conjugating enzyme E2 E3 0.127 0.057
HCK N/A 0.127 0.253
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.127 0.057
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.127 0.127
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.126 0.045
TNF TNF, TNFA, TNFSF2: Tumor necrosis factor precursor 0.126 0.975
STAT4 STAT4: Signal transducer and activator of transcription 4 0.124 0.025
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.124 0.031
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.124 0.063
SOS1 SOS1: Son of sevenless homolog 1 0.124 0.031
UHRF1 0.109 0.0688
RNF113A RNF113A, RNF113, ZNF183: RING finger protein 113A 0.109 0.0688
RNF20 0.109 0.0688
MLL2 MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2 0.109 0.0688
OPTC OPTC, OPT: Opticin precursor 0.109 0.165
C20orf18 N/A 0.109 0.0688
C14orf4 C14orf4, KIAA1865, My039: RING finger protein C14orf4 0.109 0.0688
RFFL RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin 0.109 0.0688
BIRC4 BIRC4, API3, IAP3, XIAP: Baculoviral IAP repeat-containing protein 4 0.109 0.072
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.109 0.065
TNFRSF14 TNFRSF14, HVEA, UNQ329/PRO509, HVEM: Tumor necrosis factor receptor superfamily 0.108 0.050
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.105 0.057
TNFRSF11B TNFRSF11B, OCIF, OPG: Tumor necrosis factor receptor superfamily member 11B prec 0.105 0.200
TRAF1 TRAF1, EBI6: TNF receptor-associated factor 1 0.103 0.644
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.101 0.515
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.096 0.032
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.096 0.0453
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.096 0.032
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.096 0.057
CDK4 CDK4: Cell division protein kinase 4 0.096 0.037
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.096 0.032
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.096 0.166
CDK7 CDK7, MO15: Cell division protein kinase 7 0.096 0.037
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.096 0.124
LIMK2 LIMK2: LIM domain kinase 2 0.096 0.124
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.096 0.0453
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.096 0.075
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.096 0.0453
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.096 0.0453
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.096 0.037
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.096 0.062
PRKAA1 N/A 0.096 0.037
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.096 0.037
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.096 0.091
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.091 0.852
VIM VIM: Vimentin 0.091 0.085
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.087 0.027
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.087 0.036
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.087 0.036
DNM2 N/A 0.087 0.036
TPT1 TPT1: Translationally-controlled tumor protein 0.087 0.027
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.087 0.0446
GMIP GMIP: GEM-interacting protein 0.087 0.074
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.087 0.036
FLNA FLNA, FLN, FLN1: Filamin-A 0.087 0.0446
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.087 0.027
FUBP1 N/A 0.087 0.100
LCP1 LCP1, PLS2: Plastin-2 0.087 0.027
ACTG1 ACTB: Actin, cytoplasmic 1 0.087 0.036
SLC9A3R1 SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50 0.087 0.027
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.087 0.0446
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.087 0.0446
MSN MSN: Moesin 0.087 0.125
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.087 0.037
DIAPH1 Diaphanous 1 0.087 0.027
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.087 0.036
BCL2 BCL2: Apoptosis regulator Bcl-2 0.085 0.025
GIT2 N/A 0.083 0.049
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.083 0.049
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.083 0.049
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.083 0.049
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.083 0.049
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.083 0.049
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.083 0.049
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.083 0.049
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.083 0.049
MAP2K5 N/A 0.083 0.049
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.083 0.049
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.083 0.049
CDC2 CDC2: Cell division control protein 2 homolog 0.083 0.049
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.083 0.049
KIAA0031 EFTUD2, KIAA0031, SNRP116: 116 kDa U5 small nuclear ribonucleoprotein component 0.083 0.049
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.083 0.049
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.083 0.083
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.083 0.049
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.083 0.049
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.083 0.049
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.083 0.049
MAPK15 N/A 0.083 0.049
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.083 0.049
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.083 0.049
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.083 0.049
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.083 0.049
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.083 0.049
UBE2A UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A 0.083 0.049
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.083 0.049
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.083 0.049
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.083 0.049
MAPKAPK5 N/A 0.083 0.049
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.083 0.049
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.049
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.083 0.049
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.083 0.049
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.049
EEF2K EEF2K: Elongation factor 2 kinase 0.083 0.049
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.083 0.049
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.083 0.049
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.049
NXF1 NXF1, TAP: Nuclear RNA export factor 1 0.083 0.039
TRAF5 TRAF5, RNF84: TNF receptor-associated factor 5 0.083 0.143
MYLIP MYLIP, BZF1, BM-023, PP5242: E3 ubiquitin-protein ligase MYLIP 0.083 0.032
TNFSF12 TNFSF12, APO3L, UNQ181/PRO207, DR3LG: Tumor necrosis factor ligand superfamily m 0.082 4.07
CD40LG CD40LG, CD40L, TNFSF5, TRAP: CD40 ligand 0.082 1.20
MDM4 MDM4, MDMX: Mdm4 protein 0.081 0.045
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.081 0.051
GP9 GP9: Platelet glycoprotein IX precursor 0.081 0.251
TSHR N/A 0.081 0.123
BRCA1 BRCA1, RNF53: Breast cancer type 1 susceptibility protein 0.081 0.045
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.077 0.037
CDK2 CDK2: Cell division protein kinase 2 0.077 0.037
DAPK2 DAPK2: Death-associated protein kinase 2 0.077 0.057
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.077 0.075
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.077 0.057
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.077 0.0453
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 0.077 0.0453
KIAA0664 KIAA0664: Putative eukaryotic translation initiation factor 3 subunit 0.077 0.0453
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.077 0.032
HSP90AA1 Hsp89-alpha-delta-N 0.077 0.032
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.077 0.057
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.075 0.096
STAT2 STAT2: Signal transducer and activator of transcription 2 0.075 0.031
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.075 0.260
CREBBP CREBBP, CBP: CREB-binding protein 0.074 0.029
ITGB7 ITGB7: Integrin beta-7 precursor 0.074 0.152
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.074 0.210
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.072 0.051
TPBG TPBG, 5T4: Trophoblast glycoprotein precursor 0.072 0.152
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.072 0.041
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.072 0.152
COPE COPE: Coatomer subunit epsilon 0.070 0.027
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.070 0.027
VIL2 N/A 0.070 0.037
MPG N/A 0.070 0.027
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.070 0.036
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.070 0.027
DOK1 DOK1: Docking protein 1 0.070 0.036
RAD18 RAD18, RNF73: E3 ubiquitin-protein ligase RAD18 0.0688 0.109
C1QC C1QC, C1QG: Complement C1q subcomponent subunit C precursor 0.0688 0.109
CD14 CD14: Monocyte differentiation antigen CD14 precursor 0.067 0.515
TLR2 TLR2, TIL4: Toll-like receptor 2 precursor 0.067 0.515
TRIM21 TRIM21, RNF81, RO52, SSA1: 52 kDa Ro protein 0.067 0.065
SHOC2 SHOC2, KIAA0862: Leucine-rich repeat protein SHOC-2 0.067 0.032
RNH1 RNH1, PRI, RNH: Ribonuclease inhibitor 0.067 0.065
RABGGTA RABGGTA: Geranylgeranyl transferase type-2 subunit alpha 0.067 0.032
SIGIRR SIGIRR, UNQ301/PRO342: Single Ig IL-1-related receptor 0.065 0.041
GP1BA N/A 0.065 0.123
GP1BB GP1BB: Platelet glycoprotein Ib beta chain precursor 0.065 0.123
SLITRK5 SLITRK5, KIAA0918, LRRC11: SLIT and NTRK-like protein 5 precursor 0.065 0.110
MEP1B MEP1B: Meprin A subunit beta precursor 0.065 0.975
RNF11 RNF11, CGI-123: RING finger protein 11 0.065 0.045
TRIM25 TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25 0.064 0.166
C1QA C1QA: Complement C1q subcomponent subunit A precursor 0.063 0.126
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.063 0.126
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.062 0.032
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.062 0.032
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.062 0.037
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.062 0.037
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.062 0.037
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.062 0.032
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.062 0.029
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.062 0.029
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.062 0.032
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.062 0.032
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.062 0.057
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.060 0.060
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.057 0.025
CASP14 CASP14: Caspase-14 precursor 0.056 0.109
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.056 0.032
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.056 0.029
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.056 0.032
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.056 0.032
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.056 0.055
GFAP GFAP: Glial fibrillary acidic protein 0.056 0.029
NEF3 NEFM, NEF3, NFM: Neurofilament medium polypeptide 0.056 0.033
MYO3A MYO3A: Myosin IIIA 0.056 0.029
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.056 0.033
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.055 0.037
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.055 0.0453
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.055 0.032
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.055 0.0453
WEE1 WEE1: Wee1-like protein kinase 0.055 0.032
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.055 0.065
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.055 0.033
CDK5 CDK5: Cell division protein kinase 5 0.055 0.029
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.055 0.029
KRT1 KRT1, KRTA: Keratin, type II cytoskeletal 1 0.055 0.032
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.055 0.037
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.055 0.056
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.055 0.075
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.055 0.029
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.055 0.029
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.055 0.032
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.055 0.0453
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.055 0.032
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.055 0.032
CDKL5 N/A 0.055 0.0453
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.055 0.029
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.055 0.033
BFAR BFAR, BAR, RNF47: Bifunctional apoptosis regulator 0.053 0.0308
SPOP SPOP: Speckle-type POZ protein 0.053 0.214
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.052 0.04
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.052 0.04
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.052 0.04
VASP VASP: Vasodilator-stimulated phosphoprotein 0.052 0.074
LIMS1 N/A 0.052 0.0446
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.052 0.100
RGS19 RGS19, GAIP, GNAI3IP: Regulator of G-protein signaling 19 0.052 0.036
FRG1 FRG1: Protein FRG1 0.052 0.0453
PPP2R5A PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha 0.052 0.027
ALOX5 ALOX5, LOG5: Arachidonate 5-lipoxygenase 0.052 0.153
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.052 0.036
GSK3B N/A 0.052 0.027
UNC5D UNC5D, KIAA1777, UNQ6012/PRO34692, UNC5H4: Netrin receptor UNC5D precursor 0.051 0.051
CHD3 CHD3: Chromodomain-helicase-DNA-binding protein 3 0.051 0.051
PCGF6 PCGF6, MBLR, RNF134: Polycomb group RING finger protein 6 0.051 0.051
TRIM24 TRIM24, RNF82, TIF1, TIF1A: Transcription intermediary factor 1-alpha 0.051 0.051
C1QB N/A 0.051 0.051
ERBB2IP ERBB2IP, ERBIN, KIAA1225, LAP2: Protein LAP2 0.051 0.051
IFI16 IFI16, IFNGIP1: Gamma-interferon-inducible protein Ifi-16 0.051 0.051
IL1A IL1A, IL1F1: Interleukin-1 alpha precursor 0.051 0.081
TUFM TUFM: Elongation factor Tu, mitochondrial precursor 0.0513 0.031
CFP CFP, PFC: Properdin precursor 0.0513 0.340
LTA LTA, TNFB, TNFSF1: Lymphotoxin-alpha precursor 0.051 0.859
RPL3 RPL3, OK/SW-cl.32: 60S ribosomal protein L3 0.051 0.0453
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.051 0.057
FBXL5 FBXL5, FBL4, FBL5, FLR1: F-box/LRR-repeat protein 5 0.050 0.065
UBR2 UBR2, C6orf133, KIAA0349: E3 ubiquitin-protein ligase UBR2 0.050 0.039
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.049 0.029
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.049 0.029
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.049 0.029
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.049 0.029
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.049 0.032
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.049 0.037
BMX N/A 0.049 0.032
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.049 0.034
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.049 0.083
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.049 0.083
PSEN1 PSEN1, AD3, PS1, PSNL1: Presenilin-1 0.049 0.034
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.049 0.165
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.083
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.049 0.034
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.083
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.049 0.083
DSP DSP: Desmoplakin 0.049 0.049
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.049 0.034
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.083
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.049 0.034
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.048 0.046
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.048 0.0263
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.0453 0.062
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.0453 0.191
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.0453 0.152
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.0453 0.191
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.0453 0.062
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.0453 0.096
ADIPOQ ADIPOQ, ACDC, ACRP30, APM1, GBP28: Adiponectin precursor 0.045 0.081
CD69 CD69: Early activation antigen CD69 0.0446 0.062
CRLF3 N/A 0.0446 0.155
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.0446 0.515
CCR5 CCR5: CCR5 receptor (Fragment) 0.0446 0.032
CXCR4 CXCR4: C-X-C chemokine receptor type 4 0.0446 0.026
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.0446 0.191
CD44 N/A 0.0446 0.260
EDA N/A 0.044 1.30
RTN4R RTN4R, NOGOR, UNQ330/PRO526: Reticulon-4 receptor precursor 0.044 0.165
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.044 1.30
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.044 1.30
LRG1 LRG1, LRG: Leucine-rich alpha-2-glycoprotein precursor 0.044 0.165
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.044 1.30
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.044 0.033
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.044 0.026
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.044 0.026
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.044 0.029
PRPH PRPH, NEF4, PRPH1: Peripherin 0.044 0.029
TLN1 TLN1: Uncharacterized protein TLN1 0.0425 0.153
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.0425 0.074
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.0425 0.081
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.0425 0.027
AHNAK AHNAK: AHNAK protein 0.0425 0.027
SAT SAT1, SAT: Diamine acetyltransferase 1 0.0425 0.0446
WARS WARS, IFI53, WRS: Tryptophanyl-tRNA synthetase, cytoplasmic 0.0425 0.036
MDN1 MDN1, KIAA0301: Midasin 0.0425 0.029
RRAS RRAS: Ras-related protein R-Ras precursor 0.0425 0.036
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.0425 0.100
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.0425 0.036
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.0425 0.074
ZYX ZYX: Zyxin 0.0425 0.157
RGS2 RGS2, G0S8: Regulator of G-protein signaling 2 0.0425 0.074
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.041 0.124
TLR4 TLR4: Toll-like receptor 4 precursor 0.0407 0.416
TNFRSF10C TNFRSF10C, DCR1, UNQ321/PRO366, LIT, TRAILR3, TRID: Tumor necrosis factor recept 0.0407 0.416
TRAF6 TRAF6, RNF85: TNF receptor-associated factor 6 0.041 0.162
RUFY1 N/A 0.041 0.039
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.04 0.052
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.04 0.083
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.04 0.052
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.04 0.165
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.039 0.030
DES DES: Desmin 0.039 0.030
TRIM8 TRIM8: Uncharacterized protein TRIM8 0.039 0.037
TLR7 TLR7, UNQ248/PRO285: Toll-like receptor 7 precursor 0.039 0.0308
IL18RAP IL18RAP: Interleukin-18 receptor accessory protein precursor 0.039 0.0308
TNFSF10 TNFSF10: Uncharacterized protein TNFSF10 0.039 1.36
LRRC8D LRRC8D, LRRC5, UNQ213/PRO239: Leucine-rich repeat-containing protein 8D 0.039 0.0308
PKD1 PKD1: Polycystin-1 precursor 0.038 0.0338
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.037 0.070
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.037 0.070
PSEN2 PSEN2, AD4, PS2, PSNL2, STM2: Presenilin-2 0.037 0.031
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.037 0.062
PPL PPL, KIAA0568: Periplakin 0.037 0.025
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.037 0.096
KRT18 KRT18: Uncharacterized protein KRT18 0.037 0.031
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.037 0.096
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.036 0.0971
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.036 0.070
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.036 0.032
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.036 0.075
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.036 0.191
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.036 0.032
HLA-DRA 0.036 0.032
MCL1 MCL1: Induced myeloid leukemia cell differentiation protein Mcl-1 0.034 0.034
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.033 0.056
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.032 0.077
KIT KIT: Mast/stem cell growth factor receptor precursor 0.032 0.062
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.032 0.0446
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.032 0.081
FTH1 FTH1, FTH, OK/SW-cl.84, FTHL6, PIG15: Ferritin heavy chain 0.032 0.0446
THOP1 THOP1: Thimet oligopeptidase 0.032 0.081
RNF130 RNF130: Goliath homolog precursor 0.032 0.083
TLR1 TLR1, KIAA0012: Toll-like receptor 1 precursor 0.032 0.083
MNDA MNDA: Myeloid cell nuclear differentiation antigen 0.032 0.061
OSM OSM: Oncostatin-M precursor 0.031 0.0453
RASA3 RASA3: Ras GTPase-activating protein 3 0.030 0.037
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.029 0.123
MET MET: Hepatocyte growth factor receptor precursor 0.029 0.055
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.029 0.123
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.029 0.152
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.029 0.859
GP5 GP5: Platelet glycoprotein V precursor 0.029 0.109
MEP1A MEP1A: Meprin A subunit alpha precursor 0.029 0.859
TNFSF15 TNFSF15, RP11-428F18.1-001, hCG_27396: TNF superfamily ligand TL1A 0.029 0.859
COL1A2 COL1A2: Collagen alpha-2(I) chain precursor 0.029 0.027
COL5A2 COL5A2: Collagen alpha-2(V) chain precursor 0.029 0.027
CARD9 N/A 0.0288 0.0288
IRAK2 IRAK2: Interleukin-1 receptor-associated kinase-like 2 0.0288 0.0288
CIITA MHC class II transactivator CIITA 0.0288 0.0288
CIAS1 N/A 0.0288 0.0288
NFKB1 N/A 0.0288 0.0288
NOL3 NOL3, ARC, NOP: Nucleolar protein 3 0.0288 0.0288
ANK1 ANK1, ANK: Ankyrin-1 0.0288 0.0288
UNC5A N/A 0.0288 0.0288
ANK3 ANK3: Ankyrin-3 0.0288 0.0288
NALP7 NLRP7: NLRP7 protein 0.0288 0.0288
ANK1 N/A 0.0288 0.0288
ANK2 ANK2: Ankyrin-2 0.0288 0.0288
NULL N/A 0.0288 0.0288
CASP4 mih1/Tx: Mih1/Tx protein 0.0288 0.0288
CARD6 CARD6: Caspase recruitment domain-containing protein 6 0.0288 0.0288
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
NF2 NF2, SCH: Merlin 0.028 0.04
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.028 0.109
DPP8 DPP8, DPRP1, MSTP097, MSTP135, MSTP141: Dipeptidyl peptidase 8 0.028 0.049
SNX3 N/A 0.028 0.04
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.028 0.04
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.027 0.062
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.027 0.031
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.027 0.109
TJP1 TJP1, ZO1: Tight junction protein ZO-1 0.027 0.027
TRAF4 TRAF4, CART1, MLN62, RNF83: TNF receptor-associated factor 4 0.027 0.217
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.027 0.260
LTB4R LTB4R, BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7: Leukotriene B4 receptor 1 0.027 0.0425
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.027 0.251
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.027 0.077
PLSCR1 PLSCR1: Phospholipid scramblase 1 0.027 0.087
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.027 0.062
EDG1 EDG1: Sphingosine 1-phosphate receptor Edg-1 0.027 0.0425
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.027 0.077
CEBPB CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta 0.027 0.042
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.027 0.070
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.026 0.055
FKBP1A FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A 0.026 0.036
IRS2 IRS2: Insulin receptor substrate 2 0.026 0.027
PLD1 PLD1: Phospholipase D1 0.026 0.0263
BAD BAD, BBC6, BCL2L8: Bcl2 antagonist of cell death 0.0253 0.0253
MVP MVP, LRP: Major vault protein 0.025 0.0446
ARHGDIB ARHGDIB, GDIA2, GDID4, RAP1GN1: Rho GDP-dissociation inhibitor 2 0.025 0.027
KRT8 KRT8, CYK8: Keratin, type II cytoskeletal 8 0.025 0.031
0.228
Total Score 165.00