PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between MAPK1 and DUSP19

The interaction score between MAPK1 and DUSP19 is 10.90.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

N/A

Orthology

Organism	MAPK1 Orthologue		DUSP19 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
bakers yeast	YBL016W	1	YBR276C	0.066
bakers yeast	YGR040W	0.096	YBR276C	0.066
bakers yeast	YBL016W	1	YIL113W	0.066
bakers yeast	YGR040W	0.096	YIL113W	0.066
bakers yeast	YBL016W	1	YNL053W	0.066	Immunoprecipitation CoLocalization Get References From PubMed
bakers yeast	YGR040W	0.096	YNL053W	0.066
worm	P39745	1	Q95XK5	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.119

Domains

Domains present in MAPK1 and DUSP19:

Domains in MAPK1

Domains in DUSP19

IPR000719	Protein kinase
IPR002290	Serine/threonine protein kinase
IPR011009	Protein kinase-like
IPR008271	Serine/threonine protein kinase, active site
IPR003527	MAP kinase
IPR008349	ERK1/2 MAP kinase

IPR000387	Tyrosine specific protein phosphatase and dual specificity protein phosphatase
IPR000340	Dual specificity protein phosphatase

The Chi square scores for co-occurrence of domains that are present in MAPK1 and DUSP19 are listed below.

Domain 1		Domain 2		Chi Square
IPR003527	MAP kinase	IPR000340	Dual specificity protein phosphatase	575.549
IPR008349	ERK1/2 MAP kinase	IPR000340	Dual specificity protein phosphatase	317.529
IPR003527	MAP kinase	IPR000387	Tyrosine specific protein phosphatase and dual specificity protein phosphatase	128.642
IPR002290	Serine/threonine protein kinase	IPR000340	Dual specificity protein phosphatase	108.157
IPR008349	ERK1/2 MAP kinase	IPR000387	Tyrosine specific protein phosphatase and dual specificity protein phosphatase	89.8437
IPR008271	Serine/threonine protein kinase, active site	IPR000340	Dual specificity protein phosphatase	76.5901
IPR000719	Protein kinase	IPR000340	Dual specificity protein phosphatase	30.0934
IPR011009	Protein kinase-like	IPR000340	Dual specificity protein phosphatase	15.3476
IPR000719	Protein kinase	IPR000387	Tyrosine specific protein phosphatase and dual specificity protein phosphatase	14.0817
IPR002290	Serine/threonine protein kinase	IPR000387	Tyrosine specific protein phosphatase and dual specificity protein phosphatase	10.8808
IPR011009	Protein kinase-like	IPR000387	Tyrosine specific protein phosphatase and dual specificity protein phosphatase	6.38835
IPR008271	Serine/threonine protein kinase, active site	IPR000387	Tyrosine specific protein phosphatase and dual specificity protein phosphatase	2.56073

The background colour of the table refers to:

Blue Domain is only present in MAPK1
Yellow Domain is only present in DUSP19
Green Domain is present in both MAPK1 and DUSP19

0.265

Post-translational Modifications

Protein: MAPK1

PTM	Residue	Reference
Acetylation	2	PubMed, HPRD
Dephosphorylation	187	PubMed, HPRD
N-acetylalanine	1	HPRD
Phosphorylation	29	PubMed, HPRD
Phosphorylation	41	PubMed, HPRD
Phosphorylation	181	PubMed, HPRD
Phosphorylation	185	PubMed, HPRD
Phosphorylation	187	PubMed, HPRD
Phosphorylation	202	PubMed, HPRD
Phosphothreonine	184	PubMed, HPRD
Phosphotyrosine	186	HPRD

Protein: DUSP19

PTM	Residue	Reference

Localisation

Protein: MAPK1

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD
Cytoskeleton	HPRD

Protein: DUSP19

Localisation	Reference
Cytoplasm	HPRD

Transitive Score

The common interactors between MAPK1 and DUSP19 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andDUSP19. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and DUSP19 has 136 interactors of which there are 57 common interactors.

Common Interactor	Name of Common Interactor	Score for MAPK1-Interactor (?)	Score for DUSP19-Interactor (?)
MAPK3	MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3	153.00	6.75
LCP2	LCP2: Lymphocyte cytosolic protein 2	0.416	0.027
ROCK1	ROCK1: Rho-associated protein kinase 1	0.307	0.027
IRS2	IRS2: Insulin receptor substrate 2	0.251	0.027
PIK3CD	PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i	0.210	0.027
TLK1	TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1	0.210	0.027
IKBKB	IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta	0.210	0.027
STAT2	STAT2: Signal transducer and activator of transcription 2	0.191	0.027
SCYL3	SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin	0.188	0.027
NF2	NF2, SCH: Merlin	0.165	0.027
MAP3K5	MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5	0.155	0.027
SRPK2	SRPK2: Serine/threonine-protein kinase SRPK2	0.155	0.027
RIPK1	RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1	0.155	0.027
MAP2K3	MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki	0.127	0.027
MAP3K8	MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8	0.127	0.027
MAPKAPK2	MAPKAPK2: MAP kinase-activated protein kinase 2	0.127	0.027
MAP4K1	MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1	0.127	0.027
MAPK6	MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6	0.127	0.027
CBLC	CBLC, CBL3, RNF57: Signal transduction protein CBL-C	0.109	0.027
IRS1	IRS1: Insulin receptor substrate 1	0.098	0.027
ICK	ICK, KIAA0936: Serine/threonine-protein kinase ICK	0.096	0.027
PRKR	EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki	0.096	0.027
FRAP1	FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein	0.096	0.027
MAP3K14	MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14	0.096	0.027
MAPKAPK5	N/A	0.083	0.027
MAPK8	MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8	0.083	0.217
CDC2L2	CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2	0.083	0.027
MAPK9	MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9	0.083	0.265
BMP2K	BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase	0.083	0.027
MINK1	MAP4K6, MINK1, MINK: Misshapen-like kinase 1	0.083	0.027
MAPK10	MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10	0.083	0.217
MAPK15	N/A	0.083	0.265
DYRK1A	DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin	0.083	0.027
CDC2L1	CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1	0.083	0.027
PKN1	PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1	0.083	0.027
MAPK4	MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4	0.077	0.027
PASK	PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase	0.077	0.027
NEK3	NEK3: Serine/threonine-protein kinase Nek3	0.077	0.027
PRKAA1	N/A	0.077	0.027
STK16	N/A	0.077	0.027
KIAA1804	MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase	0.075	0.027
CDK6	CDK6: Cell division protein kinase 6	0.069	0.027
SNF1LK2	SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2	0.069	0.027
PBK	PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase	0.069	0.027
MAP3K11	MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11	0.069	0.027
NEK1	NEK1, KIAA1901: Serine/threonine-protein kinase Nek1	0.062	0.027
ZAK	MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT	0.062	0.027
WEE1	WEE1: Wee1-like protein kinase	0.056	0.027
MAPK13	MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13	0.056	0.195
GRK1	GRK1, RHOK: Rhodopsin kinase precursor	0.055	0.027
TP73	TP73, P73: Tumor protein p73	0.055	0.027
MOS	MOS: Proto-oncogene serine/threonine-protein kinase mos	0.050	0.027
CDKL5	N/A	0.049	0.027
DAPK2	DAPK2: Death-associated protein kinase 2	0.049	0.027
MAPK12	MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12	0.049	0.237
DOK5	DOK5, C20orf180: Docking protein 5	0.027	0.027
TESK1	TESK1: Dual specificity testis-specific protein kinase 1	0.026	0.027

2.15E-3

Total Score

10.90