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Evidence of Interaction Between EPOR and LCP2

The interaction score between EPOR and LCP2 is 4.12.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EPOR and LCP2 = -0.02

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.62E-3
Orthology N/A N/A
Domains Domains present in EPOR and LCP2:
Domains in EPORDomains in LCP2
IPR003961 Fibronectin, type III
IPR003528 Long hematopoietin receptor, single chain
IPR009167 Erythropoietin receptor
IPR002996 Cytkn_recept_B/G.
IPR001660 Sterile alpha motif SAM
IPR010993 Sterile alpha motif homology
IPR000980 SH2 motif
IPR011510 SAM_2.
IPR013761 Sterile alpha motif-type

The Chi square scores for co-occurrence of domains that are present in EPOR and LCP2 are listed below.

Domain 1Domain 2Chi Square
IPR002996 Cytkn_recept_B/G. IPR000980 SH2 motif 227.343
IPR003961 Fibronectin, type III IPR000980 SH2 motif 184.508
IPR003528 Long hematopoietin receptor, single chain IPR000980 SH2 motif 151.135
IPR009167 Erythropoietin receptor IPR000980 SH2 motif 38.4825
IPR003961 Fibronectin, type III IPR011510 SAM_2. 37.1988
IPR003961 Fibronectin, type III IPR001660 Sterile alpha motif SAM 17.7672
IPR003961 Fibronectin, type III IPR010993 Sterile alpha motif homology 5.65123
IPR003961 Fibronectin, type III IPR013761 Sterile alpha motif-type 0.873391

The background colour of the table refers to:

  • Blue Domain is only present in EPOR
  • Yellow Domain is only present in LCP2
  • Green Domain is present in both EPOR and LCP2

 0.069
Post-translational Modifications

Protein: EPOR

PTMResidueReference
Phosphorylation 368 PubMed, HPRD
Phosphorylation 426 PubMed, HPRD
Phosphorylation 454 PubMed, HPRD
Phosphorylation 456 PubMed, HPRD
Phosphorylation 468 PubMed, HPRD
Phosphorylation 485 PubMed, HPRD
Phosphorylation 489 PubMed, HPRD
Phosphorylation 504 PubMed, HPRD

Protein: LCP2

PTMResidueReference
Dephosphorylation 113 PubMed, HPRD
Phosphorylation 113 PubMed, HPRD
Phosphorylation 128 PubMed, HPRD
Phosphorylation 145 PubMed, HPRD
Phosphorylation 173 PubMed, HPRD
Phosphorylation 207 PubMed, HPRD
Phosphorylation 423 PubMed, HPRD
Phosphorylation 426 PubMed, HPRD
Phosphoserine 207 HPRD
Localisation

Protein: EPOR

LocalisationReference
ER HPRD
Plasma membrane HPRD
Secreted HPRD

Protein: LCP2

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between EPOR and LCP2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EPOR andLCP2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EPOR has 1024 interactors and LCP2 has 1634 interactors of which there are 629 common interactors.

Common InteractorName of Common InteractorScore for EPOR-Interactor (?)Score for LCP2-Interactor (?)
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 3.59 0.072
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.541 0.152
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.340 0.126
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.253 0.0263
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.251 0.123
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.210 0.128
HSP90AA1 Hsp89-alpha-delta-N 0.202 0.0453
CRLF3 N/A 0.191 0.354
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.191 0.046
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.166 0.251
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.166 0.109
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.166 0.081
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.165 0.0688
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.165 0.540
CNTN4 CNTN4: Contactin-4 precursor 0.165 0.0688
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.0688
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.540
FN1 N/A 0.165 0.0688
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.0688
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.540
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.0688
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.0688
BSG N/A 0.165 0.0688
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.165 0.540
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.0688
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.165 0.0688
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.540
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.165 0.540
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.165 0.0688
CNTN1 CNTN1: Contactin-1 precursor 0.165 0.0688
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.540
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.165 0.0688
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.0688
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.165 0.0688
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.165 0.0688
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.0688
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.165 0.0688
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.165 0.0688
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.153 0.191
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.153 0.152
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.152 0.045
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.152 0.355
KIT KIT: Mast/stem cell growth factor receptor precursor 0.152 0.403
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.127 0.166
CRKL CRKL: Crk-like protein 0.126 0.166
EFNB1 EFNB1, EFL-3, EPLG2, LERK2: Ephrin-B1 precursor 0.126 0.355
RDX RDX: Radixin 0.126 0.065
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.126 0.191
GAB1 GAB1: GRB2-associated-binding protein 1 0.126 0.109
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.126 2.46
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.126 0.191
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.126 0.041
CD2AP CD2AP: CD2-associated protein 0.126 0.166
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.125 0.0425
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.125 0.032
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.124 0.109
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.123 0.045
INSR INSR: Insulin receptor precursor 0.123 0.320
IL9R IL9R: Interleukin-9 receptor precursor 0.123 0.045
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.123 0.355
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.123 0.046
GHR GHR: Growth hormone receptor precursor 0.123 0.045
DCC DCC: Netrin receptor DCC precursor 0.123 0.041
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.123 0.041
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.123 0.128
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.123 0.320
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.123 0.045
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.123 0.046
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.123 0.046
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.123 0.403
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.123 0.286
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.123 0.320
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.110 0.0794
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.109
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.109 0.165
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.165
STAT3 0.109 0.109
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.109 0.109
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.109 0.165
MAPK15 N/A 0.109 0.165
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 0.980
PSCD2 N/A 0.109 0.109
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.109 0.109
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.109 0.165
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.109
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.109 0.109
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 0.980
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.109 0.165
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.109 0.109
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.109 0.109
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.109
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.109 0.165
ARHGEF7 N/A 0.109 0.109
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.109
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.109 0.109
ELMO1 N/A 0.109 0.165
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 0.0688
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.109 0.165
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.109 0.109
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.109 0.109
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 0.109
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 0.980
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.109 0.165
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 0.109
NF2 NF2, SCH: Merlin 0.109 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 0.109
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.109 0.540
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.109 0.980
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.109
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.109 0.109
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.109
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.109 0.980
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.109 0.046
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.109 0.081
PRLR PRLR: Prolactin receptor precursor 0.109 0.041
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.109 0.320
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.109 0.360
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.109 0.045
F3 F3: Tissue factor precursor 0.109 0.041
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.109 0.173
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.109 0.041
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.109 1.00
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.109 0.045
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.109 0.045
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.109 0.360
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.109 0.173
ITGB4 N/A 0.109 0.041
MET MET: Hepatocyte growth factor receptor precursor 0.109 0.360
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.109 0.360
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.109 0.403
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.109 0.214
TNC TNC, HXB: Tenascin precursor 0.109 0.041
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.109 0.360
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.109 0.757
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.109 0.360
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.109 0.058
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.109 0.045
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.109 0.046
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.109 0.041
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.109 0.063
SORL1 SORL1: Sortilin-related receptor precursor 0.109 0.354
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.109 0.105
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.105 0.088
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.100 0.166
TLN1 TLN1: Uncharacterized protein TLN1 0.100 0.166
PLD2 PLD2: Phospholipase D2 0.100 0.081
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.100 0.416
DOK1 DOK1: Docking protein 1 0.100 0.416
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.100 0.515
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.100 0.274
CP CP: Ceruloplasmin precursor 0.100 0.041
STAM2 STAM2: Signal transducing adapter molecule 2 0.100 0.081
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.100 0.731
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.100 1.48
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.100 3.05
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.100 0.126
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.100 0.515
RPS6KB1 N/A 0.100 0.416
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.098 0.036
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.098 0.355
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.098 0.286
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.098 0.355
PTPRZ1 N/A 0.098 0.041
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 0.214
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.098 0.041
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.098 0.041
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.098 0.041
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.098 0.360
NEO1 NEO1, NGN: Neogenin precursor 0.098 0.046
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.098 0.360
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.098 0.360
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.098 0.403
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.096 0.0794
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.091 0.152
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.091 0.307
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.091 0.123
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.091 0.109
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.087 0.039
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.083 0.0688
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.083 0.0688
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.083 0.0688
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.083 0.034
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.083 0.0688
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.083 0.109
ATRN N/A 0.083 0.034
KIR3DL1 N/A 0.083 0.0688
SEMA4B SEMA4B: Sema domain, immunoglobulin domain 0.083 0.034
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.083 0.0688
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.083 0.0688
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.081 0.251
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.081 0.0453
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.081 0.0727
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.081 0.123
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.081 0.039
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.081 0.515
DLG2 DLG2: Disks large homolog 2 0.081 0.046
SORBS3 SORBS3, SCAM1: Vinexin 0.081 0.065
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.081 0.202
STK16 N/A 0.081 0.191
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.081 0.251
SYK SYK: Tyrosine-protein kinase SYK 0.081 1.81
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.081 0.561
STAT6 STAT6: Signal transducer and activator of transcription 6 0.081 0.561
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.081 0.166
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.081 0.081
IRS2 IRS2: Insulin receptor substrate 2 0.081 0.191
TLN2 TLN2: Uncharacterized protein TLN2 0.081 0.058
F5 F5: Coagulation factor V precursor 0.081 0.063
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.081 0.051
RIN1 RIN1: Ras and Rab interactor 1 0.081 0.123
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.081 0.416
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.081 0.126
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.081 0.416
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.081 0.561
HCK N/A 0.081 2.46
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.077 0.105
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.077 0.0513
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.077 0.202
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.077 0.173
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.075 0.416
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.075 0.416
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.075 0.100
WEE1 WEE1: Wee1-like protein kinase 0.075 0.109
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.075 0.126
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.075 0.098
CDK2 CDK2: Cell division protein kinase 2 0.075 0.152
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.075 0.123
SPTAN1 N/A 0.0727 0.065
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.072 0.166
IRS1 IRS1: Insulin receptor substrate 1 0.072 0.098
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.072 0.045
CXorf9 N/A 0.072 0.852
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.072 0.251
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.072 0.041
PSD TYL: TYL protein 0.072 0.072
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.072 0.416
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.072 0.515
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.072 0.852
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.072 0.072
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.072 0.581
PSCD4 PSCD4, CYT4: Cytohesin-4 0.072 0.561
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.072 1.19
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.072 0.072
ROCK1 ROCK1: Rho-associated protein kinase 1 0.072 0.307
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.072 0.644
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.072 5.04
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.072 0.081
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.072 0.173
TTN N/A 0.072 0.109
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.072 0.046
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.072 0.519
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.072 0.041
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.072 0.041
VIL2 N/A 0.072 0.126
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.072 1.19
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.072 0.274
GAB2 N/A 0.072 0.191
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.072 0.644
BMX N/A 0.072 0.581
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.072 0.286
LYN LYN: Tyrosine-protein kinase Lyn 0.072 2.46
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.072 0.307
MSN MSN: Moesin 0.072 0.561
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.072 5.04
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.072 0.098
VAV1 VAV1, VAV: Proto-oncogene vav 0.072 0.561
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.072 0.340
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.072 0.581
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.072 0.088
FNBP1 N/A 0.072 0.515
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.072 2.46
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.072 0.561
PLD1 PLD1: Phospholipase D1 0.072 0.072
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.072 0.561
CTTN CTTN, EMS1: Src substrate cortactin 0.072 0.058
ALK ALK: ALK tyrosine kinase receptor precursor 0.072 0.403
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.072 0.251
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.072 5.04
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.072 0.065
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.072 0.065
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.072 0.340
JAK1 0.072 5.04
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.072 0.731
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.072 0.046
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.072 0.098
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.072 0.274
CSK CSK: Tyrosine-protein kinase CSK 0.072 3.05
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.072 0.731
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.072 0.123
MCF2 MCF2, DBL: Proto-oncogene DBL 0.072 0.065
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.0688 0.165
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.0688 0.165
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.0688 0.165
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.067 0.162
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.065 0.0727
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.065 0.123
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.065 0.581
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.065 0.251
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.065 0.152
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.065 1.20
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.065 0.126
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.065 0.110
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.065 0.515
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.065 0.065
APS SH2B2, APS: SH2B adapter protein 2 0.065 0.072
NCK2 NCK2: Cytoplasmic protein NCK2 0.065 0.202
RASA3 RASA3: Ras GTPase-activating protein 3 0.065 0.274
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.065 0.088
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.065 0.065
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.065 0.065
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.065 0.0727
F8 F8, F8C: Coagulation factor VIII precursor 0.065 0.041
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 0.852
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.062 0.063
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.062 0.274
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.062 0.105
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.062 0.128
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.062 0.063
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.062 0.045
CD44 N/A 0.062 0.049
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.062 0.354
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.062 0.354
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.061 0.070
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.057 0.109
CDK6 CDK6: Cell division protein kinase 6 0.057 0.152
DYRK3 N/A 0.057 0.098
CDK4 CDK4: Cell division protein kinase 4 0.057 0.123
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.057 0.515
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.057 0.340
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.056 0.081
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.055 0.045
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.055 0.757
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.055 0.128
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.055 0.041
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.055 0.354
LILRB1 N/A 0.055 0.128
CD7 CD7: T-cell antigen CD7 precursor 0.055 0.354
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.055 0.354
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.055 0.757
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.055 0.105
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.055 0.041
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.055 0.063
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.055 0.025
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.055 0.105
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.055 0.214
EGF EGF: Pro-epidermal growth factor precursor 0.055 0.045
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.055 0.757
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.055 0.041
GPA33 GPA33: Cell surface A33 antigen precursor 0.055 0.063
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.055 0.045
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.055 0.051
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.055 0.0794
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.055 0.046
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.055 0.128
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.055 0.0794
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.055 0.041
DLG1 DLG1: Disks large homolog 1 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.617
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.617
CRK CRK: Proto-oncogene C-crk 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.051 0.051
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.051 0.051
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
PHC3 PHC3, EDR3, PH3: Polyhomeotic-like protein 3 0.051 0.051
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.617
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.051 0.617
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.617
GRB10 N/A 0.051 0.051
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.051 0.051
TJP2 TJP2, X104, ZO2: Tight junction protein ZO-2 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
UNC5D UNC5D, KIAA1777, UNQ6012/PRO34692, UNC5H4: Netrin receptor UNC5D precursor 0.051 0.051
NCAM1 N/A 0.051 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.051 0.051
PAPPA PAPPA: Pappalysin-1 precursor 0.051 0.051
DBNL DBNL, CMAP, PP5423, SH3P7: Drebrin-like protein 0.051 0.051
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.051 0.051
PTPRA N/A 0.051 0.051
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
EPB41 EPB41, E41P: Protein 4.1 0.051 0.051
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.051 0.051
RAPH1 N/A 0.051 0.051
ITIH3 ITIH3: Inter-alpha-trypsin inhibitor heavy chain H3 precursor 0.051 0.051
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.051 0.051
C9orf88 N/A 0.051 0.051
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
STIM1 STIM1, GOK: Stromal interaction molecule 1 precursor 0.051 0.051
BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 0.051 0.051
FLT4 VEGFR3 long form 0.051 0.617
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.051 0.109
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.051 0.416
TP73 TP73, P73: Tumor protein p73 0.051 0.109
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.0513 0.260
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.049 0.041
PVR PVR, PVS: Poliovirus receptor precursor 0.049 0.046
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.049 0.036
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.049 0.046
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.049 0.173
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.049 0.041
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.049 0.045
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.049 0.165
PPEF1 N/A 0.049 0.052
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.049 0.165
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.049 0.0688
MAP2K5 N/A 0.049 0.109
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.049 0.165
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.049 0.04
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.049 0.165
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.049 0.165
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.109
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.049 0.165
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.049 0.165
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.049 0.165
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.165
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.049 0.165
CNN2 CNN2: Calponin-2 0.049 0.109
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.049 0.165
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.049 0.165
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.049 0.165
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.049 0.165
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.049 0.049
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.049 0.165
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.049 0.165
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.109
CDC2 CDC2: Cell division control protein 2 homolog 0.049 0.165
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.049 0.04
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.049 0.165
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.049 0.165
MAPKAPK5 N/A 0.049 0.165
S100A16 S100A16, AAG13: Protein S100-A16 0.049 0.04
EEF2K EEF2K: Elongation factor 2 kinase 0.049 0.165
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.049 0.165
ACTN4 ACTN4: Alpha-actinin-4 0.049 0.049
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.049 0.04
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.049 0.04
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.165
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.049 0.049
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.049 0.0688
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.047 0.038
TNN TNN: Tenascin-N precursor 0.047 0.047
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.046 0.098
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.0453 0.307
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0453 0.123
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.0453 0.253
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.0453 0.0425
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0453 0.251
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.0453 0.123
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.0453 0.416
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.0453 0.100
FUBP1 N/A 0.0453 0.153
DAB1 DAB1: Disabled homolog 1 0.0453 0.098
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.0453 0.251
LIMK2 LIMK2: LIM domain kinase 2 0.0453 0.126
STAT2 STAT2: Signal transducer and activator of transcription 2 0.045 0.251
PLEK PLEK, P47: Pleckstrin 0.045 0.416
SOS1 SOS1: Son of sevenless homolog 1 0.045 0.416
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.045 0.852
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.045 0.098
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 0.0446 0.037
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.0446 0.027
COL12A1 COL12A1, COL12A1L: Collagen alpha-1(XII) chain precursor 0.044 0.0688
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.044 0.056
EFNA1 EFNA1, EPLG1, LERK1, TNFAIP4: Ephrin-A1 precursor 0.044 1.53
PCAF PCAF: Histone acetyltransferase PCAF 0.042 0.191
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.041 0.251
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.041 0.123
CENTA1 CENTA1: Centaurin-alpha 1 0.041 0.0794
STAT4 STAT4: Signal transducer and activator of transcription 4 0.041 0.852
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.04 0.028
XRCC1 XRCC1: DNA-repair protein XRCC1 0.039 0.080
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.039 0.032
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.038 0.0782
COPA COPA: Coatomer subunit alpha 0.037 0.0425
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.037 0.032
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.037 0.515
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.037 0.032
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.037 0.036
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.037 0.126
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.037 0.126
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.037 0.110
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.037 0.307
NEDD4L NEDD4L, KIAA0439, NEDL3: E3 ubiquitin-protein ligase NEDD4-like protein 0.037 0.0277
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.037 0.045
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.037 0.307
VASP VASP: Vasodilator-stimulated phosphoprotein 0.037 0.274
STK10 STK10: Uncharacterized protein STK10 0.037 1.81
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.037 0.416
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.037 0.152
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.037 0.191
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.037 0.098
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.037 0.074
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.037 0.307
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.037 0.416
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.037 0.045
FLII FLII, FLIL: Protein flightless-1 homolog 0.037 0.036
CDK7 CDK7, MO15: Cell division protein kinase 7 0.037 0.152
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.037 0.251
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.037 0.081
CSPG2 N/A 0.037 0.105
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.037 0.046
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.037 0.206
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.037 5.45
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.037 0.152
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.037 0.152
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.037 0.123
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.037 0.191
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.0338 0.034
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.0338 0.0782
CETN1 CETN1, CEN1, CETN: Centrin-1 0.034 0.052
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.034 0.028
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.034 0.165
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.034 0.165
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.034 0.165
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.033 0.340
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.032 0.561
PMP2 PMP2: Myelin P2 protein 0.032 0.029
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.032 0.098
ATM ATM: Serine-protein kinase ATM 0.032 0.852
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.032 0.123
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.061
GMIP GMIP: GEM-interacting protein 0.032 0.253
CDKL5 N/A 0.032 0.109
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.032 0.041
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.191
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.032 0.110
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.032 0.191
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.032 0.029
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.032 0.081
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.032 0.123
MYO3A MYO3A: Myosin IIIA 0.032 0.110
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.032 0.032
DAPK2 DAPK2: Death-associated protein kinase 2 0.032 0.109
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.032 0.046
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.032 0.253
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.032 0.098
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.032 0.251
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.032 0.100
ACTN1 ACTN1: Alpha-actinin-1 0.032 0.0453
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.032 0.046
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.032 0.046
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.032 0.852
LCP1 LCP1, PLS2: Plastin-2 0.032 0.206
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.032 0.202
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.032 0.037
GRLF1 N/A 0.032 0.049
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.032 0.041
VWF VWF, F8VWF: von Willebrand factor precursor 0.032 0.041
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.032 0.109
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.032 0.251
MYL3 MYL3: Myosin light polypeptide 3 0.032 0.0263
S100A7 S100A7, PSOR1: Protein S100-A7 0.032 0.0263
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.032 0.110
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.032 0.123
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.032 0.034
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.032 0.123
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.032 0.110
CHP CHP: Calcium-binding protein p22 0.032 0.046
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.032 0.191
PRKAA1 N/A 0.032 0.251
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.032 0.109
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.032 0.307
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.032 0.109
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.032 0.416
DAB2 DAB2, DOC2: Disabled homolog 2 0.032 0.109
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.032 0.030
MTMR3 MTMR3, KIAA0371, ZFYVE10: Myotubularin-related protein 3 0.032 0.039
TP53 TP53, P53: Cellular tumor antigen p53 0.031 0.096
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.031 0.032
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.031 0.052
MDN1 MDN1, KIAA0301: Midasin 0.030 0.052
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.065
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.029 0.046
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.029 0.098
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.029 0.110
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.029 0.110
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.029 0.041
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.029 0.101
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.029 0.046
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.029 0.852
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.029 0.110
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.029 0.123
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.251
CDK5 CDK5: Cell division protein kinase 5 0.029 0.123
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.029 0.100
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.029 0.098
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.152
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.029 0.041
CNN3 CNN3: Calponin-3 0.029 0.058
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.029 0.045
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.029 0.065
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.029 0.0416
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.028 0.034
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.028 0.0688
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.028 0.0688
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.028 0.034
LAT LAT: Linker for activation of T-cells family member 1 0.028 0.0688
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.028 0.0688
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.028 0.034
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.028 0.034
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.028 0.0688
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.028 0.034
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.028 0.034
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.028 0.034
FGFR2 N/A 0.027 0.141
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.217
DDR1 DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE: Epithelial discoidin domain-con 0.027 0.141
PIM1 N/A 0.027 0.041
RIOK3 RIOK3, SUDD: Serine/threonine-protein kinase RIO3 0.027 0.0308
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.027 0.026
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.027 0.081
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.027 0.070
WWOX WWOX, FOR, WOX1: WW domain-containing oxidoreductase 0.0263 0.030
GNB2L1 Lung cancer oncogene 7 0.025 0.052
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.025 0.251
ETS2 ETS2: Protein C-ets-2 0.025 0.152
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.025 0.307
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.025 0.191
NUP214 N/A 0.025 0.052
0.228
Total Score 4.12