PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between LIG1 and FEN1

The interaction score between LIG1 and FEN1 is 2.90E3.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between LIG1 and FEN1 = 0.82

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.027

Orthology

Organism	LIG1 Orthologue		FEN1 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
bakers yeast	YDL164C	1	YKL113C	1	ReconstitutedComplex Get References From PubMed
worm	Q27474	1	Q9N3T2	1
fly	Q960P4	1	O96830	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593

Domains

No domains were used in calculating likelihood of interaction

4.85E-3

Post-translational Modifications

Protein: LIG1

PTM	Residue	Reference
Phosphorylation	66	PubMed, HPRD
Phosphorylation	76	PubMed, HPRD
Phosphorylation	141	PubMed, HPRD
Phosphorylation	195	PubMed, HPRD
Phosphorylation	911	PubMed, HPRD
Phosphoserine	66	HPRD
Phosphoserine	76	HPRD
Phosphoserine	141	HPRD
Phosphoserine	911	HPRD
Phosphothreonine	195	HPRD

Protein: FEN1

PTM	Residue	Reference
Acetylation	354	PubMed, HPRD
Acetylation	375	PubMed, HPRD
Acetylation	377	PubMed, HPRD
Acetylation	380	PubMed, HPRD
Phosphorylation	187	PubMed, HPRD

Localisation

Protein: LIG1

Localisation	Reference
Nucleus	HPRD
Nucleoplasm	HPRD

Protein: FEN1

Localisation	Reference
Nucleus	HPRD
Nucleolus	HPRD

Transitive Score

The common interactors between LIG1 and FEN1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between LIG1 andFEN1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , LIG1 has 892 interactors and FEN1 has 145 interactors of which there are 82 common interactors.

Common Interactor	Name of Common Interactor	Score for LIG1-Interactor (?)	Score for FEN1-Interactor (?)
PCNA	PCNA: Proliferating cell nuclear antigen	73.00	38.00
ADPRT	PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1	0.704	0.081
TOP2A	TOP2A, TOP2: DNA topoisomerase 2-alpha	0.307	0.160
RBMX	RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G	0.307	0.053
PRKDC	PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit	0.307	0.025
ESPL1	N/A	0.307	0.053
TRIM28	TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta	0.307	0.025
EIF3S9	EIF3S9: Eukaryotic translation initiation factor 3 subunit 9	0.276	0.0479
ANP32B	ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb	0.276	0.0479
SNRPD1	SNRPD1: Small nuclear ribonucleoprotein Sm D1	0.276	0.0479
CBX3	CBX3: Chromobox protein homolog 3	0.276	0.0479
MSH6	MSH6, GTBP: DNA mismatch repair protein MSH6	0.276	0.0479
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.276	0.0479
KIF11	N/A	0.276	0.144
HMGB2	HMGB2, HMG2: High mobility group protein B2	0.276	0.144
TIMELESS	TIMELESS, TIM, TIM1, TIMELESS1: Protein timeless homolog	0.276	0.0479
MCM2	MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2	0.276	0.144
MCM3	MCM3: DNA replication licensing factor MCM3	0.276	0.144
BAZ1B	BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain	0.144	0.025
CENPA	CENPA: Histone H3-like centromeric protein A	0.144	0.053
PTMA	N/A	0.144	0.025
HMGN2	HMGN2, HMG17: Non-histone chromosomal protein HMG-17	0.144	0.025
E2F1	E2F1, RBBP3: Transcription factor E2F1	0.144	0.053
UBAP2L	UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like	0.144	0.025
MKI67	MKI67: Antigen KI-67	0.144	0.053
MLH1	MLH1, COCA2: DNA mismatch repair protein Mlh1	0.141	0.0479
MCM4	MCM4, CDC21: DNA replication licensing factor MCM4	0.129	0.144
CCNB1	Cyclin B1	0.129	0.0479
TUBB	TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain	0.129	0.0479
H2AFX	H2AFX, H2AX: Histone H2A.x	0.129	0.0479
CDC20	CDC20: Cell division cycle protein 20 homolog	0.129	0.0479
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	0.129	0.0479
NUP153	N/A	0.129	0.0479
POLA2	POLA2: DNA polymerase subunit alpha B	0.129	0.0479
MYBL2	MYBL2, BMYB: Myb-related protein B	0.129	0.0479
CDK4	CDK4: Cell division protein kinase 4	0.129	0.0479
SMC1L1	SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos	0.129	0.0479
CHEK1	CHEK1, CHK1: Serine/threonine-protein kinase Chk1	0.129	0.0479
CDC6	CDC6, CDC18L: Cell division control protein 6 homolog	0.129	0.0479
CHAF1B	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B	0.129	0.0479
CDK2	CDK2: Cell division protein kinase 2	0.129	0.0479
CSPG6	SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3	0.129	0.0479
VRK1	VRK1: Serine/threonine-protein kinase VRK1	0.129	0.144
SFRS1	SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1	0.129	0.0479
LMNB1	LMNB1, LMN2, LMNB: Lamin-B1	0.129	0.0479
XRCC6	XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1	0.087	0.025
KIF23	N/A	0.087	0.025
AURKA	AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6	0.078	0.0479
BIRC5	BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5	0.074	0.053
STOML2	STOML2, SLP2, HSPC108: Stomatin-like protein 2	0.074	0.025
RRM2	RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2	0.066	0.144
CCT2	CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta	0.066	0.0479
CTPS	CTPS: CTP synthase 1	0.066	0.0479
CCT6A	CCT6A, CCT6, CCTZ: T-complex protein 1 subunit zeta	0.066	0.0479
RAN	RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran	0.066	0.0479
COPS3	COPS3, CSN3: COP9 signalosome complex subunit 3	0.066	0.0479
RACGAP1	RACGAP1, KIAA1478, MGCRACGAP: Rac GTPase-activating protein 1	0.066	0.0479
TK1	TK1: Thymidine kinase, cytosolic	0.066	0.0479
TPX2	TPX2, C20orf1, C20orf2, DIL2, HCA519: Targeting protein for Xklp2	0.053	0.053
DKC1	DKC1, NOLA4: H/ACA ribonucleoprotein complex subunit 4	0.0479	0.0479
PA2G4	PA2G4, EBP1: Proliferation-associated protein 2G4	0.0479	0.0479
EZH2	EZH2: Enhancer of zeste homolog 2	0.0479	0.0479
SLBP	SLBP, HBP: Histone RNA hairpin-binding protein	0.0479	0.0479
KNTC2	KNTC2, HEC, HEC1: Kinetochore protein Hec1	0.0479	0.144
RANGAP1	RANGAP1, SD: Ran GTPase-activating protein 1	0.0446	0.025
STIP1	STIP1: Stress-induced-phosphoprotein 1	0.036	0.025
RPS10	RPS10: 40S ribosomal protein S10	0.032	1.49
SMC4L1	N/A	0.027	0.082
KIAA0101	PAF, KIAA0101, L5, NS5ATP9: PCNA-associated factor	0.027	0.082
ZWINT	N/A	0.027	0.082
TMPO	N/A	0.027	0.027
C18orf56	N/A	0.027	0.082
C22orf18	N/A	0.027	0.027
MCM10	N/A	0.027	0.027
RAD51AP1	N/A	0.027	0.027
PTTG1	PTTG1, EAP1, PTTG, TUTR1: Securin	0.025	0.025
PTGES3	PTGES3, P23, TEBP: Prostaglandin E synthase 3	0.025	0.053
TACC3	TACC3, ERIC1: Transforming acidic coiled-coil-containing protein 3	0.025	0.025
GMNN	GMNN: Geminin	0.025	0.160
GTSE1	GTSE1: G2 and S phase-expressed protein 1	0.025	0.053
DBF4	DBF4, ASK: Protein DBF4 homolog	0.025	0.025
NOLC1	NOLC1, KIAA0035: Nucleolar phosphoprotein p130	0.025	0.025

0.572

Total Score

2.90E3