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Evidence of Interaction Between LIG1 and CSNK2B

The interaction score between LIG1 and CSNK2B is 3.10.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between LIG1 and CSNK2B = 0.61

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 7.78E-3
Orthology
OrganismLIG1 OrthologueCSNK2B OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YDL164C 1 YOR039W 1
worm Q27474 1 P28548 1
fly Q960P4 1 P08182 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains No domains were used in calculating likelihood of interaction 4.85E-3
Post-translational Modifications

Protein: LIG1

PTMResidueReference
Phosphorylation 66 PubMed, HPRD
Phosphorylation 76 PubMed, HPRD
Phosphorylation 141 PubMed, HPRD
Phosphorylation 195 PubMed, HPRD
Phosphorylation 911 PubMed, HPRD
Phosphoserine 66 HPRD
Phosphoserine 76 HPRD
Phosphoserine 141 HPRD
Phosphoserine 911 HPRD
Phosphothreonine 195 HPRD

Protein: CSNK2B

PTMResidueReference
Phosphorylation 2 PubMed, HPRD
Phosphorylation 3 PubMed, HPRD
Phosphorylation 209 PubMed, HPRD
Phosphoserine 2 PubMed, HPRD
Localisation

Protein: LIG1

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD

Protein: CSNK2B

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between LIG1 and CSNK2B that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between LIG1 andCSNK2B. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , LIG1 has 892 interactors and CSNK2B has 148 interactors of which there are 83 common interactors.

Common InteractorName of Common InteractorScore for LIG1-Interactor (?)Score for CSNK2B-Interactor (?)
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.704 0.081
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.307 0.025
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.307 0.025
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.276 5.94
EIF3S9 EIF3S9: Eukaryotic translation initiation factor 3 subunit 9 0.276 5.94
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.144 0.025
SET SET: Protein SET 0.144 0.025
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.144 0.025
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.141 2.51
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.139 0.036
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.139 0.036
PABPC4 PABPC4, APP1, PABP4: Polyadenylate-binding protein 4 0.129 0.0479
CDK4 CDK4: Cell division protein kinase 4 0.129 0.061
CDK2 CDK2: Cell division protein kinase 2 0.129 0.061
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.129 0.049
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.129 5.94
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.129 0.049
WEE1 WEE1: Wee1-like protein kinase 0.129 0.049
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.129 0.036
SNRPC SNRPC: U1 small nuclear ribonucleoprotein C 0.129 0.0479
ROCK1 ROCK1: Rho-associated protein kinase 1 0.127 0.0407
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.114 0.036
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.111 0.027
CSK CSK: Tyrosine-protein kinase CSK 0.090 0.027
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.087 0.025
ABCF1 N/A 0.087 0.025
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.087 0.025
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.078 0.049
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.078 0.036
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.078 136.00
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.078 0.061
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.078 0.061
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 0.078 0.722
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.078 0.061
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.078 0.049
HDAC2 HDAC2: Histone deacetylase 2 0.078 2.90
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.078 0.049
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.074 0.025
RDBP RDBP, NELFE, RD: Negative elongation factor E 0.070 0.025
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.070 0.0253
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.070 0.055
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.066 0.0479
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.066 2.14
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.063 0.049
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.052 0.068
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.052 0.0407
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.046 0.049
EIF3S4 EIF3S4: Eukaryotic translation initiation factor 3 subunit 4 0.046 3.59
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.046 0.030
CDK7 CDK7, MO15: Cell division protein kinase 7 0.046 0.061
RPS6KB1 N/A 0.046 0.036
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.046 0.036
BRD2 BRD2, KIAA9001, RING3: Bromodomain-containing protein 2 0.046 0.722
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.046 0.030
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.046 0.030
LIMK2 LIMK2: LIM domain kinase 2 0.0453 0.0253
PHB2 PHB2, BAP, REA: Prohibitin-2 0.0446 0.025
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.0425 0.0253
STK16 N/A 0.0425 0.0407
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.040 0.061
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.038 0.036
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.038 0.030
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.038 0.049
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.038 0.036
KLF13 KLF13, BTEB3, NSLP1: Krueppel-like factor 13 0.038 0.566
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.032 0.033
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.032 0.0253
PRKAA1 N/A 0.032 0.033
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.032 0.0253
EIF3S8 EIF3S8: Eukaryotic translation initiation factor 3 subunit 8 0.032 5.94
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.029 0.030
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.029 0.036
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.029 0.030
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.029 0.030
BRD3 BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3 0.029 1.33
STK10 STK10: Uncharacterized protein STK10 0.029 0.030
MTF1 MTF1: Metal regulatory transcription factor 1 0.029 2.14
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.029 0.049
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.026 0.0253
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.026 0.0253
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.026 0.033
BRD4 N/A 0.025 0.232
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.025 0.025
0.572
Total Score 3.10