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Evidence of Interaction Between EPOR and BCAR1

The interaction score between EPOR and BCAR1 is 6.14.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology N/A N/A
Domains Domains present in EPOR and BCAR1:
Domains in EPORDomains in BCAR1
IPR003961 Fibronectin, type III
IPR003528 Long hematopoietin receptor, single chain
IPR009167 Erythropoietin receptor
IPR002996 Cytkn_recept_B/G.
IPR001452 SH3

The Chi square scores for co-occurrence of domains that are present in EPOR and BCAR1 are listed below.

Domain 1Domain 2Chi Square
IPR003961 Fibronectin, type III IPR001452 SH3 15.104
IPR009167 Erythropoietin receptor IPR001452 SH3 4.09597
IPR003528 Long hematopoietin receptor, single chain IPR001452 SH3 3.64257
IPR002996 Cytkn_recept_B/G. IPR001452 SH3 0.0443172

The background colour of the table refers to:

  • Blue Domain is only present in EPOR
  • Yellow Domain is only present in BCAR1
  • Green Domain is present in both EPOR and BCAR1

 0.051
Post-translational Modifications

Protein: EPOR

PTMResidueReference
Phosphorylation 368 PubMed, HPRD
Phosphorylation 426 PubMed, HPRD
Phosphorylation 454 PubMed, HPRD
Phosphorylation 456 PubMed, HPRD
Phosphorylation 468 PubMed, HPRD
Phosphorylation 485 PubMed, HPRD
Phosphorylation 489 PubMed, HPRD
Phosphorylation 504 PubMed, HPRD

Protein: BCAR1

PTMResidueReference
Phosphorylation 115 PubMed, HPRD
Phosphorylation 128 PubMed, HPRD
Phosphorylation 165 PubMed, HPRD
Phosphorylation 179 PubMed, HPRD
Phosphorylation 192 PubMed, HPRD
Phosphorylation 222 PubMed, HPRD
Phosphorylation 224 PubMed, HPRD
Phosphorylation 234 PubMed, HPRD
Phosphorylation 249 PubMed, HPRD
Phosphorylation 267 PubMed, HPRD
Phosphorylation 287 PubMed, HPRD
Phosphorylation 306 PubMed, HPRD
Phosphorylation 327 PubMed, HPRD
Phosphorylation 362 PubMed, HPRD
Phosphorylation 387 PubMed, HPRD
Phosphorylation 410 PubMed, HPRD
Phosphorylation 653 PubMed, HPRD
Phosphorylation 664 PubMed, HPRD
Phosphorylation 666 PubMed, HPRD
Phosphotyrosine 327 HPRD
Proteolytic Cleavage 318 PubMed, HPRD
Proteolytic Cleavage 650 PubMed, HPRD
Localisation

Protein: EPOR

LocalisationReference
ER HPRD
Plasma membrane HPRD
Secreted HPRD

Protein: BCAR1

LocalisationReference
ER HPRD
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between EPOR and BCAR1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EPOR andBCAR1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EPOR has 1024 interactors and BCAR1 has 462 interactors of which there are 376 common interactors.

Common InteractorName of Common InteractorScore for EPOR-Interactor (?)Score for BCAR1-Interactor (?)
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.251 0.051
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.210 0.051
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.191 0.051
CRLF3 N/A 0.191 0.051
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.166 0.046
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.166 0.046
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.166 0.046
FN1 N/A 0.165 0.051
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.051
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.051
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.051
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.051
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.051
BSG N/A 0.165 0.046
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.046
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.165 0.046
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.165 0.046
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.165 0.046
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.051
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.165 0.046
CNTN1 CNTN1: Contactin-1 precursor 0.165 0.046
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.051
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.165 0.051
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.165 0.051
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.051
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.051
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.165 0.051
CNTN4 CNTN4: Contactin-4 precursor 0.165 0.046
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.051
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.165 0.046
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.152 0.051
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.152 0.046
KIT KIT: Mast/stem cell growth factor receptor precursor 0.152 0.046
CRKL CRKL: Crk-like protein 0.126 22.10
RDX RDX: Radixin 0.126 0.046
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.126 0.046
GAB1 GAB1: GRB2-associated-binding protein 1 0.126 0.051
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.126 0.046
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.126 0.046
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.126 0.051
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.123 0.051
DCC DCC: Netrin receptor DCC precursor 0.123 0.046
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.123 0.051
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.123 0.051
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.123 0.046
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.123 0.051
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.123 0.051
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.123 0.046
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.123 0.046
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.123 0.046
INSR INSR: Insulin receptor precursor 0.123 0.046
IL9R IL9R: Interleukin-9 receptor precursor 0.123 0.051
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.123 0.046
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.123 0.046
GHR GHR: Growth hormone receptor precursor 0.123 0.051
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.123 0.051
MAPK15 N/A 0.109 0.051
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 22.10
PSCD2 N/A 0.109 0.051
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.109 0.046
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.109 0.046
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.109 0.046
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 0.051
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.109 0.051
ELMO1 N/A 0.109 0.046
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 0.051
ARHGEF7 N/A 0.109 0.046
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.051
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.109 0.046
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.109 0.051
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 0.051
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.109 0.046
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.109 0.046
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 0.051
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 0.051
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.109 0.046
NF2 NF2, SCH: Merlin 0.109 0.051
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 0.051
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.109 0.046
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.051
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.109 0.046
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.109 0.046
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.051
STAT3 0.109 0.051
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.109 0.046
FCN3 FCN3, FCNH, HAKA1: Ficolin-3 precursor 0.109 0.026
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.051
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.109 0.046
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.046
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.109 0.046
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.109 0.046
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.109 0.051
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.109 0.046
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.109 0.046
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.109 0.046
MET MET: Hepatocyte growth factor receptor precursor 0.109 0.051
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.109 0.051
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.109 0.051
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.109 0.051
TNC TNC, HXB: Tenascin precursor 0.109 0.046
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.109 0.051
ITGB4 N/A 0.109 0.051
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.109 0.051
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.109 0.046
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.109 0.046
SORL1 SORL1: Sortilin-related receptor precursor 0.109 0.051
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.109 0.051
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.109 0.051
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.109 0.046
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.109 0.051
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.109 0.051
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.109 0.046
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.109 0.046
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.109 0.046
PRLR PRLR: Prolactin receptor precursor 0.109 0.051
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.105 0.051
DOK1 DOK1: Docking protein 1 0.100 0.046
PLD2 PLD2: Phospholipase D2 0.100 0.046
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.100 0.051
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.100 0.046
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.100 0.046
STAM2 STAM2: Signal transducing adapter molecule 2 0.100 0.046
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.100 0.046
RPS6KB1 N/A 0.100 0.046
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.100 0.046
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.100 0.046
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.100 0.046
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.100 0.046
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.098 0.046
PTPRZ1 N/A 0.098 0.046
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 0.051
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.098 0.046
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.098 0.051
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.098 0.046
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.098 0.046
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.098 0.051
NEO1 NEO1, NGN: Neogenin precursor 0.098 0.046
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.098 0.046
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.098 0.046
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.098 0.051
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.098 0.046
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.098 0.051
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.091 0.051
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.091 0.046
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.083 0.051
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.083 0.051
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.083 0.051
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.083 0.051
KIR3DL1 N/A 0.083 0.051
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.083 0.046
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.083 0.051
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.081 0.046
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.081 0.046
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.081 0.046
STK16 N/A 0.081 0.051
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.081 0.046
SYK SYK: Tyrosine-protein kinase SYK 0.081 0.046
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.081 0.046
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.081 0.046
STAT6 STAT6: Signal transducer and activator of transcription 6 0.081 0.046
IRS2 IRS2: Insulin receptor substrate 2 0.081 0.051
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.081 0.051
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.081 0.051
RIN1 RIN1: Ras and Rab interactor 1 0.081 0.046
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.081 0.046
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.081 0.051
HCK N/A 0.081 0.046
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.081 0.046
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.081 0.046
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.081 0.046
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.077 0.051
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.077 0.051
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.072 0.051
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.072 0.051
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.072 0.046
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.072 0.051
PSCD4 PSCD4, CYT4: Cytohesin-4 0.072 0.046
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.072 0.046
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.072 0.051
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.072 0.046
TTN N/A 0.072 0.046
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.072 0.051
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.072 22.10
ROCK1 ROCK1: Rho-associated protein kinase 1 0.072 0.051
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.072 0.046
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.072 0.046
BMX N/A 0.072 0.051
LYN LYN: Tyrosine-protein kinase Lyn 0.072 0.051
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.072 0.051
VIL2 N/A 0.072 0.046
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.072 0.051
GAB2 N/A 0.072 0.051
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.072 0.046
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.072 0.046
MSN MSN: Moesin 0.072 0.046
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.072 0.046
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.072 0.051
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.072 0.046
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.072 0.046
VAV1 VAV1, VAV: Proto-oncogene vav 0.072 0.046
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.072 0.051
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.072 0.046
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.072 0.046
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.072 0.051
JAK1 0.072 0.046
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.072 0.051
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.072 0.046
PLD1 PLD1: Phospholipase D1 0.072 0.046
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.072 0.046
ALK ALK: ALK tyrosine kinase receptor precursor 0.072 0.046
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.072 0.046
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.072 0.051
MCF2 MCF2, DBL: Proto-oncogene DBL 0.072 0.051
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.072 0.051
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.072 0.051
CSK CSK: Tyrosine-protein kinase CSK 0.072 0.046
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.072 0.051
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.072 0.046
PSD TYL: TYL protein 0.072 0.046
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.072 0.046
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.072 0.046
IRS1 IRS1: Insulin receptor substrate 1 0.072 0.051
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.072 0.051
CXorf9 N/A 0.072 0.046
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.072 0.051
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.0688 0.046
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.0688 0.046
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.065 0.046
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.065 0.051
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.065 0.051
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.065 0.046
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.065 0.046
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.065 0.046
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.065 0.046
APS SH2B2, APS: SH2B adapter protein 2 0.065 0.046
NCK2 NCK2: Cytoplasmic protein NCK2 0.065 22.10
RASA3 RASA3: Ras GTPase-activating protein 3 0.065 0.046
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.065 0.046
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.065 0.046
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.065 0.046
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.065 0.051
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.065 0.051
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.065 0.046
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.065 0.046
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 0.046
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.062 0.051
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.062 0.046
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.062 0.051
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.062 0.051
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.055 0.051
LILRB1 N/A 0.055 0.051
CD7 CD7: T-cell antigen CD7 precursor 0.055 0.051
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.055 0.051
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.055 0.051
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.055 0.051
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.055 0.051
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.055 0.051
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.055 0.051
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.055 0.051
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.055 0.051
GPA33 GPA33: Cell surface A33 antigen precursor 0.055 0.051
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.055 0.051
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.055 0.051
F10 F10: Coagulation factor X precursor 0.055 0.026
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.055 0.051
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.055 0.051
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.055 0.051
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.055 0.051
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.055 0.051
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.055 0.051
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.055 0.051
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.055 0.051
PHC3 PHC3, EDR3, PH3: Polyhomeotic-like protein 3 0.051 0.046
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.051
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.051 0.046
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
UNC5D UNC5D, KIAA1777, UNQ6012/PRO34692, UNC5H4: Netrin receptor UNC5D precursor 0.051 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.051
GRB10 N/A 0.051 0.051
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.051 0.046
DOK2 DOK2: Docking protein 2 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.051 0.046
NCAM1 N/A 0.051 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.051 0.046
RAPH1 N/A 0.051 0.051
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.051 0.046
C9orf88 N/A 0.051 0.051
EPB41 EPB41, E41P: Protein 4.1 0.051 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.051 0.046
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.051 0.046
FLT4 VEGFR3 long form 0.051 0.046
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
STIM1 STIM1, GOK: Stromal interaction molecule 1 precursor 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.051 0.046
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.051 0.046
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.051
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.051 0.046
TP73 TP73, P73: Tumor protein p73 0.051 0.051
PVR PVR, PVS: Poliovirus receptor precursor 0.049 0.051
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.049 0.051
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.049 0.051
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.049 0.051
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.049 0.051
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.049 0.051
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.049 0.051
F7 F7: Coagulation factor VII precursor 0.049 0.026
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.049 0.051
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.049 0.046
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.049 0.046
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.049 0.046
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.051
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.049 0.051
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.049 0.046
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.047 0.051
TNN TNN: Tenascin-N precursor 0.047 0.046
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.0453 0.046
MBL2 MBL2, MBL: Mannose-binding protein C precursor 0.0453 0.026
DAB1 DAB1: Disabled homolog 1 0.0453 0.046
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.0453 0.046
STAT2 STAT2: Signal transducer and activator of transcription 2 0.045 0.051
PLEK PLEK, P47: Pleckstrin 0.045 0.051
SOS1 SOS1: Son of sevenless homolog 1 0.045 0.046
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.045 0.046
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.045 0.051
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.045 0.051
COL12A1 COL12A1, COL12A1L: Collagen alpha-1(XII) chain precursor 0.044 0.046
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.041 0.046
CENTA1 CENTA1: Centaurin-alpha 1 0.041 0.051
STAT4 STAT4: Signal transducer and activator of transcription 4 0.041 0.051
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.038 0.046
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.037 0.046
VASP VASP: Vasodilator-stimulated phosphoprotein 0.037 0.051
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.037 0.046
F9 F9: Coagulation factor IX precursor 0.037 0.026
PROZ PROZ: Vitamin K-dependent protein Z precursor 0.037 0.029
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.037 0.046
CSPG2 N/A 0.037 0.051
PROS1 PROS1, PROS: Vitamin K-dependent protein S precursor 0.037 0.029
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.037 0.046
PROC PROC: Vitamin K-dependent protein C precursor 0.037 0.026
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.0338 0.051
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.0338 0.046
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.034 0.046
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.032 0.051
VWF VWF, F8VWF: von Willebrand factor precursor 0.032 0.046
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.032 0.051
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.032 0.046
DAB2 DAB2, DOC2: Disabled homolog 2 0.032 0.046
COL5A1 N/A 0.032 0.029
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.032 0.046
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.029 0.046
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.029 0.051
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.029 0.046
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.029 0.051
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.046
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.028 0.051
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.028 0.051
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.028 0.046
LAT LAT: Linker for activation of T-cells family member 1 0.028 0.051
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.028 0.051
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.028 0.046
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.025 0.046
ETS2 ETS2: Protein C-ets-2 0.025 0.051
0.299
Total Score 6.14