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Evidence of Interaction Between MAPK1 and EPB41L3

The interaction score between MAPK1 and EPB41L3 is 16.20.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and EPB41L3 = 0.16

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.30E-3
Orthology
OrganismMAPK1 OrthologueEPB41L3 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm P39745 1 Q9TVI9 1
fly P40417 1 Q9V8R9 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in MAPK1 and EPB41L3:
Domains in MAPK1Domains in EPB41L3
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR000299 Band 4.1
IPR000798 Ezrin/radixin/moesin ERM
IPR009065 FERM
IPR007477 SAB
IPR008379 4.1, C-terminal
IPR011993 PH_type.

The Chi square scores for co-occurrence of domains that are present in MAPK1 and EPB41L3 are listed below.

Domain 1Domain 2Chi Square
IPR000719 Protein kinase IPR011993 PH_type. 37.108
IPR011009 Protein kinase-like IPR011993 PH_type. 21.3114
IPR008271 Serine/threonine protein kinase, active site IPR000299 Band 4.1 16.572
IPR002290 Serine/threonine protein kinase IPR000299 Band 4.1 9.26655
IPR002290 Serine/threonine protein kinase IPR009065 FERM 2.85621
IPR011009 Protein kinase-like IPR009065 FERM 1.3063
IPR008271 Serine/threonine protein kinase, active site IPR011993 PH_type. 0.535834
IPR011009 Protein kinase-like IPR000299 Band 4.1 0.436518
IPR000719 Protein kinase IPR009065 FERM 0.214716
IPR000719 Protein kinase IPR000299 Band 4.1 0.128068
IPR002290 Serine/threonine protein kinase IPR011993 PH_type. 0.0555974
IPR003527 MAP kinase IPR011993 PH_type. 0.0276008

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in EPB41L3
  • Green Domain is present in both MAPK1 and EPB41L3

 0.165
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: EPB41L3

PTMResidueReference
Phosphorylation 460 PubMed, HPRD
Phosphorylation 469 PubMed, HPRD
Phosphorylation 708 PubMed, HPRD
Phosphorylation 962 PubMed, HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: EPB41L3

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between MAPK1 and EPB41L3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andEPB41L3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and EPB41L3 has 1218 interactors of which there are 712 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for EPB41L3-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 0.275
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 115.00 0.072
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 94.70 0.058
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.148
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.148
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 62.30 0.098
DUSP10 DUSP10, MKP5: Dual specificity protein phosphatase 10 12.60 0.027
DUSP8 DUSP8, VH5: Dual specificity protein phosphatase 8 11.60 0.044
CDK2 CDK2: Cell division protein kinase 2 6.80 0.078
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 4.15 0.064
GNAI1 GNAI1: Guanine nucleotide-binding protein G(i), alpha-1 subunit 2.53 0.040
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 2.17 0.088
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 2.02 0.099
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 1.42 0.044
GNAQ GNAQ, GAQ: Guanine nucleotide-binding protein G(q) subunit alpha 1.03 0.067
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.975 0.202
PLEK PLEK, P47: Pleckstrin 0.515 0.029
GNAZ GNAZ: Guanine nucleotide-binding protein G(z) subunit alpha 0.509 0.027
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.461 0.044
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.461 0.111
CRKL CRKL: Crk-like protein 0.461 0.088
JAK1 0.461 0.097
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.461 0.086
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.461 0.049
MSN MSN: Moesin 0.461 0.088
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 0.088
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.088
GNA11 GNA11, GA11: Guanine nucleotide-binding protein subunit alpha-11 0.456 0.033
DUSP7 DUSP7, PYST2: Dual specificity protein phosphatase 7 0.440 0.028
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 0.109
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.416 0.065
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.385 0.111
STK10 STK10: Uncharacterized protein STK10 0.385 0.088
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.385 0.049
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.372 0.139
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 0.099
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.372 0.065
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.111
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.097
PSCD4 PSCD4, CYT4: Cytohesin-4 0.372 0.049
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.099
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.372 0.088
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.097
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.088
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 0.088
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 0.097
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.307 0.062
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.098
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.307 0.098
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.307 0.109
VASP VASP: Vasodilator-stimulated phosphoprotein 0.307 0.049
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.136
DOK1 DOK1: Docking protein 1 0.275 0.088
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.088
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.275 0.065
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.099
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 0.088
HCK N/A 0.275 0.111
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.088
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.088
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.260 0.109
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.260 0.037
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 0.110
GAB2 N/A 0.251 0.155
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.251 0.098
IRS2 IRS2: Insulin receptor substrate 2 0.251 0.191
EPM2A EPM2A: Laforin 0.244 0.0308
WASPIP N/A 0.233 0.044
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.097
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.233 0.088
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.233 0.088
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.233 0.171
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.233 0.088
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.233 0.088
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.233 0.088
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 0.088
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.078
STAT4 STAT4: Signal transducer and activator of transcription 4 0.225 0.058
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.225 0.044
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.225 0.098
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.064
RASA3 RASA3: Ras GTPase-activating protein 3 0.225 0.088
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.210 0.098
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.210 0.123
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.098
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.062
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.191 0.098
STAT2 STAT2: Signal transducer and activator of transcription 2 0.191 0.081
GMIP GMIP: GEM-interacting protein 0.188 0.049
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.188 0.028
CXorf9 N/A 0.188 0.088
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.188 0.097
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.188 0.088
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.188 0.088
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.188 0.088
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 0.111
RPS6KB1 N/A 0.188 0.099
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.188 0.251
FNBP1 N/A 0.188 0.097
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.171 0.137
RIN1 RIN1: Ras and Rab interactor 1 0.171 0.171
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.171 0.171
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 0.088
PSD TYL: TYL protein 0.171 0.139
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.171 0.044
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.049
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.171 0.097
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.165
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.083
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.165
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.165
PSCD2 N/A 0.165 0.083
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 0.165
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.165
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.165 0.083
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 0.165
NF2 NF2, SCH: Merlin 0.165 0.165
MAP2K5 N/A 0.165 0.165
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.083
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.155 0.152
HD HD, IT15: Huntingtin 0.155 0.062
ARFGAP1 N/A 0.155 0.032
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.155 0.191
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.110
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.153 0.072
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.152 0.098
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.152 0.109
SNCB SNCB: Beta-synuclein 0.152 0.163
GAB1 GAB1: GRB2-associated-binding protein 1 0.152 0.062
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.152 0.098
ETS2 ETS2: Protein C-ets-2 0.152 0.0263
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 0.098
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.148 0.148
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.148 0.075
CDC25C CDC25C: M-phase inducer phosphatase 3 0.148 0.025
CDC25A CDC25A: M-phase inducer phosphatase 1 0.148 0.025
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.075
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.148
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.148
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 0.148
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.148
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.148
STAT3 0.148 0.148
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.148
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.148
ELMO1 N/A 0.148 0.075
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.075
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.075
ARHGEF7 N/A 0.148 0.075
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.146 0.088
PPP2R5A PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha 0.146 0.043
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.146 0.097
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.139 0.088
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.139 0.058
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.139 0.097
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.139 0.088
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.139 0.099
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.139 0.088
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.139 0.461
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.139 0.088
ATM ATM: Serine-protein kinase ATM 0.139 0.088
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.139 0.044
CD2AP CD2AP: CD2-associated protein 0.139 0.099
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.139 0.097
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.139 0.099
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.139 0.044
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.136 0.067
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.136 0.188
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.114
RDX RDX: Radixin 0.136 0.171
VIL2 N/A 0.136 0.099
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.372
STMN1 STMN1, LAP18, OP18: Stathmin 0.136 0.029
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.132 0.109
ACTR3 ACTR3, ARP3: Actin-related protein 3 0.129 0.044
CENTA1 CENTA1: Centaurin-alpha 1 0.128 0.105
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.127 0.098
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.098
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.127 0.098
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.110
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.127 0.123
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.124 0.072
TNFRSF1B TNFRSF1B, TNFBR, TNFR2: Tumor necrosis factor receptor superfamily member 1B pre 0.124 0.030
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.123 0.055
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.123 0.109
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.123 0.123
NRAS NRAS, HRAS1: GTPase NRas precursor 0.118 0.088
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.114 0.111
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.114 0.099
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.114 0.139
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.114 0.225
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.114 0.050
CDK5 CDK5: Cell division protein kinase 5 0.114 0.372
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.136
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.225
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.114 0.088
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.114 0.152
EIF4G3 EIF4G3: Eukaryotic translation initiation factor 4 gamma 3 0.114 0.067
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.114 0.136
MYCBP2 MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2 0.111 0.033
PLD2 PLD2: Phospholipase D2 0.111 0.049
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.111 0.044
APS SH2B2, APS: SH2B adapter protein 2 0.111 0.097
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.111 0.097
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.056
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.111 0.171
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.111 0.111
STMN2 STMN2, SCG10, SCGN10: Stathmin-2 0.111 0.046
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.109
BMX N/A 0.110 0.123
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.109
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.109
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.077
MCF2 MCF2, DBL: Proto-oncogene DBL 0.109 0.096
SNCG SNCG, BCSG1, PERSYN, PRSN: Gamma-synuclein 0.109 0.163
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.109 0.075
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.109 0.065
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.099 0.171
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.098
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.098 0.098
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.098 0.109
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.098
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.098 0.109
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.044
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.098
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.114
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.097 0.058
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.097 0.097
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.275
PLD1 PLD1: Phospholipase D1 0.097 0.044
DAB1 DAB1: Disabled homolog 1 0.097 0.049
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.049
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.461
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.096 0.109
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.096 0.056
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.152
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.096 0.152
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.096 0.072
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.096 0.110
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.091 0.100
CD44 N/A 0.091 0.029
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.090 0.058
PTPRZ1 N/A 0.090 0.304
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 0.088
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.088 0.086
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.086 0.088
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.086 0.097
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.372
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.086 0.088
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.086 0.078
CDK7 CDK7, MO15: Cell division protein kinase 7 0.086 0.088
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.086 0.461
PITPNM1 PITPNM1: Uncharacterized protein PITPNM1 0.086 0.046
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.086 0.097
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.086 0.136
CDK5R1 CDK5R1, CDK5R, NCK5A: Cyclin-dependent kinase 5 activator 1 precursor 0.086 0.032
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.086 0.171
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.083 0.165
MAPKAPK5 N/A 0.083 0.165
AMPH AMPH, AMPH1: Amphiphysin 0.083 0.165
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.165
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.083 0.028
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.083 0.165
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.083 0.165
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.083 0.165
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.165
CASP8 CASP8, MCH5: Caspase-8 precursor 0.083 0.028
MAPK15 N/A 0.083 0.165
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.083 0.165
CASP9 CASP9, MCH6: Caspase-9 precursor 0.083 0.028
CASP1 CASP1, IL1BC, IL1BCE: Caspase-1 precursor 0.083 0.028
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.083 0.165
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.165
AKAP12 AKAP12, AKAP250: A-kinase anchor protein 12 0.083 0.028
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.083 0.165
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.0818 0.026
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.136
YWHAZ YWHAZ: 14-3-3 protein zeta/delta 0.078 0.136
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.078 0.044
LCP1 LCP1, PLS2: Plastin-2 0.078 0.044
AGTPBP1 AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein 0.078 0.029
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.078 0.136
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.077 0.110
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.077 0.098
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.077 0.123
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.077 0.152
PRKAA1 N/A 0.077 0.098
LIMK2 LIMK2: LIM domain kinase 2 0.077 0.098
STK16 N/A 0.077 0.110
TSPYL2 TSPYL2, CDA1, HRIHFB2216, DENTT, TSPX: Testis-specific Y-encoded-like protein 2 0.077 0.027
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.077 0.098
ATP2B1 N/A 0.075 0.124
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.075 0.072
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.075 0.148
CDC2 CDC2: Cell division control protein 2 homolog 0.075 0.148
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.075 0.148
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.148
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.075 0.165
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.075
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.075 0.148
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.075 0.148
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.075 0.148
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.075 0.098
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.098
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.075 0.148
GIT2 N/A 0.075 0.075
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.075 0.148
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.148
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.075 0.075
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.075 0.148
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.075 0.148
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.148
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.075 0.148
CNN2 CNN2: Calponin-2 0.075 0.083
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.075 0.148
SNX3 N/A 0.075 0.047
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.148
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.165
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.075 0.098
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.075 0.148
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.075 0.148
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.075 0.148
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.075 0.148
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.148
TSC2 TSC2, TSC4: Tuberin 0.075 0.047
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.148
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.075 0.148
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.073 0.052
CDC42 CDC42: Cell division control protein 42 homolog precursor 0.073 0.0416
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.072 0.065
RAN RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran 0.071 0.088
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.070 0.080
SLC9A3R1 SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50 0.070 0.049
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.070 0.062
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.097
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.069 0.088
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.069 0.136
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.069 0.171
CDK6 CDK6: Cell division protein kinase 6 0.069 0.088
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.069 0.088
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.069 0.225
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.069 0.225
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.069 0.097
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.069 0.049
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.069 0.099
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.069 0.088
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.069 0.097
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.069 0.097
CDK4 CDK4: Cell division protein kinase 4 0.069 0.099
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 0.090
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.064 0.090
PTPN11 N/A 0.063 0.038
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.063 0.064
ACTG1 ACTB: Actin, cytoplasmic 1 0.063 0.049
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.063 0.050
CKAP1 TBCB, CG22, CKAP1: Tubulin folding cofactor B 0.063 0.078
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.063 0.063
DYNC1LI1 DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1 0.063 0.225
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.063 0.029
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.063 0.136
ARHGDIB ARHGDIB, GDIA2, GDID4, RAP1GN1: Rho GDP-dissociation inhibitor 2 0.063 0.044
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.063 0.049
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.063 0.275
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.063 0.233
GRLF1 N/A 0.062 0.123
PEA15 PEA15: Astrocytic phosphoprotein PEA-15 0.062 0.307
COBL N/A 0.062 0.430
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.062 0.109
SPTAN1 N/A 0.062 0.515
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.062 0.072
MTMR6 MTMR6: Myotubularin-related protein 6 0.060 0.028
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.058 0.166
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.058 0.090
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.057 0.0453
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.057 0.065
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.057 0.0263
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.056 0.037
WEE1 WEE1: Wee1-like protein kinase 0.056 0.078
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.056 0.275
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.056 0.078
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 0.763
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.056 0.275
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.056 0.099
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.056 0.088
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.056 0.171
STAM2 STAM2: Signal transducing adapter molecule 2 0.056 0.088
NOS1 NOS1: Nitric-oxide synthase, brain 0.056 0.062
PRKCB1 PRKCB1, PKCB, PRKCB: Protein kinase C beta type 0.055 0.059
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.055 0.109
RAB4A N/A 0.052 0.109
YWHAQ YWHAQ: 14-3-3 protein theta 0.052 0.152
MVP MVP, LRP: Major vault protein 0.052 0.055
LIMS1 N/A 0.052 0.049
MEF2A N/A 0.052 0.027
TERF2IP TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1 0.052 0.027
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
GRB10 N/A 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
PTPRA N/A 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.051 0.058
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.050 0.050
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.050 0.049
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.050 0.097
CDKL5 N/A 0.049 0.109
DAPK2 DAPK2: Death-associated protein kinase 2 0.049 0.098
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.109
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.049 0.109
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.049 0.109
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.049 0.109
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.049
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.049 0.04
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.109
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.049 0.109
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.049
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.109
LAT LAT: Linker for activation of T-cells family member 1 0.049 0.049
ATP2A3 ATP2A3: Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 0.049 0.044
SORBS3 SORBS3, SCAM1: Vinexin 0.049 0.097
DYRK3 N/A 0.049 0.088
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.049 0.098
TUBB3 TUBB3, TUBB4: Tubulin beta-3 chain 0.048 0.027
NEFL NEFL, NF68, NFL: Neurofilament light polypeptide 0.048 0.307
KCNAB2 KCNAB2, KCNA2B, KCNK2: Voltage-gated potassium channel subunit beta-2 0.047 0.025
RAB5B RAB5B: Ras-related protein Rab-5B 0.047 0.148
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.046 0.088
HSPH1 HSPH1, HSP105, HSP110, KIAA0201: Heat shock protein 105 kDa 0.046 0.029
DLG1 N/A 0.046 0.046
XPO1 XPO1, CRM1: Exportin-1 0.046 0.044
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.046 0.114
LPXN LPXN, LDLP: Leupaxin 0.046 0.050
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.046 0.088
CCR5 CCR5: CCR5 receptor (Fragment) 0.046 0.065
VAV2 VAV2: Uncharacterized protein VAV2 0.046 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 0.046
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.046 0.033
EPOR EPOR: Erythropoietin receptor precursor 0.0453 0.065
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.0727
TNFRSF10C TNFRSF10C, DCR1, UNQ321/PRO366, LIT, TRAILR3, TRID: Tumor necrosis factor recept 0.0453 0.0263
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.044 0.111
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.044 0.097
MYO3A MYO3A: Myosin IIIA 0.044 0.111
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.044 0.136
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.044 0.225
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.044 0.111
CNN3 CNN3: Calponin-3 0.044 0.096
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.044 0.136
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.044 0.099
CTTN CTTN, EMS1: Src substrate cortactin 0.044 0.251
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.044 0.136
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.044 0.044
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.044
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.098
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.044 0.098
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 0.098
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.044
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.043 0.032
FTH1 FTH1, FTH, OK/SW-cl.84, FTHL6, PIG15: Ferritin heavy chain 0.0425 0.026
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.0425 0.062
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.0425 0.034
PDE4A N/A 0.0425 0.052
VWF VWF, F8VWF: von Willebrand factor precursor 0.041 0.041
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.064
GRM3 GRM3, GPRC1C, MGLUR3: Metabotropic glutamate receptor 3 precursor 0.041 0.503
KIT KIT: Mast/stem cell growth factor receptor precursor 0.041 0.090
GLRB GLRB: Glycine receptor subunit beta precursor 0.041 0.040
TBXA2R TBXA2R: Thromboxane A2 receptor 0.04 0.109
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.040 0.064
ITGB7 ITGB7: Integrin beta-7 precursor 0.040 0.058
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.040 0.088
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.040 0.097
RAC2 RAC2: Ras-related C3 botulinum toxin substrate 2 precursor 0.039 0.033
RAB5A RAB5A, RAB5: Ras-related protein Rab-5A 0.039 0.093
NEF3 NEFM, NEF3, NFM: Neurofilament medium polypeptide 0.039 0.307
GFAP GFAP: Glial fibrillary acidic protein 0.039 0.144
TLN1 TLN1: Uncharacterized protein TLN1 0.038 0.044
TSC1 TSC1, KIAA0243, TSC: Hamartin 0.038 0.225
MYH9 MYH9: Myosin-9 0.038 0.065
GMFB GMFB: Glia maturation factor beta 0.038 0.063
DNAJC7 DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7 0.038 0.029
APC N/A 0.038 0.046
DYNC1I2 N/A 0.038 0.063
ZFYVE16 ZFYVE16, KIAA0305: Zinc finger FYVE domain-containing protein 16 0.038 0.032
RNF11 RNF11, CGI-123: RING finger protein 11 0.038 0.032
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.038 0.043
CHP CHP: Calcium-binding protein p22 0.038 0.069
MDN1 MDN1, KIAA0301: Midasin 0.038 0.097
STUB1 STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1 0.038 0.029
EEF2 EEF2, EF2: Elongation factor 2 0.038 0.099
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.037 0.0727
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.037 0.072
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.037 0.0727
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.037 0.032
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.037 0.0727
GHR GHR: Growth hormone receptor precursor 0.037 0.065
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.037 0.081
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.036 0.032
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.036 0.065
CRLF3 N/A 0.036 0.0727
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.036 0.0727
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.036 0.0727
CD7 CD7: T-cell antigen CD7 precursor 0.036 0.065
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.036 0.0727
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.036 0.072
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.036 0.065
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.036 0.057
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.036 0.0727
RHOG RHOG, ARHG: Rho-related GTP-binding protein RhoG precursor 0.0354 0.0416
NEFH NEFH, KIAA0845, NFH: Neurofilament heavy polypeptide 0.034 0.052
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.034 0.034
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.034 0.0688
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.033 0.058
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.033 0.181
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.033 0.181
GRM1 GRM1, GPRC1A, MGLUR1: Metabotropic glutamate receptor 1 precursor 0.033 0.148
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.033 0.064
PRLR PRLR: Prolactin receptor precursor 0.033 0.065
RHO RHO, OPN2: Rhodopsin 0.033 0.065
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.033 0.065
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.033 0.081
ITGB4 N/A 0.032 0.072
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.032 0.153
F3 F3: Tissue factor precursor 0.032 0.081
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.032 0.032
IL9R IL9R: Interleukin-9 receptor precursor 0.032 0.0727
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.032 0.037
CASR CASR, GPRC2A, PCAR1: Extracellular calcium-sensing receptor precursor 0.032 0.072
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.032 0.055
CP110 N/A 0.032 0.070
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.049
ZYX ZYX: Zyxin 0.032 0.062
MAPK8IP3 MAPK8IP3, JIP3, KIAA1066: C-jun-amino-terminal kinase-interacting protein 3 0.032 0.036
YWHAH YWHAH, YWHA1: 14-3-3 protein eta 0.032 0.515
IPO7 IPO7: Uncharacterized protein IPO7 0.032 0.055
SORL1 SORL1: Sortilin-related receptor precursor 0.032 0.081
RYR2 RYR2: Ryanodine receptor 2 0.031 0.0513
RRAS RRAS: Ras-related protein R-Ras precursor 0.0308 0.088
RHOB RHOB, ARH6, ARHB: Rho-related GTP-binding protein RhoB precursor 0.0308 0.251
WSB2 WSB2: WD repeat and SOCS box-containing protein 2 0.0308 0.053
PHLPP PHLPP, KIAA0606, PLEKHE1, SCOP: PH domain leucine-rich repeat-containing protein 0.0308 0.0255
OPRM1 OPRM1, MOR1: Mu-type opioid receptor 0.030 0.062
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 0.090
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.029 0.064
NEO1 NEO1, NGN: Neogenin precursor 0.029 0.113
EGF EGF: Pro-epidermal growth factor precursor 0.029 0.072
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.029 0.032
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.029 0.0263
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.029 0.037
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.029 0.090
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.029 0.064
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.029 0.031
BCDO2 PTS: 6-pyruvoyl tetrahydrobiopterin synthase 0.029 0.029
KIAA0690 N/A 0.029 0.049
AHCYL1 AHCYL1, DCAL, XPVKONA: Putative adenosylhomocysteinase 2 0.029 0.129
PMM1 PMM1, PMMH22: Phosphomannomutase 1 0.029 0.046
EHBP1 EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1 0.029 0.038
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.029 0.086
FKBP8 DKFZp686M22160: Putative uncharacterized protein DKFZp686M22160 (Fragment) 0.029 0.038
WWOX WWOX, FOR, WOX1: WW domain-containing oxidoreductase 0.029 0.038
KPNA2 KPNA2, RCH1, SRP1: Importin subunit alpha-2 0.029 0.028
PPP2CB PPP2CB: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0.029 0.129
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.029 0.049
DPYSL2 DPYSL2, CRMP2: Dihydropyrimidinase-related protein 2 0.029 0.385
SYMPK SYMPK, SPK: Symplekin 0.029 0.044
FXR2 FXR2, FMR1L2: Fragile X mental retardation syndrome-related protein 2 0.029 0.046
PKP4 PKP4: Plakophilin-4 0.028 0.052
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.028 0.028
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.028
PDZD2 CDNA FLJ46853 fis, clone UTERU3009775, moderately similar to Rattus norvegicus P 0.028 0.083
RGS18 RGS18, RGS13: Regulator of G-protein signaling 18 0.028 0.028
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
SH2D3A SH2D3A, NSP1, UNQ175/PRO201: SH2 domain-containing protein 3A 0.028 0.028
AHSA2 AHSA2, DKFZp564C236, hCG_15158: Putative uncharacterized protein DKFZp564C236 0.028 0.028
CACNB2 N/A 0.028 0.028
DNAJC13 DNAJC13, KIAA0678, RME8: DnaJ homolog subfamily C member 13 0.028 0.052
PTPN7 N/A 0.028 0.028
STAP2 Uncharacterized protein ENSP00000317912 0.028 0.028
SYTL4 Endocrine transmitter regulatory protein 0.028 0.049
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
HNRPK HNRPK, HNRNPK: Heterogeneous nuclear ribonucleoprotein K 0.028 0.028
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.028 0.083
AXIN1 0.028 0.028
MATK 0.028 0.028
PHLDB2 N/A 0.028 0.028
CDC42 N/A 0.028 0.028
PDE5A PDE5A, PDE5: cGMP-specific 3',5'-cyclic phosphodiesterase 0.028 0.028
S100A16 S100A16, AAG13: Protein S100-A16 0.028 0.083
PPEF1 N/A 0.028 0.083
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
YWHAG YWHAG: 14-3-3 protein gamma 0.028 0.165
ABLIM1 ABLIM1, RP11-317F20.1-001: Actin binding LIM protein 1 0.028 0.028
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
NASP NASP: Nuclear autoantigenic sperm protein 0.028 0.028
SIVA SIVA1, SIVA: Apoptosis regulatory protein Siva 0.028 0.028
LNX1 N/A 0.028 0.028
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.028 0.052
CASP14 CASP14: Caspase-14 precursor 0.028 0.028
C9orf88 N/A 0.028 0.028
NCF4 N/A 0.028 0.028
SLC9A3R2 SLC9A3R2: SLC9A3R2 protein (Fragment) 0.028 0.028
FASN FASN, FAS: Fatty acid synthase 0.028 0.028
CASP6 CASP6, MCH2: Caspase-6 precursor 0.028 0.028
RRAD RRAD, RAD: GTP-binding protein RAD 0.028 0.088
PTGIR PTGIR, PRIPR: Prostacyclin receptor 0.027 0.064
PTPN13 N/A 0.027 0.027
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.027
DOK6 DOK6: Uncharacterized protein DOK6 0.027 0.027
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.027
ASB10 ASB10: Ankyrin repeat and SOCS box protein 10 0.027 0.027
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.027
ASB6 ASB6: Ankyrin repeat and SOCS box protein 6 0.027 0.027
NOXA1 NOXA1, RP13-927H1.1-001: NADPH oxidase activator 1 0.027 0.027
ASB17 ASB17: Ankyrin repeat and SOCS box protein 17 0.027 0.027
ASB2 ASB2: Ankyrin repeat and SOCS box protein 2 0.027 0.027
ASB3 ASB3: ASB3 protein 0.027 0.027
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.027
ASB14 ASB14: Ankyrin repeat and SOCS box protein 14 0.027 0.027
WSB1 WSB1, SWIP1: WD repeat and SOCS box-containing protein 1 0.027 0.027
ASB7 ASB7: Ankyrin repeat and SOCS box protein 7 0.027 0.027
ASB12 ASB12: Ankyrin repeat and SOCS box protein 12 0.027 0.027
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.027
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
DOK5 DOK5, C20orf180: Docking protein 5 0.027 0.027
ITGAE ITGAE: Integrin alpha-E precursor 0.027 0.065
LILRB1 N/A 0.027 0.081
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.027 0.081
LTB4R LTB4R, BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7: Leukotriene B4 receptor 1 0.027 0.072
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.027 0.0727
CD69 CD69: Early activation antigen CD69 0.027 0.033
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.026 0.064
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.026 0.065
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.026 0.064
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.026 0.064
MT3 MT3: Metallothionein-3 0.026 0.174
TCF7L2 N/A 0.026 0.027
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.152
DBN1 DBN1, D0S117E: Drebrin 0.026 0.026
EPN1 N/A 0.026 0.032
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.026 0.260
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.026 0.056
DCAMKL1 DCLK1, DCAMKL1, DCDC3A, KIAA0369: Serine/threonine-protein kinase DCLK1 0.026 0.087
RGS4 RGS4: Regulator of G-protein signaling 4 0.026 0.052
TNIK TNIK, KIAA0551: TRAF2 and NCK-interacting protein kinase 0.0253 0.0782
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.025 0.041
CHTF18 RUVBL, CHTF18: Protein CTF18 homolog. 0.025 0.025
PDE4B PDE4B, DPDE4: cAMP-specific 3',5'-cyclic phosphodiesterase 4B 0.025 0.025
ADK ADK: Adenosine kinase 0.025 0.025
KIAA0031 EFTUD2, KIAA0031, SNRP116: 116 kDa U5 small nuclear ribonucleoprotein component 0.025 0.148
WRNIP1 WRNIP1, WHIP: ATPase WRNIP1 0.025 0.028
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.148
BCR N/A 0.025 0.025
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.025 0.025
GSN GSN: Gelsolin precursor 0.025 0.025
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.025 0.075
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.025 0.044
LMO6 LMO6: LIM domain only protein 6 0.025 0.075
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.025 0.075
RAD50 RAD50: DNA repair protein RAD50 0.025 0.025
SCRIB N/A 0.025 0.025
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.025
UBE2R2 UBE2R2, CDC34B, UBC3B: Ubiquitin-conjugating enzyme E2 R2 0.025 0.025
NDNL2 NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1 0.025 0.025
NCOA5 NCOA5, KIAA1637: Nuclear receptor coactivator 5 0.025 0.025
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.025
MYO18A 0.025 0.075
COTL1 COTL1, CLP: Coactosin-like protein 0.025 0.025
EPN2 N/A 0.025 0.025
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.025 0.075
SH3PX3 SH3PX3, DKFZp666B159, hCG_1731072: SH3 and PX domain-containing protein 3. 0.025 0.025
DPP8 DPP8, DPRP1, MSTP097, MSTP135, MSTP141: Dipeptidyl peptidase 8 0.025 0.025
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.044
G3BP2 G3BP2, KIAA0660: Ras GTPase-activating protein-binding protein 2 0.025 0.025
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.025
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.025 0.025
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
BCOR N/A 0.025 0.025
MAP2K3 N/A 0.025 0.025
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.025 0.075
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.047
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
UBE2A UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A 0.025 0.025
SPAST SPAST, KIAA1083, SPG4: Spastin 0.025 0.025
ACTN4 ACTN4: Alpha-actinin-4 0.025 0.075
DCTN1 DCTN1: Dynactin subunit 1 0.025 0.025
ISL2 ISL2: Insulin gene enhancer protein ISL-2 0.025 0.044
RAB1B RAB1B: Ras-related protein Rab-1B 0.025 0.040
PRKCB1 N/A 0.025 0.025
HSPA8 HSPA8, HSC70, HSP73, HSPA10: Heat shock cognate 71 kDa protein 0.025 0.025
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.025
GRK6 N/A 0.025 0.025
CASP7 N/A 0.025 0.025
RASD1 RASD1, AGS1, DEXRAS1: Dexamethasone-induced Ras-related protein 1 precursor 0.025 0.148
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.025
RAC1 N/A 0.025 0.025
NLN NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor 0.025 0.025
NIPBL N/A 0.025 0.075
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.025 0.075
USP16 USP16: Ubiquitin carboxyl-terminal hydrolase 16 0.025 0.025
DCP1B DCP1B: mRNA-decapping enzyme 1B 0.025 0.025
CAMKK1 N/A 0.025 0.025
DBNL N/A 0.025 0.025
CAMK2A N/A 0.025 0.025
RSN CLIP1, CYLN1, RSN: CAP-Gly domain-containing linker protein 1 0.025 0.025
CFL2 CFL2: Cofilin-2 0.025 0.025
SVIL SVIL: Supervillin 0.025 0.025
0.299
Total Score 16.20