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Evidence of Interaction Between MAPK1 and EPHA1

The interaction score between MAPK1 and EPHA1 is 3.12.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and EPHA1 = -0.16

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.48E-3
Orthology
OrganismMAPK1 OrthologueEPHA1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm P39745 1 O61460 0.19
fly P40417 1 O96435 0.224

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in MAPK1 and EPHA1:
Domains in MAPK1Domains in EPHA1
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR006209 EGF-like domain
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR002290 Serine/threonine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR001090 Ephrin receptor, ligand binding
IPR001426 Receptor tyrosine kinase, class V
IPR001660 Sterile alpha motif SAM
IPR003961 Fibronectin, type III
IPR008957 Fibronectin, type III-like fold
IPR008979 Galactose-binding like
IPR013032 IPR006209.
IPR013761 Sterile alpha motif-type

The Chi square scores for co-occurrence of domains that are present in MAPK1 and EPHA1 are listed below.

Domain 1Domain 2Chi Square
IPR008271 Serine/threonine protein kinase, active site IPR006209 EGF-like domain 46.8567
IPR000719 Protein kinase IPR006209 EGF-like domain 42.2895
IPR008271 Serine/threonine protein kinase, active site IPR008266 Tyrosine protein kinase, active site 41.8291
IPR002290 Serine/threonine protein kinase IPR006209 EGF-like domain 38.067
IPR011009 Protein kinase-like IPR006209 EGF-like domain 34.7413
IPR000719 Protein kinase IPR000719 Protein kinase 30.6895
IPR008271 Serine/threonine protein kinase, active site IPR003961 Fibronectin, type III 30.5883
IPR000719 Protein kinase IPR013032 IPR006209. 29.2885
IPR008271 Serine/threonine protein kinase, active site IPR013032 IPR006209. 28.1386
IPR011009 Protein kinase-like IPR011009 Protein kinase-like 26.2215
IPR002290 Serine/threonine protein kinase IPR008266 Tyrosine protein kinase, active site 25.0766
IPR002290 Serine/threonine protein kinase IPR013032 IPR006209. 22.8777
IPR011009 Protein kinase-like IPR013032 IPR006209. 20.8081
IPR008271 Serine/threonine protein kinase, active site IPR008957 Fibronectin, type III-like fold 16.9163
IPR008349 ERK1/2 MAP kinase IPR002290 Serine/threonine protein kinase 13.3941
IPR002290 Serine/threonine protein kinase IPR003961 Fibronectin, type III 13.198
IPR003527 MAP kinase IPR002290 Serine/threonine protein kinase 10.9612
IPR000719 Protein kinase IPR008979 Galactose-binding like 9.37977
IPR008271 Serine/threonine protein kinase, active site IPR002290 Serine/threonine protein kinase 8.88805
IPR008271 Serine/threonine protein kinase, active site IPR001245 Tyrosine protein kinase 8.08585
IPR002290 Serine/threonine protein kinase IPR008957 Fibronectin, type III-like fold 7.79341
IPR000719 Protein kinase IPR008266 Tyrosine protein kinase, active site 6.98997
IPR008271 Serine/threonine protein kinase, active site IPR000719 Protein kinase 6.25263
IPR002290 Serine/threonine protein kinase IPR001245 Tyrosine protein kinase 5.09618
IPR011009 Protein kinase-like IPR008979 Galactose-binding like 4.37653
IPR008349 ERK1/2 MAP kinase IPR000719 Protein kinase 4.26499
IPR000719 Protein kinase IPR011009 Protein kinase-like 2.94434
IPR003527 MAP kinase IPR000719 Protein kinase 2.81413
IPR000719 Protein kinase IPR008957 Fibronectin, type III-like fold 2.73832
IPR002290 Serine/threonine protein kinase IPR011009 Protein kinase-like 2.72953
IPR008271 Serine/threonine protein kinase, active site IPR001660 Sterile alpha motif SAM 2.40254
IPR011009 Protein kinase-like IPR008957 Fibronectin, type III-like fold 2.3557
IPR000719 Protein kinase IPR001245 Tyrosine protein kinase 2.31134
IPR008271 Serine/threonine protein kinase, active site IPR011009 Protein kinase-like 2.11823
IPR011009 Protein kinase-like IPR001660 Sterile alpha motif SAM 1.72711
IPR008349 ERK1/2 MAP kinase IPR003961 Fibronectin, type III 1.72177
IPR003527 MAP kinase IPR001245 Tyrosine protein kinase 1.50703
IPR000719 Protein kinase IPR002290 Serine/threonine protein kinase 0.986464
IPR011009 Protein kinase-like IPR013761 Sterile alpha motif-type 0.981697
IPR000719 Protein kinase IPR001090 Ephrin receptor, ligand binding 0.749646
IPR000719 Protein kinase IPR001426 Receptor tyrosine kinase, class V 0.749646
IPR000719 Protein kinase IPR003961 Fibronectin, type III 0.712801
IPR011009 Protein kinase-like IPR003961 Fibronectin, type III 0.616354
IPR002290 Serine/threonine protein kinase IPR002290 Serine/threonine protein kinase 0.532451
IPR000719 Protein kinase IPR013761 Sterile alpha motif-type 0.527285
IPR008349 ERK1/2 MAP kinase IPR008957 Fibronectin, type III-like fold 0.378958
IPR011009 Protein kinase-like IPR001090 Ephrin receptor, ligand binding 0.252071
IPR011009 Protein kinase-like IPR001426 Receptor tyrosine kinase, class V 0.252071
IPR003527 MAP kinase IPR003961 Fibronectin, type III 0.246402
IPR002290 Serine/threonine protein kinase IPR001660 Sterile alpha motif SAM 0.235411
IPR011009 Protein kinase-like IPR001245 Tyrosine protein kinase 0.178275
IPR003527 MAP kinase IPR011009 Protein kinase-like 0.150555
IPR003527 MAP kinase IPR008957 Fibronectin, type III-like fold 0.0477166
IPR008349 ERK1/2 MAP kinase IPR011009 Protein kinase-like 0.0192176
IPR011009 Protein kinase-like IPR008266 Tyrosine protein kinase, active site 0.00724826
IPR000719 Protein kinase IPR001660 Sterile alpha motif SAM 0.000820457
IPR008349 ERK1/2 MAP kinase IPR001245 Tyrosine protein kinase 0.0000302204

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in EPHA1
  • Green Domain is present in both MAPK1 and EPHA1

 0.049
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: EPHA1

PTMResidueReference
Phosphotyrosine 599 PubMed, HPRD
Phosphotyrosine 605 PubMed, HPRD
Phosphotyrosine 781 PubMed, HPRD
Phosphotyrosine 930 PubMed, HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: EPHA1

LocalisationReference
Plasma membrane HPRD
Secreted HPRD
Transitive Score

The common interactors between MAPK1 and EPHA1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andEPHA1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and EPHA1 has 1262 interactors of which there are 613 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for EPHA1-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 0.026
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 115.00 0.037
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.098
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.098
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 62.30 0.062
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 4.15 0.026
HSP90AA1 Hsp89-alpha-delta-N 3.95 0.065
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 2.17 0.064
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 1.42 0.026
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.975 0.051
PLEK PLEK, P47: Pleckstrin 0.515 0.045
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.461 0.058
CRKL CRKL: Crk-like protein 0.461 0.655
JAK1 0.461 0.577
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.461 0.073
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.461 0.058
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 0.577
MSN MSN: Moesin 0.461 0.073
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.577
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.461 0.058
GNAT1 GNAT1, GNATR: Guanine nucleotide-binding protein G(t), alpha-1 subunit 0.449 0.029
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 0.644
ELF1 ELF1: ETS-related transcription factor Elf-1 0.416 0.025
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.416 0.403
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.385 0.064
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.372 0.445
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 0.577
PSCD4 PSCD4, CYT4: Cytohesin-4 0.372 0.064
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.372 0.037
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.064
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.520
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.372 0.655
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.577
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.372 0.064
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.586
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.372 0.073
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.372 0.041
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.064
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 0.655
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 0.520
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.372 0.058
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.344 0.902
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.307 0.065
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.072
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.307 0.731
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.307 0.731
VASP VASP: Vasodilator-stimulated phosphoprotein 0.307 0.072
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.307 0.045
DOK1 DOK1: Docking protein 1 0.275 0.064
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.520
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.275 0.445
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.113
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.064
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 0.808
HCK N/A 0.275 0.520
ETS1 ETS1, EWSR2: Protein C-ets-1 0.275 0.035
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.275 0.064
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.520
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.073
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.275 0.073
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.260 0.072
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.260 0.029
GAB2 N/A 0.251 0.065
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 1.13
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.251 0.063
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.251 0.026
IRS2 IRS2: Insulin receptor substrate 2 0.251 0.0727
WASPIP N/A 0.233 0.029
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.233 0.058
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.058
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.233 0.029
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.233 0.064
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.233 0.058
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.225 0.090
SH3BP5 N/A 0.225 0.065
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 0.577
STAT4 STAT4: Signal transducer and activator of transcription 4 0.225 0.558
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.113
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.225 0.090
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.225 0.808
RASA3 RASA3: Ras GTPase-activating protein 3 0.225 0.073
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.057
CCNH CCNH: Cyclin-H 0.225 0.041
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.210 0.033
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.081
TGFB1 TGFB1, TGFB: Transforming growth factor beta-1 precursor 0.192 0.026
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.072
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.191 0.644
STAT2 STAT2: Signal transducer and activator of transcription 2 0.191 0.403
CXorf9 N/A 0.188 0.064
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.188 0.026
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.188 0.064
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 0.064
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.188 0.041
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.188 0.073
RPS6KB1 N/A 0.188 0.064
FNBP1 N/A 0.188 0.064
GMIP GMIP: GEM-interacting protein 0.188 0.064
SEC24B SEC24B: Protein transport protein Sec24B 0.188 0.033
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.174 0.575
RIN1 RIN1: Ras and Rab interactor 1 0.171 0.363
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 388.00
PSD TYL: TYL protein 0.171 0.065
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.171 0.064
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.064
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.171 0.073
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.171 0.033
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.171 0.041
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.980
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.109
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.109
PSCD2 N/A 0.165 0.109
NSBP1 NSBP1: Nucleosome-binding protein 1 0.165 0.0688
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 0.543
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.980
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.165 0.109
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 0.980
NF2 NF2, SCH: Merlin 0.165 0.109
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.109
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.980
ARFGAP1 N/A 0.155 0.025
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.155 0.065
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.081
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.153 0.109
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.152 1.48
ERF ERF: ETS domain-containing transcription factor ERF 0.152 0.025
GAB1 GAB1: GRB2-associated-binding protein 1 0.152 0.065
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.152 0.902
SNCB SNCB: Beta-synuclein 0.152 0.065
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.152 0.644
ETS2 ETS2: Protein C-ets-2 0.152 0.025
CREB1 CREB1: cAMP response element-binding protein 0.148 0.062
CDC25C CDC25C: M-phase inducer phosphatase 3 0.148 0.098
CCNT2 CCNT2: Cyclin-T2 0.148 0.062
CDC25A CDC25A: M-phase inducer phosphatase 1 0.148 0.098
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.098
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.098
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.098
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.148 0.062
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 0.878
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.878
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.878
STAT3 0.148 0.878
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.098
ELMO1 N/A 0.148 0.098
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.098
ARHGEF7 N/A 0.148 0.098
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.098
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.098
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.148 0.062
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 0.483
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.148 0.878
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.148 0.044
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.139 0.029
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.139 0.090
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.139 0.041
ATM ATM: Serine-protein kinase ATM 0.139 0.041
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.139 0.033
CD2AP CD2AP: CD2-associated protein 0.139 0.073
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.139 0.090
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.139 0.028
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.139 0.029
FYN N/A 0.137 0.143
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.065
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.136 0.058
RDX RDX: Radixin 0.136 0.058
VIL2 N/A 0.136 0.090
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.065
CCNB1 Cyclin B1 0.136 0.046
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.073
STMN1 STMN1, LAP18, OP18: Stathmin 0.136 0.064
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.136 0.041
CENTA1 CENTA1: Centaurin-alpha 1 0.128 0.041
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.065
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.037
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.127 0.037
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.127 0.081
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.124 0.109
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.123 0.644
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.123 0.072
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.123 0.032
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.123 0.166
CDC37 CDC37: Hsp90 co-chaperone Cdc37 0.116 0.034
PGAM1 PGAM1, PGAMA, CDABP0006: Phosphoglycerate mutase 1 0.114 0.046
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.114 0.064
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.114 0.026
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.114 0.035
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.058
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.114 0.036
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.058
RPS10 RPS10: 40S ribosomal protein S10 0.114 0.041
THOC1 THOC1, HPR1: THO complex subunit 1 0.114 0.026
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.114 0.030
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.111 0.064
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.111 0.655
APS SH2B2, APS: SH2B adapter protein 2 0.111 0.655
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.073
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.111 0.090
STMN2 STMN2, SCG10, SCGN10: Stathmin-2 0.111 0.058
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.111 0.586
PLD2 PLD2: Phospholipase D2 0.111 0.073
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.902
BMX N/A 0.110 0.644
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.165
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.056
SNCG SNCG, BCSG1, PERSYN, PRSN: Gamma-synuclein 0.109 0.065
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.072
MCF2 MCF2, DBL: Proto-oncogene DBL 0.109 0.026
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.109 0.051
HMGA2 HMGA2, HMGIC: High mobility group protein HMGI-C 0.109 0.0794
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.109 0.821
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.099 0.655
ETV1 ETV1, ER81: ETS translocation variant 1 0.098 0.025
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.098 1.13
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.166
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.148
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.098 0.165
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.098 0.165
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.148
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.148
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.097 0.577
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.058
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.097 0.445
PLD1 PLD1: Phospholipase D1 0.097 0.090
DAB1 DAB1: Disabled homolog 1 0.097 0.064
TST TST: Thiosulfate sulfurtransferase 0.097 0.060
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.064
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.073
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.065
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.096 0.065
NFATC1 N/A 0.096 0.025
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.096 0.0453
EIF4G1 EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1 0.096 0.039
CIITA CIITA, MHC2TA: MHC class II transactivator 0.096 0.032
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.096 0.037
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.081
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.096 0.072
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.091 0.109
CD44 N/A 0.091 0.123
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.090 0.069
PTPRZ1 N/A 0.090 0.0296
CCND1 CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1 0.088 0.057
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 1.01
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.088 0.073
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.087 0.029
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.087 0.046
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.065
CTPS CTPS: CTP synthase 1 0.086 0.029
RELA RELA, NFKB3: Transcription factor p65 0.086 0.046
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.086 0.090
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.086 0.029
PITPNM1 PITPNM1: Uncharacterized protein PITPNM1 0.086 0.029
MTA1 MTA1: Metastasis-associated protein MTA1 0.086 0.028
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.086 0.033
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.083 0.049
AMPH AMPH, AMPH1: Amphiphysin 0.083 0.109
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.049
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.083 0.049
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.083 0.109
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.083 0.034
CASP8 CASP8, MCH5: Caspase-8 precursor 0.083 0.049
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.049
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.083 0.049
MAPK15 N/A 0.083 0.109
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.083 0.034
CASP9 CASP9, MCH6: Caspase-9 precursor 0.083 0.049
CASP1 CASP1, IL1BC, IL1BCE: Caspase-1 precursor 0.083 0.049
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.049
AKAP12 AKAP12, AKAP250: A-kinase anchor protein 12 0.083 0.049
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.083 0.162
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.0818 0.111
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.097
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.078 0.027
LCP1 LCP1, PLS2: Plastin-2 0.078 0.058
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.078 0.026
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.077 0.081
STK16 N/A 0.077 0.126
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.077 0.109
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.077 0.075
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.077 0.065
TNFSF12 TNFSF12, APO3L, UNQ181/PRO207, DR3LG: Tumor necrosis factor ligand superfamily m 0.075 0.033
ATP2B1 N/A 0.075 0.049
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.075 0.109
FADD FADD, MORT1: Protein FADD 0.075 0.062
GIT2 N/A 0.075 0.044
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.075 0.098
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.062
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.075 0.098
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.040
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.075 0.098
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.098
SNX3 N/A 0.075 0.040
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.098
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.075 0.044
CNN2 CNN2: Calponin-2 0.075 0.044
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.075 0.030
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.075 0.098
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.025
TSC2 TSC2, TSC4: Tuberin 0.075 0.044
RBL1 RBL1: Retinoblastoma-like protein 1 0.075 0.030
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.098
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.075 0.098
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.098
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.075 0.098
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.040
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.098
RIN3 N/A 0.074 0.128
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.073 0.136
GABRB1 GABRB1: Gamma-aminobutyric acid receptor subunit beta-1 precursor 0.073 0.088
GABRR1 N/A 0.0727 0.123
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.072 0.0416
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.071 0.041
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.071 0.026
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.071 0.037
CAPNS1 CAPNS1, CAPN4, CAPNS: Calpain small subunit 1 0.070 0.033
SLC9A3R1 SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50 0.070 0.037
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.070 0.029
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.070 0.065
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.069 0.030
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.069 0.026
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.069 0.073
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.069 0.064
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.069 0.073
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 0.069 0.033
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.064
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.069 0.114
MCL1 MCL1: Induced myeloid leukemia cell differentiation protein Mcl-1 0.0688 0.034
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 42.20
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.064 0.033
IL1B IL1B, IL1F2: Interleukin-1 beta precursor 0.063 0.033
BCL2 BCL2: Apoptosis regulator Bcl-2 0.063 0.031
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.063 0.027
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.063 0.028
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.063 0.036
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.063 0.029
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.063 0.029
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.063 0.033
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.063 0.036
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.063 0.065
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.063 0.065
PEA15 PEA15: Astrocytic phosphoprotein PEA-15 0.062 0.029
COBL N/A 0.062 0.029
SPTAN1 N/A 0.062 0.072
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.062 0.0416
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.062 0.0794
GRLF1 N/A 0.062 0.100
CHAT CHAT: Choline O-acetyltransferase 0.062 0.062
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.058 0.097
GLRA1 N/A 0.058 0.111
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.058 0.033
PFKFB2 PFKFB2: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.057 0.041
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.057 0.0416
TNF TNF, TNFA, TNFSF2: Tumor necrosis factor precursor 0.057 0.110
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.057 0.123
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.057 0.109
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.056 0.030
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.056 0.090
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.056 0.026
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 0.058
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.056 0.026
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.056 0.067
STAM2 STAM2: Signal transducing adapter molecule 2 0.056 0.073
NOS1 NOS1: Nitric-oxide synthase, brain 0.056 0.029
CDKN1A CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1: Cyclin-dependent kinase inhi 0.055 0.031
TP73 TP73, P73: Tumor protein p73 0.055 0.046
TUBB TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain 0.054 0.041
EIF4EBP1 EIF4EBP1: Eukaryotic translation initiation factor 4E-binding protein 1 0.053 0.053
FUBP1 N/A 0.052 0.081
TERF2 TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2 0.052 0.025
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.052 0.0263
PSMB4 PSMB4: Proteasome subunit beta type-4 precursor 0.051 0.051
PPP1R14C PPP1R14C, KEPI: Protein phosphatase 1 regulatory subunit 14C 0.051 0.051
GRB10 N/A 0.051 0.617
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
PTPRA N/A 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.617
DOK2 DOK2: Docking protein 2 0.051 0.051
PPP1R1B PPP1R1B, DARPP32: Protein phosphatase 1 regulatory subunit 1B 0.051 0.051
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.617
CRK CRK: Proto-oncogene C-crk 0.051 0.617
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
FGF23 FGF23, HYPF, UNQ3027/PRO9828: Fibroblast growth factor 23 precursor 0.051 0.026
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.051 0.044
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.050 0.040
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.050 0.064
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.049 0.165
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.049 0.056
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.049 0.165
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.049 0.165
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.165
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.049 0.056
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.049 0.083
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.165
EDA N/A 0.049 0.056
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.049 0.056
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.049 0.165
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.165
LAT LAT: Linker for activation of T-cells family member 1 0.049 0.083
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.049 0.083
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.165
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.049 0.056
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.165
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.049 0.033
SORBS3 SORBS3, SCAM1: Vinexin 0.049 0.090
TUBB3 TUBB3, TUBB4: Tubulin beta-3 chain 0.048 0.045
KCNAB2 KCNAB2, KCNA2B, KCNK2: Voltage-gated potassium channel subunit beta-2 0.047 0.044
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.046 0.033
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.046 0.026
FLII FLII, FLIL: Protein flightless-1 homolog 0.046 0.041
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.046 0.090
CCR5 CCR5: CCR5 receptor (Fragment) 0.046 0.096
TH TH, TYH: Tyrosine 3-monooxygenase 0.046 0.046
PPP1R14A PPP1R14A, CPI17, PPP1INL: Protein phosphatase 1 regulatory subunit 14A 0.046 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 0.553
VAV2 VAV2: Uncharacterized protein VAV2 0.046 0.553
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.046 0.046
EPB41 EPB41, E41P: Protein 4.1 0.046 0.046
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.046 0.036
EFNB1 EFNB1, EFL-3, EPLG2, LERK2: Ephrin-B1 precursor 0.046 99.70
HMGCR HMGCR: 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.046 0.028
COASY COASY, PSEC0106: Bifunctional coenzyme A synthase 0.046 0.035
MT1X MT1X: Metallothionein-1X 0.046 0.082
MT2A MT2A, CES1, MT2: Metallothionein-2 0.046 0.082
LTA LTA, TNFB, TNFSF1: Lymphotoxin-alpha precursor 0.0453 0.037
EPOR EPOR: Erythropoietin receptor precursor 0.0453 0.098
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.0453 0.037
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.191
CD40LG CD40LG, CD40L, TNFSF5, TRAP: CD40 ligand 0.0453 0.064
GDF15 GDF15, MIC1, PDF, PLAB, PTGFB: Growth/differentiation factor 15 precursor 0.045 0.100
CGA CGA: Glycoprotein hormones alpha chain precursor 0.045 0.029
TSHB TSHB: Thyrotropin subunit beta precursor 0.045 0.072
FSHB FSHB: Follitropin subunit beta precursor 0.045 0.072
LHB LHB: Lutropin subunit beta precursor 0.045 0.026
CGB CGB, CGB3, CGB5, CGB7, CGB8: Choriogonadotropin subunit beta precursor 0.045 0.081
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.0446 0.109
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.044 0.051
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.044 0.090
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.044 0.029
CTTN CTTN, EMS1: Src substrate cortactin 0.044 0.100
CNN3 CNN3: Calponin-3 0.044 0.072
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.044 0.046
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.044 0.113
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.044 0.073
MYST4 MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4 0.044 0.035
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.075
AQP4 AQP4: Aquaporin-4 0.044 0.075
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.075
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 0.025
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.075
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.044 0.050
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.043 0.037
TXN TXN, TRDX, TRX, TRX1: Thioredoxin 0.043 0.041
GNB2L1 Lung cancer oncogene 7 0.0425 0.031
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.0425 0.072
XRCC1 XRCC1: DNA-repair protein XRCC1 0.0425 0.045
ALOX5 ALOX5, LOG5: Arachidonate 5-lipoxygenase 0.0425 0.032
TBC1D1 TBC1D1, KIAA1108: TBC1 domain family member 1 0.042 0.053
SLC4A7 SLC4A7: Uncharacterized protein SLC4A7 0.041 0.035
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.041 1.08E3
VWF VWF, F8VWF: von Willebrand factor precursor 0.041 0.090
MT1F MT1F, PRO0376: Metallothionein-1F 0.041 0.082
INHA INHA: Inhibin alpha chain precursor 0.041 0.033
FGF5 FGF5: Fibroblast growth factor 5 precursor 0.041 0.029
NDP NDP: Norrin precursor 0.041 0.065
PDGFA PDGFA, PDGF1: Platelet-derived growth factor A chain precursor 0.041 0.033
LOC645745 MT1H: Metallothionein-1H 0.041 0.082
KIT KIT: Mast/stem cell growth factor receptor precursor 0.041 0.097
GLRB GLRB: Glycine receptor subunit beta precursor 0.041 0.044
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.111
GRM3 GRM3, GPRC1C, MGLUR3: Metabotropic glutamate receptor 3 precursor 0.041 0.044
SH2D1A SH2D1A, DSHP, SAP: SH2 domain-containing protein 1A 0.041 0.200
FGF9 FGF9: Glia-activating factor precursor 0.041 0.026
BMP7 BMP7, OP1: Bone morphogenetic protein 7 precursor 0.041 0.073
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.04 0.052
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.040 0.088
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.040 0.097
ITGB7 ITGB7: Integrin beta-7 precursor 0.040 0.097
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.040 0.041
MYH9 MYH9: Myosin-9 0.038 0.035
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 0.038 0.033
CFL1 CFL1, CFL: Cofilin-1 0.038 0.033
CHP CHP: Calcium-binding protein p22 0.038 0.073
MDN1 MDN1, KIAA0301: Midasin 0.038 0.041
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.038 0.028
TLN1 TLN1: Uncharacterized protein TLN1 0.038 0.073
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.037 0.055
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.037 0.109
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.037 0.191
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.037 0.0416
GHR GHR: Growth hormone receptor precursor 0.037 0.123
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.037 0.098
CD5 CD5, LEU1: T-cell surface glycoprotein CD5 precursor 0.037 0.127
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.037 0.123
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.037 0.191
PFKFB1 N/A 0.037 0.057
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.036 0.0416
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.036 0.033
CRLF3 N/A 0.036 0.0416
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.036 0.123
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.036 0.109
CD7 CD7: T-cell antigen CD7 precursor 0.036 0.0416
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.036 0.0416
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.036 0.033
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.036 0.123
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.036 0.123
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.036 0.033
PDK1 PDK1: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial precu 0.035 0.028
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.034 0.0273
GJA1 GJA1, GJAL: Gap junction alpha-1 protein 0.0338 0.0338
TPH1 N/A 0.0338 0.030
NOS2A NOS2A, NOS2: Nitric oxide synthase, inducible 0.034 0.030
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.034 0.109
SLC4A1 SLC4A1, AE1, DI, EPB3: Band 3 anion transport protein 0.033 0.028
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.033 0.044
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.033 0.049
GRM1 GRM1, GPRC1A, MGLUR1: Metabotropic glutamate receptor 1 precursor 0.033 0.049
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.033 0.049
RHO RHO, OPN2: Rhodopsin 0.033 0.062
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.033 0.077
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.033 0.109
PRLR PRLR: Prolactin receptor precursor 0.033 0.109
F3 F3: Tissue factor precursor 0.032 0.191
TNFSF15 TNFSF15, RP11-428F18.1-001, hCG_27396: TNF superfamily ligand TL1A 0.032 0.037
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.032 0.123
IL9R IL9R: Interleukin-9 receptor precursor 0.032 0.152
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.032 0.191
CASR CASR, GPRC2A, PCAR1: Extracellular calcium-sensing receptor precursor 0.032 0.077
ITGB4 N/A 0.032 0.085
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.032 0.098
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.100
SNAPC4 SNAPC4, SNAP190: snRNA-activating protein complex subunit 4 0.032 0.031
REST REST, NRSF, XBR: RE1-silencing transcription factor 0.032 0.041
PLSCR1 PLSCR1: Phospholipid scramblase 1 0.032 0.044
SORL1 SORL1: Sortilin-related receptor precursor 0.032 0.0416
RYR2 RYR2: Ryanodine receptor 2 0.031 0.041
GJB1 GJB1, CX32: Gap junction beta-1 protein 0.030 0.0782
PPP1R1A PPP1R1A, IPP1: Protein phosphatase 1 regulatory subunit 1A 0.030 0.059
GJA5 GJA5: Gap junction alpha-5 protein 0.030 0.038
PEBP1 PEBP1, PBP, PEBP: Phosphatidylethanolamine-binding protein 1 0.030 0.034
OPRM1 OPRM1, MOR1: Mu-type opioid receptor 0.030 0.030
ABCB9 ABCB9, KIAA1520: ATP-binding cassette sub-family B member 9 precursor 0.030 0.030
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 0.097
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.029 0.136
NEO1 NEO1, NGN: Neogenin precursor 0.029 0.046
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.029 0.062
EGF EGF: Pro-epidermal growth factor precursor 0.029 0.037
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.029 0.0416
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.029 0.109
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.029 0.049
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.029 0.136
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.029 0.044
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.029 0.073
THOP1 THOP1: Thimet oligopeptidase 0.029 0.073
SYMPK SYMPK, SPK: Symplekin 0.029 0.033
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.029 0.041
FXR2 FXR2, FMR1L2: Fragile X mental retardation syndrome-related protein 2 0.029 0.027
TRIM25 TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25 0.029 0.029
DSP DSP: Desmoplakin 0.028 0.049
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
HDAC8 N/A 0.028 0.034
S100A16 S100A16, AAG13: Protein S100-A16 0.028 0.109
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.028 0.044
PPEF1 N/A 0.028 0.044
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.028 0.049
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.04
PKP4 PKP4: Plakophilin-4 0.028 0.049
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.028 0.049
VAV3 VAV3: Protein vav-3 0.028 0.128
PTGIR PTGIR, PRIPR: Prostacyclin receptor 0.027 0.0308
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.217
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.217
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.265
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.217
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.217
LILRB1 N/A 0.027 0.098
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.027 0.098
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.027 0.0416
CD69 CD69: Early activation antigen CD69 0.027 0.123
ITGAE ITGAE: Integrin alpha-E precursor 0.027 0.037
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.026 0.086
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.026 46.80
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.026 0.086
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.026 0.026
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.081
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.026 0.065
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.026 0.126
IL1A IL1A, IL1F1: Interleukin-1 alpha precursor 0.025 0.126
IL18 IL18, IGIF, IL1F4: Interleukin-18 precursor 0.025 0.0407
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.025 0.033
F5 F5: Coagulation factor V precursor 0.025 0.902
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.025 0.040
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.025 0.098
GSN GSN: Gelsolin precursor 0.025 0.036
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.025 0.098
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.036
MYO18A 0.025 0.036
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.025 0.044
DPP8 DPP8, DPRP1, MSTP097, MSTP135, MSTP141: Dipeptidyl peptidase 8 0.025 0.044
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.062
ACTN4 ACTN4: Alpha-actinin-4 0.025 0.098
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.025 0.036
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.025 0.062
UBE2A UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A 0.025 0.044
RNF20 0.025 0.030
TRERF1 TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1 0.025 0.030
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.025 0.098
NLN NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor 0.025 0.040
CFL2 CFL2: Cofilin-2 0.025 0.036
SVIL SVIL: Supervillin 0.025 0.036
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.025 0.030
MIER1 MIER1, KIAA1610: Mesoderm induction early response protein 1 0.025 0.030
0.299
Total Score 3.12