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Evidence of Interaction Between SNRPG and EIF2S2

The interaction score between SNRPG and EIF2S2 is 3.36.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SNRPG and EIF2S2 = 0.85

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismSNRPG OrthologueEIF2S2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YFL017W-A 1 YPL237W 1
worm Q9N4G9 1 Q21230 1
fly Q9VXE0 1 P41375 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains No domains were used in calculating likelihood of interaction 1.48E-3
Post-translational Modifications

Protein: SNRPG

PTMResidueReference

Protein: EIF2S2

PTMResidueReference
Phosphorylation 2 PubMed, HPRD
Phosphorylation 13 PubMed, HPRD
Phosphorylation 67 PubMed, HPRD
Phosphorylation 218 PubMed, HPRD
Localisation

Protein: SNRPG

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: EIF2S2

LocalisationReference
Nucleolus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between SNRPG and EIF2S2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPG andEIF2S2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPG has 256 interactors and EIF2S2 has 864 interactors of which there are 64 common interactors.

Common InteractorName of Common InteractorScore for SNRPG-Interactor (?)Score for EIF2S2-Interactor (?)
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 2.07E3 0.276
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 2.07E3 0.276
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 32.60 0.078
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 2.60 0.048
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 1.22 0.129
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.890 0.046
SNRP70 SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa 0.657 0.046
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.354 0.025
DDX21 DDX21: Nucleolar RNA helicase 2 0.293 0.144
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.263 0.078
CDC20 CDC20: Cell division cycle protein 20 homolog 0.263 0.129
GNB2L1 Lung cancer oncogene 7 0.137 0.087
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.137 0.087
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.137 0.087
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.123 0.078
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.123 0.078
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.123 0.276
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.123 0.078
SND1 SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1 0.123 0.129
PAK1IP1 PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1 0.123 0.063
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.123 0.078
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.083 0.144
SERBP1 N/A 0.082 0.027
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.082 0.053
BLM BLM, RECQ2, RECQL3: Bloom syndrome protein 0.074 0.078
WRN WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase 0.074 0.063
CORO1C CORO1C, CRNN4: Coronin-1C 0.074 0.063
SEC31L1 N/A 0.074 0.063
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.074 0.046
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.074 0.063
COPB2 COPB2: Coatomer subunit beta' 0.074 0.078
COPA COPA: Coatomer subunit alpha 0.074 0.063
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.074 0.078
PA2G4 PA2G4, EBP1: Proliferation-associated protein 2G4 0.0739 0.0479
WDR1 N/A 0.067 0.070
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.060 0.063
WDHD1 WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1 0.060 0.046
REXO2 REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor 0.060 0.046
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.044 0.046
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.044 0.038
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.044 0.046
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.044 0.046
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.044 0.029
ERCC3 ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit 0.044 0.038
SKIV2L SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti 0.044 0.063
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.044 0.046
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.044 0.046
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.044 431.00
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.044 0.129
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.036 0.038
DDX24 DDX24: ATP-dependent RNA helicase DDX24 0.036 0.029
BCDO2 PTS: 6-pyruvoyl tetrahydrobiopterin synthase 0.036 0.046
NUP214 N/A 0.0308 0.026
DYNC1I2 N/A 0.028 0.038
BRIP1 BRIP1, BACH1, FANCJ: Fanconi anemia group J protein 0.028 0.029
PTD004 N/A 0.027 0.027
RTCD1 RTCD1, RPC, RPC1, RTC1: RNA 3'-terminal phosphate cyclase 0.027 0.027
HSPC185 CGI-117, HSPC111: UPF0384 protein CGI-117 0.027 0.027
PSME3 PSME3: Proteasome activator complex subunit 3 0.027 0.025
NOLC1 NOLC1, KIAA0035: Nucleolar phosphoprotein p130 0.027 0.025
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.027 0.231
WDR54 N/A 0.027 0.028
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.027 0.028
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.027 0.028
0.572
Total Score 3.36