PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between SNRPG and SMN2

The interaction score between SNRPG and SMN2 is 5.47.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

N/A

Orthology

Organism	SNRPG Orthologue		SMN2 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
worm	Q9N4G9	1	Q93365	1
fly	Q9VXE0	1	Q9VV74	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3

Domains

Domains present in SNRPG and SMN2:

Domains in SNRPG

Domains in SMN2

IPR001163	Small nuclear ribonucleoprotein (Sm protein)
IPR010920	Small nuclear-like ribonucleoprotein
IPR006649	snRNP domain

IPR002999	Tudor domain
IPR010304	Survival motor neuron

The Chi square scores for co-occurrence of domains that are present in SNRPG and SMN2 are listed below.

Domain 1		Domain 2		Chi Square
IPR001163	Small nuclear ribonucleoprotein (Sm protein)	IPR010304	Survival motor neuron	702.603
IPR006649	snRNP domain	IPR010304	Survival motor neuron	613.43
IPR010920	Small nuclear-like ribonucleoprotein	IPR010304	Survival motor neuron	470.051
IPR001163	Small nuclear ribonucleoprotein (Sm protein)	IPR002999	Tudor domain	398.076
IPR006649	snRNP domain	IPR002999	Tudor domain	346.98
IPR010920	Small nuclear-like ribonucleoprotein	IPR002999	Tudor domain	265.147

The background colour of the table refers to:

Blue Domain is only present in SNRPG
Yellow Domain is only present in SMN2
Green Domain is present in both SNRPG and SMN2

0.027

Post-translational Modifications

Protein: SNRPG

PTM	Residue	Reference

Protein: SMN2

PTM	Residue	Reference
Phosphorylation	28	PubMed, HPRD

Localisation

Protein: SNRPG

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Protein: SMN2

Localisation	Reference
Nucleus	HPRD
Nucleolus	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between SNRPG and SMN2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPG andSMN2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPG has 256 interactors and SMN2 has 939 interactors of which there are 60 common interactors.

Common Interactor	Name of Common Interactor	Score for SNRPG-Interactor (?)	Score for SMN2-Interactor (?)
SNRPD1	SNRPD1: Small nuclear ribonucleoprotein Sm D1	2.07E3	0.148
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	2.07E3	0.148
LSM5	LSM5: U6 snRNA-associated Sm-like protein LSm5	691.00	0.050
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	32.60	0.025
SNRPE	SNRPE: Small nuclear ribonucleoprotein E	8.73	0.027
SNRPB	SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B'	2.91	0.027
LSM8	LSM8: U6 snRNA-associated Sm-like protein LSm8	2.60	0.050
LSM3	LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3	2.60	0.050
LSM2	LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2	1.22	0.148
SF3B1	SF3B1, SAP155: Splicing factor 3B subunit 1	0.890	0.025
SNRP70	SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa	0.657	0.148
SF3A1	SF3A1, SAP114: Splicing factor 3 subunit 1	0.412	0.030
PLK1	PLK1, PLK: Serine/threonine-protein kinase PLK1	0.354	0.025
DDX21	DDX21: Nucleolar RNA helicase 2	0.293	0.028
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.263	0.025
CDC20	CDC20: Cell division cycle protein 20 homolog	0.263	0.025
GNB2L1	Lung cancer oncogene 7	0.137	0.028
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.137	0.028
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.137	0.028
CSTF1	CSTF1: Cleavage stimulation factor 50 kDa subunit	0.123	0.025
CGI-48	UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho	0.123	0.025
EIF3S2	EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2	0.123	0.025
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.123	0.025
SND1	SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1	0.123	0.025
PAK1IP1	PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1	0.123	0.025
CHAF1B	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B	0.123	0.025
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.083	0.028
BLM	BLM, RECQ2, RECQL3: Bloom syndrome protein	0.074	0.025
WRN	WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase	0.074	0.025
CORO1C	CORO1C, CRNN4: Coronin-1C	0.074	0.025
SEC31L1	N/A	0.074	0.025
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	0.074	0.025
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.074	0.025
COPB2	COPB2: Coatomer subunit beta'	0.074	0.025
COPA	COPA: Coatomer subunit alpha	0.074	0.025
DDX41	DDX41, ABS: Probable ATP-dependent RNA helicase DDX41	0.074	0.025
WDR1	N/A	0.067	0.028
DHX16	DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN	0.060	0.025
WDHD1	WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1	0.060	0.025
REXO2	REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor	0.060	0.025
GNB2	GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.044	0.025
DDX5	DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5	0.044	0.025
HIRA	HIRA, DGCR1, HIR, TUPLE1: Protein HIRA	0.044	0.025
SMARCA3	HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor	0.044	0.028
DICER1	DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer	0.044	0.025
ERCC3	ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit	0.044	0.025
SKIV2L	SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti	0.044	0.025
ARPC1B	ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B	0.044	0.025
GNB1	GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.044	0.025
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	0.044	0.025
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.044	0.025
DDX3Y	DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y	0.036	0.025
DDX24	DDX24: ATP-dependent RNA helicase DDX24	0.036	0.025
BCDO2	PTS: 6-pyruvoyl tetrahydrobiopterin synthase	0.036	0.025
NUP214	N/A	0.0308	0.028
DYNC1I2	N/A	0.028	0.025
BRIP1	BRIP1, BACH1, FANCJ: Fanconi anemia group J protein	0.028	0.025
WDR54	N/A	0.027	0.028
TLE3	TLE3, KIAA1547: Transducin-like enhancer protein 3	0.027	0.028
SMARCAD1	SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator	0.027	0.028

0.572

Total Score

5.47