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Evidence of Interaction Between RFC4 and PSMC4

The interaction score between RFC4 and PSMC4 is 5.47.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismRFC4 OrthologuePSMC4 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YJR068W 1 YDR394W 1
worm P53016 1 P46502 1
fly Q9VX15 1 Q9V405 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in RFC4 and PSMC4:
Domains in RFC4Domains in PSMC4
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR008921 DNA polymerase III clamp loader subunit, C-terminal
IPR000862 RFC
IPR013748 Replication factor C
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR005937 26S proteasome subunit P45
IPR001270 Chaperonin clpA/B

The Chi square scores for co-occurrence of domains that are present in RFC4 and PSMC4 are listed below.

Domain 1Domain 2Chi Square
IPR003959 AAA ATPase, central region IPR003960 AAA-protein subdomain 196.989
IPR000862 RFC IPR003959 AAA ATPase, central region 182.174
IPR003959 AAA ATPase, central region IPR005937 26S proteasome subunit P45 175.434
IPR003959 AAA ATPase, central region IPR003959 AAA ATPase, central region 167.459
IPR003593 AAA ATPase IPR003959 AAA ATPase, central region 133.351
IPR000862 RFC IPR003593 AAA ATPase 128.851
IPR003593 AAA ATPase IPR003593 AAA ATPase 89.0695
IPR003593 AAA ATPase IPR003960 AAA-protein subdomain 88.087
IPR003593 AAA ATPase IPR005937 26S proteasome subunit P45 80.4077

The background colour of the table refers to:

  • Blue Domain is only present in RFC4
  • Yellow Domain is only present in PSMC4
  • Green Domain is present in both RFC4 and PSMC4

 0.027
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: RFC4

LocalisationReference
Nucleoplasm HPRD

Protein: PSMC4

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between RFC4 and PSMC4 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RFC4 andPSMC4. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RFC4 has 123 interactors and PSMC4 has 83 interactors of which there are 16 common interactors.

Common InteractorName of Common InteractorScore for RFC4-Interactor (?)Score for PSMC4-Interactor (?)
RFC5 RFC5: Replication factor C subunit 5 691.00 6.33
RFC2 RFC2: Replication factor C subunit 2 62.80 6.33
TAF9 AK6, AD-004, CGI-137: Adenylate kinase isoenzyme 6 0.137 0.027
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.137 0.027
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.083 0.027
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.074 6.33
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.074 6.33
PSMC6 PSMC6, SUG2: 26S protease regulatory subunit S10B 0.074 6.33
PSMC3 PSMC3, TBP1: 26S protease regulatory subunit 6A 0.074 32.20
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.067 0.027
MDN1 MDN1, KIAA0301: Midasin 0.060 6.33
SRPR SRPR: Uncharacterized protein SRPR 0.041 0.027
RPA3 RPA3, REPA3, RPA14: Replication protein A 14 kDa subunit 0.027 0.027
RAD51L1 RAD51L1, RAD51B, REC2: DNA repair protein RAD51 homolog 2 0.027 0.027
DNAH11 N/A 0.027 0.027
RAD51L3 RAD51L3, RAD51D: DNA repair protein RAD51 homolog 4 0.027 0.027
0.572
Total Score 5.47