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Evidence of Interaction Between EPOR and ZAP70

The interaction score between EPOR and ZAP70 is 9.94.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EPOR and ZAP70 = -0.06

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.62E-3
Orthology N/A N/A
Domains Domains present in EPOR and ZAP70:
Domains in EPORDomains in ZAP70
IPR003961 Fibronectin, type III
IPR003528 Long hematopoietin receptor, single chain
IPR009167 Erythropoietin receptor
IPR002996 Cytkn_recept_B/G.
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR000980 SH2 motif
IPR012234 TyrPK_SYK.

The Chi square scores for co-occurrence of domains that are present in EPOR and ZAP70 are listed below.

Domain 1Domain 2Chi Square
IPR002996 Cytkn_recept_B/G. IPR000980 SH2 motif 227.343
IPR003961 Fibronectin, type III IPR000980 SH2 motif 184.508
IPR003528 Long hematopoietin receptor, single chain IPR000980 SH2 motif 151.135
IPR009167 Erythropoietin receptor IPR000980 SH2 motif 38.4825
IPR002996 Cytkn_recept_B/G. IPR008266 Tyrosine protein kinase, active site 29.0781
IPR003961 Fibronectin, type III IPR008266 Tyrosine protein kinase, active site 22.1621
IPR002996 Cytkn_recept_B/G. IPR001245 Tyrosine protein kinase 15.1473
IPR003528 Long hematopoietin receptor, single chain IPR008266 Tyrosine protein kinase, active site 10.4494
IPR003961 Fibronectin, type III IPR001245 Tyrosine protein kinase 6.5864
IPR003528 Long hematopoietin receptor, single chain IPR001245 Tyrosine protein kinase 5.65936
IPR003528 Long hematopoietin receptor, single chain IPR011009 Protein kinase-like 3.32619
IPR009167 Erythropoietin receptor IPR008266 Tyrosine protein kinase, active site 1.98391
IPR003528 Long hematopoietin receptor, single chain IPR000719 Protein kinase 1.94307
IPR002996 Cytkn_recept_B/G. IPR011009 Protein kinase-like 1.93327
IPR002996 Cytkn_recept_B/G. IPR000719 Protein kinase 1.43014
IPR009167 Erythropoietin receptor IPR000719 Protein kinase 0.93762
IPR009167 Erythropoietin receptor IPR001245 Tyrosine protein kinase 0.822994
IPR003961 Fibronectin, type III IPR000719 Protein kinase 0.712801
IPR003961 Fibronectin, type III IPR011009 Protein kinase-like 0.616354
IPR009167 Erythropoietin receptor IPR011009 Protein kinase-like 0.331462
IPR003961 Fibronectin, type III IPR012234 TyrPK_SYK. 0.026544

The background colour of the table refers to:

  • Blue Domain is only present in EPOR
  • Yellow Domain is only present in ZAP70
  • Green Domain is present in both EPOR and ZAP70

 0.109
Post-translational Modifications

Protein: EPOR

PTMResidueReference
Phosphorylation 368 PubMed, HPRD
Phosphorylation 426 PubMed, HPRD
Phosphorylation 454 PubMed, HPRD
Phosphorylation 456 PubMed, HPRD
Phosphorylation 468 PubMed, HPRD
Phosphorylation 485 PubMed, HPRD
Phosphorylation 489 PubMed, HPRD
Phosphorylation 504 PubMed, HPRD

Protein: ZAP70

PTMResidueReference
Dephosphorylation 292 PubMed, HPRD
Phosphorylation 69 PubMed, HPRD
Phosphorylation 126 PubMed, HPRD
Phosphorylation 178 PubMed, HPRD
Phosphorylation 289 PubMed, HPRD
Phosphorylation 292 PubMed, HPRD
Phosphorylation 293 PubMed, HPRD
Phosphorylation 315 PubMed, HPRD
Phosphorylation 319 PubMed, HPRD
Phosphorylation 474 PubMed, HPRD
Phosphorylation 492 PubMed, HPRD
Phosphorylation 493 PubMed, HPRD
Phosphorylation 494 PubMed, HPRD
Phosphoserine 289 HPRD
Phosphotyrosine 248 HPRD
Phosphotyrosine 292 HPRD
Phosphotyrosine 315 HPRD
Phosphotyrosine 319 HPRD
Phosphotyrosine 492 PubMed, HPRD
Phosphotyrosine 493 HPRD
Localisation

Protein: EPOR

LocalisationReference
ER HPRD
Plasma membrane HPRD
Secreted HPRD

Protein: ZAP70

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between EPOR and ZAP70 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EPOR andZAP70. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EPOR has 1024 interactors and ZAP70 has 1506 interactors of which there are 661 common interactors.

Common InteractorName of Common InteractorScore for EPOR-Interactor (?)Score for ZAP70-Interactor (?)
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 3.59 0.109
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.541 0.123
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.340 0.171
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.253 0.097
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.251 0.072
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.210 0.126
HSP90AA1 Hsp89-alpha-delta-N 0.202 0.069
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.191 0.065
CRLF3 N/A 0.191 0.274
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.166 0.171
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.166 0.097
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.166 0.111
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.980
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.109
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.109
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.980
FN1 N/A 0.165 0.109
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.109
BSG N/A 0.165 0.098
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.165 0.878
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.165 0.098
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.165 0.878
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.109
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.165 0.098
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.878
CNTN1 CNTN1: Contactin-1 precursor 0.165 0.098
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.980
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.165 0.098
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.109
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.165 0.109
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.165 0.109
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.109
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.165 0.109
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.165 0.109
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.165 0.109
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.165 0.878
CNTN4 CNTN4: Contactin-4 precursor 0.165 0.098
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.109
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.153 0.136
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.153 0.136
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.152 0.072
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.152 0.655
KIT KIT: Mast/stem cell growth factor receptor precursor 0.152 0.577
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.127 0.171
CRKL CRKL: Crk-like protein 0.126 1.35
EFNB1 EFNB1, EFL-3, EPLG2, LERK2: Ephrin-B1 precursor 0.126 0.041
RDX RDX: Radixin 0.126 0.088
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.126 0.171
GAB1 GAB1: GRB2-associated-binding protein 1 0.126 0.109
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.126 650.00
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.126 0.041
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.126 0.171
CD2AP CD2AP: CD2-associated protein 0.126 0.171
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.125 0.038
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.124 0.097
DCC DCC: Netrin receptor DCC precursor 0.123 0.058
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.123 0.072
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.123 0.081
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.123 0.520
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.123 0.072
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.123 0.065
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.123 0.065
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.123 0.655
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.123 0.586
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.123 0.520
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.123 0.577
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.123 0.058
GHR GHR: Growth hormone receptor precursor 0.123 0.065
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.123 0.072
INSR INSR: Insulin receptor precursor 0.123 0.520
IL9R IL9R: Interleukin-9 receptor precursor 0.123 0.081
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.110 0.113
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.109 0.148
MAPK15 N/A 0.109 0.165
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 563.00
PSCD2 N/A 0.109 0.165
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.109 0.148
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.109 0.148
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.148
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.109 0.148
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 1.30
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.109 0.165
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.109 0.148
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.109 1.17
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.165
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.109 0.148
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 0.0688
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.109 0.148
ARHGEF7 N/A 0.109 0.148
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.165
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.109 0.148
ELMO1 N/A 0.109 0.148
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 1.30
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.109 0.148
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.109 0.148
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 1.30
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 1.30
ANGPTL6 AGF, UNQ152/PRO178, ANGPTL6, ARP5: Angiopoietin-related protein 6 precursor 0.109 0.030
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.109 0.165
NF2 NF2, SCH: Merlin 0.109 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 1.30
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.109 0.483
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.109 1.17
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.109 1.17
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.165
FGG FGG, PRO2061: Fibrinogen gamma chain precursor 0.109 0.030
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.109 0.148
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.165
FCN3 FCN3, FCNH, HAKA1: Ficolin-3 precursor 0.109 0.030
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.165
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.109 0.148
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.148
STAT3 0.109 1.30
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.109 1.17
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.109 0.064
F3 F3: Tissue factor precursor 0.109 0.072
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.109 0.100
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.109 0.058
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.109 0.655
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.109 0.072
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.109 0.520
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.109 0.064
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.109 0.340
TNC TNC, HXB: Tenascin precursor 0.109 0.058
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.109 1.19
ITGB4 N/A 0.109 0.072
MET MET: Hepatocyte growth factor receptor precursor 0.109 0.581
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.109 0.581
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.109 0.644
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.109 0.654
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.109 0.274
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.109 0.520
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.109 0.099
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.109 0.166
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.109 0.081
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.109 0.058
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.109 0.065
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.109 0.072
SORL1 SORL1: Sortilin-related receptor precursor 0.109 0.202
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.109 0.065
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.109 0.123
PRLR PRLR: Prolactin receptor precursor 0.109 0.065
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.109 0.655
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.109 0.520
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.105 0.0727
TLN1 TLN1: Uncharacterized protein TLN1 0.100 0.136
DOK1 DOK1: Docking protein 1 0.100 0.136
PLD2 PLD2: Phospholipase D2 0.100 0.097
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.100 0.136
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.100 0.416
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.100 856.00
CP CP: Ceruloplasmin precursor 0.100 0.041
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.100 0.874
STAM2 STAM2: Signal transducing adapter molecule 2 0.100 0.097
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.100 0.694
RPS6KB1 N/A 0.100 0.275
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.100 2.17
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.100 0.111
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.100 0.275
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.100 0.136
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.098 0.520
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.098 0.586
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.098 0.655
PTPRZ1 N/A 0.098 0.058
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 0.340
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.098 0.058
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.098 0.072
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.098 0.081
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.098 0.520
NEO1 NEO1, NGN: Neogenin precursor 0.098 0.058
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.098 0.581
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.098 0.586
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.098 0.655
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.098 0.0727
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.096 0.0446
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.096 0.090
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.091 0.136
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.091 0.171
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.091 0.123
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.091 0.111
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.087 0.029
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.083 0.109
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.083 0.109
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.083 0.049
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.083 0.109
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.083 0.148
ATRN N/A 0.083 0.044
KIR3DL1 N/A 0.083 0.109
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.083 0.098
SEMA4B SEMA4B: Sema domain, immunoglobulin domain 0.083 0.049
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.083 0.098
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.083 0.109
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.081 0.781
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.081 0.097
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.081 0.028
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.081 0.225
DLG2 DLG2: Disks large homolog 2 0.081 0.041
SORBS3 SORBS3, SCAM1: Vinexin 0.081 0.088
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.081 0.123
STK16 N/A 0.081 0.123
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.081 0.111
SYK SYK: Tyrosine-protein kinase SYK 0.081 1.07
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.081 0.171
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.081 6.03
STAT6 STAT6: Signal transducer and activator of transcription 6 0.081 856.00
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.081 0.859
IRS2 IRS2: Insulin receptor substrate 2 0.081 0.109
TLN2 TLN2: Uncharacterized protein TLN2 0.081 0.099
F5 F5: Coagulation factor V precursor 0.081 0.045
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.081 0.051
RIN1 RIN1: Ras and Rab interactor 1 0.081 0.874
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.081 0.225
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.081 0.171
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.081 0.275
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.081 2.42
HCK N/A 0.081 0.874
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.081 0.171
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.081 0.062
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.077 0.037
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.077 0.225
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.077 0.340
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.077 0.100
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.075 0.225
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.075 0.111
WEE1 WEE1: Wee1-like protein kinase 0.075 0.097
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.075 0.097
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.075 0.069
CDK2 CDK2: Cell division protein kinase 2 0.075 0.136
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.075 0.111
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.075 0.225
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.074 0.032
SPTAN1 N/A 0.0727 0.109
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.072 0.109
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.072 0.416
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.072 0.097
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.072 0.859
PSCD4 PSCD4, CYT4: Cytohesin-4 0.072 0.275
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.072 0.372
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.072 375.00
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.072 0.037
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.072 0.037
ROCK1 ROCK1: Rho-associated protein kinase 1 0.072 0.251
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.072 0.770
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.072 0.859
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.072 55.00
TTN N/A 0.072 0.097
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.072 0.041
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.072 0.123
VIL2 N/A 0.072 65.60
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.072 0.416
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.072 4.07
GAB2 N/A 0.072 0.109
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.072 370.00
BMX N/A 0.072 0.775
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.072 0.041
LYN LYN: Tyrosine-protein kinase Lyn 0.072 1.50
MSN MSN: Moesin 0.072 0.372
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.072 12.80
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.072 0.097
FNBP1 N/A 0.072 0.372
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.072 1.78
VAV1 VAV1, VAV: Proto-oncogene vav 0.072 2.94
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.072 0.225
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.072 0.975
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.072 0.099
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.072 0.859
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.072 0.037
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.072 132.00
PLD1 PLD1: Phospholipase D1 0.072 0.097
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.072 3.64
CTTN CTTN, EMS1: Src substrate cortactin 0.072 0.110
ALK ALK: ALK tyrosine kinase receptor precursor 0.072 0.318
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.072 0.111
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.072 14.30
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.072 0.097
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.072 0.111
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.072 1.98
JAK1 0.072 12.80
MCF2 MCF2, DBL: Proto-oncogene DBL 0.072 0.109
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.072 0.109
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.072 6.73
CSK CSK: Tyrosine-protein kinase CSK 0.072 2.17
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.072 0.975
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.072 0.109
PSD TYL: TYL protein 0.072 0.111
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.072 0.461
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.072 0.461
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.072 0.123
IRS1 IRS1: Insulin receptor substrate 1 0.072 0.098
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.072 0.045
CXorf9 N/A 0.072 0.372
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.072 0.251
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.072 0.037
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.0688 422.00
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.0688 0.098
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.0688 0.098
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.067 0.177
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.065 0.152
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.065 1.50
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.065 0.225
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.065 0.099
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.065 0.097
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.065 0.461
APS SH2B2, APS: SH2B adapter protein 2 0.065 0.770
NCK2 NCK2: Cytoplasmic protein NCK2 0.065 1.78
RASA3 RASA3: Ras GTPase-activating protein 3 0.065 0.461
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.065 0.099
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.065 0.088
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.065 0.088
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.065 0.099
F8 F8, F8C: Coagulation factor VIII precursor 0.065 0.045
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.065 0.088
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.065 0.111
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.065 0.859
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.065 0.251
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 784.00
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.062 0.072
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.062 0.029
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.062 0.166
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.062 0.041
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.062 0.064
CD44 N/A 0.062 0.057
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.062 0.202
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.062 0.081
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.062 0.274
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.062 0.113
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.062 0.461
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.062 0.072
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.061 0.067
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.057 0.123
CDK6 CDK6: Cell division protein kinase 6 0.057 0.111
DYRK3 N/A 0.057 0.088
CDK4 CDK4: Cell division protein kinase 4 0.057 0.111
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.057 0.275
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.057 0.225
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.056 0.171
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.055 0.274
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.055 0.072
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.055 0.029
CD7 CD7: T-cell antigen CD7 precursor 0.055 3.59
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.055 0.274
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.055 0.100
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.055 0.065
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.055 0.181
LILRB1 N/A 0.055 0.081
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.055 0.029
ITGB7 ITGB7: Integrin beta-7 precursor 0.055 0.227
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.055 0.340
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.055 0.100
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.055 0.064
GPA33 GPA33: Cell surface A33 antigen precursor 0.055 0.126
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.055 0.081
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.055 0.274
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.055 0.141
EGF EGF: Pro-epidermal growth factor precursor 0.055 0.072
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.055 1.19
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.055 0.065
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.055 0.072
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.055 0.081
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.055 0.065
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.055 0.100
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.055 0.065
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.055 0.081
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.055 0.081
CD69 CD69: Early activation antigen CD69 0.055 0.074
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.055 0.065
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
PHC3 PHC3, EDR3, PH3: Polyhomeotic-like protein 3 0.051 0.046
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.617
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.051 0.553
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.617
GRB10 N/A 0.051 0.617
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.051 0.046
TJP2 TJP2, X104, ZO2: Tight junction protein ZO-2 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
UNC5D UNC5D, KIAA1777, UNQ6012/PRO34692, UNC5H4: Netrin receptor UNC5D precursor 0.051 0.051
NCAM1 N/A 0.051 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.051 0.046
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.617
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.617
PAPPA PAPPA: Pappalysin-1 precursor 0.051 0.051
DBNL DBNL, CMAP, PP5423, SH3P7: Drebrin-like protein 0.051 0.051
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.051 0.046
PTPRA N/A 0.051 0.051
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
EPB41 EPB41, E41P: Protein 4.1 0.051 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.051 0.553
RAPH1 N/A 0.051 0.051
ITIH3 ITIH3: Inter-alpha-trypsin inhibitor heavy chain H3 precursor 0.051 0.051
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.051 0.046
C9orf88 N/A 0.051 0.051
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.051 0.046
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
STIM1 STIM1, GOK: Stromal interaction molecule 1 precursor 0.051 0.051
BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 0.051 0.046
FLT4 VEGFR3 long form 0.051 0.553
DLG1 DLG1: Disks large homolog 1 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.617
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.617
CRK CRK: Proto-oncogene C-crk 0.051 0.617
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.051 0.553
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.051 0.046
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.051 277.00
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.051 0.090
TP73 TP73, P73: Tumor protein p73 0.051 0.072
ST3GAL1 ST3GAL1, SIAT4, SIAT4A: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sia 0.051 0.036
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.0513 0.181
PVR PVR, PVS: Poliovirus receptor precursor 0.049 0.0727
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.049 0.065
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.049 0.065
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.049 0.202
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.049 0.065
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.049 0.065
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.049 0.026
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.049 0.065
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.049 0.148
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.049 0.0688
MAP2K5 N/A 0.049 0.165
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.049 0.148
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.049 0.165
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.049 0.165
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.049 0.148
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.165
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.049 0.148
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.049 71.20
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.165
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.049 0.148
SNX3 N/A 0.049 0.148
CNN2 CNN2: Calponin-2 0.049 0.165
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.049 0.148
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.049 0.148
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.049 0.165
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.049 0.148
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.049 0.148
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.049 0.165
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.049 0.148
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.165
CDC2 CDC2: Cell division control protein 2 homolog 0.049 0.165
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.049 0.165
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.049 0.165
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.049 0.025
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.049 0.165
MAPKAPK5 N/A 0.049 0.165
S100A16 S100A16, AAG13: Protein S100-A16 0.049 0.165
EEF2K EEF2K: Elongation factor 2 kinase 0.049 0.165
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.049 0.165
ACTN4 ACTN4: Alpha-actinin-4 0.049 0.148
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.049 0.148
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.049 0.148
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.165
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.049 0.165
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.049 0.062
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.049 0.025
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.049 0.148
PPEF1 N/A 0.049 0.165
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.049 0.165
TSHR N/A 0.048 0.029
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.047 0.0338
TNN TNN: Tenascin-N precursor 0.047 0.042
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.046 0.0727
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0453 0.152
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.0453 0.038
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.0453 0.136
FUBP1 N/A 0.0453 0.210
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.0453 0.372
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.0453 0.111
DAB1 DAB1: Disabled homolog 1 0.0453 0.097
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.0453 0.171
LIMK2 LIMK2: LIM domain kinase 2 0.0453 0.123
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.0453 0.225
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0453 0.123
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.0453 0.461
SOS1 SOS1: Son of sevenless homolog 1 0.045 0.181
STAT2 STAT2: Signal transducer and activator of transcription 2 0.045 0.902
PLEK PLEK, P47: Pleckstrin 0.045 0.166
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.045 9.65
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.045 0.644
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.045 5.04
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.0446 0.038
COL12A1 COL12A1, COL12A1L: Collagen alpha-1(XII) chain precursor 0.044 0.062
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.044 0.050
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.041 0.073
CENTA1 CENTA1: Centaurin-alpha 1 0.041 0.063
STAT4 STAT4: Signal transducer and activator of transcription 4 0.041 10.70
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.041 0.113
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.04 0.025
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.04 0.075
CDC20 CDC20: Cell division cycle protein 20 homolog 0.039 0.029
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.039 0.0453
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.038 0.030
TBCE TBCE: Tubulin-specific chaperone E 0.037 0.029
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.037 0.041
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.037 0.171
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.037 0.099
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.037 0.136
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.037 0.275
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.037 0.251
VASP VASP: Vasodilator-stimulated phosphoprotein 0.037 0.191
STK10 STK10: Uncharacterized protein STK10 0.037 0.763
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.037 0.045
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.037 0.111
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.037 0.225
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.037 0.088
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.037 0.109
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.037 0.136
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.037 0.307
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.037 0.191
FLII FLII, FLIL: Protein flightless-1 homolog 0.037 0.054
CDK7 CDK7, MO15: Cell division protein kinase 7 0.037 0.111
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.037 0.191
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.037 0.111
CSPG2 N/A 0.037 0.045
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.037 0.032
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.037 0.461
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.037 0.763
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.037 0.111
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.037 0.111
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.037 0.109
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.037 0.111
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.037 0.372
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.037 0.055
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.037 0.225
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.037 0.171
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.034 0.032
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.0338 0.030
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.0338 0.053
CETN1 CETN1, CEN1, CETN: Centrin-1 0.034 0.098
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.034 0.098
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.034 0.098
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.034 0.098
LETM1 LETM1: Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial 0.034 0.098
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.033 0.416
NDP NDP: Norrin precursor 0.033 0.046
SPARC SPARC, ON: SPARC precursor 0.032 0.037
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.032 0.097
ATM ATM: Serine-protein kinase ATM 0.032 0.763
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.032 0.097
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.123
GMIP GMIP: GEM-interacting protein 0.032 0.275
CDKL5 N/A 0.032 0.109
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.032 0.045
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.152
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.032 0.088
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.032 0.111
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.032 0.044
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.032 0.111
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.032 0.109
MYO3A MYO3A: Myosin IIIA 0.032 0.088
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.032 0.055
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.032 0.109
ACTN1 ACTN1: Alpha-actinin-1 0.032 0.111
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.032 0.041
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.032 0.041
FSTL1 FSTL1, FRP: Follistatin-related protein 1 precursor 0.032 0.041
S100A3 S100A3, S100E: Protein S100-A3 0.032 0.109
DAPK2 DAPK2: Death-associated protein kinase 2 0.032 0.098
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.032 0.136
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.032 0.372
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.032 0.097
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.032 0.136
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.032 0.416
LCP1 LCP1, PLS2: Plastin-2 0.032 0.275
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.032 0.136
S100B S100B: Protein S100-B 0.032 0.109
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.032 0.136
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.032 0.088
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 0.032 0.088
GRLF1 N/A 0.032 0.109
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.032 0.045
VWF VWF, F8VWF: von Willebrand factor precursor 0.032 0.037
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.032 46.80
FREQ FREQ, FLUP, NCS1: Neuronal calcium sensor 1 0.032 0.099
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.032 0.191
MYL3 MYL3: Myosin light polypeptide 3 0.032 0.097
CHP CHP: Calcium-binding protein p22 0.032 0.111
S100A7 S100A7, PSOR1: Protein S100-A7 0.032 0.109
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.032 0.088
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.032 0.191
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.032 0.109
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.032 0.097
HPCA HPCA, BDR2: Neuron-specific calcium-binding protein hippocalcin 0.032 0.097
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.032 0.098
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.032 0.097
PRKAA1 N/A 0.032 0.251
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.032 0.111
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.032 0.171
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.032 0.152
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.032 0.275
DAB2 DAB2, DOC2: Disabled homolog 2 0.032 0.097
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.032 0.275
PMP2 PMP2: Myelin P2 protein 0.032 0.049
CD82 CD82, KAI1, SAR2, ST6, TSPAN27: CD82 antigen 0.032 0.027
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.032 0.039
TP53 TP53, P53: Cellular tumor antigen p53 0.031 0.033
MDN1 MDN1, KIAA0301: Midasin 0.030 0.038
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.029 0.037
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.029 0.109
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.029 0.041
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.029 0.275
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.029 0.461
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.029 0.097
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.029 0.088
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.225
CDK5 CDK5: Cell division protein kinase 5 0.029 0.111
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.029 0.136
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.029 0.088
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.029 0.098
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.136
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.029 0.041
CNN3 CNN3: Calponin-3 0.029 0.110
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.029 0.041
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.029 0.098
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.029 0.088
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.088
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.029 0.041
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.029 0.088
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.029 0.099
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.029 0.037
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.028 0.049
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.028 0.109
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.028 0.109
LAT LAT: Linker for activation of T-cells family member 1 0.028 0.109
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.028 0.049
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.028 0.109
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.028 0.098
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.028 0.044
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.028 0.109
AQP4 AQP4: Aquaporin-4 0.028 0.036
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.028 0.044
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.028 0.044
STOM STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein 0.028 0.036
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.028 0.036
TBXA2R TBXA2R: Thromboxane A2 receptor 0.028 0.04
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.028 0.049
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.028 0.049
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.028 0.04
FGFR2 N/A 0.027 0.217
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.265
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
DDR1 DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE: Epithelial discoidin domain-con 0.027 0.195
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
PIM1 N/A 0.027 0.036
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.027 0.026
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.027 0.046
THOC1 THOC1, HPR1: THO complex subunit 1 0.027 0.114
AQP1 AQP1, CHIP28: Aquaporin-1 0.027 0.028
RHO RHO, OPN2: Rhodopsin 0.026 0.029
FADD FADD, MORT1: Protein FADD 0.026 0.0453
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.025 0.090
ETS2 ETS2: Protein C-ets-2 0.025 0.072
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.025 0.148
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.025 0.100
0.347
Total Score 9.94