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Evidence of Interaction Between PSMA4 and PSMA3

The interaction score between PSMA4 and PSMA3 is 1.58E5.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PSMA4 and PSMA3 = 0.88

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismPSMA4 OrthologuePSMA3 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YGR135W 1 YOR362C 1
  • AffinityCaptureMS

Get References From PubMed
worm Q9N599 1 Q09583 1
fly P18053 1 Q9V5C6 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in PSMA4 and PSMA3:
Domains in PSMA4Domains in PSMA3
IPR000243 Peptidase T1A, proteasome beta-subunit
IPR001353 20S proteasome, A and B subunits
IPR000426 Proteasome alpha-subunit
IPR001353 20S proteasome, A and B subunits
IPR000426 Proteasome alpha-subunit

The Chi square scores for co-occurrence of domains that are present in PSMA4 and PSMA3 are listed below.

Domain 1Domain 2Chi Square
IPR001353 20S proteasome, A and B subunits IPR000426 Proteasome alpha-subunit 1084.67
IPR000243 Peptidase T1A, proteasome beta-subunit IPR000426 Proteasome alpha-subunit 998.751
IPR001353 20S proteasome, A and B subunits IPR001353 20S proteasome, A and B subunits 972.655
IPR000243 Peptidase T1A, proteasome beta-subunit IPR001353 20S proteasome, A and B subunits 960.483
IPR000426 Proteasome alpha-subunit IPR000426 Proteasome alpha-subunit 78.5459

The background colour of the table refers to:

  • Blue Domain is only present in PSMA4
  • Yellow Domain is only present in PSMA3
  • Green Domain is present in both PSMA4 and PSMA3

 0.265
Post-translational Modifications

Protein: PSMA4

PTMResidueReference

Protein: PSMA3

PTMResidueReference
Acetylation 2 PubMed, HPRD
N-acetylserine 1 HPRD
Phosphorylation 243 PubMed, HPRD
Phosphorylation 250 PubMed, HPRD
Phosphoserine 249 HPRD
Phosphotyrosine 160 HPRD
Localisation

Protein: PSMA4

LocalisationReference
ER HPRD
Nucleus HPRD
Cytoplasm HPRD

Protein: PSMA3

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between PSMA4 and PSMA3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PSMA4 andPSMA3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PSMA4 has 196 interactors and PSMA3 has 1068 interactors of which there are 172 common interactors.

Common InteractorName of Common InteractorScore for PSMA4-Interactor (?)Score for PSMA3-Interactor (?)
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 2.07E3 3.41E3
PSMA5 PSMA5: Proteasome subunit alpha type-5 2.07E3 3.41E3
PSMB2 PSMB2: Proteasome subunit beta type-2 691.00 691.00
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 691.00 1.59E3
PSMB1 PSMB1, PSC5: Proteasome subunit beta type-1 precursor 691.00 691.00
PSMA6 PSMA6, PROS27: Proteasome subunit alpha type-6 323.00 1.64E3
PSMB6 PSMB6, LMPY: Proteasome subunit beta type-6 precursor 323.00 195.00
PSMB3 PSMB3: Proteasome subunit beta type-3 323.00 195.00
PSMA7 PSMA7: Proteasome subunit alpha type-7 323.00 323.00
PSMB9 PSMB9, LMP2, RING12: Proteasome subunit beta type-9 precursor 31.70 31.70
PSMA8 PSMA8, PSMA7L: Proteasome subunit alpha type-7-like 12.60 12.60
PSMA1 PSMA1, PROS30, PSC2: Proteasome subunit alpha type-1 2.91 2.91
PSMB4 N/A 1.82 1.82
NULL RcPSMB3 (Fragment) 1.37 1.37
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 1.01 0.040
EIF1B EIF1B: Eukaryotic translation initiation factor 1b 0.902 0.685
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.739 0.739
CTRL PSMB10, MECL1: Proteasome subunit beta type-10 precursor 0.666 0.824
TPR TPR: Nucleoprotein TPR 0.612 0.040
PSMB5 DKFZp686I0180: Putative uncharacterized protein DKFZp686I0180 (Fragment) 0.593 0.593
PSMA1 N/A 0.354 1.79
GNPNAT1 GNPNAT1, GNA1: Glucosamine 6-phosphate N-acetyltransferase 0.354 1.79
EIF1 EIF1, SUI1: Eukaryotic translation initiation factor 1 0.300 0.583
PSMB5 PSMB5, LMPX: Proteasome subunit beta type-5 precursor 0.265 0.265
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.263 1.62
PPP2CB PPP2CB: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0.233 4.36
PLK3 PLK3, CNK, FNK, PRK: Serine/threonine-protein kinase PLK3 0.225 0.225
PSMB8 PSMB8, DAQB-69D7.6-002, DASS-67H14.1-002, XXbac-BCX32M13.6-002, XXbac-BPG246D15. 0.221 0.366
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.195 0.878
PPP2CA PPP2CA: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 0.179 3.35
PLK2 PLK2, SNK: Serine/threonine-protein kinase PLK2 0.145 0.145
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.137 1.81
MELK MELK, KIAA0175: Maternal embryonic leucine zipper kinase 0.123 0.123
BUB1B BUB1B, BUBR1, MAD3L: Mitotic checkpoint serine/threonine-protein kinase BUB1 bet 0.123 0.123
CDK4 CDK4: Cell division protein kinase 4 0.123 0.763
CDK7 CDK7, MO15: Cell division protein kinase 7 0.123 0.763
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.123 0.763
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.123 0.763
AURKB AURKB, AIK2, AIM1, ARK2, STK12: Serine/threonine-protein kinase 12 0.123 0.263
LOC647058 similar to suppressor of initiator codon mutations, related sequence 1 0.119 0.119
VRK2 VRK2: Serine/threonine-protein kinase VRK2 0.0968 0.059
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.0968 0.503
RIPK2 RIPK2, CARDIAK, UNQ277/PRO314/PRO34092, RICK, RIP2: Receptor-interacting serine/ 0.083 0.067
ROCK1 ROCK1: Rho-associated protein kinase 1 0.083 0.416
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.083 0.852
CSNK1G3 CSNK1G3: Casein kinase I isoform gamma-3 0.083 0.083
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.081 0.385
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.074 0.461
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.074 0.763
BUB1 0.074 0.123
RP6-213H19.1 MST4, MASK: Serine/threonine-protein kinase MST4 0.074 0.074
CDK2 CDK2: Cell division protein kinase 2 0.074 0.763
WEE1 WEE1: Wee1-like protein kinase 0.074 0.372
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.074 0.461
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.074 0.372
CSNK1A1 CSNK1A1: Casein kinase I isoform alpha 0.074 0.060
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.074 0.461
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.074 0.372
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.067 0.515
CSNK1G2 CSNK1G2: Casein kinase I isoform gamma-2 0.060 0.060
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.060 0.275
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.060 0.372
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.060 0.372
RPS6KB1 N/A 0.060 0.461
DYRK4 DYRK4: Dual specificity tyrosine-phosphorylation-regulated kinase 4 0.060 0.044
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.060 0.461
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.060 0.372
PIK3R4 PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4 0.060 0.044
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.060 0.044
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.060 0.275
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.060 0.275
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.060 0.372
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.060 0.372
TTK TTK, MPS1L1: Dual specificity protein kinase TTK 0.059 0.059
CAMK2G Calcium/calmodulin-dependent protein kinase isoform A (Fragment) 0.050 0.067
STK16 N/A 0.050 0.307
CDK9 CDK9, CDC2L4: Cell division protein kinase 9 0.047 0.047
NEK2 NEK2, NLK1: Serine/threonine-protein kinase Nek2 0.044 0.044
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.044 0.275
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.044 0.372
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.044 0.275
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.044 0.275
MAP4K2 MAP4K2, GCK, RAB8IP: Mitogen-activated protein kinase kinase kinase kinase 2 0.044 0.074
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.044 0.275
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.044 0.275
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.044 0.225
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.044 0.275
MAP4K5 MAP4K5: Mitogen-activated protein kinase kinase kinase kinase 5 0.044 0.044
ADRBK2 ADRBK2, BARK2, GRK3: Beta-adrenergic receptor kinase 2 0.044 0.036
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.044 0.275
STK17A STK17A, DRAK1: Serine/threonine-protein kinase 17A 0.044 0.036
CLK3 CLK3: Dual specificity protein kinase CLK3 0.044 0.036
CSNK1D CSNK1D: Casein kinase I isoform delta 0.044 0.044
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.044 0.275
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.044 0.225
STK10 STK10: Uncharacterized protein STK10 0.044 0.225
EIF2AK1 N/A 0.041 0.0308
LIMK2 LIMK2: LIM domain kinase 2 0.041 0.191
DYRK2 DYRK2: Dual specificity tyrosine-phosphorylation-regulated kinase 2 0.041 0.041
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.041 0.251
VRK3 N/A 0.041 0.0308
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.041 0.251
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.041 0.251
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.041 0.251
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.036 0.225
WNK1 WNK1, KDP, KIAA0344, PRKWNK1: Serine/threonine-protein kinase WNK1 0.036 0.028
PIM1 N/A 0.036 0.028
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.036 0.275
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.036 0.225
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.036 0.225
PCTK2 PCTK2: Serine/threonine-protein kinase PCTAIRE-2 0.036 0.028
ARAF ARAF, ARAF1, PKS, PKS2: A-Raf proto-oncogene serine/threonine-protein kinase 0.036 0.036
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.036 0.225
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.036 0.225
CSNK2A2 CSNK2A2, CK2A2: Casein kinase II subunit alpha' 0.036 0.028
IRAK4 IRAK4: Interleukin-1 receptor-associated kinase 4 0.036 0.036
PRKX PRKX, PKX1: Serine/threonine-protein kinase PRKX 0.036 0.036
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.036 0.171
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.036 0.171
ACVR2A ACVR2A, ACVR2: Activin receptor type-2A precursor 0.035 0.035
GAK GAK: Cyclin G-associated kinase 0.035 0.035
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.032 0.166
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.0308 0.191
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.0308 0.191
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.0308 0.152
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.0308 0.251
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.0308 0.191
PRKAA1 N/A 0.0308 0.152
PSMB8 PSMB8, LMP7, RING10, Y2: Proteasome subunit beta type-8 precursor 0.0288 0.0288
PSMB4 PSMB4: Proteasome subunit beta type-4 precursor 0.0288 0.617
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.028 0.136
CDK6 CDK6: Cell division protein kinase 6 0.028 0.136
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.028 0.171
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.028 0.171
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.028 0.171
PSME3 PSME3: Proteasome activator complex subunit 3 0.027 0.053
E2IG3 N/A 0.027 0.027
HSPC185 CGI-117, HSPC111: UPF0384 protein CGI-117 0.027 0.027
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.027 0.053
SERBP1 N/A 0.027 0.027
BUB3 N/A 0.027 0.027
NOLC1 NOLC1, KIAA0035: Nucleolar phosphoprotein p130 0.027 0.053
ILF2 ILF2, NF45, PRO3063: Interleukin enhancer-binding factor 2 0.027 0.027
PTD004 N/A 0.027 0.027
RTCD1 RTCD1, RPC, RPC1, RTC1: RNA 3'-terminal phosphate cyclase 0.027 0.027
MRPL22 MRPL22, HSPC158: 39S ribosomal protein L22, mitochondrial precursor 0.027 0.027
HNRPD N/A 0.027 0.027
ERN2 ERN2, IRE2: Serine/threonine-protein kinase/endoribonuclease IRE2 precursor 0.027 0.0331
EIF2AK3 EIF2AK3, PEK, PERK: Eukaryotic translation initiation factor 2-alpha kinase 3 pr 0.027 0.027
MAP2K5 N/A 0.027 0.165
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.027 0.165
PDIK1L PDIK1L, CLIK1L: Serine/threonine-protein kinase PDIK1L 0.027 0.027
STK35 STK35, CLIK1, PDIK1: Serine/threonine-protein kinase 35 0.027 0.027
CDC2L2 N/A 0.027 0.027
NEK4 NEK4, STK2: Serine/threonine-protein kinase Nek4 0.027 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.027 0.165
RIPK5 RIPK5, KIAA0472, HDCMD38P, RIP5, SGK496: Receptor-interacting serine/threonine-p 0.027 0.027
CAMKK1 CAMKK1, CAMKKA: Calcium/calmodulin-dependent protein kinase kinase 1 0.027 0.027
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.027 0.056
MAPK15 N/A 0.027 0.165
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.027 0.165
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.027 0.165
ANKK1 ANKK1, PKK2, SGK288: Ankyrin repeat and protein kinase domain-containing protein 0.027 0.027
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.027 0.165
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.027 0.165
NEK11 NEK11: Serine/threonine-protein kinase Nek11 0.027 0.027
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.027 0.165
ALS2CR7 ALS2CR7: Serine/threonine-protein kinase ALS2CR7 0.027 0.027
MAPKAPK5 N/A 0.027 0.165
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.027 0.165
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.027 0.056
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.027 0.165
0.572
Total Score 1.58E5