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Evidence of Interaction Between EPOR and RAF1

The interaction score between EPOR and RAF1 is 6.78.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EPOR and RAF1 = 0.24

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.88E-3
Orthology N/A N/A
Domains Domains present in EPOR and RAF1:
Domains in EPORDomains in RAF1
IPR003961 Fibronectin, type III
IPR003528 Long hematopoietin receptor, single chain
IPR009167 Erythropoietin receptor
IPR002996 Cytkn_recept_B/G.
IPR000719 Protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR002219 Protein kinase C, phorbol ester/diacylglycerol binding
IPR003116 Raf-like Ras-binding

The Chi square scores for co-occurrence of domains that are present in EPOR and RAF1 are listed below.

Domain 1Domain 2Chi Square
IPR003961 Fibronectin, type III IPR008271 Serine/threonine protein kinase, active site 30.5883
IPR003528 Long hematopoietin receptor, single chain IPR011009 Protein kinase-like 3.32619
IPR003528 Long hematopoietin receptor, single chain IPR000719 Protein kinase 1.94307
IPR002996 Cytkn_recept_B/G. IPR011009 Protein kinase-like 1.93327
IPR002996 Cytkn_recept_B/G. IPR000719 Protein kinase 1.43014
IPR009167 Erythropoietin receptor IPR000719 Protein kinase 0.93762
IPR003961 Fibronectin, type III IPR000719 Protein kinase 0.712801
IPR003961 Fibronectin, type III IPR011009 Protein kinase-like 0.616354
IPR009167 Erythropoietin receptor IPR011009 Protein kinase-like 0.331462
IPR003961 Fibronectin, type III IPR002219 Protein kinase C, phorbol ester/diacylglycerol binding 0.121917
IPR002996 Cytkn_recept_B/G. IPR002219 Protein kinase C, phorbol ester/diacylglycerol binding 0.0435319

The background colour of the table refers to:

  • Blue Domain is only present in EPOR
  • Yellow Domain is only present in RAF1
  • Green Domain is present in both EPOR and RAF1

 0.049
Post-translational Modifications

Protein: EPOR

PTMResidueReference
Phosphorylation 368 PubMed, HPRD
Phosphorylation 426 PubMed, HPRD
Phosphorylation 454 PubMed, HPRD
Phosphorylation 456 PubMed, HPRD
Phosphorylation 468 PubMed, HPRD
Phosphorylation 485 PubMed, HPRD
Phosphorylation 489 PubMed, HPRD
Phosphorylation 504 PubMed, HPRD

Protein: RAF1

PTMResidueReference
Dephosphorylation 340 PubMed, HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 43 PubMed, HPRD
Phosphorylation 233 PubMed, HPRD
Phosphorylation 259 PubMed, HPRD
Phosphorylation 268 PubMed, HPRD
Phosphorylation 269 PubMed, HPRD
Phosphorylation 289 PubMed, HPRD
Phosphorylation 296 PubMed, HPRD
Phosphorylation 301 PubMed, HPRD
Phosphorylation 338 PubMed, HPRD
Phosphorylation 339 PubMed, HPRD
Phosphorylation 340 PubMed, HPRD
Phosphorylation 341 PubMed, HPRD
Phosphorylation 491 PubMed, HPRD
Phosphorylation 494 PubMed, HPRD
Phosphorylation 499 PubMed, HPRD
Phosphorylation 621 PubMed, HPRD
Phosphorylation 642 PubMed, HPRD
Phosphoserine 43 HPRD
Phosphoserine 259 PubMed, HPRD
Phosphoserine 338 PubMed, HPRD
Phosphoserine 499 PubMed, HPRD
Phosphoserine 621 HPRD
Phosphothreonine 268 PubMed, HPRD
Localisation

Protein: EPOR

LocalisationReference
ER HPRD
Plasma membrane HPRD
Secreted HPRD

Protein: RAF1

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between EPOR and RAF1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EPOR andRAF1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EPOR has 1024 interactors and RAF1 has 1538 interactors of which there are 568 common interactors.

Common InteractorName of Common InteractorScore for EPOR-Interactor (?)Score for RAF1-Interactor (?)
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 3.59 0.077
SLC4A1 SLC4A1, AE1, DI, EPB3: Band 3 anion transport protein 0.923 0.033
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.541 0.127
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.340 0.372
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.251 0.126
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.210 0.0446
HSP90AA1 Hsp89-alpha-delta-N 0.202 0.139
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.191 0.029
CRLF3 N/A 0.191 0.074
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.166 0.136
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.166 0.086
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.166 0.233
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.165 0.044
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.109
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.044
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.165 0.044
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.165 0.098
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.109
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.165 0.098
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.049
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.049
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.165 0.109
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.165 0.109
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.165 0.044
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.049
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.109
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.049
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.049
CAT CAT: Catalase 0.157 0.046
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.153 0.275
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.153 0.139
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.152 0.037
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.152 0.041
KIT KIT: Mast/stem cell growth factor receptor precursor 0.152 0.051
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.127 501.00
RDX RDX: Radixin 0.126 0.111
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.126 0.275
GAB1 GAB1: GRB2-associated-binding protein 1 0.126 0.152
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.126 0.461
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.126 0.372
CD2AP CD2AP: CD2-associated protein 0.126 0.188
CRKL CRKL: Crk-like protein 0.126 0.372
EFNB1 EFNB1, EFL-3, EPLG2, LERK2: Ephrin-B1 precursor 0.126 0.041
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.125 0.046
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.125 0.040
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.124 0.171
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.124 0.063
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.123 0.153
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.123 0.064
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.123 0.041
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.123 0.026
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.123 0.033
INSR INSR: Insulin receptor precursor 0.123 0.029
IL9R IL9R: Interleukin-9 receptor precursor 0.123 0.032
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.123 0.033
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.123 0.064
GHR GHR: Growth hormone receptor precursor 0.123 0.0453
UROD UROD: Uroporphyrinogen decarboxylase 0.111 0.029
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.110 0.113
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.109 0.075
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.109 0.148
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.075
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.109 0.075
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 0.165
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.109 0.148
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.109 0.075
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.109 0.148
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.083
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.109 0.148
ARHGEF7 N/A 0.109 0.148
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.165
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.109 0.148
ELMO1 N/A 0.109 0.148
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 0.034
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.109 0.148
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 0.165
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 0.165
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.109 0.148
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 0.165
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.109 0.148
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.109 0.148
NF2 NF2, SCH: Merlin 0.109 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 0.165
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.109 0.030
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.109 0.075
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.165
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.109 0.148
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.083
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.109 0.148
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.165
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.109 0.148
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.148
STAT3 0.109 0.148
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.109 0.148
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.109 0.148
MAPK15 N/A 0.109 0.165
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 0.148
PSCD2 N/A 0.109 0.165
F3 F3: Tissue factor precursor 0.109 0.032
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.109 0.153
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.109 0.064
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.109 0.0818
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.109 0.029
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.109 0.0453
ITGB4 N/A 0.109 0.032
MET MET: Hepatocyte growth factor receptor precursor 0.109 0.033
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.109 0.029
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.109 0.051
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.109 0.057
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.109 0.124
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.109 0.026
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.109 0.099
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.109 0.033
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.109 0.058
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.109 0.0453
SORL1 SORL1: Sortilin-related receptor precursor 0.109 0.0446
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.109 0.0453
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.109 0.065
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.109 0.077
PRLR PRLR: Prolactin receptor precursor 0.109 0.033
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.109 0.033
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.109 0.026
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.105 0.072
PLD2 PLD2: Phospholipase D2 0.100 0.136
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.100 0.763
DOK1 DOK1: Docking protein 1 0.100 0.372
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.100 0.307
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.100 0.461
STAM2 STAM2: Signal transducing adapter molecule 2 0.100 0.086
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.100 0.111
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.100 0.461
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.100 0.763
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.100 0.139
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.100 0.763
RPS6KB1 N/A 0.100 0.372
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.100 0.225
TLN1 TLN1: Uncharacterized protein TLN1 0.100 0.188
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.098 0.029
NEO1 NEO1, NGN: Neogenin precursor 0.098 0.029
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.098 0.026
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.098 0.026
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.098 0.064
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.098 0.033
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.098 0.026
PTPRZ1 N/A 0.098 0.064
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 0.057
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.098 0.058
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.096 0.074
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.096 0.067
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.091 0.372
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.091 0.077
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.091 0.114
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.091 0.171
SLC2A1 SLC2A1, GLUT1: Solute carrier family 2, facilitated glucose transporter member 1 0.087 0.027
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.087 0.0818
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.083 0.049
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.083 0.148
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.083 0.044
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.083 0.044
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.083 0.049
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.081 0.225
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.081 0.046
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.081 0.763
SORBS3 SORBS3, SCAM1: Vinexin 0.081 0.056
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.081 0.852
STK16 N/A 0.081 0.251
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.081 0.372
SYK SYK: Tyrosine-protein kinase SYK 0.081 0.461
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.081 0.225
STAT6 STAT6: Signal transducer and activator of transcription 6 0.081 0.763
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.081 0.275
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.081 0.152
IRS2 IRS2: Insulin receptor substrate 2 0.081 0.251
TLN2 TLN2: Uncharacterized protein TLN2 0.081 0.050
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.081 0.025
RIN1 RIN1: Ras and Rab interactor 1 0.081 0.136
F5 F5: Coagulation factor V precursor 0.081 0.039
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.081 0.225
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.081 0.372
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.081 0.852
HCK N/A 0.081 0.461
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.081 0.372
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.081 0.372
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.081 0.155
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.081 0.088
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.077 0.027
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.077 0.188
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.077 0.036
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.077 0.027
WEE1 WEE1: Wee1-like protein kinase 0.075 0.086
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.075 0.046
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.075 0.086
CDK2 CDK2: Cell division protein kinase 2 0.075 0.275
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.075 0.225
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.075 0.763
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.075 0.461
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.075 0.139
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.074 0.0425
SPTAN1 N/A 0.0727 0.049
ROCK1 ROCK1: Rho-associated protein kinase 1 0.072 0.416
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.072 0.111
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.072 0.225
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.072 0.251
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.072 0.155
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.072 0.044
VIL2 N/A 0.072 0.275
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.072 0.260
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.072 0.191
GAB2 N/A 0.072 0.307
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.072 0.097
BMX N/A 0.072 0.109
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.072 0.037
LYN LYN: Tyrosine-protein kinase Lyn 0.072 0.461
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.072 0.515
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.072 0.171
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.072 0.049
MSN MSN: Moesin 0.072 0.763
VAV1 VAV1, VAV: Proto-oncogene vav 0.072 0.461
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.072 0.385
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.072 0.097
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.072 0.044
FNBP1 N/A 0.072 0.233
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.072 0.461
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.072 0.385
PLD1 PLD1: Phospholipase D1 0.072 0.111
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.072 0.461
CTTN CTTN, EMS1: Src substrate cortactin 0.072 0.056
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.072 0.139
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.072 0.251
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.072 0.044
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.072 0.088
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.072 0.515
JAK1 0.072 0.372
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.072 0.191
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.072 0.152
CSK CSK: Tyrosine-protein kinase CSK 0.072 0.461
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.072 0.152
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.072 0.123
MCF2 MCF2, DBL: Proto-oncogene DBL 0.072 0.098
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.072 0.098
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.072 0.210
IRS1 IRS1: Insulin receptor substrate 1 0.072 0.109
CXorf9 N/A 0.072 0.233
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.072 0.251
PSD TYL: TYL protein 0.072 0.097
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.072 0.275
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.072 0.372
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.072 0.260
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.072 0.111
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.072 0.109
PSCD4 PSCD4, CYT4: Cytohesin-4 0.072 0.461
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.072 0.461
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.072 0.123
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.0688 0.098
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.0688 0.098
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.0688 0.098
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.067 0.036
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.065 0.099
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.065 0.275
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.065 0.088
APS SH2B2, APS: SH2B adapter protein 2 0.065 0.136
NCK2 NCK2: Cytoplasmic protein NCK2 0.065 0.372
RASA3 RASA3: Ras GTPase-activating protein 3 0.065 0.136
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.065 0.078
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.065 0.088
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.065 0.056
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.065 0.088
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.065 0.088
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.065 0.097
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.065 0.098
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.065 0.191
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.065 0.251
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.065 0.077
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.065 0.136
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 0.503
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.062 0.067
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.062 0.040
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.062 0.029
CD44 N/A 0.062 0.153
TLR2 TLR2, TIL4: Toll-like receptor 2 precursor 0.062 0.032
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.062 0.074
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.062 0.032
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.062 0.036
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.062 0.074
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.062 0.033
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.062 0.171
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.062 0.075
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.062 0.036
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.061 0.066
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.057 0.109
CDK6 CDK6: Cell division protein kinase 6 0.057 0.171
DYRK3 N/A 0.057 0.097
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.057 0.763
CDK4 CDK4: Cell division protein kinase 4 0.057 0.275
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.056 0.097
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.055 0.137
LILRB1 N/A 0.055 0.036
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.055 0.074
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.055 0.027
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.055 0.074
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.055 0.027
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.055 0.058
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.055 0.040
ITGB7 ITGB7: Integrin beta-7 precursor 0.055 0.067
EGF EGF: Pro-epidermal growth factor precursor 0.055 0.032
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.055 0.036
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.055 0.036
ITGAE ITGAE: Integrin alpha-E precursor 0.055 0.036
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.055 0.057
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.055 0.027
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.055 0.027
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.055 0.074
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.055 0.0446
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.055 0.032
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.055 0.033
GNA12 GNA12: Guanine nucleotide-binding protein alpha-12 subunit 0.052 0.051
GRB10 N/A 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.051 0.046
PTPRA N/A 0.051 0.051
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.051 0.046
RAPH1 N/A 0.051 0.051
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.051 0.046
C9orf88 N/A 0.051 0.051
EPB41 EPB41, E41P: Protein 4.1 0.051 0.046
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.051 0.046
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.051 0.046
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.051 0.046
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.051 0.073
ST8SIA4 ST8SIA4, PST, PST1, SIAT8D: CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransfe 0.051 0.0446
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.051 0.245
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.0513 0.227
GP5 GP5: Platelet glycoprotein V precursor 0.049 1.15
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.049 0.026
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.049 0.148
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.165
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.049 0.148
SNX3 N/A 0.049 0.075
CNN2 CNN2: Calponin-2 0.049 0.083
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.049 0.148
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.049 0.083
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.049 0.148
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.049 0.075
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.049 0.148
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.049 0.075
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.165
CDC2 CDC2: Cell division control protein 2 homolog 0.049 0.148
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.049 0.028
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.049 0.083
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.049 0.165
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.049 0.025
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.049 0.165
MAPKAPK5 N/A 0.049 0.083
S100A16 S100A16, AAG13: Protein S100-A16 0.049 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.049 0.083
ACTN4 ACTN4: Alpha-actinin-4 0.049 0.025
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.049 0.025
EEF2K EEF2K: Elongation factor 2 kinase 0.049 0.148
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.165
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.049 0.075
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.049 0.075
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.049 0.025
PPEF1 N/A 0.049 0.028
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.049 0.075
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.049 0.148
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.049 0.148
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.049 0.025
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.049 0.083
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.049 0.148
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.165
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.049 0.075
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.049 0.148
MAP2K5 N/A 0.049 0.165
TSHR N/A 0.048 0.027
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.047 0.042
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.046 0.072
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.0453 0.136
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.0453 0.225
FUBP1 N/A 0.0453 0.087
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.0453 0.372
DAB1 DAB1: Disabled homolog 1 0.0453 0.088
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.0453 0.233
LIMK2 LIMK2: LIM domain kinase 2 0.0453 0.155
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.0453 0.188
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0453 0.077
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.0453 0.139
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.0453 0.063
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0453 0.416
STAT2 STAT2: Signal transducer and activator of transcription 2 0.045 0.166
PLEK PLEK, P47: Pleckstrin 0.045 0.340
SOS1 SOS1: Son of sevenless homolog 1 0.045 0.181
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.045 0.181
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.045 0.072
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.045 0.340
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.0446 0.188
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 0.0446 0.038
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.0446 0.078
PRDX6 PRDX6, AOP2, KIAA0106: Peroxiredoxin-6 0.0446 0.038
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.044 0.050
CENTA1 CENTA1: Centaurin-alpha 1 0.041 0.0794
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.041 0.073
STAT4 STAT4: Signal transducer and activator of transcription 4 0.041 0.090
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.041 0.181
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.04 0.025
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.04 0.075
CDC20 CDC20: Cell division cycle protein 20 homolog 0.039 0.067
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.039 0.124
CD14 CD14: Monocyte differentiation antigen CD14 precursor 0.039 0.027
XRCC1 XRCC1: DNA-repair protein XRCC1 0.039 0.036
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.038 0.086
TBCE TBCE: Tubulin-specific chaperone E 0.037 0.046
COPA COPA: Coatomer subunit alpha 0.037 0.063
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.037 0.063
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.037 0.416
VASP VASP: Vasodilator-stimulated phosphoprotein 0.037 0.515
STK10 STK10: Uncharacterized protein STK10 0.037 0.461
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.037 0.372
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.037 0.114
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.037 0.097
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.037 0.070
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.037 0.275
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.037 0.251
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.037 0.111
CDK7 CDK7, MO15: Cell division protein kinase 7 0.037 0.225
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.037 0.127
FLII FLII, FLIL: Protein flightless-1 homolog 0.037 0.078
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.037 0.127
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.037 0.0425
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.037 0.097
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.037 0.461
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.037 0.171
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.037 0.063
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.037 0.123
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.037 0.114
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.037 82.20
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.037 0.233
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.037 0.171
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.037 0.461
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.037 0.038
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.037 0.050
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.037 0.372
TK1 TK1: Thymidine kinase, cytosolic 0.036 0.038
RRM2 RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2 0.036 0.038
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.036 0.080
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.034 0.029
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.0338 0.053
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.034 0.098
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.034 0.098
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.033 0.260
NDP NDP: Norrin precursor 0.033 0.036
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.032 0.171
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.032 0.251
MYO3A MYO3A: Myosin IIIA 0.032 0.099
DAPK2 DAPK2: Death-associated protein kinase 2 0.032 0.077
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.032 0.029
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.032 0.233
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.032 0.099
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.032 23.50
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.032 0.225
ACTN1 ACTN1: Alpha-actinin-1 0.032 0.029
LCP1 LCP1, PLS2: Plastin-2 0.032 0.129
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.032 0.233
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.032 0.029
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.032 0.260
GRLF1 N/A 0.032 0.123
VWF VWF, F8VWF: von Willebrand factor precursor 0.032 0.041
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.032 0.097
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.032 0.307
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.032 0.040
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.032 0.152
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.032 0.136
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.032 0.111
CHP CHP: Calcium-binding protein p22 0.032 0.038
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.032 0.275
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.032 0.109
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.032 0.188
DAB2 DAB2, DOC2: Disabled homolog 2 0.032 0.111
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.032 0.275
PRKAA1 N/A 0.032 0.152
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.032 0.056
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.032 0.763
ATM ATM: Serine-protein kinase ATM 0.032 0.139
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.032 0.111
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.052
GMIP GMIP: GEM-interacting protein 0.032 0.385
CDKL5 N/A 0.032 0.109
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.251
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.032 0.097
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.032 0.171
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.032 0.088
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.032 0.0425
GPR23 LPA4, GPR23, P2RY9: Lysophosphatidic acid receptor 4 0.032 0.037
MTMR3 MTMR3, KIAA0371, ZFYVE10: Myotubularin-related protein 3 0.032 0.060
MELK MELK, KIAA0175: Maternal embryonic leucine zipper kinase 0.032 0.036
TP53 TP53, P53: Cellular tumor antigen p53 0.031 0.032
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.031 0.040
MDN1 MDN1, KIAA0301: Midasin 0.030 0.046
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.029 0.046
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.029 0.088
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.029 0.111
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.029 0.275
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.171
CDK5 CDK5: Cell division protein kinase 5 0.029 0.136
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.029 0.136
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.029 0.049
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.086
CNN3 CNN3: Calponin-3 0.029 0.049
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.029 0.044
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.099
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.029 0.041
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.029 0.111
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.029 0.099
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.029 0.099
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.029 0.058
LAT LAT: Linker for activation of T-cells family member 1 0.028 0.049
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.028 0.049
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.028 0.049
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.028 0.098
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.028 0.036
GPRC5A GPRC5A, GPCR5A, RAI3, RAIG1: Retinoic acid-induced protein 3 0.028 0.049
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.028 0.049
AQP4 AQP4: Aquaporin-4 0.028 0.044
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.028 0.036
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.028 0.098
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.028 0.044
DRD2 DRD2: D(2) dopamine receptor 0.028 0.04
TBXA2R TBXA2R: Thromboxane A2 receptor 0.028 0.04
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.028 0.049
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.028 0.04
EDNRB EDNRB, ETRB: Endothelin B receptor precursor 0.028 0.04
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.028 0.044
PTAFR PTAFR, PAFR: Platelet-activating factor receptor 0.028 0.04
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.028 0.044
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.028 0.04
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.028 0.049
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.028 0.049
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.027
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
PIM1 N/A 0.027 0.036
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.027 0.063
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.027 0.038
RACGAP1 RACGAP1, KIAA1478, MGCRACGAP: Rac GTPase-activating protein 1 0.027 0.038
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.027 0.129
THOC1 THOC1, HPR1: THO complex subunit 1 0.027 0.139
AQP1 AQP1, CHIP28: Aquaporin-1 0.027 0.049
CIITA CIITA, MHC2TA: MHC class II transactivator 0.0263 0.127
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 0.026 0.227
PLSCR1 PLSCR1: Phospholipid scramblase 1 0.026 0.040
F2RL3 F2RL3, PAR4: Proteinase-activated receptor 4 precursor 0.026 0.0263
GNA15 GNA15, GNA16: Guanine nucleotide-binding protein alpha-15 subunit 0.026 0.091
RHO RHO, OPN2: Rhodopsin 0.026 0.029
APLP2 APLP2, APPL2: Amyloid-like protein 2 precursor 0.026 0.032
FADD FADD, MORT1: Protein FADD 0.026 0.124
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.025 0.032
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.025 0.304
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.025 0.075
NUP214 N/A 0.025 0.036
GNB2L1 Lung cancer oncogene 7 0.025 0.0446
0.299
Total Score 6.78