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Evidence of Interaction Between MAPK1 and ITGB2

The interaction score between MAPK1 and ITGB2 is 4.77.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and ITGB2 = 0.66

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 7.78E-3
Orthology
OrganismMAPK1 OrthologueITGB2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm P39745 1 Q27874 0.084
fly P40417 1 P11584 0.081

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in MAPK1 and ITGB2:
Domains in MAPK1Domains in ITGB2
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR006209 EGF-like domain
IPR001450 4Fe-4S ferredoxin, iron-sulfur binding domain
IPR003659 Plexin/semaphorin/integrin
IPR002035 von Willebrand factor, type A
IPR001169 Integrin beta, C-terminal
IPR002369 Integrin, beta chain
IPR013032 IPR006209.
IPR012012 Integrin_B.
IPR012896 Integrin_B_tail.
IPR013111 EGF_extracell.

The Chi square scores for co-occurrence of domains that are present in MAPK1 and ITGB2 are listed below.

Domain 1Domain 2Chi Square
IPR008271 Serine/threonine protein kinase, active site IPR006209 EGF-like domain 46.8567
IPR000719 Protein kinase IPR006209 EGF-like domain 42.2895
IPR002290 Serine/threonine protein kinase IPR006209 EGF-like domain 38.067
IPR011009 Protein kinase-like IPR006209 EGF-like domain 34.7413
IPR000719 Protein kinase IPR013032 IPR006209. 29.2885
IPR008271 Serine/threonine protein kinase, active site IPR013032 IPR006209. 28.1386
IPR002290 Serine/threonine protein kinase IPR013032 IPR006209. 22.8777
IPR011009 Protein kinase-like IPR013032 IPR006209. 20.8081
IPR000719 Protein kinase IPR002035 von Willebrand factor, type A 9.66837
IPR011009 Protein kinase-like IPR002035 von Willebrand factor, type A 6.08917
IPR008271 Serine/threonine protein kinase, active site IPR002035 von Willebrand factor, type A 5.89123
IPR002290 Serine/threonine protein kinase IPR002035 von Willebrand factor, type A 5.04392
IPR000719 Protein kinase IPR003659 Plexin/semaphorin/integrin 4.54004
IPR011009 Protein kinase-like IPR013111 EGF_extracell. 3.07475
IPR000719 Protein kinase IPR013111 EGF_extracell. 2.13494
IPR011009 Protein kinase-like IPR012012 Integrin_B. 1.70042
IPR011009 Protein kinase-like IPR001169 Integrin beta, C-terminal 1.20532
IPR011009 Protein kinase-like IPR002369 Integrin, beta chain 1.20532
IPR002290 Serine/threonine protein kinase IPR001450 4Fe-4S ferredoxin, iron-sulfur binding domain 1.15035
IPR008271 Serine/threonine protein kinase, active site IPR001450 4Fe-4S ferredoxin, iron-sulfur binding domain 1.04743
IPR011009 Protein kinase-like IPR012896 Integrin_B_tail. 1.03188
IPR008271 Serine/threonine protein kinase, active site IPR001169 Integrin beta, C-terminal 0.965324
IPR008271 Serine/threonine protein kinase, active site IPR002369 Integrin, beta chain 0.965324
IPR008271 Serine/threonine protein kinase, active site IPR012896 Integrin_B_tail. 0.830089
IPR008271 Serine/threonine protein kinase, active site IPR012012 Integrin_B. 0.639406
IPR000719 Protein kinase IPR012012 Integrin_B. 0.552655
IPR000719 Protein kinase IPR001169 Integrin beta, C-terminal 0.459388
IPR000719 Protein kinase IPR002369 Integrin, beta chain 0.459388
IPR000719 Protein kinase IPR012896 Integrin_B_tail. 0.317906
IPR000719 Protein kinase IPR001450 4Fe-4S ferredoxin, iron-sulfur binding domain 0.242285
IPR011009 Protein kinase-like IPR001450 4Fe-4S ferredoxin, iron-sulfur binding domain 0.220168

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in ITGB2
  • Green Domain is present in both MAPK1 and ITGB2

 0.014
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: ITGB2

PTMResidueReference
N-linked 212 PubMed, HPRD
Phosphorylation 745 PubMed, HPRD
Phosphorylation 756 PubMed, HPRD
Phosphorylation 758 PubMed, HPRD
Phosphorylation 760 PubMed, HPRD
Phosphoserine 745 PubMed, HPRD
Phosphoserine 756 HPRD
Phosphothreonine 758 PubMed, HPRD
Phosphothreonine 760 PubMed, HPRD
Pyrrolidone carboxylic acid 23 HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: ITGB2

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between MAPK1 and ITGB2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andITGB2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and ITGB2 has 1443 interactors of which there are 652 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for ITGB2-Interactor (?)
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 115.00 0.332
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 94.70 0.056
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.044
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.044
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 62.30 0.030
DIAPH1 Diaphanous 1 20.60 0.066
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 10.50 0.078
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 4.15 0.111
HSP90AA1 Hsp89-alpha-delta-N 3.95 0.033
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 3.35 0.051
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 2.17 0.137
GNAI2 Galphai2 protein 1.71 0.129
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 1.42 0.026
GNAQ GNAQ, GAQ: Guanine nucleotide-binding protein G(q) subunit alpha 1.03 0.029
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.683 0.025
PLEK PLEK, P47: Pleckstrin 0.515 0.354
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.461 1.07
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.461 0.227
CRKL CRKL: Crk-like protein 0.461 0.113
JAK1 0.461 0.503
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.461 0.245
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.461 1.07
MSN MSN: Moesin 0.461 1.07
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 0.503
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.503
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 1.19
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.416 0.354
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.385 0.040
STK10 STK10: Uncharacterized protein STK10 0.385 0.141
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.385 0.394
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.372 0.148
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 1.07
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.372 0.114
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.304
LYN LYN: Tyrosine-protein kinase Lyn 0.372 1.07
PSCD4 PSCD4, CYT4: Cytohesin-4 0.372 0.503
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.304
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.372 0.051
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.372 0.245
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.503
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.137
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 0.181
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 3.22
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.307 0.340
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.274
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.307 0.202
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.307 1.19
VASP VASP: Vasodilator-stimulated phosphoprotein 0.307 0.561
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.067
DOK1 DOK1: Docking protein 1 0.275 0.304
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.245
JUNB JUNB: Transcription factor jun-B 0.275 0.038
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.275 0.155
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.245
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 0.148
HCK N/A 0.275 1.07
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.181
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.304
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.260 1.62
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.260 0.059
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 0.166
GAB2 N/A 0.251 0.274
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.251 0.340
IRS2 IRS2: Insulin receptor substrate 2 0.251 0.274
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.233 0.072
WASPIP N/A 0.233 0.066
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.137
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.233 0.227
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.233 0.394
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.233 0.484
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.233 0.484
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 0.181
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.181
STAT4 STAT4: Signal transducer and activator of transcription 4 0.225 0.071
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.225 0.113
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.225 0.148
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.094
RASA3 RASA3: Ras GTPase-activating protein 3 0.225 0.148
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.210 0.153
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.210 0.440
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.153
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.208 0.079
TGFB1 TGFB1, TGFB: Transforming growth factor beta-1 precursor 0.192 0.484
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.100
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.191 0.100
STAT2 STAT2: Signal transducer and activator of transcription 2 0.191 0.0794
GMIP GMIP: GEM-interacting protein 0.188 1.45
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.188 0.304
CXorf9 N/A 0.188 0.227
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.188 0.051
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 0.111
RPS6KB1 N/A 0.188 0.0818
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.188 0.245
FNBP1 N/A 0.188 0.111
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.171 0.041
RIN1 RIN1: Ras and Rab interactor 1 0.171 0.090
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.171 0.090
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 0.113
PSD TYL: TYL protein 0.171 0.064
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.171 0.148
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.073
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.171 0.033
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.109
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.109
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.109
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.109
PSCD2 N/A 0.165 0.109
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 0.109
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.109
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 0.109
NF2 NF2, SCH: Merlin 0.165 0.109
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.109
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.155 0.027
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.155 0.057
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.155 0.101
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.091
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.153 0.210
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.152 0.100
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.152 0.081
GAB1 GAB1: GRB2-associated-binding protein 1 0.152 0.081
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.152 0.100
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 0.062
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.148 0.098
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.148 0.044
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.098
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.044
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.098
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 0.098
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.098
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.098
STAT3 0.148 0.098
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.098
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.098
ELMO1 N/A 0.148 0.098
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.098
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.098
ARHGEF7 N/A 0.148 0.098
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.146 0.066
PPP2R5A PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha 0.146 0.066
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.146 0.066
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.139 0.054
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.139 0.0818
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.139 0.067
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.139 0.076
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.139 0.067
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.139 0.032
ATM ATM: Serine-protein kinase ATM 0.139 0.067
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.139 0.067
CD2AP CD2AP: CD2-associated protein 0.139 0.051
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.139 0.038
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.139 0.090
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.139 0.067
FYN N/A 0.137 0.108
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.136 0.046
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.136 0.058
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.058
RDX RDX: Radixin 0.136 0.058
VIL2 N/A 0.136 0.113
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.064
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.026
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.132 0.074
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.129 0.137
ACTR3 ACTR3, ARP3: Actin-related protein 3 0.129 0.227
CENTA1 CENTA1: Centaurin-alpha 1 0.128 0.128
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.091
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.127 0.124
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.127 0.030
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.124 0.917
TNFRSF1B TNFRSF1B, TNFBR, TNFR2: Tumor necrosis factor receptor superfamily member 1B pre 0.124 1.72
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.123 0.100
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.123 0.072
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.114 0.051
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.114 0.033
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.114 0.033
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.114 0.090
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.148
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.067
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.114 0.040
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.114 0.112
RPS10 RPS10: 40S ribosomal protein S10 0.114 0.067
THOC1 THOC1, HPR1: THO complex subunit 1 0.114 0.033
PLD2 PLD2: Phospholipase D2 0.111 0.064
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.111 0.073
APS SH2B2, APS: SH2B adapter protein 2 0.111 0.073
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.111 0.058
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.073
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.111 0.073
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.111 0.064
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.0727
BMX N/A 0.110 0.065
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.083
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.165
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.0727
MCF2 MCF2, DBL: Proto-oncogene DBL 0.109 0.065
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.109 0.036
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.109 0.045
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.099 0.065
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.065
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.098 0.072
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.098 0.083
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.075
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.098 0.083
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.025
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.148
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.065
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.097 0.046
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.097 0.064
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.065
PLD1 PLD1: Phospholipase D1 0.097 0.064
DAB1 DAB1: Disabled homolog 1 0.097 0.058
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.064
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.052
NBN NBN, NBS, NBS1, P95: Nibrin 0.0971 0.063
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.096 0.340
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.096 0.0453
NFATC1 N/A 0.096 0.0513
CIITA CIITA, MHC2TA: MHC class II transactivator 0.096 0.061
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.096 0.037
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.081
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.091 0.917
CD44 N/A 0.091 0.852
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.090 0.129
PTPRZ1 N/A 0.090 0.044
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 0.064
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.088 0.065
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.087 0.036
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.087 0.101
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.029
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.086 0.054
RELA RELA, NFKB3: Transcription factor p65 0.086 0.046
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.086 0.067
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.086 0.041
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.086 0.029
AMPH AMPH, AMPH1: Amphiphysin 0.083 0.049
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.083 0.049
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.083 0.049
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.083 0.034
CASP8 CASP8, MCH5: Caspase-8 precursor 0.083 0.04
MAPK15 N/A 0.083 0.049
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.083 0.034
CASP9 CASP9, MCH6: Caspase-9 precursor 0.083 0.04
CASP1 CASP1, IL1BC, IL1BCE: Caspase-1 precursor 0.083 0.04
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.04
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.083 0.039
ARHGEF3 ARHGEF3: Rho guanine nucleotide exchange factor 3 0.083 0.065
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.0818 0.372
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.099
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.078 0.090
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.078 0.032
LCP1 LCP1, PLS2: Plastin-2 0.078 0.227
UBE2E3 UBE2E3, UBCE4, UBCH9: Ubiquitin-conjugating enzyme E2 E3 0.078 0.054
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.078 0.112
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.078 0.032
AGTPBP1 AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein 0.078 0.066
PPID PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase 0.078 0.0818
HNRPK N/A 0.078 0.032
KIAA1012 KIAA1012: Protein TRS85 homolog 0.078 0.137
USP47 USP47: Ubiquitin carboxyl-terminal hydrolase 47 0.078 0.032
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.078 0.032
UBE4A N/A 0.078 0.032
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.078 0.040
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.078 0.076
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.077 0.032
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.077 0.0453
LIMK2 LIMK2: LIM domain kinase 2 0.077 0.057
STK16 N/A 0.077 0.0453
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.077 0.062
TNFSF12 TNFSF12, APO3L, UNQ181/PRO207, DR3LG: Tumor necrosis factor ligand superfamily m 0.075 0.852
ATP2B1 N/A 0.075 0.026
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.075 0.210
FADD FADD, MORT1: Protein FADD 0.075 0.080
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.075 0.036
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.075 0.036
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.044
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.075 0.04
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.044
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.075 0.044
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.075 0.036
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.030
GIT2 N/A 0.075 0.036
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.075 0.044
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.044
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.075 0.044
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.075 0.044
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.044
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.075 0.044
CNN2 CNN2: Calponin-2 0.075 0.04
SNX3 N/A 0.075 0.098
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.036
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.025
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.075 0.044
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.075 0.044
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.036
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.098
PLCB2 0.074 0.207
RIN3 N/A 0.074 0.620
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.073 0.086
CDC42 CDC42: Cell division control protein 42 homolog precursor 0.073 0.037
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.072 0.055
LMNB1 LMNB1, LMN2, LMNB: Lamin-B1 0.071 0.035
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.071 0.113
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.070 0.126
SLC9A3R1 SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50 0.070 0.153
CAPNS1 CAPNS1, CAPN4, CAPNS: Calpain small subunit 1 0.070 0.035
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.070 0.091
CASP8 N/A 0.070 0.074
IFI35 N/A 0.070 0.0446
WDR1 N/A 0.070 0.105
MARK2 N/A 0.070 0.0446
SEL1L SEL1L, TSA305, UNQ128/PRO1063: Protein sel-1 homolog 1 precursor 0.070 0.030
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.051
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.069 0.069
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.069 0.041
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.069 0.073
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.069 0.027
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.069 0.029
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.069 0.111
SCAP2 SKAP2, PRAP, RA70, SAPS, SCAP2, SKAP55R: Src kinase-associated phosphoprotein 2 0.067 0.108
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 0.461
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.064 0.044
IL1B IL1B, IL1F2: Interleukin-1 beta precursor 0.063 0.0453
USP10 USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10 0.063 0.032
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.063 0.332
FRG1 FRG1: Protein FRG1 0.063 0.0818
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.063 0.040
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.063 0.056
GSK3B N/A 0.063 0.040
COPA COPA: Coatomer subunit alpha 0.063 0.0818
ACTG1 ACTB: Actin, cytoplasmic 1 0.063 0.137
MAD1L1 MAD1L1, MAD1, TXBP181: Mitotic spindle assembly checkpoint protein MAD1 0.063 0.040
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.063 0.137
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.063 0.067
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.063 0.032
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.063 0.041
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.063 0.067
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.063 0.067
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 0.063 0.156
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.063 0.063
TOPBP1 TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1 0.063 0.046
ARHGDIB ARHGDIB, GDIA2, GDID4, RAP1GN1: Rho GDP-dissociation inhibitor 2 0.063 0.066
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.063 0.137
PPP1CB PPP1CB: Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0.063 0.111
EXOC2 N/A 0.063 0.067
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.063 0.051
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.063 0.051
SPTAN1 N/A 0.062 0.029
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.062 0.062
VIM VIM: Vimentin 0.060 0.063
CERK CERK, KIAA1646: Ceramide kinase 0.060 0.047
NUP50 NUP50, NPAP60L, PRO1146: Nucleoporin 50 kDa 0.060 0.035
SOS2 SOS2: Son of sevenless homolog 2 0.060 0.027
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.058 0.099
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.058 0.049
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.057 0.307
TNF TNF, TNFA, TNFSF2: Tumor necrosis factor precursor 0.057 0.191
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.057 0.096
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.057 0.515
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.056 0.113
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.056 0.181
CASP2 CASP2, ICH1, NEDD2: Caspase-2 precursor 0.056 0.027
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 0.065
STAM2 STAM2: Signal transducing adapter molecule 2 0.056 0.041
NOS1 NOS1: Nitric-oxide synthase, brain 0.056 0.026
PRKCB1 PRKCB1, PKCB, PRKCB: Protein kinase C beta type 0.055 0.0407
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.055 0.0263
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.053 0.116
FLNA FLNA, FLN, FLN1: Filamin-A 0.052 0.125
SRPR SRPR: Uncharacterized protein SRPR 0.052 0.027
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.052 0.0446
STIP1 STIP1: Stress-induced-phosphoprotein 1 0.052 0.0453
FUBP1 N/A 0.052 0.166
RGS2 RGS2, G0S8: Regulator of G-protein signaling 2 0.052 0.157
DNM2 N/A 0.052 0.036
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.052 0.027
MVP MVP, LRP: Major vault protein 0.052 0.253
LIMS1 N/A 0.052 0.0446
DEF6 DEF6, IBP: Differentially expressed in FDCP 6 0.052 0.036
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.052 0.037
AHNAK AHNAK: AHNAK protein 0.052 0.0446
TERF2IP TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1 0.052 0.031
C9orf88 N/A 0.051 0.051
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
EVL EVL, RNB6: Ena/VASP-like protein 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
GRB10 N/A 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
RAPH1 N/A 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
FGF23 FGF23, HYPF, UNQ3027/PRO9828: Fibroblast growth factor 23 precursor 0.051 0.0453
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.051 0.029
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.051 0.139
NCF2 NCF2: Neutrophil cytosol factor 2 0.050 0.057
APBA3 APBA3, MINT3, X11L2: Amyloid beta A4 precursor protein-binding family A member 3 0.050 0.030
ARHGEF18 ARHGEF18: ARHGEF18 protein 0.050 0.039
RANBP3 N/A 0.050 0.032
PLEKHO1 PLEKHO1, CKIP1, OC120, HQ0024c: Pleckstrin homology domain-containing family O m 0.050 0.108
KRT1 KRT1, KRTA: Keratin, type II cytoskeletal 1 0.049 0.032
ARRB2 N/A 0.049 0.0479
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.165
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.049 0.165
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.049 0.083
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.049 0.165
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.049 0.165
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.049 0.083
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.049 0.083
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.052
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.049 0.165
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.049 0.052
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.165
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.049 0.028
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.052
EDA N/A 0.049 0.165
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.049 0.165
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.165
LAT LAT: Linker for activation of T-cells family member 1 0.049 0.028
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.049 0.028
SORBS3 SORBS3, SCAM1: Vinexin 0.049 0.029
NEFL NEFL, NF68, NFL: Neurofilament light polypeptide 0.048 0.029
LMNA LMNA, LMN1: Lamin-A/C 0.047 0.030
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.046 0.181
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.046 0.051
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.046 0.094
HIST3H3 HIST3H3, H3FT: Histone H3.1t 0.046 0.076
CDC23 CDC23: Cell division cycle protein 23 homolog 0.046 0.051
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.046 0.032
TBCE TBCE: Tubulin-specific chaperone E 0.046 0.033
PPP2CA PPP2CA: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 0.046 0.051
CORO1C CORO1C, CRNN4: Coronin-1C 0.046 0.056
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.046 0.051
WARS WARS, IFI53, WRS: Tryptophanyl-tRNA synthetase, cytoplasmic 0.046 0.032
NAPG NAPG, SNAPG: Gamma-soluble NSF attachment protein 0.046 0.051
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.046 0.112
TAF10 TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10 0.046 0.076
FLII FLII, FLIL: Protein flightless-1 homolog 0.046 0.112
RGS19 RGS19, GAIP, GNAI3IP: Regulator of G-protein signaling 19 0.046 0.066
SEC31L1 N/A 0.046 0.046
PREP PREP, PEP: Prolyl endopeptidase 0.046 0.067
COPE COPE: Coatomer subunit epsilon 0.046 0.0818
LPXN LPXN, LDLP: Leupaxin 0.046 0.032
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.046 0.033
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.046 0.032
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.046 0.041
CCR5 CCR5: CCR5 receptor (Fragment) 0.046 0.052
TBC1D4 TBC1D4: TBC1D4 protein 0.046 0.046
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.046 0.046
VAV2 VAV2: Uncharacterized protein VAV2 0.046 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 0.046
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.046 0.046
EPB41 EPB41, E41P: Protein 4.1 0.046 0.046
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.046 0.046
EFNB1 EFNB1, EFL-3, EPLG2, LERK2: Ephrin-B1 precursor 0.046 0.064
CD40LG CD40LG, CD40L, TNFSF5, TRAP: CD40 ligand 0.0453 0.191
LTA LTA, TNFB, TNFSF1: Lymphotoxin-alpha precursor 0.0453 0.123
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.0453 0.152
EPOR EPOR: Erythropoietin receptor precursor 0.0453 0.055
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.191
TNFRSF10C TNFRSF10C, DCR1, UNQ321/PRO366, LIT, TRAILR3, TRID: Tumor necrosis factor recept 0.0453 0.0971
CGB CGB, CGB3, CGB5, CGB7, CGB8: Choriogonadotropin subunit beta precursor 0.045 0.032
GDF15 GDF15, MIC1, PDF, PLAB, PTGFB: Growth/differentiation factor 15 precursor 0.045 0.032
CGA CGA: Glycoprotein hormones alpha chain precursor 0.045 0.032
TSHB TSHB: Thyrotropin subunit beta precursor 0.045 0.032
FSHB FSHB: Follitropin subunit beta precursor 0.045 0.032
LHB LHB: Lutropin subunit beta precursor 0.045 0.032
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.0446 0.515
PIP3-E N/A 0.044 0.029
ARHGAP26 ARHGAP26, GRAF, KIAA0621, OPHN1L: Rho GTPase-activating protein 26 0.044 0.0968
CENTB1 CENTB1, KIAA0050: Centaurin-beta 1 0.044 0.035
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.044 0.026
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.044 0.029
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.044 0.026
CTTN CTTN, EMS1: Src substrate cortactin 0.044 0.026
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.044 0.026
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.044 0.148
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.044 0.025
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.025
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.025
AQP4 AQP4: Aquaporin-4 0.044 0.025
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.044 0.025
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 0.025
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.047
FTH1 FTH1, FTH, OK/SW-cl.84, FTHL6, PIG15: Ferritin heavy chain 0.0425 0.027
ALOX5 ALOX5, LOG5: Arachidonate 5-lipoxygenase 0.0425 0.253
NUP214 N/A 0.0425 0.105
SAT SAT1, SAT: Diamine acetyltransferase 1 0.0425 0.0446
GNB2L1 Lung cancer oncogene 7 0.0425 0.063
DAPP1 N/A 0.0425 0.036
MPG N/A 0.0425 0.027
SH3BP3 0.0425 0.063
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.0425 0.253
TP53BP1 TP53BP1: Tumor suppressor p53-binding protein 1 0.0425 0.031
XRCC1 XRCC1: DNA-repair protein XRCC1 0.0425 0.105
TBC1D1 TBC1D1, KIAA1108: TBC1 domain family member 1 0.042 0.053
SLC4A7 SLC4A7: Uncharacterized protein SLC4A7 0.041 0.029
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.041 0.065
VWF VWF, F8VWF: von Willebrand factor precursor 0.041 0.058
NDP NDP: Norrin precursor 0.041 0.033
FGF5 FGF5: Fibroblast growth factor 5 precursor 0.041 0.029
PDGFA PDGFA, PDGF1: Platelet-derived growth factor A chain precursor 0.041 0.0727
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.136
KIT KIT: Mast/stem cell growth factor receptor precursor 0.041 0.097
SH2D1A SH2D1A, DSHP, SAP: SH2 domain-containing protein 1A 0.041 0.032
CENTA2 CENTA2: Centaurin-alpha 2 0.041 0.108
MYLIP MYLIP, BZF1, BM-023, PP5242: E3 ubiquitin-protein ligase MYLIP 0.041 0.032
FGF9 FGF9: Glia-activating factor precursor 0.041 0.029
TBXA2R TBXA2R: Thromboxane A2 receptor 0.04 0.028
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.04 0.028
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.040 0.461
ITGB7 ITGB7: Integrin beta-7 precursor 0.040 0.372
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.040 0.029
CST7 CST7: Cystatin-F precursor 0.039 0.036
NEF3 NEFM, NEF3, NFM: Neurofilament medium polypeptide 0.039 0.029
GFAP GFAP: Glial fibrillary acidic protein 0.039 0.029
TLN1 TLN1: Uncharacterized protein TLN1 0.038 0.245
TPT1 TPT1: Translationally-controlled tumor protein 0.038 0.032
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.038 0.028
COPB2 COPB2: Coatomer subunit beta' 0.038 0.035
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 0.038 0.033
RP2 RP2: Protein XRP2 0.038 0.040
DNAJC7 DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7 0.038 0.051
MRE11A MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A 0.038 0.035
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.038 0.051
DYNC1I2 N/A 0.038 0.033
CHP CHP: Calcium-binding protein p22 0.038 0.067
MDN1 MDN1, KIAA0301: Midasin 0.038 0.041
STUB1 STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1 0.038 0.041
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.038 0.035
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.037 0.152
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.037 0.077
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.037 0.026
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.037 0.152
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.037 0.123
GHR GHR: Growth hormone receptor precursor 0.037 0.055
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.037 0.055
RASA4 RASA4, CAPRI, GAPL, KIAA0538: Ras GTPase-activating protein 4 0.036 0.035
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.036 0.044
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.036 1.81
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.036 1.81
CRLF3 N/A 0.036 0.430
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.036 0.416
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.036 0.416
CD7 CD7: T-cell antigen CD7 precursor 0.036 0.307
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.036 1.81
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.036 1.81
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.036 1.81
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.036 0.515
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.036 1.81
RHOG RHOG, ARHG: Rho-related GTP-binding protein RhoG precursor 0.0354 0.037
TRAF1 TRAF1, EBI6: TNF receptor-associated factor 1 0.035 0.033
NEFH NEFH, KIAA0845, NFH: Neurofilament heavy polypeptide 0.034 0.029
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.034 0.042
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.034 0.109
SCARB2 SCARB2, CD36L2, LIMPII: Lysosome membrane protein 2 0.033 0.049
PRLR PRLR: Prolactin receptor precursor 0.033 0.049
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.033 0.056
ITGB4 N/A 0.032 0.109
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.032 0.110
F3 F3: Tissue factor precursor 0.032 0.049
TNFSF15 TNFSF15, RP11-428F18.1-001, hCG_27396: TNF superfamily ligand TL1A 0.032 0.109
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.032 0.123
IL9R IL9R: Interleukin-9 receptor precursor 0.032 0.055
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.032 0.098
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.032 0.0453
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.124
ZYX ZYX: Zyxin 0.032 0.0446
PLSCR1 PLSCR1: Phospholipid scramblase 1 0.032 0.385
NCSTN NCSTN, KIAA0253, UNQ1874/PRO4317: Nicastrin precursor 0.032 0.078
SORL1 SORL1: Sortilin-related receptor precursor 0.032 0.852
DES DES: Desmin 0.031 0.032
RGS3 RGS3: Regulator of G-protein signaling 3 0.030 0.053
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 0.099
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.029 0.049
NEO1 NEO1, NGN: Neogenin precursor 0.029 0.078
EGF EGF: Pro-epidermal growth factor precursor 0.029 0.109
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.029 0.123
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.029 0.098
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.029 0.031
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.029 0.097
HIST1H3A HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, 0.029 0.035
BCDO2 PTS: 6-pyruvoyl tetrahydrobiopterin synthase 0.029 0.029
EML4 EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4 0.029 0.051
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.029 0.067
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.029 0.028
FKBP8 DKFZp686M22160: Putative uncharacterized protein DKFZp686M22160 (Fragment) 0.029 0.033
PAK1IP1 PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1 0.029 0.028
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.029 0.051
THOP1 THOP1: Thimet oligopeptidase 0.029 0.073
PPP2CB PPP2CB: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0.029 0.029
AIP AIP, XAP2: AH receptor-interacting protein 0.029 0.067
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.029 0.041
TRIM25 TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25 0.029 0.051
COL1A2 COL1A2: Collagen alpha-2(I) chain precursor 0.029 0.027
COL5A2 COL5A2: Collagen alpha-2(V) chain precursor 0.029 0.027
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.028 0.049
PDZD2 CDNA FLJ46853 fis, clone UTERU3009775, moderately similar to Rattus norvegicus P 0.028 0.049
WDR54 N/A 0.028 0.034
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
SYTL4 Endocrine transmitter regulatory protein 0.028 0.034
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.028 0.049
S100A16 S100A16, AAG13: Protein S100-A16 0.028 0.049
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.028 0.034
PPEF1 N/A 0.028 0.049
NASP NASP: Nuclear autoantigenic sperm protein 0.028 0.049
PRPH PRPH, NEF4, PRPH1: Peripherin 0.0277 0.026
APBB1IP APBB1IP, PREL1, RARP1, RIAM: Amyloid beta A4 precursor protein-binding family B 0.028 0.029
ADRBK2 ADRBK2, BARK2, GRK3: Beta-adrenergic receptor kinase 2 0.028 0.035
VAV3 VAV3: Protein vav-3 0.028 0.029
PTGIR PTGIR, PRIPR: Prostacyclin receptor 0.027 0.046
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.027
ITGAE ITGAE: Integrin alpha-E precursor 0.027 0.307
LILRB1 N/A 0.027 1.81
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.027 0.852
LTB4R LTB4R, BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7: Leukotriene B4 receptor 1 0.027 0.087
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.027 0.416
CD69 CD69: Early activation antigen CD69 0.027 0.251
CD59 CD59, MIC11, MIN1, MIN2, MIN3, MSK21: CD59 glycoprotein precursor 0.0263 0.049
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.026 0.088
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.026 0.097
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.0453
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.026 0.029
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.026 0.057
OSTF1 N/A 0.0255 0.057
SIPA1 SIPA1, SPA1: Signal-induced proliferation-associated protein 1 0.0255 0.027
PLA2G4A PLA2G4A, CPLA2, PLA2G4: Cytosolic phospholipase A2 0.0253 0.0253
IL1A IL1A, IL1F1: Interleukin-1 alpha precursor 0.025 0.032
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.025 0.081
F5 F5: Coagulation factor V precursor 0.025 0.166
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.025 0.030
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.025 0.098
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.025 0.044
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.025 0.030
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.025 0.044
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.036
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.036
MYO18A 0.025 0.044
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.025 0.044
DPP8 DPP8, DPRP1, MSTP097, MSTP135, MSTP141: Dipeptidyl peptidase 8 0.025 0.044
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.030
BUB3 BUB3: Mitotic checkpoint protein BUB3 0.025 0.030
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.025 0.036
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.025 0.044
UBE2A UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A 0.025 0.036
ACTN4 ACTN4: Alpha-actinin-4 0.025 0.044
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.025 0.030
NLN NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor 0.025 0.098
GEMIN5 GEMIN5: Gem-associated protein 5 0.025 0.030
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.025 0.044
ARPC4 ARPC4, ARC20: Actin-related protein 2/3 complex subunit 4 0.025 0.053
0.299
Total Score 4.77