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Evidence of Interaction Between MAPK1 and MEF2C

The interaction score between MAPK1 and MEF2C is 2.75.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and MEF2C = 0.16

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.30E-3
Orthology
OrganismMAPK1 OrthologueMEF2C OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm P39745 1 Q9U325 0.302
fly P40417 1 P40791 0.335

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains No domains were used in calculating likelihood of interaction 0.028
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: MEF2C

PTMResidueReference
Phosphorylation 59 PubMed, HPRD
Phosphorylation 293 PubMed, HPRD
Phosphorylation 300 PubMed, HPRD
Phosphorylation 387 PubMed, HPRD
Phosphoserine 396 HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: MEF2C

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between MAPK1 and MEF2C that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andMEF2C. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and MEF2C has 511 interactors of which there are 461 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for MEF2C-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 0.029
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.025
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.025
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 62.30 0.025
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 3.35 0.041
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.975 0.026
PLEK PLEK, P47: Pleckstrin 0.515 0.026
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.461 0.029
ID2 ID2: DNA-binding protein inhibitor ID-2 0.430 0.123
BATF BATF: Basic leucine zipper transcriptional factor ATF-like 0.416 0.062
ELF1 ELF1: ETS-related transcription factor Elf-1 0.416 0.077
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.385 0.029
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.372 0.056
JUND JUND: Transcription factor jun-D 0.372 0.086
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.307 0.026
JUNB JUNB: Transcription factor jun-B 0.275 0.069
MAFG MAFG: Transcription factor MafG 0.275 0.056
ETS1 ETS1, EWSR2: Protein C-ets-1 0.275 0.049
FOS FOS, G0S7: Proto-oncogene protein c-fos 0.275 0.069
GAB2 N/A 0.251 0.032
BACH1 BACH1: Transcription regulator protein BACH1 0.251 0.077
IRS2 IRS2: Insulin receptor substrate 2 0.251 0.026
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.233 0.038
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.233 0.029
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.233 0.069
JUN JUN: Transcription factor AP-1 0.225 0.069
ATF6 ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha 0.225 0.056
NFE2L2 NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2 0.225 0.049
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.225 0.069
NR3C1 NR3C1, GRL: Glucocorticoid receptor 0.210 0.062
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.210 0.026
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.210 0.032
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.210 0.032
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.026
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.208 0.126
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.032
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.188 0.086
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.188 0.029
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.188 0.029
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.174 0.028
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.171 0.038
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.171 0.056
PSD TYL: TYL protein 0.171 0.032
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.033
NSBP1 NSBP1: Nucleosome-binding protein 1 0.165 0.028
BID BID: BH3-interacting domain death agonist 0.165 0.028
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.165 0.083
NF2 NF2, SCH: Merlin 0.165 0.028
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.155 0.026
H1FX H1FX: Histone H1x 0.155 0.096
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.155 0.032
ERF ERF: ETS domain-containing transcription factor ERF 0.152 0.055
GAB1 GAB1: GRB2-associated-binding protein 1 0.152 0.026
ETS2 ETS2: Protein C-ets-2 0.152 0.062
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.148 0.025
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 0.025
CREB1 CREB1: cAMP response element-binding protein 0.148 0.075
CDC25C CDC25C: M-phase inducer phosphatase 3 0.148 0.025
CCNT2 CCNT2: Cyclin-T2 0.148 0.025
CDC25A CDC25A: M-phase inducer phosphatase 1 0.148 0.025
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.075
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.025
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.148 0.025
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.025
ELMO1 N/A 0.148 0.025
CDKN1B CDKN1B, KIP1: Cyclin-dependent kinase inhibitor 1B 0.139 0.029
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.139 0.046
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.139 0.069
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.139 0.086
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.137 0.025
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.137 0.025
FOSL2 FOSL2, FRA2: Fos-related antigen 2 0.136 0.049
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.136 0.044
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.129 0.069
RBM8A RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A 0.129 0.038
RB1 RB1: Retinoblastoma-associated protein 0.127 0.026
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.026
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.127 0.026
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.026
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.127 0.026
RXRA RXRA, NR2B1: Retinoic acid receptor RXR-alpha 0.127 0.062
ERG ERG: Transcriptional regulator ERG 0.123 0.055
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.118 0.056
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.118 0.069
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.114 0.029
CEBPB CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta 0.114 0.049
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.114 0.029
HIF1A HIF1A, MOP1: Hypoxia-inducible factor 1 alpha 0.114 0.136
CDK5 CDK5: Cell division protein kinase 5 0.114 0.038
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.029
EIF4G3 EIF4G3: Eukaryotic translation initiation factor 4 gamma 3 0.114 0.038
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.114 0.069
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.114 0.038
ELK1 ELK1: ETS domain-containing protein Elk-1 0.111 0.056
CEBPE CEBPE: CCAAT/enhancer-binding protein epsilon 0.111 0.049
STMN2 STMN2, SCG10, SCGN10: Stathmin-2 0.111 0.066
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.026
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.109 0.026
ETV1 ETV1, ER81: ETS translocation variant 1 0.098 0.055
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.029
SP100 N/A 0.0971 0.026
PTMA N/A 0.0971 0.026
NBN NBN, NBS, NBS1, P95: Nibrin 0.0971 0.026
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.096 0.055
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.055
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.096 0.032
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.096 0.026
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.096 0.026
SMAD7 SMAD7, MADH7, MADH8: Mothers against decapentaplegic homolog 7 0.096 0.055
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.087 0.0425
MATR3 MATR3, KIAA0723: Matrin-3 0.087 0.052
IFI16 N/A 0.087 0.026
AHR AHR: Aryl hydrocarbon receptor precursor 0.086 0.097
TCF3 TCF3, E2A, ITF1: Transcription factor E2-alpha 0.086 0.136
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.029
SMAD3 SMAD3, MADH3: Mothers against decapentaplegic homolog 3 0.086 0.056
CDK5R1 CDK5R1, CDK5R, NCK5A: Cyclin-dependent kinase 5 activator 1 precursor 0.086 0.078
SMAD4 SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4 0.086 0.056
MAPKAPK5 N/A 0.083 0.028
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.028
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.083 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.083 0.028
ARNT ARNT: Aryl hydrocarbon receptor nuclear translocator 0.083 0.165
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.028
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.083 0.028
CASP8 CASP8, MCH5: Caspase-8 precursor 0.083 0.049
MAPK15 N/A 0.083 0.028
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.083 0.028
CASP9 CASP9, MCH6: Caspase-9 precursor 0.083 0.049
CASP1 CASP1, IL1BC, IL1BCE: Caspase-1 precursor 0.083 0.049
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.083 0.028
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.028
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.083 0.028
HES6 HES6: Transcription cofactor HES-6 0.083 0.165
IRF3 IRF3: Interferon regulatory factor 3 0.080 0.062
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.078 0.029
AGTPBP1 AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein 0.078 0.038
PPID PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase 0.078 0.041
KIAA1012 KIAA1012: Protein TRS85 homolog 0.078 0.086
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.078 0.046
MYB MYB: Myb proto-oncogene protein 0.077 0.062
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.077 0.026
LIMK2 LIMK2: LIM domain kinase 2 0.077 0.029
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.077 0.032
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.075 0.025
SMAD1 SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1 0.075 0.075
CDC2 CDC2: Cell division control protein 2 homolog 0.075 0.025
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.075 0.025
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.025
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.075 0.028
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.075 0.025
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.075 0.025
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.075 0.025
NCOA3 NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3 0.075 0.148
MAX MAX: Protein max 0.075 0.148
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.075 0.025
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.025
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.075 0.025
GIT2 N/A 0.075 0.025
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.025
GATAD2B GATAD2B, KIAA1150: Transcriptional repressor p66 beta 0.075 0.025
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.075 0.025
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.025
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.075 0.025
TAL2 TAL2: T-cell acute lymphocytic leukemia protein 2 0.075 0.148
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.025
MLXIPL MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein 0.075 0.148
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.075 0.025
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.075 0.075
TFAP4 TFAP4: Transcription factor AP-4 0.075 0.148
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.075 0.025
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.075 0.025
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.025
RBL1 RBL1: Retinoblastoma-like protein 1 0.075 0.025
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.075 0.025
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.071 0.038
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.071 0.029
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.070 0.032
USP24 USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24 0.070 0.026
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.070 0.026
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.070 0.026
PHF3 PHF3, KIAA0244: PHD finger protein 3 0.070 0.026
ZNF148 ZNF148, ZBP89: Zinc finger protein 148 0.070 0.032
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.070 0.0425
RFXDC2 RFXDC2: Regulatory factor X domain-containing protein 2. 0.070 0.026
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.070 0.026
TOP2B N/A 0.070 0.0425
MARK2 N/A 0.070 0.026
MYCN MYCN, NMYC: N-myc proto-oncogene protein 0.069 0.372
NR5A1 NR5A1, AD4BP, FTZF1, SF1: Steroidogenic factor 1 0.069 0.049
TAL1 TAL1, SCL, TCL5: T-cell acute lymphocytic leukemia protein 1 0.069 0.097
VDR VDR, NR1I1: Vitamin D3 receptor 0.069 0.049
NR4A2 NR4A2, NOT, NURR1, TINUR: Orphan nuclear receptor NR4A2 0.069 0.056
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.063 0.069
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.063 0.029
DYNC1LI1 DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1 0.063 0.046
CUL5 CUL5, VACM1: Cullin-5 0.063 0.029
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.063 0.029
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.063 0.029
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 0.063 0.111
ZNF24 ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24 0.063 0.029
NCOR1 NCOR1, KIAA1047: Nuclear receptor corepressor 1 0.063 0.069
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.062 0.055
GTF2F2 N/A 0.060 0.062
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.060 0.055
CASP2 CASP2, ICH1, NEDD2: Caspase-2 precursor 0.056 0.029
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.056 0.078
TERT TERT, EST2, TCS1, TRT: Telomerase reverse transcriptase 0.056 0.026
RERE RERE, ARG, ARP, ATN1L, KIAA0458: Arginine-glutamic acid dipeptide repeats protei 0.056 0.086
ESRRA ESRRA, ERR1, ESRL1, NR3B1: Steroid hormone receptor ERR1 0.056 0.049
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.056 0.038
NR1D1 NR1D1, EAR1, HREV, THRAL: Orphan nuclear receptor NR1D1 0.056 0.056
DDIT3 DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3 0.055 0.049
PPARA PPARA, NR1C1, PPAR: Peroxisome proliferator-activated receptor alpha 0.055 0.062
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.054 0.049
RAB4A N/A 0.052 0.028
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.052 0.083
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.052 0.083
STIP1 STIP1: Stress-induced-phosphoprotein 1 0.052 0.037
MECP2 MECP2: Methyl-CpG-binding protein 2 0.052 0.026
TERF1 TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1 0.052 0.096
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.052 0.032
NCOA3 N/A 0.052 0.032
TERF2 TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2 0.052 0.127
SET SET: Protein SET 0.052 0.026
LIMS1 N/A 0.052 0.032
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.052 0.032
ZNF638 ZNF638, NP220, ZFML: Zinc finger protein 638 0.052 0.032
MEF2A N/A 0.052 0.070
API5 N/A 0.052 0.026
ZNF318 ZNF318, HRIHFB2436: Zinc finger protein 318 0.052 0.026
TERF2IP TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1 0.052 0.096
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.052 0.026
NR4A1 CDNA FLJ16818 fis, clone TRACH1000193, highly similar to Orphan nuclear receptor 0.050 0.044
HES1 HES1, HL, HRY: Transcription factor HES-1 0.050 0.088
ID3 ID3, 1R21, HEIR-1: DNA-binding protein inhibitor ID-3 0.049 0.109
NFIB N/A 0.049 0.062
PGR PGR, NR3C3: Progesterone receptor 0.049 0.049
PPARG CREB3L2-PPARgamma 0.049 0.049
HIST1H1A HIST1H1A, H1F1: Histone H1.1 0.049 0.049
MYF5 MYF5: Myogenic factor 5 0.049 0.097
HIST1H1B HIST1H1B, H1F5: Histone H1.5 0.049 0.056
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.048 0.055
TUBB3 TUBB3, TUBB4: Tubulin beta-3 chain 0.048 0.087
FARSLA FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain 0.047 0.075
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.047 0.025
SOX8 SOX8: Transcription factor SOX-8 0.047 0.025
LMNA LMNA, LMN1: Lamin-A/C 0.047 0.025
WDR44 WDR44: WD repeat-containing protein 44 0.046 0.038
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.046 0.056
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.046 0.029
HDAC3 HDAC3: Histone deacetylase 3 0.046 0.136
CDC23 CDC23: Cell division cycle protein 23 homolog 0.046 0.033
DMXL2 DMXL2, KIAA0856: DmX-like protein 2 0.046 0.029
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.046 0.033
NAPG NAPG, SNAPG: Gamma-soluble NSF attachment protein 0.046 0.029
HDAC4 HDAC4, KIAA0288: Histone deacetylase 4 0.046 82.20
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.046 0.038
COPE COPE: Coatomer subunit epsilon 0.046 0.056
LPXN LPXN, LDLP: Leupaxin 0.046 0.033
SPEN SPEN, KIAA0929, MINT, SHARP: Msx2-interacting protein 0.046 0.029
DDX24 DDX24: ATP-dependent RNA helicase DDX24 0.046 0.029
CLTC CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1 0.046 0.069
HAND1 HAND1, EHAND: Heart- and neural crest derivatives-expressed protein 1 0.044 0.088
MYST4 MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4 0.044 0.069
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.044 0.029
ESR1 ESR1, ESR, NR3A1: Estrogen receptor 0.044 0.049
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.043 0.078
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.043 0.044
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.043 0.049
SOX4 SOX4: Transcription factor SOX-4 0.043 0.029
SREBF2 N/A 0.0425 0.026
GNB2L1 Lung cancer oncogene 7 0.0425 0.026
SH3BP3 0.0425 0.026
SMARCC2 N/A 0.0425 0.032
AOF2 AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1 0.0425 0.026
TP53BP1 TP53BP1: Tumor suppressor p53-binding protein 1 0.0425 0.032
FNBP4 FNBP4, FBP30, KIAA1014: Formin-binding protein 4 0.0425 0.026
SATB1 SATB1: DNA-binding protein SATB1 0.038 0.069
TSC1 TSC1, KIAA0243, TSC: Hamartin 0.038 0.029
YEATS2 KIAA1197, YEATS2: YEATS domain-containing protein 2 0.038 0.029
HDAC2 HDAC2: Histone deacetylase 2 0.038 0.136
KCTD12 KCTD12, C13orf2, KIAA1778, PFET1: BTB/POZ domain-containing protein KCTD12 0.038 0.029
DNAJC7 DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7 0.038 0.069
APC N/A 0.038 0.040
CREBBP CREBBP, CBP: CREB-binding protein 0.038 11.10
DYNC1I2 N/A 0.038 0.038
ZFYVE16 ZFYVE16, KIAA0305: Zinc finger FYVE domain-containing protein 16 0.038 0.029
RNF11 RNF11, CGI-123: RING finger protein 11 0.038 0.038
STUB1 STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1 0.038 0.033
FOXO1A FOXO1A, FKHR: Forkhead box protein O1A 0.035 0.056
HIVEP1 N/A 0.032 0.026
RBM6 RBM6, DEF3: RNA-binding protein 6 0.032 0.032
ZYX ZYX: Zyxin 0.032 0.032
SNAPC4 SNAPC4, SNAP190: snRNA-activating protein complex subunit 4 0.032 0.062
MAPK8IP3 MAPK8IP3, JIP3, KIAA1066: C-jun-amino-terminal kinase-interacting protein 3 0.032 0.0425
TGIF2 TGIF2: Homeobox protein TGIF2 0.032 0.062
SOX11 SOX11: Transcription factor SOX-11 0.0308 0.129
CASP3 CASP3, CPP32: Caspase-3 precursor 0.029 19.50
RBMX2 RBMX2, CGI-79: RNA-binding motif protein, X-linked 2 0.029 0.029
FKBP8 DKFZp686M22160: Putative uncharacterized protein DKFZp686M22160 (Fragment) 0.029 0.033
MYBL2 MYBL2, BMYB: Myb-related protein B 0.029 0.049
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.029 0.056
TCF8 ZEB1, AREB6, TCF8: Zinc finger E-box-binding homeobox 1 0.029 0.069
SIRT1 SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1 0.029 0.029
DPYSL2 DPYSL2, CRMP2: Dihydropyrimidinase-related protein 2 0.029 0.032
AIP AIP, XAP2: AH receptor-interacting protein 0.029 0.056
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.029 0.086
ZCCHC3 ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3 0.028 0.028
ZNF295 ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295 0.028 0.028
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.028
PTBP1 PTBP1: Polypyrimidine tract binding protein 1 0.028 0.028
WDR54 N/A 0.028 0.028
NFIA NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A 0.028 0.028
IRF7 N/A 0.028 0.028
C13orf8 N/A 0.028 0.028
C20orf18 N/A 0.028 0.028
DSP DSP: Desmoplakin 0.028 0.028
JDP2 jdp2, JDP2: Jun dimerization protein 2 0.028 0.028
CUTL1 CUTL1: Homeobox protein cut-like 1 0.028 0.083
HDAC8 N/A 0.028 0.165
SYTL4 Endocrine transmitter regulatory protein 0.028 0.028
NIPA1 NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1 0.028 0.028
DKFZp434K1815 DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815 0.028 0.028
KIAA1443 HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez 0.028 0.083
ZNF579 ZNF579: Zinc finger protein 579 0.028 0.028
CABLES1 N/A 0.028 0.028
TCF20 TCF20, KIAA0292, SPBP: Transcription factor 20 0.028 0.028
SNRPB N/A 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
ZNF265 N/A 0.028 0.028
ZFP91 ZFP91, FKSG11: Zinc finger protein 91 homolog 0.028 0.028
DUSP15 N/A 0.028 0.028
UHRF1 0.028 0.028
ZNF644 ZNF644, KIAA1221, ZEP2: Zinc finger protein 644 0.028 0.028
ZC3HAV1 ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1 0.028 0.028
PHLDB2 N/A 0.028 0.028
AR AR, DHTR, NR3C4: Androgen receptor 0.028 0.028
FLJ21816 PALB2, FANCN: Partner and localizer of BRCA2 0.028 0.028
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.028 0.028
POGZ POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain 0.028 0.028
PPEF1 N/A 0.028 0.028
ATXN2L ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein 0.028 0.028
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
CORO6 N/A 0.028 0.028
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
ILF3 ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3 0.028 0.028
NASP NASP: Nuclear autoantigenic sperm protein 0.028 0.049
RAVER1 RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1 0.028 0.028
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.028 0.028
CBFA2T2 CBFA2T2, EHT, MTGR1: Protein CBFA2T2 0.028 0.028
KIF1B N/A 0.028 0.028
CASP14 CASP14: Caspase-14 precursor 0.028 0.049
TMPO TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha 0.028 0.028
HNRPC HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2 0.028 0.028
MLL2 MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2 0.028 0.028
LOC642558 FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1 0.028 0.028
ZHX1 ZHX1: Zinc fingers and homeoboxes protein 1 0.028 0.083
MITF MITF: Microphthalmia-associated transcription factor 0.028 0.028
CASP6 CASP6, MCH2: Caspase-6 precursor 0.028 0.049
RFX1 RFX1: MHC class II regulatory factor RFX1 0.028 0.056
FOXL2 FOXL2: Forkhead box protein L2 0.028 0.044
CEP170 CEP170, FAM68A, KAB, KIAA0470: Centrosomal protein of 170 kDa 0.026 0.144
PPARGC1A PPARGC1A, LEM6, PGC1, PGC1A, PPARGC1: Peroxisome proliferator-activated receptor 0.026 0.026
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.026
POU2F1 POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1 0.026 0.062
DCAMKL1 DCLK1, DCAMKL1, DCDC3A, KIAA0369: Serine/threonine-protein kinase DCLK1 0.026 0.087
SSBP4 SSBP4: Single-stranded DNA-binding protein 4 0.025 0.025
WWTR1 WWTR1, TAZ: WW domain-containing transcription regulator protein 1 0.025 0.025
ZNF598 ZNF598: Zinc finger protein 598 0.025 0.025
FLJ40432 FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227 0.025 0.025
MIER1 MIER1, KIAA1610: Mesoderm induction early response protein 1 0.025 0.025
MSL3L1 MSL3L1: Male-specific lethal 3-like 1 0.025 0.025
MLL4 WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7 0.025 0.025
PSIP1 PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein 0.025 0.025
ADK ADK: Adenosine kinase 0.025 0.025
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.025 0.025
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.025
NFYA NFYA: Nuclear transcription factor Y subunit alpha 0.025 0.025
REXO1 REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog 0.025 0.025
ZFPM1 ZFPM1, FOG1: Zinc finger protein ZFPM1 0.025 0.025
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.025 0.025
PRDM2 PRDM2, RIZ: PR domain zinc finger protein 2 0.025 0.025
NEDD4 NEDD4: Uncharacterized protein NEDD4 0.025 0.025
LMO6 LMO6: LIM domain only protein 6 0.025 0.044
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.025
HOXA10 HOXA10, HOX1H: Homeobox protein Hox-A10 0.025 0.075
TCEA1 N/A 0.025 0.025
ZNF174 ZNF174, ZSCAN8: Zinc finger protein 174 0.025 0.025
NHN1 NHN1: Conserved nuclear protein NHN1 0.025 0.025
HIST3H2A HIST3H2A: Histone H2A type 3 0.025 0.025
POLR1C POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1 0.025 0.025
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.025
RFFL RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin 0.025 0.025
EDF1 EDF1: Endothelial differentiation-related factor 1 0.025 0.025
FAF1 FAF1, CGI-03: FAS-associated factor 1 0.025 0.025
SAP14 SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14 0.025 0.025
SETD3 SETD3, C14orf154: SET domain-containing protein 3 0.025 0.025
HNRPM HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M 0.025 0.025
SMN2 SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein 0.025 0.025
MAPK8IP3 N/A 0.025 0.025
SEC13L1 N/A 0.025 0.025
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.025
C20orf77 N/A 0.025 0.025
SFRS9 SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9 0.025 0.025
BUB3 BUB3: Mitotic checkpoint protein BUB3 0.025 0.025
ARID4A ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A 0.025 0.025
HTATIP N/A 0.025 0.025
TIA1 TIA1: Nucleolysin TIA-1 isoform p40 0.025 0.025
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.025
RBM10 RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10 0.025 0.025
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
BCOR N/A 0.025 0.025
MAP2K3 N/A 0.025 0.025
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.025
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.025 0.025
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
PHF16 PHF16, JADE3, KIAA0215: Protein Jade-3 0.025 0.025
BRD4 N/A 0.025 0.025
HNRPD HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0 0.025 0.025
ISL2 ISL2: Insulin gene enhancer protein ISL-2 0.025 0.075
DHX8 DHX8, DDX8: ATP-dependent RNA helicase DHX8 0.025 0.025
TRERF1 TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1 0.025 0.025
IWS1 IWS1, IWS1L: IWS1 homolog 0.025 0.025
SON 0.025 0.025
MKI67IP MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein 0.025 0.025
PRKCB1 N/A 0.025 0.025
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.025 0.025
NSUN2 NSUN2, SAKI, TRM4: tRNA 0.025 0.025
HEXIM2 HEXIM2, L3: Protein HEXIM2 0.025 0.025
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.025
OSR1 OSR1, ODD: Protein odd-skipped-related 1 0.025 0.025
GRK6 N/A 0.025 0.025
NUP98 N/A 0.025 0.025
SYAP1 SYAP1, PRO3113: Synapse-associated protein 1 0.025 0.025
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.025
RNF20 0.025 0.025
PURB PURB: Transcriptional activator protein Pur-beta 0.025 0.025
HNRPUL1 HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1 0.025 0.025
FLJ23436 N/A 0.025 0.025
C14orf4 C14orf4, KIAA1865, My039: RING finger protein C14orf4 0.025 0.025
RBBP6 RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6 0.025 0.025
NIPBL N/A 0.025 0.025
GEMIN5 GEMIN5: Gem-associated protein 5 0.025 0.025
DDX20 DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20 0.025 0.025
ATXN2L N/A 0.025 0.025
DLX3 DLX3: Homeobox protein DLX-3 0.025 0.075
SMARCA2 SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2 0.025 0.025
HNRPA2B1 HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1 0.025 0.025
NES N/A 0.025 0.028
KCTD1 0.025 0.025
HDAC7A N/A 0.025 0.148
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.025 0.025
DIDO1 N/A 0.025 0.025
CAMKK1 N/A 0.025 0.025
RNF113A RNF113A, RNF113, ZNF183: RING finger protein 113A 0.025 0.025
CAMK2A N/A 0.025 0.025
0.299
Total Score 2.75