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Evidence of Interaction Between RFC4 and MSH6

The interaction score between RFC4 and MSH6 is 1.86.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between RFC4 and MSH6 = 0.89

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismRFC4 OrthologueMSH6 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YJR068W 1 YDR097C 1
worm P53016 1 Q9N3T8 1
fly Q9VX15 1 Q9VUM0 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains No domains were used in calculating likelihood of interaction 8.25E-4
Post-translational Modifications

Protein: RFC4

PTMResidueReference

Protein: MSH6

PTMResidueReference
Phosphorylation 227 PubMed, HPRD
Phosphorylation 252 PubMed, HPRD
Phosphorylation 254 PubMed, HPRD
Phosphorylation 256 PubMed, HPRD
Phosphorylation 261 PubMed, HPRD
Phosphorylation 830 PubMed, HPRD
Phosphoserine 227 HPRD
Phosphoserine 252 HPRD
Phosphoserine 254 HPRD
Phosphoserine 256 HPRD
Phosphoserine 261 HPRD
Phosphoserine 830 HPRD
Localisation

Protein: RFC4

LocalisationReference
Nucleoplasm HPRD

Protein: MSH6

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between RFC4 and MSH6 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RFC4 andMSH6. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RFC4 has 123 interactors and MSH6 has 857 interactors of which there are 48 common interactors.

Common InteractorName of Common InteractorScore for RFC4-Interactor (?)Score for MSH6-Interactor (?)
PCNA PCNA: Proliferating cell nuclear antigen 54.70 73.00
RFC1 N/A 9.26 0.123
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 3.89 0.141
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.612 0.129
LAMR1 RPSA, LAMBR, LAMR1: 40S ribosomal protein SA 0.221 0.040
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.207 0.129
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.207 0.129
MCM3 MCM3: DNA replication licensing factor MCM3 0.207 0.827
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.207 0.276
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.207 0.129
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.123 0.129
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.123 0.066
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.123 0.066
RPA1 RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit 0.0968 1.82
POLR2H POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3 0.0968 0.048
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.0968 0.129
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.0968 0.129
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.083 0.070
SMC4L1 N/A 0.082 0.027
KIAA0101 PAF, KIAA0101, L5, NS5ATP9: PCNA-associated factor 0.082 0.027
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.074 0.040
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.074 0.066
RUVBL2 RUVBL2, TIP48, CGI-46, TIP49B: RuvB-like 2 0.074 0.612
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.074 0.040
FEN1 FEN1, RAD2: Flap endonuclease 1 0.0739 0.0479
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.067 0.087
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.060 0.063
MDN1 MDN1, KIAA0301: Midasin 0.060 0.078
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.059 0.923
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.059 0.078
CSE1L CSE1L, CAS, XPO2: Exportin-2 0.053 0.033
CCNB2 CCNB2: G2/mitotic-specific cyclin-B2 0.051 1.82
CCNB1 Cyclin B1 0.051 6.86
VCP VCP: Transitional endoplasmic reticulum ATPase 0.044 0.032
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.042 1.62
SRPR SRPR: Uncharacterized protein SRPR 0.041 0.027
RFC1 RFC1, RFC140: Replication factor C subunit 1 0.0288 0.051
TPX2 TPX2, C20orf1, C20orf2, DIL2, HCA519: Targeting protein for Xklp2 0.027 0.025
NOLC1 NOLC1, KIAA0035: Nucleolar phosphoprotein p130 0.027 0.053
HMMR HMMR: Hyaluronan-mediated motility receptor 0.027 0.027
C22orf18 N/A 0.027 0.027
RAD51AP1 N/A 0.027 0.027
GMNN GMNN: Geminin 0.027 0.053
ILF2 ILF2, NF45, PRO3063: Interleukin enhancer-binding factor 2 0.027 0.027
SPAG5 SPAG5: Sperm-associated antigen 5 0.027 0.027
DBF4 DBF4, ASK: Protein DBF4 homolog 0.027 0.053
ITGB3BP N/A 0.027 0.027
C21orf45 C21orf45, C21orf46, FASP1: Uncharacterized protein C21orf45 0.027 0.027
0.572
Total Score 1.86