PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between SNRPG and GEMIN5

The interaction score between SNRPG and GEMIN5 is 5.47.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

N/A

Orthology

Organism	SNRPG Orthologue		GEMIN5 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
fly	Q9VXE0	1	Q86BY9	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3

Domains

Domains present in SNRPG and GEMIN5:

Domains in SNRPG

Domains in GEMIN5

IPR001163	Small nuclear ribonucleoprotein (Sm protein)
IPR010920	Small nuclear-like ribonucleoprotein
IPR006649	snRNP domain

IPR001680

G-protein beta WD-40 repeat

The Chi square scores for co-occurrence of domains that are present in SNRPG and GEMIN5 are listed below.

Domain 1		Domain 2		Chi Square
IPR010920	Small nuclear-like ribonucleoprotein	IPR001680	G-protein beta WD-40 repeat	22.3132
IPR006649	snRNP domain	IPR001680	G-protein beta WD-40 repeat	19.3621
IPR001163	Small nuclear ribonucleoprotein (Sm protein)	IPR001680	G-protein beta WD-40 repeat	18.7041

The background colour of the table refers to:

Blue Domain is only present in SNRPG
Yellow Domain is only present in GEMIN5
Green Domain is present in both SNRPG and GEMIN5

0.027

Post-translational Modifications

Protein: SNRPG

PTM	Residue	Reference

Protein: GEMIN5

PTM	Residue	Reference
Phosphorylation	778	PubMed, HPRD
Phosphoserine	778	HPRD

Localisation

Protein: SNRPG

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Protein: GEMIN5

Localisation	Reference
Nucleus	HPRD
Nucleoplasm	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between SNRPG and GEMIN5 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPG andGEMIN5. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPG has 256 interactors and GEMIN5 has 945 interactors of which there are 60 common interactors.

Common Interactor	Name of Common Interactor	Score for SNRPG-Interactor (?)	Score for GEMIN5-Interactor (?)
SNRPD1	SNRPD1: Small nuclear ribonucleoprotein Sm D1	2.07E3	0.148
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	2.07E3	0.148
LSM5	LSM5: U6 snRNA-associated Sm-like protein LSm5	691.00	0.050
LSM4	LSM4: U6 snRNA-associated Sm-like protein LSm4	691.00	0.027
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	32.60	0.047
SNRPE	SNRPE: Small nuclear ribonucleoprotein E	8.73	0.027
SNRPB	SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B'	2.91	0.027
LSM3	LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3	2.60	0.050
LSM8	LSM8: U6 snRNA-associated Sm-like protein LSm8	2.60	0.050
LSM2	LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2	1.22	0.148
SF3B1	SF3B1, SAP155: Splicing factor 3B subunit 1	0.890	0.025
SNRP70	SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa	0.657	0.025
PLK1	PLK1, PLK: Serine/threonine-protein kinase PLK1	0.354	0.025
DDX21	DDX21: Nucleolar RNA helicase 2	0.293	0.052
CDC20	CDC20: Cell division cycle protein 20 homolog	0.263	0.025
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.263	0.047
GNB2L1	Lung cancer oncogene 7	0.137	0.028
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.137	0.052
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.137	0.052
CGI-48	UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho	0.123	0.025
EIF3S2	EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2	0.123	0.025
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.123	0.025
SND1	SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1	0.123	0.025
CHAF1B	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B	0.123	0.025
PAK1IP1	PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1	0.123	0.025
CSTF1	CSTF1: Cleavage stimulation factor 50 kDa subunit	0.123	0.025
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.083	0.052
CORO1C	CORO1C, CRNN4: Coronin-1C	0.074	0.025
SEC31L1	N/A	0.074	0.025
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	0.074	0.047
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.074	0.047
COPB2	COPB2: Coatomer subunit beta'	0.074	0.025
COPA	COPA: Coatomer subunit alpha	0.074	0.025
DDX41	DDX41, ABS: Probable ATP-dependent RNA helicase DDX41	0.074	0.047
BLM	BLM, RECQ2, RECQL3: Bloom syndrome protein	0.074	0.047
WRN	WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase	0.074	0.047
WDR1	N/A	0.067	0.028
WDHD1	WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1	0.060	0.025
REXO2	REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor	0.060	0.025
DHX16	DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN	0.060	0.047
DICER1	DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer	0.044	0.047
ERCC3	ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit	0.044	0.047
SKIV2L	SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti	0.044	0.047
ARPC1B	ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B	0.044	0.025
GNB1	GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.044	0.025
GNB2	GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.044	0.025
DDX5	DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5	0.044	0.047
HIRA	HIRA, DGCR1, HIR, TUPLE1: Protein HIRA	0.044	0.025
SMARCA3	HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor	0.044	0.052
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	0.044	0.025
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.044	0.025
BCDO2	PTS: 6-pyruvoyl tetrahydrobiopterin synthase	0.036	0.025
DDX24	DDX24: ATP-dependent RNA helicase DDX24	0.036	0.047
DDX3Y	DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y	0.036	0.047
NUP214	N/A	0.0308	0.028
BRIP1	BRIP1, BACH1, FANCJ: Fanconi anemia group J protein	0.028	0.052
DYNC1I2	N/A	0.028	0.025
SMARCAD1	SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator	0.027	0.052
TLE3	TLE3, KIAA1547: Transducin-like enhancer protein 3	0.027	0.028
WDR54	N/A	0.027	0.028

0.572

Total Score

5.47