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Evidence of Interaction Between SNRPG and WDR77

The interaction score between SNRPG and WDR77 is 28.2.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SNRPG and WDR77 = 0.78

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology
OrganismSNRPG OrthologueWDR77 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
fly Q9VXE0 1 Q9VIP8 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in SNRPG and WDR77:
Domains in SNRPGDomains in WDR77
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain
IPR001680 G-protein beta WD-40 repeat
IPR011046 WD40-like

The Chi square scores for co-occurrence of domains that are present in SNRPG and WDR77 are listed below.

Domain 1Domain 2Chi Square
IPR010920 Small nuclear-like ribonucleoprotein IPR001680 G-protein beta WD-40 repeat 22.3132
IPR006649 snRNP domain IPR001680 G-protein beta WD-40 repeat 19.3621
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR001680 G-protein beta WD-40 repeat 18.7041
IPR010920 Small nuclear-like ribonucleoprotein IPR011046 WD40-like 13.0624
IPR006649 snRNP domain IPR011046 WD40-like 11.3909
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR011046 WD40-like 11.0178

The background colour of the table refers to:

  • Blue Domain is only present in SNRPG
  • Yellow Domain is only present in WDR77
  • Green Domain is present in both SNRPG and WDR77

 0.027
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: SNRPG

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: WDR77

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between SNRPG and WDR77 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SNRPG andWDR77. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SNRPG has 256 interactors and WDR77 has 118 interactors of which there are 27 common interactors.

Common InteractorName of Common InteractorScore for SNRPG-Interactor (?)Score for WDR77-Interactor (?)
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 2.07E3 0.123
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 2.07E3 0.123
SNRPD2 SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2 691.00 0.263
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 691.00 0.123
LSM4 LSM4: U6 snRNA-associated Sm-like protein LSm4 691.00 0.293
SNRPE SNRPE: Small nuclear ribonucleoprotein E 8.73 0.137
SF3B3 N/A 3.89 0.123
SNRPB SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B' 2.91 0.137
LSM3 LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3 2.60 0.074
LSM7 LSM7: U6 snRNA-associated Sm-like protein LSm7 2.60 0.123
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 2.60 0.123
SNRPF SNRPF, PBSCF: Small nuclear ribonucleoprotein F 2.60 0.263
TXNL4A TXNL4A, DIM1, TXNL4: Thioredoxin-like protein 4A 1.82 0.038
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 1.22 0.263
LSM6 LSM6: U6 snRNA-associated Sm-like protein LSm6 1.22 0.074
LSM1 LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1 1.22 0.044
DDX21 DDX21: Nucleolar RNA helicase 2 0.293 0.0278
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.293 0.0278
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.137 0.0278
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.123 0.053
NUTF2 NUTF2, NTF2: Nuclear transport factor 2 0.0968 0.0968
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.083 0.0278
JMJD2C JMJD2C, GASC1, JHDM3C, KIAA0780: JmjC domain-containing histone demethylation pr 0.060 0.028
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.044 0.038
HSPC185 CGI-117, HSPC111: UPF0384 protein CGI-117 0.027 0.027
PSME3 PSME3: Proteasome activator complex subunit 3 0.027 0.027
BUB3 N/A 0.027 0.027
0.572
Total Score 28.2